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Protein

Embryonic growth/differentiation factor 1

Gene

Gdf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate cell differentiation events during embryonic development.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiREACT_331083. Signaling by NODAL.
REACT_335233. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Embryonic growth/differentiation factor 1
Short name:
GDF-1
Gene namesi
Name:Gdf1
Synonyms:Gdf-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:95683. Gdf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 237214Sequence AnalysisPRO_0000033900Add
BLAST
Chaini238 – 357120Embryonic growth/differentiation factor 1PRO_0000033901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi251 ↔ 322By similarity
Disulfide bondi280 ↔ 354By similarity
Disulfide bondi284 ↔ 356By similarity
Disulfide bondi321 – 321InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP20863.

Expressioni

Tissue specificityi

Expressed almost exclusively in the nervous system.

Gene expression databases

BgeeiP20863.
CleanExiMM_GDF1.
ExpressionAtlasiP20863. baseline and differential.
GenevestigatoriP20863.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045892.

Structurei

3D structure databases

ProteinModelPortaliP20863.
SMRiP20863. Positions 251-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG255568.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP20863.
KOiK05495.
OMAiGAAWARN.
OrthoDBiEOG71CFMF.
TreeFamiTF351789.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPVCHRFCD HLLLLLLLPS TTLAPAPASM GPAAALLQVL GLPEAPRSVP
60 70 80 90 100
THRPVPPVMW RLFRRRDPQE ARVGRPLRPC HVEELGVAGN IVRHIPDSGL
110 120 130 140 150
SSRPAQPART SGLCPEWTVV FDLSNVEPTE RPTRARLELR LEAESEDTGG
160 170 180 190 200
WELSVALWAD AEHPGPELLR VPAPPGVLLR ADLLGTAVAA NASVPCTVRL
210 220 230 240 250
ALSLHPGATA ACGRLAEASL LLVTLDPRLC PLPRLRRHTE PRVEVGPVGT
260 270 280 290 300
CRTRRLHVSF REVGWHRWVI APRGFLANFC QGTCALPETL RGPGGPPALN
310 320 330 340 350
HAVLRALMHA AAPTPGAGSP CCVPERLSPI SVLFFDNSDN VVLRHYEDMV

VDECGCR
Length:357
Mass (Da):38,660
Last modified:July 27, 2011 - v2
Checksum:iCF3EA5056F9D6A49
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451S → C in AAA37674 (PubMed:1704486).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57639 mRNA. Translation: AAA37674.1.
M62301 mRNA. Translation: AAA37676.1.
BC079555 mRNA. Translation: AAH79555.1.
CCDSiCCDS52571.1.
PIRiA39364.
RefSeqiNP_001156754.1. NM_001163282.2.
NP_032133.2. NM_008107.4.
UniGeneiMm.258280.

Genome annotation databases

EnsembliENSMUST00000046516; ENSMUSP00000045892; ENSMUSG00000055694.
ENSMUST00000165819; ENSMUSP00000128325; ENSMUSG00000087408.
GeneIDi14559.
KEGGimmu:14559.
UCSCiuc009lzz.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57639 mRNA. Translation: AAA37674.1.
M62301 mRNA. Translation: AAA37676.1.
BC079555 mRNA. Translation: AAH79555.1.
CCDSiCCDS52571.1.
PIRiA39364.
RefSeqiNP_001156754.1. NM_001163282.2.
NP_032133.2. NM_008107.4.
UniGeneiMm.258280.

3D structure databases

ProteinModelPortaliP20863.
SMRiP20863. Positions 251-357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045892.

Proteomic databases

PRIDEiP20863.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046516; ENSMUSP00000045892; ENSMUSG00000055694.
ENSMUST00000165819; ENSMUSP00000128325; ENSMUSG00000087408.
GeneIDi14559.
KEGGimmu:14559.
UCSCiuc009lzz.3. mouse.

Organism-specific databases

CTDi2657.
MGIiMGI:95683. Gdf1.

Phylogenomic databases

eggNOGiNOG255568.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP20863.
KOiK05495.
OMAiGAAWARN.
OrthoDBiEOG71CFMF.
TreeFamiTF351789.

Enzyme and pathway databases

ReactomeiREACT_331083. Signaling by NODAL.
REACT_335233. Sphingolipid de novo biosynthesis.

Miscellaneous databases

NextBioi286254.
PROiP20863.
SOURCEiSearch...

Gene expression databases

BgeeiP20863.
CleanExiMM_GDF1.
ExpressionAtlasiP20863. baseline and differential.
GenevestigatoriP20863.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily."
    Lee S.-J.
    Mol. Endocrinol. 4:1034-1040(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure."
    Lee S.-J.
    Proc. Natl. Acad. Sci. U.S.A. 88:4250-4254(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGDF1_MOUSE
AccessioniPrimary (citable) accession number: P20863
Secondary accession number(s): Q6AXH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the CERS1 protein from a non-overlapping reading frame.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.