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Protein

Endoglucanase 1

Gene

end1

Organism
Butyrivibrio fibrisolvens
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei189 – 1891Proton donorBy similarity
Active sitei321 – 3211NucleophileBy similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC
  2. polysaccharide binding Source: InterPro

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiCBM2. Carbohydrate-Binding Module Family 2.
GH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase 1 (EC:3.2.1.4)
Alternative name(s):
Cellulase 1
Endo-1,4-beta-glucanase 1
Gene namesi
Name:end1
OrganismiButyrivibrio fibrisolvens
Taxonomic identifieri831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Endoglucanase 1PRO_0000184046Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP20847.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini448 – 547100CBM2Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR018366. CBM2_CS.
IPR001919. Cellulose-bd_dom_fam2_bac.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00553. CBM_2. 1 hit.
PF00150. Cellulase. 1 hit.
[Graphical view]
SMARTiSM00637. CBD_II. 1 hit.
[Graphical view]
SUPFAMiSSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS51173. CBM2. 1 hit.
PS00561. CBM2_A. 1 hit.
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20847-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKSKCIKRV FTFLLALFVF VMAIPATKVS AAGGTDRSAT QVVSDMRVGW
60 70 80 90 100
NIGNSLDSFG QSYNFPYTSL NETYWGNPAT TKALIDEVAK AGFNTIRIPV
110 120 130 140 150
SWGQYTTGSD YQIPDFVMNR VKEVVDYCIV NDMYVILNSH HDINSDYCFY
160 170 180 190 200
VPNNANKDRS EKYFKSIWTQ IAKEFKNYDY HLVFETMNEP RLVGHGEEWW
210 220 230 240 250
FPRNNPSNDI REAVACINDY NQVALDAIRA TGGNNATRCV MVPGYDASIE
260 270 280 290 300
GCMTDGFKMP NDTASGRLIL SVHAYIPYYF ALASDTYVTR FDDNLKYDID
310 320 330 340 350
SFFNDLNSKF LSRNIPVVVG ETSATNRNNT AERVKWADYY WGRAARYSNV
360 370 380 390 400
AMVLWDNNIY QNNSAGSDGE CHMYIDRNSL QWKDPEIIST IMKHVDGTPA
410 420 430 440 450
TINGKEIPST EQPDPTPVDP DPTPVDPDPT PVDPDPTPVD PDPQPVDPTP
460 470 480 490 500
VSGALKAEYT INNWGSGYQV LIKVKNDSAS RVDGWTLKIS KSEVKIDSSW
510 520 530 540
CVNIAEEGGY YVITPMSWNS SLEPSASVDF GIQGSGSIGT SVNISVQ
Length:547
Mass (Da):61,078
Last modified:February 1, 1991 - v1
Checksum:iC62EE40E6442ECF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17538 Genomic DNA. Translation: CAA35574.1.
PIRiJQ0356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17538 Genomic DNA. Translation: CAA35574.1.
PIRiJQ0356.

3D structure databases

ProteinModelPortaliP20847.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM2. Carbohydrate-Binding Module Family 2.
GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR018366. CBM2_CS.
IPR001919. Cellulose-bd_dom_fam2_bac.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00553. CBM_2. 1 hit.
PF00150. Cellulase. 1 hit.
[Graphical view]
SMARTiSM00637. CBD_II. 1 hit.
[Graphical view]
SUPFAMiSSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS51173. CBM2. 1 hit.
PS00561. CBM2_A. 1 hit.
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of an endoglucanase (end1) gene from Butyrivibrio fibrisolvens H17c."
    Berger E., Jones W.A., Jones D.T., Woods D.R.
    Mol. Gen. Genet. 219:193-198(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: H17C.

Entry informationi

Entry nameiGUN1_BUTFI
AccessioniPrimary (citable) accession number: P20847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.