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Protein

Cytochrome P450 2A7

Gene

CYP2A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi439Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS09585-MONOMER.
ReactomeiR-HSA-211935. Fatty acids.
R-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2A7 (EC:1.14.14.1)
Alternative name(s):
CYPIIA7
Cytochrome P450 IIA4
Gene namesi
Name:CYP2A7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:2611. CYP2A7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1549.
OpenTargetsiENSG00000198077.
PharmGKBiPA27102.

Polymorphism and mutation databases

BioMutaiCYP2A7.
DMDMi215273959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516691 – 494Cytochrome P450 2A7Add BLAST494

Proteomic databases

PaxDbiP20853.
PeptideAtlasiP20853.
PRIDEiP20853.
TopDownProteomicsiP20853.

PTM databases

iPTMnetiP20853.
PhosphoSitePlusiP20853.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSG00000198077.
ExpressionAtlasiP20853. baseline and differential.
GenevisibleiP20853. HS.

Organism-specific databases

HPAiCAB033510.
HPA046713.
HPA047262.

Interactioni

Protein-protein interaction databases

BioGridi107928. 2 interactors.
STRINGi9606.ENSP00000301146.

Structurei

3D structure databases

ProteinModelPortaliP20853.
SMRiP20853.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP20853.
KOiK17684.
OMAiLNTEHIC.
OrthoDBiEOG091G0BT8.
PhylomeDBiP20853.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN
60 70 80 90 100
TEHICDSIMK FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG
110 120 130 140 150
RGEQATFDWV FKGYGVAFSN GERAKQLLRF AIATLRDFGV GKRGIEERIQ
160 170 180 190 200
EESGFLIEAI RSTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS
210 220 230 240 250
LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL LQGLEDFIAK
260 270 280 290 300
KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI
310 320 330 340 350
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP
360 370 380 390 400
YMEAVIHEIQ RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR
410 420 430 440 450
DPSFFSNPQD FNPQHFLDDK GQFKKSDAFV PFSIGKRNCF GEGLARMELF
460 470 480 490
LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF ATIPRNYTMS FLPR
Length:494
Mass (Da):56,425
Last modified:November 25, 2008 - v2
Checksum:i4DA10D0C2714E6AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108D → E in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti163T → S in AAA52138 (PubMed:2322567).Curated1
Sequence conflicti226V → L in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti242Q → L in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti402 – 403PS → LR in AAB40520 (PubMed:7668294).Curated2
Sequence conflicti409Q → R in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti418 – 419DD → GE in AAB40520 (PubMed:7668294).Curated2
Sequence conflicti426S → R in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti435G → R in AAB40520 (PubMed:7668294).Curated1
Sequence conflicti438N → Y in AAA52138 (PubMed:2322567).Curated1
Sequence conflicti475P → S in AAA52138 (PubMed:2322567).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04781561F → I.Corresponds to variant rs10425176dbSNPEnsembl.1
Natural variantiVAR_04781664C → R.Corresponds to variant rs10425169dbSNPEnsembl.1
Natural variantiVAR_061043169D → E.Corresponds to variant rs4142867dbSNPEnsembl.1
Natural variantiVAR_047817274H → R.Corresponds to variant rs4079366dbSNPEnsembl.1
Natural variantiVAR_047818301A → G.Corresponds to variant rs2545754dbSNPEnsembl.1
Natural variantiVAR_047819311R → C.Corresponds to variant rs3869579dbSNPEnsembl.1
Natural variantiVAR_047820368M → T.Corresponds to variant rs2261144dbSNPEnsembl.1
Natural variantiVAR_061044479V → G.1 PublicationCorresponds to variant rs12460590dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33317 mRNA. Translation: AAA52138.1.
U22029 mRNA. Translation: AAB40520.1.
AC008537 Genomic DNA. No translation available.
CCDSiCCDS12569.1.
PIRiC34271.
I38967.
RefSeqiNP_000755.2. NM_000764.2.
NP_085079.2. NM_030589.2.
UniGeneiHs.719890.

Genome annotation databases

EnsembliENST00000301146; ENSP00000301146; ENSG00000198077.
GeneIDi1549.
KEGGihsa:1549.
UCSCiuc002opm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33317 mRNA. Translation: AAA52138.1.
U22029 mRNA. Translation: AAB40520.1.
AC008537 Genomic DNA. No translation available.
CCDSiCCDS12569.1.
PIRiC34271.
I38967.
RefSeqiNP_000755.2. NM_000764.2.
NP_085079.2. NM_030589.2.
UniGeneiHs.719890.

3D structure databases

ProteinModelPortaliP20853.
SMRiP20853.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107928. 2 interactors.
STRINGi9606.ENSP00000301146.

PTM databases

iPTMnetiP20853.
PhosphoSitePlusiP20853.

Polymorphism and mutation databases

BioMutaiCYP2A7.
DMDMi215273959.

Proteomic databases

PaxDbiP20853.
PeptideAtlasiP20853.
PRIDEiP20853.
TopDownProteomicsiP20853.

Protocols and materials databases

DNASUi1549.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301146; ENSP00000301146; ENSG00000198077.
GeneIDi1549.
KEGGihsa:1549.
UCSCiuc002opm.3. human.

Organism-specific databases

CTDi1549.
DisGeNETi1549.
GeneCardsiCYP2A7.
H-InvDBHIX0137215.
HGNCiHGNC:2611. CYP2A7.
HPAiCAB033510.
HPA046713.
HPA047262.
MIMi608054. gene.
neXtProtiNX_P20853.
OpenTargetsiENSG00000198077.
PharmGKBiPA27102.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP20853.
KOiK17684.
OMAiLNTEHIC.
OrthoDBiEOG091G0BT8.
PhylomeDBiP20853.
TreeFamiTF352043.

Enzyme and pathway databases

BioCyciZFISH:HS09585-MONOMER.
ReactomeiR-HSA-211935. Fatty acids.
R-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.

Miscellaneous databases

GeneWikiiCYP2A7.
GenomeRNAii1549.
PROiP20853.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198077.
ExpressionAtlasiP20853. baseline and differential.
GenevisibleiP20853. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2A7_HUMAN
AccessioniPrimary (citable) accession number: P20853
Secondary accession number(s): Q13121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.