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P20902 (CISY_ACIAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.16
Gene names
Name:gltA
OrganismAcinetobacter calcoaceticus subsp. anitratus
Taxonomic identifier107673 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homohexamer.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termAllosteric enzyme
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 424423Citrate synthase
PRO_0000169924

Sites

Active site3071 By similarity
Active site3641 By similarity

Sequences

Sequence LengthMass (Da)Tools
P20902 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 9EF5DA81E9FEB41E

FASTA42447,461
        10         20         30         40         50         60 
MSEATGKKAV LHLDGKEIEL PIYSGTLGPD VIDVKDVLAS GHFTFDPGFM ATASCESKIT 

        70         80         90        100        110        120 
FIDGDKGILL HRGYPIDQLA TQADYLETCY LLLNGELPTA EQKVEFDAKV RAHTMVHDQV 

       130        140        150        160        170        180 
SRFFNGFRRD AHPMAIMVGV VGALSAFYHN NLDIEDINHR EITAIRLIAK IPTLAAWSYK 

       190        200        210        220        230        240 
YTVGQPFIYP RNDLNYAENF LHMMFATPAD RDYKVNPVLA RAMDRIFTLH ADHEQNASTS 

       250        260        270        280        290        300 
TVRLAGSTGA NPYACISAGI SALWGPAHGG ANEAVLKMLD EIGSVENVAE FMEKVKRKEV 

       310        320        330        340        350        360 
KLMGFGHRVY KNFDPRAKVM KQTCDEVLEA LGINDPQLAL AMELERIALN DPYFVERKLY 

       370        380        390        400        410        420 
PNVDFYSGII LKAIGIPTEM FTVIFALART VGWISHWLEM HSGPYKIGRP RQLYTGEVQR 


DIKR 

« Hide

References

[1]"Expression and base sequence of the citrate synthase gene of Acinetobacter anitratum."
Donald L.J., Duckworth H.W.
Biochem. Cell Biol. 65:930-938(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33037 Genomic DNA. Translation: AAA21893.1.
PIRI39506.

3D structure databases

ProteinModelPortalP20902.
SMRP20902. Positions 8-423.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP20902.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_ACIAN
AccessionPrimary (citable) accession number: P20902
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways