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Protein

Retrovirus-related Pol polyprotein from transposon 297

Gene

pol

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei30 – 301For protease activityPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Protein family/group databases

MEROPSiA02.052.

Names & Taxonomyi

Protein namesi
Recommended name:
Retrovirus-related Pol polyprotein from transposon 297
Including the following 3 domains:
Protease (EC:3.4.23.-)
Reverse transcriptase (EC:2.7.7.49)
Endonuclease
Gene namesi
Name:pol
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0027622. 297\pol.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10591059Retrovirus-related Pol polyprotein from transposon 297PRO_0000199556Add
BLAST

Proteomic databases

PRIDEiP20825.

Structurei

3D structure databases

ProteinModelPortaliP20825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini230 – 414185Reverse transcriptasePROSITE-ProRule annotationAdd
BLAST
Domaini812 – 967156Integrase catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 integrase catalytic domain.PROSITE-ProRule annotation
Contains 1 peptidase A2 domain.Curated
Contains 1 reverse transcriptase domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TKRKFSVNSS GKYEYIKIVY KGRSYKCLLD TGSTINMINE NIFCLPIQNS
60 70 80 90 100
RCEVLTSNGP ITLNDLIMLP RNSIFKKTEP FYVHRFSNNY DMLIGRKLLK
110 120 130 140 150
NAQSVINYKN DTVTLFDQTY KLITSESERN QNLYIQRTPE SIASSDQESI
160 170 180 190 200
KKLDFSQFRL DHLNQEETFK LKGLLNKFRN LEYKEGEKLT FTNTIKHVLN
210 220 230 240 250
TTHNSPIYSK QYPLAQTHEI EVENQVQEML NQGLIRESNS PYNSPTWVVP
260 270 280 290 300
KKPDASGANK YRVVIDYRKL NEITIPDRYP IPNMDEILGK LGKCQYFTTI
310 320 330 340 350
DLAKGFHQIE MDEESISKTA FSTKSGHYEY LRMPFGLRNA PATFQRCMNN
360 370 380 390 400
ILRPLLNKHC LVYLDDIIIF STSLTEHLNS IQLVFTKLAD ANLKLQLDKC
410 420 430 440 450
EFLKKEANFL GHIVTPDGIK PNPIKVKAIV SYPIPTKDKE IRAFLGLTGY
460 470 480 490 500
YRKFIPNYAD IAKPMTSCLK KRTKIDTQKL EYIEAFEKLK ALIIRDPILQ
510 520 530 540 550
LPDFEKKFVL TTDASNLALG AVLSQNGHPI SFISRTLNDH ELNYSAIEKE
560 570 580 590 600
LLAIVWATKT FRHYLLGRQF LIASDHQPLR WLHNLKEPGA KLERWRVRLS
610 620 630 640 650
EYQFKIDYIK GKENSVADAL SRIKIEENHH SEATQHSAEE DNSNLIHLTE
660 670 680 690 700
KPINYFKKQI IFIKSDKNKV EHSKIFGNSI TTIQYDVMTL EKAKQILLDH
710 720 730 740 750
FIHRNITIYI ESDVDFEIVQ RAHIEIVNTT YTKVIRSLFL LKNVGSYAEF
760 770 780 790 800
KEIILQSHEK LLHPGIQKMT KLFKENHFFP NSQLLIQNII NECNICNLAK
810 820 830 840 850
TEHRNTKMPL KITPNPEHCR EKFVVDIYSS EGKHYISCID IYSKFATLEQ
860 870 880 890 900
IKTKDWIECR NALMRIFNQL GKPKLLKADR DGAFSSLALK RWLEEEEVEL
910 920 930 940 950
QLNTAKNGVA DVERLHKTIN EKIRIINSSD DEEVKLSKIE TILYTYNQKI
960 970 980 990 1000
KHDTTGQRPA QIFLYAGHPI LDTQKIKEKK IEKINEDRRE FNIDTNYRKG
1010 1020 1030 1040 1050
PLQKGKLENP FKPTKNVEQT DPDHYKITNR NRVTHYYKTQ FKKQKKNNKL

SISQAPGTR
Length:1,059
Mass (Da):123,311
Last modified:February 1, 1991 - v1
Checksum:i3905CF38E914173D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03431 Genomic DNA. Translation: CAB57796.1. Sequence problems.
PIRiB24872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03431 Genomic DNA. Translation: CAB57796.1. Sequence problems.
PIRiB24872.

3D structure databases

ProteinModelPortaliP20825.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA02.052.

Proteomic databases

PRIDEiP20825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0027622. 297\pol.

Miscellaneous databases

PROiP20825.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOL2_DROME
AccessioniPrimary (citable) accession number: P20825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Transposable element

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.