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P20851

- C4BPB_HUMAN

UniProt

P20851 - C4BPB_HUMAN

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Protein

C4b-binding protein beta chain

Gene

C4BPB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.

GO - Biological processi

  1. blood coagulation Source: ProtInc
  2. complement activation, classical pathway Source: UniProtKB-KW
  3. innate immune response Source: Reactome
  4. negative regulation of complement activation, classical pathway Source: BHF-UCL
  5. positive regulation of protein catabolic process Source: BHF-UCL
  6. regulation of complement activation Source: Reactome
  7. regulation of opsonization Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_118707. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
C4b-binding protein beta chain
Gene namesi
Name:C4BPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1328. C4BPB.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: BHF-UCL
  3. other organism cell Source: ParkinsonsUK-UCL
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Add
BLAST
Chaini18 – 252235C4b-binding protein beta chainPRO_0000005892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 63PROSITE-ProRule annotation
Disulfide bondi49 ↔ 76PROSITE-ProRule annotation
Glycosylationi64 – 641N-linked (GlcNAc...)2 Publications
Glycosylationi71 – 711N-linked (GlcNAc...)1 Publication
Disulfide bondi81 ↔ 121PROSITE-ProRule annotation
Glycosylationi98 – 981N-linked (GlcNAc...)3 Publications
Disulfide bondi107 ↔ 134PROSITE-ProRule annotation
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi139 ↔ 179PROSITE-ProRule annotation
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi165 ↔ 191PROSITE-ProRule annotation
Disulfide bondi202 – 202Interchain (with alpha chain)PROSITE-ProRule annotation
Disulfide bondi216 – 216Interchain (with alpha chain)PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP20851.
PaxDbiP20851.
PRIDEiP20851.

Expressioni

Gene expression databases

BgeeiP20851.
CleanExiHS_C4BPB.
ExpressionAtlasiP20851. baseline and differential.
GenevestigatoriP20851.

Organism-specific databases

HPAiHPA051620.

Interactioni

Subunit structurei

Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at the end.

Protein-protein interaction databases

BioGridi107186. 14 interactions.
STRINGi9606.ENSP00000243611.

Structurei

3D structure databases

ProteinModelPortaliP20851.
SMRiP20851. Positions 40-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 7858Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini79 – 13658Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini137 – 19357Sushi 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG260856.
GeneTreeiENSGT00730000111397.
HOGENOMiHOG000032571.
HOVERGENiHBG004922.
InParanoidiP20851.
KOiK04003.
OMAiILKGSNW.
OrthoDBiEOG7QRQVH.
PhylomeDBiP20851.
TreeFamiTF342864.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00084. Sushi. 3 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50923. SUSHI. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P20851-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFFWCACCLM VAWRVSASDA EHCPELPPVD NSIFVAKEVE GQILGTYVCI
60 70 80 90 100
KGYHLVGKKT LFCNASKEWD NTTTECRLGH CPDPVLVNGE FSSSGPVNVS
110 120 130 140 150
DKITFMCNDH YILKGSNRSQ CLEDHTWAPP FPICKSRDCD PPGNPVHGYF
160 170 180 190 200
EGNNFTLGST ISYYCEDRYY LVGVQEQQCV DGEWSSALPV CKLIQEAPKP
210 220 230 240 250
ECEKALLAFQ ESKNLCEAME NFMQQLKESG MTMEELKYSL ELKKAELKAK

LL
Length:252
Mass (Da):28,357
Last modified:February 1, 1991 - v1
Checksum:i0F6CC64067C5E2E7
GO
Isoform 2 (identifier: P20851-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Missing.

Note: No experimental confirmation available.

Show »
Length:251
Mass (Da):28,286
Checksum:i2BA0722033999AF4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021K → Q.1 Publication
Corresponds to variant rs56258224 [ dbSNP | Ensembl ].
VAR_038734
Natural varianti198 – 1981P → S.
Corresponds to variant rs1803226 [ dbSNP | Ensembl ].
VAR_012039

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 201Missing in isoform 2. 1 PublicationVSP_022594

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11244 mRNA. Translation: AAA35615.1.
L11245 mRNA. Translation: AAA35616.1.
M29964 mRNA. Translation: AAB59520.1.
EF613556 Genomic DNA. Translation: ABQ52216.1.
AL445493 Genomic DNA. Translation: CAH70780.1.
AL445493 Genomic DNA. Translation: CAH70781.1.
CH471100 Genomic DNA. Translation: EAW93504.1.
CH471100 Genomic DNA. Translation: EAW93506.1.
BC005378 mRNA. Translation: AAH05378.1.
CCDSiCCDS1476.1. [P20851-1]
CCDS31005.1. [P20851-2]
PIRiA47107. A34877.
RefSeqiNP_000707.1. NM_000716.3. [P20851-1]
NP_001017364.1. NM_001017364.1. [P20851-2]
NP_001017365.1. NM_001017365.1. [P20851-1]
NP_001017366.1. NM_001017366.1. [P20851-2]
NP_001017367.1. NM_001017367.1. [P20851-1]
XP_005273310.1. XM_005273253.2. [P20851-1]
XP_005273311.1. XM_005273254.2. [P20851-1]
UniGeneiHs.99886.

Genome annotation databases

EnsembliENST00000243611; ENSP00000243611; ENSG00000123843. [P20851-1]
ENST00000367076; ENSP00000356043; ENSG00000123843. [P20851-2]
ENST00000367078; ENSP00000356045; ENSG00000123843. [P20851-1]
ENST00000391923; ENSP00000375790; ENSG00000123843. [P20851-1]
ENST00000451804; ENSP00000405649; ENSG00000123843. [P20851-1]
GeneIDi725.
KEGGihsa:725.
UCSCiuc001hfi.3. human. [P20851-2]
uc001hfj.3. human. [P20851-1]

Polymorphism databases

DMDMi115213.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11244 mRNA. Translation: AAA35615.1 .
L11245 mRNA. Translation: AAA35616.1 .
M29964 mRNA. Translation: AAB59520.1 .
EF613556 Genomic DNA. Translation: ABQ52216.1 .
AL445493 Genomic DNA. Translation: CAH70780.1 .
AL445493 Genomic DNA. Translation: CAH70781.1 .
CH471100 Genomic DNA. Translation: EAW93504.1 .
CH471100 Genomic DNA. Translation: EAW93506.1 .
BC005378 mRNA. Translation: AAH05378.1 .
CCDSi CCDS1476.1. [P20851-1 ]
CCDS31005.1. [P20851-2 ]
PIRi A47107. A34877.
RefSeqi NP_000707.1. NM_000716.3. [P20851-1 ]
NP_001017364.1. NM_001017364.1. [P20851-2 ]
NP_001017365.1. NM_001017365.1. [P20851-1 ]
NP_001017366.1. NM_001017366.1. [P20851-2 ]
NP_001017367.1. NM_001017367.1. [P20851-1 ]
XP_005273310.1. XM_005273253.2. [P20851-1 ]
XP_005273311.1. XM_005273254.2. [P20851-1 ]
UniGenei Hs.99886.

3D structure databases

ProteinModelPortali P20851.
SMRi P20851. Positions 40-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107186. 14 interactions.
STRINGi 9606.ENSP00000243611.

Polymorphism databases

DMDMi 115213.

Proteomic databases

MaxQBi P20851.
PaxDbi P20851.
PRIDEi P20851.

Protocols and materials databases

DNASUi 725.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243611 ; ENSP00000243611 ; ENSG00000123843 . [P20851-1 ]
ENST00000367076 ; ENSP00000356043 ; ENSG00000123843 . [P20851-2 ]
ENST00000367078 ; ENSP00000356045 ; ENSG00000123843 . [P20851-1 ]
ENST00000391923 ; ENSP00000375790 ; ENSG00000123843 . [P20851-1 ]
ENST00000451804 ; ENSP00000405649 ; ENSG00000123843 . [P20851-1 ]
GeneIDi 725.
KEGGi hsa:725.
UCSCi uc001hfi.3. human. [P20851-2 ]
uc001hfj.3. human. [P20851-1 ]

Organism-specific databases

CTDi 725.
GeneCardsi GC01P207262.
HGNCi HGNC:1328. C4BPB.
HPAi HPA051620.
MIMi 120831. gene.
neXtProti NX_P20851.
PharmGKBi PA25908.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG260856.
GeneTreei ENSGT00730000111397.
HOGENOMi HOG000032571.
HOVERGENi HBG004922.
InParanoidi P20851.
KOi K04003.
OMAi ILKGSNW.
OrthoDBi EOG7QRQVH.
PhylomeDBi P20851.
TreeFami TF342864.

Enzyme and pathway databases

Reactomei REACT_118707. Regulation of Complement cascade.

Miscellaneous databases

GenomeRNAii 725.
NextBioi 2944.
PROi P20851.
SOURCEi Search...

Gene expression databases

Bgeei P20851.
CleanExi HS_C4BPB.
ExpressionAtlasi P20851. baseline and differential.
Genevestigatori P20851.

Family and domain databases

InterProi IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00084. Sushi. 3 hits.
[Graphical view ]
SMARTi SM00032. CCP. 3 hits.
[Graphical view ]
SUPFAMi SSF57535. SSF57535. 3 hits.
PROSITEi PS50923. SUSHI. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human C4b-binding protein beta-chain gene."
    Hillarp A., Pardo-Manuel F., Ruiz R., de Cordoba S., Dahlback B.
    J. Biol. Chem. 268:15017-15023(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: sequence homology with the alpha chain."
    Hillarp A., Dahlback B.
    Proc. Natl. Acad. Sci. U.S.A. 87:1183-1187(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. SeattleSNPs variation discovery resource
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-102.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skeletal muscle.
  7. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
    Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
    Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64; ASN-71 AND ASN-98.
    Tissue: Plasma.
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64 AND ASN-98.
    Tissue: Plasma.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-98.
    Tissue: Liver.

Entry informationi

Entry nameiC4BPB_HUMAN
AccessioniPrimary (citable) accession number: P20851
Secondary accession number(s): A5JYP8
, D3DT81, Q5VVR0, Q9BS25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3