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P20822

- UBX_DROPS

UniProt

P20822 - UBX_DROPS

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Protein

Homeotic protein ultrabithorax

Gene

Ubx

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi290 – 34960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein ultrabithorax
Gene namesi
Name:Ubx
ORF Names:GA10294
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Chromosome 2, UP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0243536. Dpse\Ubx.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Homeotic protein ultrabithoraxPRO_0000200269Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7237.FBpp0281796.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi243 – 2486Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 397Poly-Ala
Compositional biasi107 – 212106Gly-richAdd
BLAST
Compositional biasi224 – 2274Poly-Ala
Compositional biasi362 – 37615Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG252841.
InParanoidiP20822.
KOiK09311.
OrthoDBiEOG7M98H2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Ia (identifier: P20822-1) [UniParc]FASTAAdd to Basket

Also known as: Major

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSYFEQASG FYGHPHQATG MAMGSGGHHD QTASAAAAAY RGFPLSLGMS
60 70 80 90 100
PYANHHLQRT TQDSPYDASI TAACNKIYGD GASAYKQDCL NIKADAVNGY
110 120 130 140 150
KDIWNTGGSN GGGTGGGGGG GGAGGNASNG SNAGNAANGQ NNAAGGMPVR
160 170 180 190 200
PSACTPDSRV GGYLDTSGGS PVSHRGGSAG GNVSAGGGGQ SGQSGAPGVG
210 220 230 240 250
VGVGVGVGAG AGTAWNANCT ISGAAAAQTA AASSLHQASN HTFYPWMAIA
260 270 280 290 300
GKIRSDLTQY GGISTDMGKR YSESLAGSLL PDWLGTNGLR RRGRQTYTRY
310 320 330 340 350
QTLELEKEFH TNHYLTRRRR IEMAHALCLT ERQIKIWFQN RRMKLKKEIQ
360 370 380
AIKELNEQEK QAQAQKAAAA AAAAAAVQGG HLDQN
Length:385
Mass (Da):39,512
Last modified:December 16, 2008 - v3
Checksum:i780545118A537517
GO
Isoform Ib (identifier: P20822-2) [UniParc]FASTAAdd to Basket

Also known as: Minor

The sequence of this isoform differs from the canonical sequence as follows:
     252-259: KIRSDLTQ → ECPEDPTK

Show »
Length:385
Mass (Da):39,470
Checksum:i4305DA91DB57925F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231Missing in CAA28814. (PubMed:16453766)Curated
Sequence conflicti123 – 1231Missing in CAA28815. (PubMed:16453766)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei252 – 2598KIRSDLTQ → ECPEDPTK in isoform Ib. CuratedVSP_036065

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000070 Genomic DNA. Translation: EAL28209.2.
X05179 Genomic DNA. Translation: CAA28814.1.
X05179 Genomic DNA. Translation: CAA28815.1.
U03179 mRNA. Translation: AAA03569.1.
PIRiA29259.
RefSeqiXP_001359066.2. XM_001359029.2. [P20822-1]

Genome annotation databases

EnsemblMetazoaiFBtr0283358; FBpp0281796; FBgn0243536. [P20822-1]
GeneIDi4802074.
KEGGidpo:Dpse_GA10294.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000070 Genomic DNA. Translation: EAL28209.2 .
X05179 Genomic DNA. Translation: CAA28814.1 .
X05179 Genomic DNA. Translation: CAA28815.1 .
U03179 mRNA. Translation: AAA03569.1 .
PIRi A29259.
RefSeqi XP_001359066.2. XM_001359029.2. [P20822-1 ]

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0281796.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0283358 ; FBpp0281796 ; FBgn0243536 . [P20822-1 ]
GeneIDi 4802074.
KEGGi dpo:Dpse_GA10294.

Organism-specific databases

FlyBasei FBgn0243536. Dpse\Ubx.

Phylogenomic databases

eggNOGi NOG252841.
InParanoidi P20822.
KOi K09311.
OrthoDBi EOG7M98H2.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.
  2. "Conserved sequence elements in the 5' region of the Ultrabithorax transcription unit."
    Wilde C.D., Akam M.
    EMBO J. 6:1393-1401(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-259, ALTERNATIVE SPLICING (ISOFORMS IA AND IB).
  3. "Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila."
    Bomze H.M., Lopez A.J.
    Genetics 136:965-977(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 222-298 (ISOFORM IA).

Entry informationi

Entry nameiUBX_DROPS
AccessioniPrimary (citable) accession number: P20822
Secondary accession number(s): Q23833, Q297J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3