ID GDF1_MOUSE Reviewed; 357 AA. AC P20863; Q6AXH1; DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot. DT 27-JUL-2011, sequence version 2. DT 27-MAR-2024, entry version 168. DE RecName: Full=Embryonic growth/differentiation factor 1; DE Short=GDF-1; DE Flags: Precursor; GN Name=Gdf1; Synonyms=Gdf-1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1704486; DOI=10.1210/mend-4-7-1034; RA Lee S.-J.; RT "Identification of a novel member (GDF-1) of the transforming growth RT factor-beta superfamily."; RL Mol. Endocrinol. 4:1034-1040(1990). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2034669; DOI=10.1073/pnas.88.10.4250; RA Lee S.-J.; RT "Expression of growth/differentiation factor 1 in the nervous system: RT conservation of a bicistronic structure."; RL Proc. Natl. Acad. Sci. U.S.A. 88:4250-4254(1991). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May mediate cell differentiation events during embryonic CC development. CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed almost exclusively in the nervous system. CC -!- MISCELLANEOUS: This protein is produced by a bicistronic gene which CC also produces the CERS1 protein from a non-overlapping reading frame. CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M57639; AAA37674.1; -; mRNA. DR EMBL; M62301; AAA37676.1; -; mRNA. DR EMBL; BC079555; AAH79555.1; -; mRNA. DR CCDS; CCDS52571.1; -. DR PIR; A39364; A39364. DR RefSeq; NP_001156754.1; NM_001163282.2. DR RefSeq; NP_032133.2; NM_008107.4. DR AlphaFoldDB; P20863; -. DR SMR; P20863; -. DR STRING; 10090.ENSMUSP00000128325; -. DR GlyCosmos; P20863; 1 site, No reported glycans. DR GlyGen; P20863; 1 site. DR PhosphoSitePlus; P20863; -. DR PaxDb; 10090-ENSMUSP00000045892; -. DR DNASU; 14559; -. DR Ensembl; ENSMUST00000165819.9; ENSMUSP00000128325.3; ENSMUSG00000087408.11. DR Ensembl; ENSMUST00000207684.2; ENSMUSP00000146749.2; ENSMUSG00000109523.2. DR GeneID; 14559; -. DR KEGG; mmu:14559; -. DR UCSC; uc009lzz.4; mouse. DR AGR; MGI:95683; -. DR CTD; 2657; -. DR MGI; MGI:95683; Gdf1. DR VEuPathDB; HostDB:ENSMUSG00000087408; -. DR VEuPathDB; HostDB:ENSMUSG00000109523; -. DR eggNOG; KOG3900; Eukaryota. DR GeneTree; ENSGT00940000162926; -. DR HOGENOM; CLU_020515_4_0_1; -. DR InParanoid; P20863; -. DR OMA; AGHCPEW; -. DR OrthoDB; 2912454at2759; -. DR PhylomeDB; P20863; -. DR TreeFam; TF351789; -. DR BioGRID-ORCS; 14559; 3 hits in 29 CRISPR screens. DR ChiTaRS; Gdf1; mouse. DR PRO; PR:P20863; -. DR Proteomes; UP000000589; Chromosome 8. DR RNAct; P20863; Protein. DR Bgee; ENSMUSG00000087408; Expressed in striatum and 45 other cell types or tissues. DR ExpressionAtlas; P20863; baseline and differential. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0007492; P:endoderm development; IGI:MGI. DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI. DR GO; GO:0007498; P:mesoderm development; IGI:MGI. DR GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; ISO:MGI. DR GO; GO:0007165; P:signal transduction; IMP:MGI. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR001839; TGF-b_C. DR InterPro; IPR015615; TGF-beta-rel. DR InterPro; IPR017948; TGFb_CS. DR PANTHER; PTHR11848:SF151; EMBRYONIC GROWTH_DIFFERENTIATION FACTOR 1; 1. DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1. DR Pfam; PF00019; TGF_beta; 1. DR PRINTS; PR00669; INHIBINA. DR SMART; SM00204; TGFB; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS00250; TGF_BETA_1; 1. DR PROSITE; PS51362; TGF_BETA_2; 1. DR Genevisible; P20863; MM. PE 2: Evidence at transcript level; KW Cleavage on pair of basic residues; Cytokine; Disulfide bond; Glycoprotein; KW Growth factor; Reference proteome; Secreted; Signal. FT SIGNAL 1..23 FT /evidence="ECO:0000255" FT PROPEP 24..237 FT /evidence="ECO:0000255" FT /id="PRO_0000033900" FT CHAIN 238..357 FT /note="Embryonic growth/differentiation factor 1" FT /id="PRO_0000033901" FT CARBOHYD 191 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 251..322 FT /evidence="ECO:0000250" FT DISULFID 280..354 FT /evidence="ECO:0000250" FT DISULFID 284..356 FT /evidence="ECO:0000250" FT DISULFID 321 FT /note="Interchain" FT /evidence="ECO:0000250" FT CONFLICT 145 FT /note="S -> C (in Ref. 1; AAA37674)" FT /evidence="ECO:0000305" SQ SEQUENCE 357 AA; 38660 MW; CF3EA5056F9D6A49 CRC64; MLPVCHRFCD HLLLLLLLPS TTLAPAPASM GPAAALLQVL GLPEAPRSVP THRPVPPVMW RLFRRRDPQE ARVGRPLRPC HVEELGVAGN IVRHIPDSGL SSRPAQPART SGLCPEWTVV FDLSNVEPTE RPTRARLELR LEAESEDTGG WELSVALWAD AEHPGPELLR VPAPPGVLLR ADLLGTAVAA NASVPCTVRL ALSLHPGATA ACGRLAEASL LLVTLDPRLC PLPRLRRHTE PRVEVGPVGT CRTRRLHVSF REVGWHRWVI APRGFLANFC QGTCALPETL RGPGGPPALN HAVLRALMHA AAPTPGAGSP CCVPERLSPI SVLFFDNSDN VVLRHYEDMV VDECGCR //