true1991-02-012024-03-27162CP2A3_RATComplete sequence of the rat CYP2A3 gene specifically transcribed in lung.Ueno T.Gonzalez F.doi:10.1093/nar/18.15.46231990Nucleic Acids Res.184623-4624NUCLEOTIDE SEQUENCE [GENOMIC DNA]Sprague-DawleyLungIdentification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene.Kimura S.Kozak C.A.Gonzalez F.J.doi:10.1021/bi00435a0261989Biochemistry283798-3803NUCLEOTIDE SEQUENCE [MRNA] OF 8-494A32030ratCyp2a3EukaryotaFatty acidsXenobioticsCYP2E1 reactionsCYP2ACytochrome P450Cyt_P450Cyt_P450_CSCyt_P450_E_grp-ICyt_P450_E_grp-I_CYP2A-likeCyt_P450_sfCYTOCHROME P450 2A13CYTOCHROME P450 508A4-RELATEDp450EP450IEP450ICYP2AP450Cytochrome P450CYTOCHROME_P450Cytochrome P450 2A31.14.14.1CYPIIA3Coumarin 7-hydroxylaseCyp2a3Cyp2a-3Cyp2a3aCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Lung.By 3-methylcholanthrene (3MC).Belongs to the cytochrome P450 family.Cytochrome P450 2A3565101494axial binding residue439Phosphoserine131N6-acetyllysine379G109N3351991-02-01156510f4e40ffa2450af60761db11d28806353MLASGLLLVASVAFLSVLVLMSVWKQRKLSGKLPPGPTPLPFIGNYLQLNTEKMYSSLMKISQRYGPVFTIHLGPRRVVVLCGQEAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSSGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIESFRKTNGALIDPTFYLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFITKKVEQNQRTLDPNSPRDFIDSFLIRMLEEKKNPNTEFYMKNLVLTTLNLFFAGTETVSTTLRYGFLLLMKHPDIEAKVHEEIDRVIGRNRQAKYEDRMKMPYTEAVIHEIQRFADMIPMGLARRVTKDTKFREFLLPKGTEVFPMLGSVLKDPKFFSNPNDFNPKHFLDDKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFLTNIMQNFCFKSPQAPQDIDVSPRLVGFATIPPNYTMSFLSRtruetruetruetruetruetruetrue