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P20863

- GDF1_MOUSE

UniProt

P20863 - GDF1_MOUSE

Protein

Embryonic growth/differentiation factor 1

Gene

Gdf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May mediate cell differentiation events during embryonic development.

    GO - Biological processi

    1. growth Source: InterPro

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_220645. Signaling by NODAL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Embryonic growth/differentiation factor 1
    Short name:
    GDF-1
    Gene namesi
    Name:Gdf1
    Synonyms:Gdf-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:95683. Gdf1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 237214Sequence AnalysisPRO_0000033900Add
    BLAST
    Chaini238 – 357120Embryonic growth/differentiation factor 1PRO_0000033901Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi251 ↔ 322By similarity
    Disulfide bondi280 ↔ 354By similarity
    Disulfide bondi284 ↔ 356By similarity
    Disulfide bondi321 – 321InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP20863.

    Expressioni

    Tissue specificityi

    Expressed almost exclusively in the nervous system.

    Gene expression databases

    BgeeiP20863.
    CleanExiMM_GDF1.
    GenevestigatoriP20863.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000045892.

    Structurei

    3D structure databases

    ProteinModelPortaliP20863.
    SMRiP20863. Positions 251-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG255568.
    GeneTreeiENSGT00730000110209.
    HOGENOMiHOG000249476.
    HOVERGENiHBG004860.
    InParanoidiQ6AXH1.
    KOiK05495.
    OMAiLRPCHVE.
    OrthoDBiEOG71CFMF.
    TreeFamiTF351789.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20863-1 [UniParc]FASTAAdd to Basket

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    MLPVCHRFCD HLLLLLLLPS TTLAPAPASM GPAAALLQVL GLPEAPRSVP    50
    THRPVPPVMW RLFRRRDPQE ARVGRPLRPC HVEELGVAGN IVRHIPDSGL 100
    SSRPAQPART SGLCPEWTVV FDLSNVEPTE RPTRARLELR LEAESEDTGG 150
    WELSVALWAD AEHPGPELLR VPAPPGVLLR ADLLGTAVAA NASVPCTVRL 200
    ALSLHPGATA ACGRLAEASL LLVTLDPRLC PLPRLRRHTE PRVEVGPVGT 250
    CRTRRLHVSF REVGWHRWVI APRGFLANFC QGTCALPETL RGPGGPPALN 300
    HAVLRALMHA AAPTPGAGSP CCVPERLSPI SVLFFDNSDN VVLRHYEDMV 350
    VDECGCR 357
    Length:357
    Mass (Da):38,660
    Last modified:July 27, 2011 - v2
    Checksum:iCF3EA5056F9D6A49
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti145 – 1451S → C in AAA37674. (PubMed:1704486)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57639 mRNA. Translation: AAA37674.1.
    M62301 mRNA. Translation: AAA37676.1.
    BC079555 mRNA. Translation: AAH79555.1.
    CCDSiCCDS52571.1.
    PIRiA39364.
    RefSeqiNP_001156754.1. NM_001163282.2.
    NP_032133.2. NM_008107.4.
    UniGeneiMm.258280.

    Genome annotation databases

    EnsembliENSMUST00000046516; ENSMUSP00000045892; ENSMUSG00000055694.
    ENSMUST00000165819; ENSMUSP00000128325; ENSMUSG00000055694.
    GeneIDi14559.
    KEGGimmu:14559.
    UCSCiuc009lzz.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57639 mRNA. Translation: AAA37674.1 .
    M62301 mRNA. Translation: AAA37676.1 .
    BC079555 mRNA. Translation: AAH79555.1 .
    CCDSi CCDS52571.1.
    PIRi A39364.
    RefSeqi NP_001156754.1. NM_001163282.2.
    NP_032133.2. NM_008107.4.
    UniGenei Mm.258280.

    3D structure databases

    ProteinModelPortali P20863.
    SMRi P20863. Positions 251-357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000045892.

    Proteomic databases

    PRIDEi P20863.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046516 ; ENSMUSP00000045892 ; ENSMUSG00000055694 .
    ENSMUST00000165819 ; ENSMUSP00000128325 ; ENSMUSG00000055694 .
    GeneIDi 14559.
    KEGGi mmu:14559.
    UCSCi uc009lzz.3. mouse.

    Organism-specific databases

    CTDi 2657.
    MGIi MGI:95683. Gdf1.

    Phylogenomic databases

    eggNOGi NOG255568.
    GeneTreei ENSGT00730000110209.
    HOGENOMi HOG000249476.
    HOVERGENi HBG004860.
    InParanoidi Q6AXH1.
    KOi K05495.
    OMAi LRPCHVE.
    OrthoDBi EOG71CFMF.
    TreeFami TF351789.

    Enzyme and pathway databases

    Reactomei REACT_220645. Signaling by NODAL.

    Miscellaneous databases

    NextBioi 286254.
    PROi P20863.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20863.
    CleanExi MM_GDF1.
    Genevestigatori P20863.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily."
      Lee S.-J.
      Mol. Endocrinol. 4:1034-1040(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure."
      Lee S.-J.
      Proc. Natl. Acad. Sci. U.S.A. 88:4250-4254(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiGDF1_MOUSE
    AccessioniPrimary (citable) accession number: P20863
    Secondary accession number(s): Q6AXH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is produced by a bicistronic gene which also produces the CERS1 protein from a non-overlapping reading frame.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3