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Protein

Protein L2

Gene

L2R

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Early protein involved in early virion morphogenesis. Participates in the formation and elongation of crescent-shaped membrane precursors of immature virions in cytoplasmic factories (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein L2
Gene namesi
ORF Names:L2R
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008269 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000996171 – 87Protein L2Add BLAST87

Expressioni

Inductioni

Expressed in the early phase of the viral replicative cycle.

Keywords - Developmental stagei

Early protein

Structurei

3D structure databases

SMRiP20843.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chordopoxvirinae L2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG0900023P.

Family and domain databases

InterProiView protein in InterPro
IPR008447. Prot_L2.
PfamiView protein in Pfam
PF05803. Chordopox_L2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD019912. Chordopox_L2. 1 hit.

Sequencei

Sequence statusi: Complete.

P20843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVIADRLDD IVKQNIADEK FVDFVIHGLE HQCPAILRPL IRLFIDILLF
60 70 80
VIVIYIFTVR LVSRNYQMLL ALVALVITLT IFYYFIL
Length:87
Mass (Da):10,225
Last modified:February 1, 1991 - v1
Checksum:iC3BA27F8E59C448E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA. Translation: AAA48077.1.
PIRiI42512.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiL2_VACCC
AccessioniPrimary (citable) accession number: P20843
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 15, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families