Cytochrome P450 2A7 - Homo sapiens (Human)

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P20853 (CP2A7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 124. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome P450 2A7
EC=1.14.14.1

Alternative name(s):
CYPIIA7
Cytochrome P450 IIA4

Gene names

Name:

CYP2A7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Polymorphism
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Traceable author statement PubMed 7864805. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 494

494

Cytochrome P450 2A7

PRO_0000051669

Sites

Metal binding

439

Iron (heme axial ligand) By similarity

Natural variations

Natural variant

F → I.
Corresponds to variant rs10425176 [ dbSNP | Ensembl ].

VAR_047815

Natural variant

C → R.
Corresponds to variant rs10425169 [ dbSNP | Ensembl ].

VAR_047816

Natural variant

169

D → E.
Corresponds to variant rs4142867 [ dbSNP | Ensembl ].

VAR_061043

Natural variant

274

H → R.
Corresponds to variant rs4079366 [ dbSNP | Ensembl ].

VAR_047817

Natural variant

301

A → G.
Corresponds to variant rs2545754 [ dbSNP | Ensembl ].

VAR_047818

Natural variant

311

R → C.
Corresponds to variant rs3869579 [ dbSNP | Ensembl ].

VAR_047819

Natural variant

368

M → T.
Corresponds to variant rs2261144 [ dbSNP | Ensembl ].

VAR_047820

Natural variant

479

V → G. Ref.1
Corresponds to variant rs12460590 [ dbSNP | Ensembl ].

VAR_061044

Experimental info

Sequence conflict

108

D → E in AAB40520. Ref.2

Sequence conflict

163

T → S in AAA52138. Ref.1

Sequence conflict

226

V → L in AAB40520. Ref.2

Sequence conflict

242

Q → L in AAB40520. Ref.2

Sequence conflict

402 – 403

PS → LR in AAB40520. Ref.2

Sequence conflict

409

Q → R in AAB40520. Ref.2

Sequence conflict

418 – 419

DD → GE in AAB40520. Ref.2

Sequence conflict

426

S → R in AAB40520. Ref.2

Sequence conflict

435

G → R in AAB40520. Ref.2

Sequence conflict

438

N → Y in AAA52138. Ref.1

Sequence conflict

475

P → S in AAA52138. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P20853 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 4DA10D0C2714E6AA
Show »

FASTA

494

56,425

        10         20         30         40         50         60 
MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN TEHICDSIMK 

        70         80         90        100        110        120 
FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG RGEQATFDWV FKGYGVAFSN 

       130        140        150        160        170        180 
GERAKQLLRF AIATLRDFGV GKRGIEERIQ EESGFLIEAI RSTHGANIDP TFFLSRTVSN 

       190        200        210        220        230        240 
VISSIVFGDR FDYEDKEFLS LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL 

       250        260        270        280        290        300 
LQGLEDFIAK KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI 

       310        320        330        340        350        360 
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP YMEAVIHEIQ 

       370        380        390        400        410        420 
RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR DPSFFSNPQD FNPQHFLDDK 

       430        440        450        460        470        480 
GQFKKSDAFV PFSIGKRNCF GEGLARMELF LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF 

       490 
ATIPRNYTMS FLPR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes." Yamano S., Tatsuno J., Gonzalez F.J. Biochemistry 29:1322-1329(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-479. Tissue: Liver.
[2]	"A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles." Fernandez-Salguero P., Hoffman S.M., Cholerton S., Mohrenweiser H., Raunio H., Rautio A., Pelkonen O., Huang J.D., Evans W.E., Idle J.R. Am. J. Hum. Genet. 57:651-660(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M33317 mRNA. Translation: AAA52138.1. U22029 mRNA. Translation: AAB40520.1. AC008537 Genomic DNA. No translation available.
IPI	IPI00302839.
PIR	C34271. I38967.
RefSeq	NP_000755.2. NM_000764.2. NP_085079.2. NM_030589.2.
UniGene	Hs.719890.
3D structure databases
ProteinModelPortal	P20853.
ModBase	Search...
PTM databases
PhosphoSite	P20853.
Polymorphism databases
DMDM	215273959.
Proteomic databases
PRIDE	P20853.
Protocols and materials databases
DNASU	1549.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301146; ENSP00000301146; ENSG00000198077.
GeneID	1549.
KEGG	hsa:1549.
UCSC	uc002opm.3. human.
Organism-specific databases
CTD	1549.
GeneCards	GC19M041381.
H-InvDB	HIX0137215.
HGNC	HGNC:2611. CYP2A7.
HPA	CAB033510.
MIM	608054. gene.
neXtProt	NX_P20853.
PharmGKB	PA27102.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000036992.
HOVERGEN	HBG015789.
InParanoid	P20853.
KO	K07411.
PhylomeDB	P20853.
Gene expression databases
ArrayExpress	P20853.
Bgee	P20853.
Genevestigator	P20853.
GermOnline	ENSG00000198077. Homo sapiens.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008067. Cyt_P450_E_grp-I_CYP2A-like. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01684. EP450ICYP2A. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1549.
NextBio	6405.
SOURCE	Search...

Entry information

Entry name

CP2A7_HUMAN

Accession

Primary (citable) accession number: P20853
Secondary accession number(s): Q13121

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 124 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents