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P20822

- UBX_DROPS

UniProt

P20822 - UBX_DROPS

Protein

Homeotic protein ultrabithorax

Gene

Ubx

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi290 – 34960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeotic protein ultrabithorax
    Gene namesi
    Name:Ubx
    ORF Names:GA10294
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Chromosome 2, UP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0243536. Dpse\Ubx.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385Homeotic protein ultrabithoraxPRO_0000200269Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7237.FBpp0281796.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi243 – 2486Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi33 – 397Poly-Ala
    Compositional biasi107 – 212106Gly-richAdd
    BLAST
    Compositional biasi224 – 2274Poly-Ala
    Compositional biasi362 – 37615Ala-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG252841.
    InParanoidiP20822.
    KOiK09311.
    OrthoDBiEOG7M98H2.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Ia (identifier: P20822-1) [UniParc]FASTAAdd to Basket

    Also known as: Major

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSYFEQASG FYGHPHQATG MAMGSGGHHD QTASAAAAAY RGFPLSLGMS    50
    PYANHHLQRT TQDSPYDASI TAACNKIYGD GASAYKQDCL NIKADAVNGY 100
    KDIWNTGGSN GGGTGGGGGG GGAGGNASNG SNAGNAANGQ NNAAGGMPVR 150
    PSACTPDSRV GGYLDTSGGS PVSHRGGSAG GNVSAGGGGQ SGQSGAPGVG 200
    VGVGVGVGAG AGTAWNANCT ISGAAAAQTA AASSLHQASN HTFYPWMAIA 250
    GKIRSDLTQY GGISTDMGKR YSESLAGSLL PDWLGTNGLR RRGRQTYTRY 300
    QTLELEKEFH TNHYLTRRRR IEMAHALCLT ERQIKIWFQN RRMKLKKEIQ 350
    AIKELNEQEK QAQAQKAAAA AAAAAAVQGG HLDQN 385
    Length:385
    Mass (Da):39,512
    Last modified:December 16, 2008 - v3
    Checksum:i780545118A537517
    GO
    Isoform Ib (identifier: P20822-2) [UniParc]FASTAAdd to Basket

    Also known as: Minor

    The sequence of this isoform differs from the canonical sequence as follows:
         252-259: KIRSDLTQ → ECPEDPTK

    Show »
    Length:385
    Mass (Da):39,470
    Checksum:i4305DA91DB57925F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1231Missing in CAA28814. (PubMed:16453766)Curated
    Sequence conflicti123 – 1231Missing in CAA28815. (PubMed:16453766)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei252 – 2598KIRSDLTQ → ECPEDPTK in isoform Ib. CuratedVSP_036065

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000070 Genomic DNA. Translation: EAL28209.2.
    X05179 Genomic DNA. Translation: CAA28814.1.
    X05179 Genomic DNA. Translation: CAA28815.1.
    U03179 mRNA. Translation: AAA03569.1.
    PIRiA29259.
    RefSeqiXP_001359066.2. XM_001359029.2. [P20822-1]

    Genome annotation databases

    EnsemblMetazoaiFBtr0283358; FBpp0281796; FBgn0243536. [P20822-1]
    GeneIDi4802074.
    KEGGidpo:Dpse_GA10294.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000070 Genomic DNA. Translation: EAL28209.2 .
    X05179 Genomic DNA. Translation: CAA28814.1 .
    X05179 Genomic DNA. Translation: CAA28815.1 .
    U03179 mRNA. Translation: AAA03569.1 .
    PIRi A29259.
    RefSeqi XP_001359066.2. XM_001359029.2. [P20822-1 ]

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0281796.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0283358 ; FBpp0281796 ; FBgn0243536 . [P20822-1 ]
    GeneIDi 4802074.
    KEGGi dpo:Dpse_GA10294.

    Organism-specific databases

    FlyBasei FBgn0243536. Dpse\Ubx.

    Phylogenomic databases

    eggNOGi NOG252841.
    InParanoidi P20822.
    KOi K09311.
    OrthoDBi EOG7M98H2.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.
    2. "Conserved sequence elements in the 5' region of the Ultrabithorax transcription unit."
      Wilde C.D., Akam M.
      EMBO J. 6:1393-1401(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-259, ALTERNATIVE SPLICING (ISOFORMS IA AND IB).
    3. "Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila."
      Bomze H.M., Lopez A.J.
      Genetics 136:965-977(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 222-298 (ISOFORM IA).

    Entry informationi

    Entry nameiUBX_DROPS
    AccessioniPrimary (citable) accession number: P20822
    Secondary accession number(s): Q23833, Q297J6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3