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P20863

- GDF1_MOUSE

UniProt

P20863 - GDF1_MOUSE

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Protein

Embryonic growth/differentiation factor 1

Gene
Gdf1, Gdf-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May mediate cell differentiation events during embryonic development.

GO - Biological processi

  1. growth Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiREACT_220645. Signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Embryonic growth/differentiation factor 1
Short name:
GDF-1
Gene namesi
Name:Gdf1
Synonyms:Gdf-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:95683. Gdf1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Propeptidei24 – 237214 Reviewed predictionPRO_0000033900Add
BLAST
Chaini238 – 357120Embryonic growth/differentiation factor 1PRO_0000033901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi251 ↔ 322 By similarity
Disulfide bondi280 ↔ 354 By similarity
Disulfide bondi284 ↔ 356 By similarity
Disulfide bondi321 – 321Interchain By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP20863.

Expressioni

Tissue specificityi

Expressed almost exclusively in the nervous system.

Gene expression databases

BgeeiP20863.
CleanExiMM_GDF1.
GenevestigatoriP20863.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045892.

Structurei

3D structure databases

ProteinModelPortaliP20863.
SMRiP20863. Positions 251-357.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG255568.
GeneTreeiENSGT00730000110209.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiQ6AXH1.
KOiK05495.
OMAiLRPCHVE.
OrthoDBiEOG71CFMF.
TreeFamiTF351789.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20863-1 [UniParc]FASTAAdd to Basket

« Hide

MLPVCHRFCD HLLLLLLLPS TTLAPAPASM GPAAALLQVL GLPEAPRSVP    50
THRPVPPVMW RLFRRRDPQE ARVGRPLRPC HVEELGVAGN IVRHIPDSGL 100
SSRPAQPART SGLCPEWTVV FDLSNVEPTE RPTRARLELR LEAESEDTGG 150
WELSVALWAD AEHPGPELLR VPAPPGVLLR ADLLGTAVAA NASVPCTVRL 200
ALSLHPGATA ACGRLAEASL LLVTLDPRLC PLPRLRRHTE PRVEVGPVGT 250
CRTRRLHVSF REVGWHRWVI APRGFLANFC QGTCALPETL RGPGGPPALN 300
HAVLRALMHA AAPTPGAGSP CCVPERLSPI SVLFFDNSDN VVLRHYEDMV 350
VDECGCR 357
Length:357
Mass (Da):38,660
Last modified:July 27, 2011 - v2
Checksum:iCF3EA5056F9D6A49
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451S → C in AAA37674. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57639 mRNA. Translation: AAA37674.1.
M62301 mRNA. Translation: AAA37676.1.
BC079555 mRNA. Translation: AAH79555.1.
CCDSiCCDS52571.1.
PIRiA39364.
RefSeqiNP_001156754.1. NM_001163282.2.
NP_032133.2. NM_008107.4.
UniGeneiMm.258280.

Genome annotation databases

EnsembliENSMUST00000046516; ENSMUSP00000045892; ENSMUSG00000055694.
ENSMUST00000165819; ENSMUSP00000128325; ENSMUSG00000055694.
GeneIDi14559.
KEGGimmu:14559.
UCSCiuc009lzz.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57639 mRNA. Translation: AAA37674.1 .
M62301 mRNA. Translation: AAA37676.1 .
BC079555 mRNA. Translation: AAH79555.1 .
CCDSi CCDS52571.1.
PIRi A39364.
RefSeqi NP_001156754.1. NM_001163282.2.
NP_032133.2. NM_008107.4.
UniGenei Mm.258280.

3D structure databases

ProteinModelPortali P20863.
SMRi P20863. Positions 251-357.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000045892.

Proteomic databases

PRIDEi P20863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046516 ; ENSMUSP00000045892 ; ENSMUSG00000055694 .
ENSMUST00000165819 ; ENSMUSP00000128325 ; ENSMUSG00000055694 .
GeneIDi 14559.
KEGGi mmu:14559.
UCSCi uc009lzz.3. mouse.

Organism-specific databases

CTDi 2657.
MGIi MGI:95683. Gdf1.

Phylogenomic databases

eggNOGi NOG255568.
GeneTreei ENSGT00730000110209.
HOGENOMi HOG000249476.
HOVERGENi HBG004860.
InParanoidi Q6AXH1.
KOi K05495.
OMAi LRPCHVE.
OrthoDBi EOG71CFMF.
TreeFami TF351789.

Enzyme and pathway databases

Reactomei REACT_220645. Signaling by NODAL.

Miscellaneous databases

NextBioi 286254.
PROi P20863.
SOURCEi Search...

Gene expression databases

Bgeei P20863.
CleanExi MM_GDF1.
Genevestigatori P20863.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily."
    Lee S.-J.
    Mol. Endocrinol. 4:1034-1040(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure."
    Lee S.-J.
    Proc. Natl. Acad. Sci. U.S.A. 88:4250-4254(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGDF1_MOUSE
AccessioniPrimary (citable) accession number: P20863
Secondary accession number(s): Q6AXH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the CERS1 protein from a non-overlapping reading frame.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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