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P20822 (UBX_DROPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Ia (identifier: P20822-1)

Also known as: Major;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Ib (identifier: P20822-2)

Also known as: Minor;

The sequence of this isoform differs from the canonical sequence as follows:
     252-259: KIRSDLTQ → ECPEDPTK

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 385385Homeotic protein ultrabithorax
PRO_0000200269

Regions

DNA binding290 – 34960Homeobox
Motif243 – 2486Antp-type hexapeptide
Compositional bias33 – 397Poly-Ala
Compositional bias107 – 212106Gly-rich
Compositional bias224 – 2274Poly-Ala
Compositional bias362 – 37615Ala-rich

Natural variations

Alternative sequence252 – 2598KIRSDLTQ → ECPEDPTK in isoform Ib.
VSP_036065

Experimental info

Sequence conflict1231Missing in CAA28814. Ref.2
Sequence conflict1231Missing in CAA28815. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform Ia (Major) [UniParc].

Last modified December 16, 2008. Version 3.
Checksum: 780545118A537517

FASTA38539,512
        10         20         30         40         50         60 
MNSYFEQASG FYGHPHQATG MAMGSGGHHD QTASAAAAAY RGFPLSLGMS PYANHHLQRT 

        70         80         90        100        110        120 
TQDSPYDASI TAACNKIYGD GASAYKQDCL NIKADAVNGY KDIWNTGGSN GGGTGGGGGG 

       130        140        150        160        170        180 
GGAGGNASNG SNAGNAANGQ NNAAGGMPVR PSACTPDSRV GGYLDTSGGS PVSHRGGSAG 

       190        200        210        220        230        240 
GNVSAGGGGQ SGQSGAPGVG VGVGVGVGAG AGTAWNANCT ISGAAAAQTA AASSLHQASN 

       250        260        270        280        290        300 
HTFYPWMAIA GKIRSDLTQY GGISTDMGKR YSESLAGSLL PDWLGTNGLR RRGRQTYTRY 

       310        320        330        340        350        360 
QTLELEKEFH TNHYLTRRRR IEMAHALCLT ERQIKIWFQN RRMKLKKEIQ AIKELNEQEK 

       370        380 
QAQAQKAAAA AAAAAAVQGG HLDQN 

« Hide

Isoform Ib (Minor) [UniParc].

Checksum: 4305DA91DB57925F
Show »

FASTA38539,470

References

« Hide 'large scale' references
[1]"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. expand/collapse author list , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MV2-25 / Tucson 14011-0121.94.
[2]"Conserved sequence elements in the 5' region of the Ultrabithorax transcription unit."
Wilde C.D., Akam M.
EMBO J. 6:1393-1401(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-259, ALTERNATIVE SPLICING (ISOFORMS IA AND IB).
[3]"Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila."
Bomze H.M., Lopez A.J.
Genetics 136:965-977(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 222-298 (ISOFORM IA).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000070 Genomic DNA. Translation: EAL28209.2.
X05179 Genomic DNA. Translation: CAA28814.1.
X05179 Genomic DNA. Translation: CAA28815.1.
U03179 mRNA. Translation: AAA03569.1.
PIRA29259.
RefSeqXP_001359066.2. XM_001359029.2. [P20822-1]

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7237.FBpp0281796.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0283358; FBpp0281796; FBgn0243536. [P20822-1]
GeneID4802074.
KEGGdpo:Dpse_GA10294.

Organism-specific databases

FlyBaseFBgn0243536. Dpse\Ubx.

Phylogenomic databases

eggNOGNOG252841.
InParanoidP20822.
KOK09311.
OrthoDBEOG7M98H2.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBX_DROPS
AccessionPrimary (citable) accession number: P20822
Secondary accession number(s): Q23833, Q297J6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase