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P20901

- CISY_ACEAC

UniProt

P20901 - CISY_ACEAC

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Protein
Citrate synthase
Gene
aarA
Organism
Acetobacter aceti
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei313 – 3131 By similarity
Active sitei371 – 3711 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17983.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Alternative name(s):
Acetic acid resistance protein
Gene namesi
Name:aarA
OrganismiAcetobacter aceti
Taxonomic identifieri435 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacterAcetobacter subgen. Acetobacter

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Citrate synthase
PRO_0000169923Add
BLAST

Proteomic databases

PRIDEiP20901.

Interactioni

Subunit structurei

Homohexamer.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 176
Beta strandi20 – 278
Beta strandi30 – 323
Beta strandi35 – 373
Helixi41 – 455
Beta strandi48 – 503
Beta strandi57 – 6812
Turni69 – 724
Beta strandi73 – 764
Helixi81 – 877
Helixi90 – 9910
Helixi105 – 11612
Helixi123 – 1253
Helixi126 – 1294
Helixi138 – 14912
Helixi150 – 1523
Helixi165 – 18824
Helixi201 – 21010
Helixi221 – 23414
Helixi241 – 25010
Turni251 – 2533
Helixi256 – 26813
Turni270 – 2745
Helixi275 – 28612
Helixi289 – 2913
Helixi292 – 3009
Helixi321 – 33616
Helixi343 – 35715
Helixi359 – 3635
Helixi371 – 38010
Helixi385 – 3873
Helixi388 – 40922
Beta strandi419 – 4224
Helixi433 – 4353

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2H12X-ray1.85A/B/C/D/E/F1-436[»]
ProteinModelPortaliP20901.
SMRiP20901. Positions 11-436.

Miscellaneous databases

EvolutionaryTraceiP20901.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20901-1 [UniParc]FASTAAdd to Basket

« Hide

MSASQKEGKL STATISVDGK SAEMPVLSGT LGPDVIDIRK LPAQLGVFTF    50
DPGYGETAAC NSKITFIDGD KGVLLHRGYP IAQLDENASY EEVIYLLLNG 100
ELPNKVQYDT FTNTLTNHTL LHEQIRNFFN GFRRDAHPMA ILCGTVGALS 150
AFYPDANDIA IPANRDLAAM RLIAKIPTIA AWAYKYTQGE AFIYPRNDLN 200
YAENFLSMMF ARMSEPYKVN PVLARAMNRI LILHADHEQN ASTSTVRLAG 250
STGANPFACI AAGIAALWGP AHGGANEAVL KMLARIGKKE NIPAFIAQVK 300
DKNSGVKLMG FGHRVYKNFD PRAKIMQQTC HEVLTELGIK DDPLLDLAVE 350
LEKIALSDDY FVQRKLYPNV DFYSGIILKA MGIPTSMFTV LFAVARTTGW 400
VSQWKEMIEE PGQRISRPRQ LYIGAPQRDY VPLAKR 436
Length:436
Mass (Da):48,197
Last modified:February 1, 1991 - v1
Checksum:i3E6F0DD5D4216244
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34830 Genomic DNA. Translation: AAA21883.1.
PIRiA35157. YKQPC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34830 Genomic DNA. Translation: AAA21883.1 .
PIRi A35157. YKQPC.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2H12 X-ray 1.85 A/B/C/D/E/F 1-436 [» ]
ProteinModelPortali P20901.
SMRi P20901. Positions 11-436.
ModBasei Search...

Proteomic databases

PRIDEi P20901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci MetaCyc:MONOMER-17983.

Miscellaneous databases

EvolutionaryTracei P20901.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of genes responsible for acetic acid resistance in Acetobacter aceti."
    Fukaya M., Takemura H., Okumura H., Kawamura Y., Horinouchi S., Beppu T.
    J. Bacteriol. 172:2096-2104(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCISY_ACEAC
AccessioniPrimary (citable) accession number: P20901
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

3D-structure, Allosteric enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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