P20822 (UBX_DROPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeotic protein ultrabithorax

Gene names

Name:	Ubx
ORF Names:	GA10294

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome]

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › obscura group › pseudoobscura subgroup › Drosophila pseudoobscura

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator Developmental protein Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Traceable author statement PubMed 1673656. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Ia (identifier: P20822-1)

Also known as: Major;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Ib (identifier: P20822-2)

Also known as: Minor;

The sequence of this isoform differs from the canonical sequence as follows:
     252-259: KIRSDLTQ → ECPEDPTK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Homeotic protein ultrabithorax		PRO_0000200269
Regions
	DNA binding	290 – 349	60	Homeobox
	Motif	243 – 248	6	Antp-type hexapeptide
	Compositional bias	33 – 39	7	Poly-Ala
	Compositional bias	107 – 212	106	Gly-rich
	Compositional bias	224 – 227	4	Poly-Ala
	Compositional bias	362 – 376	15	Ala-rich
Natural variations
	Alternative sequence	252 – 259	8	KIRSDLTQ → ECPEDPTK in isoform Ib.		VSP_036065
Experimental info
	Sequence conflict	123	1	Missing in CAA28814. Ref.2
	Sequence conflict	123	1	Missing in CAA28815. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform Ia (Major) [UniParc]. Last modified December 16, 2008. Version 3. Checksum: 780545118A537517	FASTA	385	39,512
	10 20 30 40 50 60 MNSYFEQASG FYGHPHQATG MAMGSGGHHD QTASAAAAAY RGFPLSLGMS PYANHHLQRT 70 80 90 100 110 120 TQDSPYDASI TAACNKIYGD GASAYKQDCL NIKADAVNGY KDIWNTGGSN GGGTGGGGGG 130 140 150 160 170 180 GGAGGNASNG SNAGNAANGQ NNAAGGMPVR PSACTPDSRV GGYLDTSGGS PVSHRGGSAG 190 200 210 220 230 240 GNVSAGGGGQ SGQSGAPGVG VGVGVGVGAG AGTAWNANCT ISGAAAAQTA AASSLHQASN 250 260 270 280 290 300 HTFYPWMAIA GKIRSDLTQY GGISTDMGKR YSESLAGSLL PDWLGTNGLR RRGRQTYTRY 310 320 330 340 350 360 QTLELEKEFH TNHYLTRRRR IEMAHALCLT ERQIKIWFQN RRMKLKKEIQ AIKELNEQEK 370 380 QAQAQKAAAA AAAAAAVQGG HLDQN
	Isoform Ib (Minor) [UniParc]. Checksum: 4305DA91DB57925F	FASTA	385	39,470
	10 20 30 40 50 60 MNSYFEQASG FYGHPHQATG MAMGSGGHHD QTASAAAAAY RGFPLSLGMS PYANHHLQRT 70 80 90 100 110 120 TQDSPYDASI TAACNKIYGD GASAYKQDCL NIKADAVNGY KDIWNTGGSN GGGTGGGGGG 130 140 150 160 170 180 GGAGGNASNG SNAGNAANGQ NNAAGGMPVR PSACTPDSRV GGYLDTSGGS PVSHRGGSAG 190 200 210 220 230 240 GNVSAGGGGQ SGQSGAPGVG VGVGVGVGAG AGTAWNANCT ISGAAAAQTA AASSLHQASN 250 260 270 280 290 300 HTFYPWMAIA GECPEDPTKY GGISTDMGKR YSESLAGSLL PDWLGTNGLR RRGRQTYTRY 310 320 330 340 350 360 QTLELEKEFH TNHYLTRRRR IEMAHALCLT ERQIKIWFQN RRMKLKKEIQ AIKELNEQEK 370 380 QAQAQKAAAA AAAAAAVQGG HLDQN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25 / Tucson 14011-0121.94.
[2]	"Conserved sequence elements in the 5' region of the Ultrabithorax transcription unit." Wilde C.D., Akam M. EMBO J. 6:1393-1401(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-259, ALTERNATIVE SPLICING (ISOFORMS IA AND IB).
[3]	"Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila." Bomze H.M., Lopez A.J. Genetics 136:965-977(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 222-298 (ISOFORM IA).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CM000070 Genomic DNA. Translation: EAL28209.2. X05179 Genomic DNA. Translation: CAA28814.1. X05179 Genomic DNA. Translation: CAA28815.1. U03179 mRNA. Translation: AAA03569.1.
PIR	A29259.
RefSeq	XP_001359066.2. XM_001359029.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	7237.FBpp0281796.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0283358; FBpp0281796; FBgn0243536.
GeneID	4802074.
KEGG	dpo:Dpse_GA10294.
Organism-specific databases
FlyBase	FBgn0243536. Dpse\Ubx.
Phylogenomic databases
eggNOG	NOG252841.
InParanoid	P20822.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBX_DROPS

Accession

Primary (citable) accession number: P20822
Secondary accession number(s): Q23833, Q297J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project