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P20853

- CP2A7_HUMAN

UniProt

P20853 - CP2A7_HUMAN

Protein

Cytochrome P450 2A7

Gene

CYP2A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi439 – 4391Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. oxygen binding Source: ProtInc

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13543. Xenobiotics.
    REACT_13797. CYP2E1 reactions.
    REACT_13814. Fatty acids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2A7 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIA7
    Cytochrome P450 IIA4
    Gene namesi
    Name:CYP2A7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:2611. CYP2A7.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27102.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Cytochrome P450 2A7PRO_0000051669Add
    BLAST

    Proteomic databases

    PRIDEiP20853.

    PTM databases

    PhosphoSiteiP20853.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    BgeeiP20853.
    GenevestigatoriP20853.

    Organism-specific databases

    HPAiCAB033510.

    Structurei

    3D structure databases

    ProteinModelPortaliP20853.
    SMRiP20853. Positions 31-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP20853.
    KOiK17684.
    OMAiIPLECIN.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP20853.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20853-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN    50
    TEHICDSIMK FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG 100
    RGEQATFDWV FKGYGVAFSN GERAKQLLRF AIATLRDFGV GKRGIEERIQ 150
    EESGFLIEAI RSTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS 200
    LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL LQGLEDFIAK 250
    KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI 300
    AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP 350
    YMEAVIHEIQ RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR 400
    DPSFFSNPQD FNPQHFLDDK GQFKKSDAFV PFSIGKRNCF GEGLARMELF 450
    LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF ATIPRNYTMS FLPR 494
    Length:494
    Mass (Da):56,425
    Last modified:November 25, 2008 - v2
    Checksum:i4DA10D0C2714E6AA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti108 – 1081D → E in AAB40520. (PubMed:7668294)Curated
    Sequence conflicti163 – 1631T → S in AAA52138. (PubMed:2322567)Curated
    Sequence conflicti226 – 2261V → L in AAB40520. (PubMed:7668294)Curated
    Sequence conflicti242 – 2421Q → L in AAB40520. (PubMed:7668294)Curated
    Sequence conflicti402 – 4032PS → LR in AAB40520. (PubMed:7668294)Curated
    Sequence conflicti409 – 4091Q → R in AAB40520. (PubMed:7668294)Curated
    Sequence conflicti418 – 4192DD → GE in AAB40520. (PubMed:7668294)Curated
    Sequence conflicti426 – 4261S → R in AAB40520. (PubMed:7668294)Curated
    Sequence conflicti435 – 4351G → R in AAB40520. (PubMed:7668294)Curated
    Sequence conflicti438 – 4381N → Y in AAA52138. (PubMed:2322567)Curated
    Sequence conflicti475 – 4751P → S in AAA52138. (PubMed:2322567)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611F → I.
    Corresponds to variant rs10425176 [ dbSNP | Ensembl ].
    VAR_047815
    Natural varianti64 – 641C → R.
    Corresponds to variant rs10425169 [ dbSNP | Ensembl ].
    VAR_047816
    Natural varianti169 – 1691D → E.
    Corresponds to variant rs4142867 [ dbSNP | Ensembl ].
    VAR_061043
    Natural varianti274 – 2741H → R.
    Corresponds to variant rs4079366 [ dbSNP | Ensembl ].
    VAR_047817
    Natural varianti301 – 3011A → G.
    Corresponds to variant rs2545754 [ dbSNP | Ensembl ].
    VAR_047818
    Natural varianti311 – 3111R → C.
    Corresponds to variant rs3869579 [ dbSNP | Ensembl ].
    VAR_047819
    Natural varianti368 – 3681M → T.
    Corresponds to variant rs2261144 [ dbSNP | Ensembl ].
    VAR_047820
    Natural varianti479 – 4791V → G.1 Publication
    Corresponds to variant rs12460590 [ dbSNP | Ensembl ].
    VAR_061044

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33317 mRNA. Translation: AAA52138.1.
    U22029 mRNA. Translation: AAB40520.1.
    AC008537 Genomic DNA. No translation available.
    CCDSiCCDS12569.1.
    PIRiC34271.
    I38967.
    RefSeqiNP_000755.2. NM_000764.2.
    NP_085079.2. NM_030589.2.
    UniGeneiHs.719890.

    Genome annotation databases

    EnsembliENST00000301146; ENSP00000301146; ENSG00000198077.
    GeneIDi1549.
    KEGGihsa:1549.
    UCSCiuc002opm.3. human.

    Polymorphism databases

    DMDMi215273959.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33317 mRNA. Translation: AAA52138.1 .
    U22029 mRNA. Translation: AAB40520.1 .
    AC008537 Genomic DNA. No translation available.
    CCDSi CCDS12569.1.
    PIRi C34271.
    I38967.
    RefSeqi NP_000755.2. NM_000764.2.
    NP_085079.2. NM_030589.2.
    UniGenei Hs.719890.

    3D structure databases

    ProteinModelPortali P20853.
    SMRi P20853. Positions 31-494.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P20853.

    Polymorphism databases

    DMDMi 215273959.

    Proteomic databases

    PRIDEi P20853.

    Protocols and materials databases

    DNASUi 1549.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301146 ; ENSP00000301146 ; ENSG00000198077 .
    GeneIDi 1549.
    KEGGi hsa:1549.
    UCSCi uc002opm.3. human.

    Organism-specific databases

    CTDi 1549.
    GeneCardsi GC19M041381.
    H-InvDB HIX0137215.
    HGNCi HGNC:2611. CYP2A7.
    HPAi CAB033510.
    MIMi 608054. gene.
    neXtProti NX_P20853.
    PharmGKBi PA27102.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi P20853.
    KOi K17684.
    OMAi IPLECIN.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P20853.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_13543. Xenobiotics.
    REACT_13797. CYP2E1 reactions.
    REACT_13814. Fatty acids.

    Miscellaneous databases

    GeneWikii CYP2A7.
    GenomeRNAii 1549.
    NextBioi 6405.
    PROi P20853.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20853.
    Genevestigatori P20853.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes."
      Yamano S., Tatsuno J., Gonzalez F.J.
      Biochemistry 29:1322-1329(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-479.
      Tissue: Liver.
    2. "A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles."
      Fernandez-Salguero P., Hoffman S.M., Cholerton S., Mohrenweiser H., Raunio H., Rautio A., Pelkonen O., Huang J.D., Evans W.E., Idle J.R.
      Am. J. Hum. Genet. 57:651-660(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCP2A7_HUMAN
    AccessioniPrimary (citable) accession number: P20853
    Secondary accession number(s): Q13121
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3