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P20853

- CP2A7_HUMAN

UniProt

P20853 - CP2A7_HUMAN

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Protein

Cytochrome P450 2A7

Gene

CYP2A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi439 – 4391Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. oxygen binding Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13543. Xenobiotics.
REACT_13797. CYP2E1 reactions.
REACT_13814. Fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2A7 (EC:1.14.14.1)
Alternative name(s):
CYPIIA7
Cytochrome P450 IIA4
Gene namesi
Name:CYP2A7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:2611. CYP2A7.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Cytochrome P450 2A7PRO_0000051669Add
BLAST

Proteomic databases

PRIDEiP20853.

PTM databases

PhosphoSiteiP20853.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiP20853.
ExpressionAtlasiP20853. baseline.
GenevestigatoriP20853.

Organism-specific databases

HPAiCAB033510.

Structurei

3D structure databases

ProteinModelPortaliP20853.
SMRiP20853. Positions 31-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP20853.
KOiK17684.
OMAiIPLECIN.
OrthoDBiEOG7RBZ85.
PhylomeDBiP20853.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20853-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN
60 70 80 90 100
TEHICDSIMK FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG
110 120 130 140 150
RGEQATFDWV FKGYGVAFSN GERAKQLLRF AIATLRDFGV GKRGIEERIQ
160 170 180 190 200
EESGFLIEAI RSTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS
210 220 230 240 250
LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL LQGLEDFIAK
260 270 280 290 300
KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI
310 320 330 340 350
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP
360 370 380 390 400
YMEAVIHEIQ RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR
410 420 430 440 450
DPSFFSNPQD FNPQHFLDDK GQFKKSDAFV PFSIGKRNCF GEGLARMELF
460 470 480 490
LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF ATIPRNYTMS FLPR
Length:494
Mass (Da):56,425
Last modified:November 25, 2008 - v2
Checksum:i4DA10D0C2714E6AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081D → E in AAB40520. (PubMed:7668294)Curated
Sequence conflicti163 – 1631T → S in AAA52138. (PubMed:2322567)Curated
Sequence conflicti226 – 2261V → L in AAB40520. (PubMed:7668294)Curated
Sequence conflicti242 – 2421Q → L in AAB40520. (PubMed:7668294)Curated
Sequence conflicti402 – 4032PS → LR in AAB40520. (PubMed:7668294)Curated
Sequence conflicti409 – 4091Q → R in AAB40520. (PubMed:7668294)Curated
Sequence conflicti418 – 4192DD → GE in AAB40520. (PubMed:7668294)Curated
Sequence conflicti426 – 4261S → R in AAB40520. (PubMed:7668294)Curated
Sequence conflicti435 – 4351G → R in AAB40520. (PubMed:7668294)Curated
Sequence conflicti438 – 4381N → Y in AAA52138. (PubMed:2322567)Curated
Sequence conflicti475 – 4751P → S in AAA52138. (PubMed:2322567)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611F → I.
Corresponds to variant rs10425176 [ dbSNP | Ensembl ].
VAR_047815
Natural varianti64 – 641C → R.
Corresponds to variant rs10425169 [ dbSNP | Ensembl ].
VAR_047816
Natural varianti169 – 1691D → E.
Corresponds to variant rs4142867 [ dbSNP | Ensembl ].
VAR_061043
Natural varianti274 – 2741H → R.
Corresponds to variant rs4079366 [ dbSNP | Ensembl ].
VAR_047817
Natural varianti301 – 3011A → G.
Corresponds to variant rs2545754 [ dbSNP | Ensembl ].
VAR_047818
Natural varianti311 – 3111R → C.
Corresponds to variant rs3869579 [ dbSNP | Ensembl ].
VAR_047819
Natural varianti368 – 3681M → T.
Corresponds to variant rs2261144 [ dbSNP | Ensembl ].
VAR_047820
Natural varianti479 – 4791V → G.1 Publication
Corresponds to variant rs12460590 [ dbSNP | Ensembl ].
VAR_061044

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33317 mRNA. Translation: AAA52138.1.
U22029 mRNA. Translation: AAB40520.1.
AC008537 Genomic DNA. No translation available.
CCDSiCCDS12569.1.
PIRiC34271.
I38967.
RefSeqiNP_000755.2. NM_000764.2.
NP_085079.2. NM_030589.2.
UniGeneiHs.719890.

Genome annotation databases

EnsembliENST00000301146; ENSP00000301146; ENSG00000198077.
GeneIDi1549.
KEGGihsa:1549.
UCSCiuc002opm.3. human.

Polymorphism databases

DMDMi215273959.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33317 mRNA. Translation: AAA52138.1 .
U22029 mRNA. Translation: AAB40520.1 .
AC008537 Genomic DNA. No translation available.
CCDSi CCDS12569.1.
PIRi C34271.
I38967.
RefSeqi NP_000755.2. NM_000764.2.
NP_085079.2. NM_030589.2.
UniGenei Hs.719890.

3D structure databases

ProteinModelPortali P20853.
SMRi P20853. Positions 31-494.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P20853.

Polymorphism databases

DMDMi 215273959.

Proteomic databases

PRIDEi P20853.

Protocols and materials databases

DNASUi 1549.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301146 ; ENSP00000301146 ; ENSG00000198077 .
GeneIDi 1549.
KEGGi hsa:1549.
UCSCi uc002opm.3. human.

Organism-specific databases

CTDi 1549.
GeneCardsi GC19M041381.
H-InvDB HIX0137215.
HGNCi HGNC:2611. CYP2A7.
HPAi CAB033510.
MIMi 608054. gene.
neXtProti NX_P20853.
PharmGKBi PA27102.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P20853.
KOi K17684.
OMAi IPLECIN.
OrthoDBi EOG7RBZ85.
PhylomeDBi P20853.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_13543. Xenobiotics.
REACT_13797. CYP2E1 reactions.
REACT_13814. Fatty acids.

Miscellaneous databases

GeneWikii CYP2A7.
GenomeRNAii 1549.
NextBioi 6405.
PROi P20853.
SOURCEi Search...

Gene expression databases

Bgeei P20853.
ExpressionAtlasi P20853. baseline.
Genevestigatori P20853.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes."
    Yamano S., Tatsuno J., Gonzalez F.J.
    Biochemistry 29:1322-1329(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-479.
    Tissue: Liver.
  2. "A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles."
    Fernandez-Salguero P., Hoffman S.M., Cholerton S., Mohrenweiser H., Raunio H., Rautio A., Pelkonen O., Huang J.D., Evans W.E., Idle J.R.
    Am. J. Hum. Genet. 57:651-660(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCP2A7_HUMAN
AccessioniPrimary (citable) accession number: P20853
Secondary accession number(s): Q13121
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 25, 2008
Last modified: November 26, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3