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P20848

- A1ATR_HUMAN

UniProt

P20848 - A1ATR_HUMAN

Protein

Putative alpha-1-antitrypsin-related protein

Gene

SERPINA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Putative serine protease inhibitor.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei384 – 3852Reactive bondSequence Analysis

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative alpha-1-antitrypsin-related protein
    Alternative name(s):
    Protease inhibitor 1-like
    Serpin A2
    Gene namesi
    Name:SERPINA2
    Synonyms:ARGS, ATR, PIL, SERPINA2P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:8985. SERPINA2.

    Subcellular locationi

    Endoplasmic reticulum 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. extracellular region Source: RefGenome
    3. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 420399Putative alpha-1-antitrypsin-related proteinPRO_0000032410Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP20848.
    PRIDEiP20848.

    PTM databases

    PhosphoSiteiP20848.

    Expressioni

    Tissue specificityi

    Expressed in the liver, leukocytes and testis. Also detected in brain, colon, uterus, esophagus, spleen, trachea, kidney and lung.2 Publications

    Gene expression databases

    CleanExiHS_ATR.
    GenevestigatoriP20848.

    Interactioni

    Subunit structurei

    Interacts with CANX AND PDIA3.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000238576.

    Structurei

    3D structure databases

    ProteinModelPortaliP20848.
    SMRiP20848. Positions 52-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable By similarity.By similarity

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238521.
    HOVERGENiHBG005957.
    InParanoidiP20848.
    PhylomeDBiP20848.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20848-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPFSVSWGVL LLAGLCCLVP SSLVEDPQGD AAQKTDTSHH DQGDWEDLAC    50
    QKISYNVTDL AFDLYKSWLI YHNQHVLVTP TSVAMAFRML SLGTKADTRT 100
    EILEGLNVNL TETPEAKIHE CFQQVLQALS RPDTRLQLTT GSSLFVNKSM 150
    KLVDTFLEDT KKLYHSEASS INFRDTEEAK EQINNYVEKR TGRKVVDLVK 200
    HLKKDTSLAL VDYISFHGKW KDKFKAERIM VEGFHVDDKT IIRVPMINHL 250
    GRFDIHRDRE LSSWVLAQHY VGNATAFFIL PDPKKMWQLE EKLTYSHLEN 300
    IQRAFDIRSI NLHFPKLSIS GTYKLKRVPR NLGITKIFSN EADLSGVSQE 350
    APLKLSKAVH VAVLTIDEKG TEATGAPHLE EKAWSKYQTV MFNRPFLVII 400
    KEYITNFPLF IGKVVNPTQK 420
    Length:420
    Mass (Da):47,891
    Last modified:February 1, 1991 - v1
    Checksum:i4A5A7B9BE05BCEAA
    GO

    Polymorphismi

    The sequence shown is that of the V3 allele. Other alleles are: V1 and V2.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti329 – 3291P → L in V2. 1 Publication
    VAR_070190
    Natural varianti341 – 3411E → K in V1. 1 Publication
    VAR_070191

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19684, M19685 Genomic DNA. Translation: AAA51544.1.
    PIRiA28882.
    UniGeneiHs.525557.

    Polymorphism databases

    DMDMi112891.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19684 , M19685 Genomic DNA. Translation: AAA51544.1 .
    PIRi A28882.
    UniGenei Hs.525557.

    3D structure databases

    ProteinModelPortali P20848.
    SMRi P20848. Positions 52-420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000238576.

    Protein family/group databases

    MEROPSi I04.952.

    PTM databases

    PhosphoSitei P20848.

    Polymorphism databases

    DMDMi 112891.

    Proteomic databases

    PaxDbi P20848.
    PRIDEi P20848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC14M094831.
    HGNCi HGNC:8985. SERPINA2.
    MIMi 107410. gene.
    neXtProti NX_P20848.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238521.
    HOVERGENi HBG005957.
    InParanoidi P20848.
    PhylomeDBi P20848.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    CleanExi HS_ATR.
    Genevestigatori P20848.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular structure and sequence homology of a gene related to alpha 1-antitrypsin in the human genome."
      Bao J.J., Reed-Fourquet L., Sifers R.N., Kidd V.J., Woo S.L.C.
      Genomics 2:165-173(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular linkage of the human alpha 1-antitrypsin and corticosteroid-binding globulin genes on chromosome 14q32.1."
      Rollini P., Fournier R.E.
      Mamm. Genome 8:913-916(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: POTENTIAL PSEUDOGENE.
    3. "Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2."
      Seixas S., Suriano G., Carvalho F., Seruca R., Rocha J., Di Rienzo A.
      Mol. Biol. Evol. 24:587-598(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    4. Cited for: VARIANT V2 LEU-329, VARIANT V1 LYS-341, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, INTERACTION WITH CANX AND PDIA3.

    Entry informationi

    Entry nameiA1ATR_HUMAN
    AccessioniPrimary (citable) accession number: P20848
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Has been originally thought to be the product of a pseudogene (PubMed:9383284). New lines of evidence suggest it is a truely active gene (PubMed:23826168).2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3