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P20863 (GDF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Embryonic growth/differentiation factor 1

Short name=GDF-1
Gene names
Name:Gdf1
Synonyms:Gdf-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May mediate cell differentiation events during embryonic development.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed almost exclusively in the nervous system.

Miscellaneous

This protein is produced by a bicistronic gene which also produces the CERS1 protein from a non-overlapping reading frame.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgrowth

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 237214 Potential
PRO_0000033900
Chain238 – 357120Embryonic growth/differentiation factor 1
PRO_0000033901

Amino acid modifications

Glycosylation1911N-linked (GlcNAc...) Potential
Disulfide bond251 ↔ 322 By similarity
Disulfide bond280 ↔ 354 By similarity
Disulfide bond284 ↔ 356 By similarity
Disulfide bond321Interchain By similarity

Experimental info

Sequence conflict1451S → C in AAA37674. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P20863 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: CF3EA5056F9D6A49

FASTA35738,660
        10         20         30         40         50         60 
MLPVCHRFCD HLLLLLLLPS TTLAPAPASM GPAAALLQVL GLPEAPRSVP THRPVPPVMW 

        70         80         90        100        110        120 
RLFRRRDPQE ARVGRPLRPC HVEELGVAGN IVRHIPDSGL SSRPAQPART SGLCPEWTVV 

       130        140        150        160        170        180 
FDLSNVEPTE RPTRARLELR LEAESEDTGG WELSVALWAD AEHPGPELLR VPAPPGVLLR 

       190        200        210        220        230        240 
ADLLGTAVAA NASVPCTVRL ALSLHPGATA ACGRLAEASL LLVTLDPRLC PLPRLRRHTE 

       250        260        270        280        290        300 
PRVEVGPVGT CRTRRLHVSF REVGWHRWVI APRGFLANFC QGTCALPETL RGPGGPPALN 

       310        320        330        340        350 
HAVLRALMHA AAPTPGAGSP CCVPERLSPI SVLFFDNSDN VVLRHYEDMV VDECGCR 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily."
Lee S.-J.
Mol. Endocrinol. 4:1034-1040(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure."
Lee S.-J.
Proc. Natl. Acad. Sci. U.S.A. 88:4250-4254(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57639 mRNA. Translation: AAA37674.1.
M62301 mRNA. Translation: AAA37676.1.
BC079555 mRNA. Translation: AAH79555.1.
CCDSCCDS52571.1.
PIRA39364.
RefSeqNP_001156754.1. NM_001163282.2.
NP_032133.2. NM_008107.4.
UniGeneMm.258280.

3D structure databases

ProteinModelPortalP20863.
SMRP20863. Positions 251-357.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000045892.

Proteomic databases

PRIDEP20863.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046516; ENSMUSP00000045892; ENSMUSG00000055694.
ENSMUST00000165819; ENSMUSP00000128325; ENSMUSG00000055694.
GeneID14559.
KEGGmmu:14559.
UCSCuc009lzz.3. mouse.

Organism-specific databases

CTD2657.
MGIMGI:95683. Gdf1.

Phylogenomic databases

eggNOGNOG255568.
GeneTreeENSGT00730000110209.
HOGENOMHOG000249476.
HOVERGENHBG004860.
InParanoidQ6AXH1.
KOK05495.
OMALRPCHVE.
OrthoDBEOG71CFMF.
TreeFamTF351789.

Enzyme and pathway databases

ReactomeREACT_188576. Developmental Biology.

Gene expression databases

BgeeP20863.
CleanExMM_GDF1.
GenevestigatorP20863.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286254.
PROP20863.
SOURCESearch...

Entry information

Entry nameGDF1_MOUSE
AccessionPrimary (citable) accession number: P20863
Secondary accession number(s): Q6AXH1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot