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P20848 (A1ATR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative alpha-1-antitrypsin-related protein
Alternative name(s):
Protease inhibitor 1-like
Serpin A2
Gene names
Name:SERPINA2
Synonyms:ARGS, ATR, PIL, SERPINA2P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative serine protease inhibitor.

Subunit structure

Interacts with CANX AND PDIA3. Ref.4

Subcellular location

Endoplasmic reticulum Ref.4.

Tissue specificity

Expressed in the liver, leukocytes and testis. Also detected in brain, colon, uterus, esophagus, spleen, trachea, kidney and lung. Ref.3 Ref.4

Domain

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable By similarity.

Post-translational modification

Glycosylated. Ref.4

Polymorphism

The sequence shown is that of the V3 allele. Other alleles are: V1 and V2.

Sequence similarities

Belongs to the serpin family.

Caution

Has been originally thought to be the product of a pseudogene (Ref.2). New lines of evidence suggest it is a truely active gene (Ref.4).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 420399Putative alpha-1-antitrypsin-related protein
PRO_0000032410

Sites

Site384 – 3852Reactive bond Potential

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation1471N-linked (GlcNAc...) Potential
Glycosylation2731N-linked (GlcNAc...) Potential

Natural variations

Natural variant3291P → L in V2. Ref.4
VAR_070190
Natural variant3411E → K in V1. Ref.4
VAR_070191

Sequences

Sequence LengthMass (Da)Tools
P20848 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 4A5A7B9BE05BCEAA

FASTA42047,891
        10         20         30         40         50         60 
MPFSVSWGVL LLAGLCCLVP SSLVEDPQGD AAQKTDTSHH DQGDWEDLAC QKISYNVTDL 

        70         80         90        100        110        120 
AFDLYKSWLI YHNQHVLVTP TSVAMAFRML SLGTKADTRT EILEGLNVNL TETPEAKIHE 

       130        140        150        160        170        180 
CFQQVLQALS RPDTRLQLTT GSSLFVNKSM KLVDTFLEDT KKLYHSEASS INFRDTEEAK 

       190        200        210        220        230        240 
EQINNYVEKR TGRKVVDLVK HLKKDTSLAL VDYISFHGKW KDKFKAERIM VEGFHVDDKT 

       250        260        270        280        290        300 
IIRVPMINHL GRFDIHRDRE LSSWVLAQHY VGNATAFFIL PDPKKMWQLE EKLTYSHLEN 

       310        320        330        340        350        360 
IQRAFDIRSI NLHFPKLSIS GTYKLKRVPR NLGITKIFSN EADLSGVSQE APLKLSKAVH 

       370        380        390        400        410        420 
VAVLTIDEKG TEATGAPHLE EKAWSKYQTV MFNRPFLVII KEYITNFPLF IGKVVNPTQK 

« Hide

References

[1]"Molecular structure and sequence homology of a gene related to alpha 1-antitrypsin in the human genome."
Bao J.J., Reed-Fourquet L., Sifers R.N., Kidd V.J., Woo S.L.C.
Genomics 2:165-173(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular linkage of the human alpha 1-antitrypsin and corticosteroid-binding globulin genes on chromosome 14q32.1."
Rollini P., Fournier R.E.
Mamm. Genome 8:913-916(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: POTENTIAL PSEUDOGENE.
[3]"Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2."
Seixas S., Suriano G., Carvalho F., Seruca R., Rocha J., Di Rienzo A.
Mol. Biol. Evol. 24:587-598(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
[4]"SERPINA2 is a novel gene with a divergent function from SERPINA1."
Marques P.I., Ferreira Z., Martins M., Figueiredo J., Silva D.I., Castro P., Morales-Hojas R., Simoes-Correia J., Seixas S.
PLoS ONE 8:E66889-E66889(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT V2 LEU-329, VARIANT V1 LYS-341, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, INTERACTION WITH CANX AND PDIA3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M19684, M19685 Genomic DNA. Translation: AAA51544.1.
PIRA28882.
UniGeneHs.525557.

3D structure databases

ProteinModelPortalP20848.
SMRP20848. Positions 52-420.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000238576.

Protein family/group databases

MEROPSI04.952.

PTM databases

PhosphoSiteP20848.

Polymorphism databases

DMDM112891.

Proteomic databases

PaxDbP20848.
PRIDEP20848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC14M094831.
HGNCHGNC:8985. SERPINA2.
MIM107410. gene.
neXtProtNX_P20848.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238521.
HOVERGENHBG005957.
InParanoidP20848.
PhylomeDBP20848.

Gene expression databases

CleanExHS_ATR.
GenevestigatorP20848.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameA1ATR_HUMAN
AccessionPrimary (citable) accession number: P20848
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 11, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM