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P20848

- A1ATR_HUMAN

UniProt

P20848 - A1ATR_HUMAN

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Protein

Putative alpha-1-antitrypsin-related protein

Gene
SERPINA2, ARGS, ATR, PIL, SERPINA2P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Putative serine protease inhibitor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei384 – 3852Reactive bond Reviewed prediction

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative alpha-1-antitrypsin-related protein
Alternative name(s):
Protease inhibitor 1-like
Serpin A2
Gene namesi
Synonyms:ARGS, ATR, PIL, SERPINA2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:8985. SERPINA2.

Subcellular locationi

Endoplasmic reticulum 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. extracellular region Source: RefGenome
  3. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 420399Putative alpha-1-antitrypsin-related proteinPRO_0000032410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi147 – 1471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi273 – 2731N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP20848.
PRIDEiP20848.

PTM databases

PhosphoSiteiP20848.

Expressioni

Tissue specificityi

Expressed in the liver, leukocytes and testis. Also detected in brain, colon, uterus, esophagus, spleen, trachea, kidney and lung.2 Publications

Gene expression databases

CleanExiHS_ATR.
GenevestigatoriP20848.

Interactioni

Subunit structurei

Interacts with CANX AND PDIA3.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000238576.

Structurei

3D structure databases

ProteinModelPortaliP20848.
SMRiP20848. Positions 52-420.

Family & Domainsi

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable By similarity.

Sequence similaritiesi

Belongs to the serpin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiP20848.
PhylomeDBiP20848.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20848-1 [UniParc]FASTAAdd to Basket

« Hide

MPFSVSWGVL LLAGLCCLVP SSLVEDPQGD AAQKTDTSHH DQGDWEDLAC    50
QKISYNVTDL AFDLYKSWLI YHNQHVLVTP TSVAMAFRML SLGTKADTRT 100
EILEGLNVNL TETPEAKIHE CFQQVLQALS RPDTRLQLTT GSSLFVNKSM 150
KLVDTFLEDT KKLYHSEASS INFRDTEEAK EQINNYVEKR TGRKVVDLVK 200
HLKKDTSLAL VDYISFHGKW KDKFKAERIM VEGFHVDDKT IIRVPMINHL 250
GRFDIHRDRE LSSWVLAQHY VGNATAFFIL PDPKKMWQLE EKLTYSHLEN 300
IQRAFDIRSI NLHFPKLSIS GTYKLKRVPR NLGITKIFSN EADLSGVSQE 350
APLKLSKAVH VAVLTIDEKG TEATGAPHLE EKAWSKYQTV MFNRPFLVII 400
KEYITNFPLF IGKVVNPTQK 420
Length:420
Mass (Da):47,891
Last modified:February 1, 1991 - v1
Checksum:i4A5A7B9BE05BCEAA
GO

Polymorphismi

The sequence shown is that of the V3 allele. Other alleles are: V1 and V2.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti329 – 3291P → L in V2. 1 Publication
VAR_070190
Natural varianti341 – 3411E → K in V1. 1 Publication
VAR_070191

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19684, M19685 Genomic DNA. Translation: AAA51544.1.
PIRiA28882.
UniGeneiHs.525557.

Polymorphism databases

DMDMi112891.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19684 , M19685 Genomic DNA. Translation: AAA51544.1 .
PIRi A28882.
UniGenei Hs.525557.

3D structure databases

ProteinModelPortali P20848.
SMRi P20848. Positions 52-420.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000238576.

Protein family/group databases

MEROPSi I04.952.

PTM databases

PhosphoSitei P20848.

Polymorphism databases

DMDMi 112891.

Proteomic databases

PaxDbi P20848.
PRIDEi P20848.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC14M094831.
HGNCi HGNC:8985. SERPINA2.
MIMi 107410. gene.
neXtProti NX_P20848.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238521.
HOVERGENi HBG005957.
InParanoidi P20848.
PhylomeDBi P20848.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

CleanExi HS_ATR.
Genevestigatori P20848.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular structure and sequence homology of a gene related to alpha 1-antitrypsin in the human genome."
    Bao J.J., Reed-Fourquet L., Sifers R.N., Kidd V.J., Woo S.L.C.
    Genomics 2:165-173(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular linkage of the human alpha 1-antitrypsin and corticosteroid-binding globulin genes on chromosome 14q32.1."
    Rollini P., Fournier R.E.
    Mamm. Genome 8:913-916(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: POTENTIAL PSEUDOGENE.
  3. "Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2."
    Seixas S., Suriano G., Carvalho F., Seruca R., Rocha J., Di Rienzo A.
    Mol. Biol. Evol. 24:587-598(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  4. Cited for: VARIANT V2 LEU-329, VARIANT V1 LYS-341, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, INTERACTION WITH CANX AND PDIA3.

Entry informationi

Entry nameiA1ATR_HUMAN
AccessioniPrimary (citable) accession number: P20848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 11, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has been originally thought to be the product of a pseudogene (1 Publication). New lines of evidence suggest it is a truely active gene (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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