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P20901

- CISY_ACEAC

UniProt

P20901 - CISY_ACEAC

Protein

Citrate synthase

Gene

aarA

Organism
Acetobacter aceti
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei313 – 3131PROSITE-ProRule annotation
    Active sitei371 – 3711PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17983.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Alternative name(s):
    Acetic acid resistance protein
    Gene namesi
    Name:aarA
    OrganismiAcetobacter aceti
    Taxonomic identifieri435 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacterAcetobacter subgen. Acetobacter

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Citrate synthasePRO_0000169923Add
    BLAST

    Proteomic databases

    PRIDEiP20901.

    Interactioni

    Subunit structurei

    Homohexamer.

    Structurei

    Secondary structure

    1
    436
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi12 – 176
    Beta strandi20 – 278
    Beta strandi30 – 323
    Beta strandi35 – 373
    Helixi41 – 455
    Beta strandi48 – 503
    Beta strandi57 – 6812
    Turni69 – 724
    Beta strandi73 – 764
    Helixi81 – 877
    Helixi90 – 9910
    Helixi105 – 11612
    Helixi123 – 1253
    Helixi126 – 1294
    Helixi138 – 14912
    Helixi150 – 1523
    Helixi165 – 18824
    Helixi201 – 21010
    Helixi221 – 23414
    Helixi241 – 25010
    Turni251 – 2533
    Helixi256 – 26813
    Turni270 – 2745
    Helixi275 – 28612
    Helixi289 – 2913
    Helixi292 – 3009
    Helixi321 – 33616
    Helixi343 – 35715
    Helixi359 – 3635
    Helixi371 – 38010
    Helixi385 – 3873
    Helixi388 – 40922
    Beta strandi419 – 4224
    Helixi433 – 4353

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2H12X-ray1.85A/B/C/D/E/F1-436[»]
    ProteinModelPortaliP20901.
    SMRiP20901. Positions 11-436.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP20901.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20901-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASQKEGKL STATISVDGK SAEMPVLSGT LGPDVIDIRK LPAQLGVFTF    50
    DPGYGETAAC NSKITFIDGD KGVLLHRGYP IAQLDENASY EEVIYLLLNG 100
    ELPNKVQYDT FTNTLTNHTL LHEQIRNFFN GFRRDAHPMA ILCGTVGALS 150
    AFYPDANDIA IPANRDLAAM RLIAKIPTIA AWAYKYTQGE AFIYPRNDLN 200
    YAENFLSMMF ARMSEPYKVN PVLARAMNRI LILHADHEQN ASTSTVRLAG 250
    STGANPFACI AAGIAALWGP AHGGANEAVL KMLARIGKKE NIPAFIAQVK 300
    DKNSGVKLMG FGHRVYKNFD PRAKIMQQTC HEVLTELGIK DDPLLDLAVE 350
    LEKIALSDDY FVQRKLYPNV DFYSGIILKA MGIPTSMFTV LFAVARTTGW 400
    VSQWKEMIEE PGQRISRPRQ LYIGAPQRDY VPLAKR 436
    Length:436
    Mass (Da):48,197
    Last modified:February 1, 1991 - v1
    Checksum:i3E6F0DD5D4216244
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34830 Genomic DNA. Translation: AAA21883.1.
    PIRiA35157. YKQPC.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34830 Genomic DNA. Translation: AAA21883.1 .
    PIRi A35157. YKQPC.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2H12 X-ray 1.85 A/B/C/D/E/F 1-436 [» ]
    ProteinModelPortali P20901.
    SMRi P20901. Positions 11-436.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P20901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci MetaCyc:MONOMER-17983.

    Miscellaneous databases

    EvolutionaryTracei P20901.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of genes responsible for acetic acid resistance in Acetobacter aceti."
      Fukaya M., Takemura H., Okumura H., Kawamura Y., Horinouchi S., Beppu T.
      J. Bacteriol. 172:2096-2104(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCISY_ACEAC
    AccessioniPrimary (citable) accession number: P20901
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    3D-structure, Allosteric enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3