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P20815

- CP3A5_HUMAN

UniProt

P20815 - CP3A5_HUMAN

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Protein
Cytochrome P450 3A5
Gene
CYP3A5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi441 – 4411Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
  5. oxidoreductase activity Source: BHF-UCL
  6. oxygen binding Source: ProtInc

GO - Biological processi

  1. alkaloid catabolic process Source: BHF-UCL
  2. drug catabolic process Source: BHF-UCL
  3. oxidative demethylation Source: BHF-UCL
  4. small molecule metabolic process Source: Reactome
  5. steroid metabolic process Source: ProtInc
  6. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13543. Xenobiotics.
SABIO-RKP20815.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A5 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA5
Cytochrome P450 HLp2
Cytochrome P450-PCN3
Gene namesi
Name:CYP3A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:2638. CYP3A5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. intracellular membrane-bounded organelle Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

Orphaneti240945. Resistance to tacrolimus in transplantation.
241043. Tacrolimus dose selection in transplantation.
PharmGKBiPA131.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Cytochrome P450 3A5
PRO_0000051787Add
BLAST

Proteomic databases

PaxDbiP20815.
PRIDEiP20815.

PTM databases

PhosphoSiteiP20815.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

ArrayExpressiP20815.
BgeeiP20815.
CleanExiHS_CYP3A5.
GenevestigatoriP20815.

Interactioni

Protein-protein interaction databases

BioGridi107949. 3 interactions.
IntActiP20815. 4 interactions.
STRINGi9606.ENSP00000222982.

Structurei

3D structure databases

ProteinModelPortaliP20815.
SMRiP20815. Positions 30-495.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000082412.
HOVERGENiHBG108567.
InParanoidiP20815.
KOiK17690.
OMAiPKDTINF.
OrthoDBiEOG744TBS.
PhylomeDBiP20815.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P20815-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDLIPNLAVE TWLLLAVSLV LLYLYGTRTH GLFKRLGIPG PTPLPLLGNV    50
LSYRQGLWKF DTECYKKYGK MWGTYEGQLP VLAITDPDVI RTVLVKECYS 100
VFTNRRSLGP VGFMKSAISL AEDEEWKRIR SLLSPTFTSG KLKEMFPIIA 150
QYGDVLVRNL RREAEKGKPV TLKDIFGAYS MDVITGTSFG VNIDSLNNPQ 200
DPFVESTKKF LKFGFLDPLF LSIILFPFLT PVFEALNVSL FPKDTINFLS 250
KSVNRMKKSR LNDKQKHRLD FLQLMIDSQN SKETESHKAL SDLELAAQSI 300
IFIFAGYETT SSVLSFTLYE LATHPDVQQK LQKEIDAVLP NKAPPTYDAV 350
VQMEYLDMVV NETLRLFPVA IRLERTCKKD VEINGVFIPK GSMVVIPTYA 400
LHHDPKYWTE PEEFRPERFS KKKDSIDPYI YTPFGTGPRN CIGMRFALMN 450
MKLALIRVLQ NFSFKPCKET QIPLKLDTQG LLQPEKPIVL KVDSRDGTLS 500
GE 502
Length:502
Mass (Da):57,109
Last modified:February 1, 1991 - v1
Checksum:iD5A2302E2633E717
GO
Isoform 2 (identifier: P20815-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-140: SLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG → ICATTSTIKMQTHSVTMWLPPAVLQSQHGVCLFL
     141-502: Missing.

Note: No experimental confirmation available.

Show »
Length:140
Mass (Da):15,846
Checksum:iF40CE9C9DAE2CAC3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281R → C in allele CYP3A5*8. 1 Publication
Corresponds to variant rs55817950 [ dbSNP | Ensembl ].
VAR_024731
Natural varianti30 – 301H → Y.1 Publication
Corresponds to variant rs28383468 [ dbSNP | Ensembl ].
VAR_024728
Natural varianti200 – 2001Q → R in allele CYP3A5*4. 1 Publication
Corresponds to variant rs56411402 [ dbSNP | Ensembl ].
VAR_024732
Natural varianti277 – 2771D → E.1 Publication
Corresponds to variant rs28383477 [ dbSNP | Ensembl ].
VAR_024729
Natural varianti337 – 3371A → T in allele CYP3A5*9. 2 Publications
Corresponds to variant rs28383479 [ dbSNP | Ensembl ].
VAR_024730
Natural varianti371 – 3711I → V.
Corresponds to variant rs28365092 [ dbSNP | Ensembl ].
VAR_029161
Natural varianti398 – 3981T → N in allele CYP3A5*2. 2 Publications
Corresponds to variant rs28365083 [ dbSNP | Ensembl ].
VAR_008365
Natural varianti446 – 4461F → S.1 Publication
Corresponds to variant rs41279854 [ dbSNP | Ensembl ].
VAR_024733
Natural varianti488 – 4881I → T.
Corresponds to variant rs28365085 [ dbSNP | Ensembl ].
VAR_029162

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei107 – 14034SLGPV…TFTSG → ICATTSTIKMQTHSVTMWLP PAVLQSQHGVCLFL in isoform 2.
VSP_042734Add
BLAST
Alternative sequencei141 – 502362Missing in isoform 2.
VSP_042735Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti305 – 3051A → P no nucleotide entry 1 Publication
Sequence conflicti318 – 3181L → F no nucleotide entry 1 Publication
Sequence conflicti324 – 3241H → D no nucleotide entry 1 Publication
Sequence conflicti377 – 3771C → G no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04813 mRNA. Translation: AAA02993.1.
AK299002 mRNA. Translation: BAH12923.1.
AC005020 Genomic DNA. Translation: AAS02016.1.
CH236956 Genomic DNA. Translation: EAL23868.1.
CH471091 Genomic DNA. Translation: EAW76638.1.
CH471091 Genomic DNA. Translation: EAW76642.1.
BC033862 mRNA. Translation: AAH33862.1.
AF280107 Genomic DNA. Translation: AAG32288.1.
L35912 Genomic DNA. Translation: AAB00083.1.
S74699 Genomic DNA. Translation: AAD14157.1.
S74700 Genomic DNA. Translation: AAD14158.1.
CCDSiCCDS55134.1. [P20815-2]
CCDS5672.1. [P20815-1]
PIRiA34101.
A60558.
RefSeqiNP_000768.1. NM_000777.4. [P20815-1]
NP_001177413.1. NM_001190484.2. [P20815-2]
UniGeneiHs.571258.

Genome annotation databases

EnsembliENST00000222982; ENSP00000222982; ENSG00000106258. [P20815-1]
ENST00000439761; ENSP00000401269; ENSG00000106258. [P20815-2]
GeneIDi1577.
KEGGihsa:1577.
UCSCiuc003urq.3. human. [P20815-1]
uc003urt.3. human. [P20815-2]

Polymorphism databases

DMDMi117157.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP3A5 alleles

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04813 mRNA. Translation: AAA02993.1 .
AK299002 mRNA. Translation: BAH12923.1 .
AC005020 Genomic DNA. Translation: AAS02016.1 .
CH236956 Genomic DNA. Translation: EAL23868.1 .
CH471091 Genomic DNA. Translation: EAW76638.1 .
CH471091 Genomic DNA. Translation: EAW76642.1 .
BC033862 mRNA. Translation: AAH33862.1 .
AF280107 Genomic DNA. Translation: AAG32288.1 .
L35912 Genomic DNA. Translation: AAB00083.1 .
S74699 Genomic DNA. Translation: AAD14157.1 .
S74700 Genomic DNA. Translation: AAD14158.1 .
CCDSi CCDS55134.1. [P20815-2 ]
CCDS5672.1. [P20815-1 ]
PIRi A34101.
A60558.
RefSeqi NP_000768.1. NM_000777.4. [P20815-1 ]
NP_001177413.1. NM_001190484.2. [P20815-2 ]
UniGenei Hs.571258.

3D structure databases

ProteinModelPortali P20815.
SMRi P20815. Positions 30-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107949. 3 interactions.
IntActi P20815. 4 interactions.
STRINGi 9606.ENSP00000222982.

Chemistry

BindingDBi P20815.
ChEMBLi CHEMBL2111472.
DrugBanki DB00802. Alfentanil.
DB00758. Clopidogrel.
DB00091. Cyclosporine.
DB00694. Daunorubicin.
DB00224. Indinavir.
DB00762. Irinotecan.
DB01026. Ketoconazole.
DB01259. Lapatinib.
DB00532. Mephenytoin.
DB00683. Midazolam.
DB00834. Mifepristone.
DB00252. Phenytoin.
DB00468. Quinine.
DB01232. Saquinavir.
DB00864. Tacrolimus.
DB01361. Troleandomycin.
DB00661. Verapamil.
DB00541. Vincristine.

PTM databases

PhosphoSitei P20815.

Polymorphism databases

DMDMi 117157.

Proteomic databases

PaxDbi P20815.
PRIDEi P20815.

Protocols and materials databases

DNASUi 1577.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222982 ; ENSP00000222982 ; ENSG00000106258 . [P20815-1 ]
ENST00000439761 ; ENSP00000401269 ; ENSG00000106258 . [P20815-2 ]
GeneIDi 1577.
KEGGi hsa:1577.
UCSCi uc003urq.3. human. [P20815-1 ]
uc003urt.3. human. [P20815-2 ]

Organism-specific databases

CTDi 1577.
GeneCardsi GC07M099246.
HGNCi HGNC:2638. CYP3A5.
MIMi 605325. gene.
neXtProti NX_P20815.
Orphaneti 240945. Resistance to tacrolimus in transplantation.
241043. Tacrolimus dose selection in transplantation.
PharmGKBi PA131.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000082412.
HOVERGENi HBG108567.
InParanoidi P20815.
KOi K17690.
OMAi PKDTINF.
OrthoDBi EOG744TBS.
PhylomeDBi P20815.
TreeFami TF105087.

Enzyme and pathway databases

Reactomei REACT_13543. Xenobiotics.
SABIO-RK P20815.

Miscellaneous databases

GeneWikii CYP3A5.
GenomeRNAii 1577.
NextBioi 6479.
PROi P20815.
SOURCEi Search...

Gene expression databases

ArrayExpressi P20815.
Bgeei P20815.
CleanExi HS_CYP3A5.
Genevestigatori P20815.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine."
    Aoyama T., Yamano S., Waxman D.J., Lapenson D.P., Meyer U.A., Fischer V., Tyndale R., Inaba T., Kalow W., Gelboin H.V., Gonzalez F.J.
    J. Biol. Chem. 264:10388-10395(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver."
    Schuetz J.D., Molowa D.T., Guzelian P.S.
    Arch. Biochem. Biophys. 274:355-365(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
    Tissue: Liver.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-106.
  9. "Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells."
    Schuetz J.D., Schuetz E.G., Thottassery J.V., Guzelian P.S., Strom S., Sun D.
    Mol. Pharmacol. 49:63-72(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24.
  10. "Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7."
    Jounaidi Y., Guzelian P.S., Maurel P., Vilarem M.J.
    Biochem. Biophys. Res. Commun. 205:1741-1747(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24.
  11. "Intergenic mRNA molecules resulting from trans-splicing."
    Finta C., Zaphiropoulos P.G.
    J. Biol. Chem. 277:5882-5890(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANS-SPLICING.
  12. "Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?"
    Jounaidi Y., Hyrailles V., Gervot L., Maurel P.
    Biochem. Biophys. Res. Commun. 221:466-470(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP3A5*2 ASN-398.
  13. "Genetic polymorphism of cytochrome P450 3A5 in Chinese."
    Chou F.C., Tzeng S.J., Huang J.D.
    Drug Metab. Dispos. 29:1205-1209(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP3A5*4 ARG-200.
  14. "Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups."
    Lee S.J., Usmani K.A., Chanas B., Ghanayem B., Xi T., Hodgson E., Mohrenweiser H.W., Goldstein J.A.
    Pharmacogenetics 13:461-472(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYS-28; THR-337 AND SER-446.
  15. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
    Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
    Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TYR-30; GLU-277; THR-337 AND ASN-398.

Entry informationi

Entry nameiCP3A5_HUMAN
AccessioniPrimary (citable) accession number: P20815
Secondary accession number(s): A4D289
, B7Z5I7, Q53WY8, Q75MV0, Q9HB56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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