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Protein

Calpastatin

Gene

CAST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
  • endopeptidase inhibitor activity Source: ProtInc
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • negative regulation of type B pancreatic cell apoptotic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153113-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.

Protein family/group databases

MEROPSiI27.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpastatin
Alternative name(s):
Calpain inhibitor
Sperm BS-17 component
Gene namesi
Name:CAST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1515. CAST.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: HPA
  • cytosol Source: BHF-UCL
  • endoplasmic reticulum Source: HPA
  • membrane Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by generalized, continuous shedding of the outer layers of the epidermis, leukonychia, acral punctate keratosis, cheilitis, knuckle pads with multiple hyperkeratotic micropapules involving the interphalangeal joints, and palmoplantar keratoderma.
See also OMIM:616295

Keywords - Diseasei

Palmoplantar keratoderma

Organism-specific databases

DisGeNETi831.
MIMi616295. phenotype.
OpenTargetsiENSG00000153113.
PharmGKBiPA26098.

Polymorphism and mutation databases

BioMutaiCAST.
DMDMi126302556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476321 – 708CalpastatinAdd BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei50N6-acetyllysineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei133PhosphoserineCombined sources1
Modified residuei135PhosphothreonineBy similarity1
Modified residuei222PhosphoserineBy similarity1
Modified residuei243PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei563PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Isoform 5 (identifier: P20810-5)
Modified residuei11PhosphoserineCombined sources1
Isoform 6 (identifier: P20810-6)
Modified residuei11PhosphoserineCombined sources1
Isoform 7 (identifier: P20810-7)
Modified residuei11PhosphoserineCombined sources1
Isoform 9 (identifier: P20810-9)
Modified residuei11PhosphoserineCombined sources1
Isoform 10 (identifier: P20810-10)
Modified residuei11PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP20810.
PeptideAtlasiP20810.
PRIDEiP20810.
TopDownProteomicsiP20810-5. [P20810-5]

PTM databases

iPTMnetiP20810.
PhosphoSitePlusiP20810.

Expressioni

Gene expression databases

BgeeiENSG00000153113.
CleanExiHS_CAST.
ExpressionAtlasiP20810. baseline and differential.
GenevisibleiP20810. HS.

Organism-specific databases

HPAiCAB009491.
HPA036881.
HPA036882.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9Z3052EBI-1268770,EBI-9084208From a different organism.
NCK1P163332EBI-1268770,EBI-389883

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi107281. 30 interactors.
IntActiP20810. 13 interactors.

Structurei

3D structure databases

DisProtiDP00196.
ProteinModelPortaliP20810.
SMRiP20810.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati170 – 222Inhibitory domain 1Add BLAST53
Repeati304 – 356Inhibitory domain 2Add BLAST53
Repeati446 – 499Inhibitory domain 3Add BLAST54
Repeati583 – 636Inhibitory domain 4Add BLAST54

Domaini

Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000002993.
HOGENOMiHOG000082405.
HOVERGENiHBG000183.
InParanoidiP20810.
KOiK04281.
OMAiKSSSMNP.
OrthoDBiEOG091G0553.
PhylomeDBiP20810.
TreeFamiTF332525.

Family and domain databases

InterProiIPR026998. Calpastatin.
IPR001259. Prot_inh_calpain.
[Graphical view]
PANTHERiPTHR10077. PTHR10077. 1 hit.
PfamiPF00748. Calpain_inhib. 4 hits.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P20810-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPTETKAIP VSQQMEGPHL PNKKKHKKQA VKTEPEKKSQ STKLSVVHEK
60 70 80 90 100
KSQEGKPKEH TEPKSLPKQA SDTGSNDAHN KKAVSRSAEQ QPSEKSTEPK
110 120 130 140 150
TKPQDMISAG GESVAGITAI SGKPGDKKKE KKSLTPAVPV ESKPDKPSGK
160 170 180 190 200
SGMDAALDDL IDTLGGPEET EEENTTYTGP EVSDPMSSTY IEELGKREVT
210 220 230 240 250
IPPKYRELLA KKEGITGPPA DSSKPIGPDD AIDALSSDFT CGSPTAAGKK
260 270 280 290 300
TEKEESTEVL KAQSAGTVRS AAPPQEKKRK VEKDTMSDQA LEALSASLGT
310 320 330 340 350
RQAEPELDLR SIKEVDEAKA KEEKLEKCGE DDETIPSEYR LKPATDKDGK
360 370 380 390 400
PLLPEPEEKP KPRSESELID ELSEDFDRSE CKEKPSKPTE KTEESKAAAP
410 420 430 440 450
APVSEAVCRT SMCSIQSAPP EPATLKGTVP DDAVEALADS LGKKEADPED
460 470 480 490 500
GKPVMDKVKE KAKEEDREKL GEKEETIPPD YRLEEVKDKD GKPLLPKESK
510 520 530 540 550
EQLPPMSEDF LLDALSEDFS GPQNASSLKF EDAKLAAAIS EVVSQTPAST
560 570 580 590 600
TQAGAPPRDT SQSDKDLDDA LDKLSDSLGQ RQPDPDENKP MEDKVKEKAK
610 620 630 640 650
AEHRDKLGER DDTIPPEYRH LLDDNGQDKP VKPPTKKSED SKKPADDQDP
660 670 680 690 700
IDALSGDLDS CPSTTETSQN TAKDKCKKAA SSSKAPKNGG KAKDSAKTTE

ETSKPKDD
Length:708
Mass (Da):76,573
Last modified:February 20, 2007 - v4
Checksum:i2DB0C14B860E89C7
GO
Isoform 2 (identifier: P20810-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-224: Missing.

Show »
Length:695
Mass (Da):75,304
Checksum:i9DBFF022F785D117
GO
Isoform 3 (identifier: P20810-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     212-224: Missing.

Show »
Length:590
Mass (Da):63,665
Checksum:iDB776EDB8EC13005
GO
Isoform 4 (identifier: P20810-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-30: Missing.
     44-62: Missing.

Show »
Length:667
Mass (Da):71,894
Checksum:i47831647A417E024
GO
Isoform 5 (identifier: P20810-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MNPTETKAIPVSQQMEGPHLPNKKKHKKQ → MSQPGQKPAA...SSSMNPTETK
     212-224: Missing.

Show »
Length:756
Mass (Da):81,169
Checksum:i18BA3EAB0A9989D3
GO
Isoform 6 (identifier: P20810-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQPGQKPAA...SGATSKSSSM

Show »
Length:791
Mass (Da):84,943
Checksum:iDC3DC0A4FC0F0825
GO
Isoform 7 (identifier: P20810-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQPGQKPAA...SGATSKSSSM
     44-62: Missing.

Show »
Length:772
Mass (Da):82,771
Checksum:i1B147E0CE4CD15E9
GO
Isoform 8 (identifier: P20810-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-30: Missing.

Note: No experimental confirmation available.
Show »
Length:686
Mass (Da):74,067
Checksum:i3B383857507798D3
GO
Isoform 9 (identifier: P20810-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: MNPTETKAIP...QEGKPKEHTE → MSQPGQKPAA...EPEKKSQSTK

Note: Gene prediction based on EST data.Combined sources
Show »
Length:750
Mass (Da):80,265
Checksum:i41EF9956565188AD
GO
Isoform 10 (identifier: P20810-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MNPTETKAIPVSQQMEGPHLPNKKKHKKQ → MSQPGQKPAA...SSSMNPTETK

Note: No experimental confirmation available.Combined sources
Show »
Length:769
Mass (Da):82,437
Checksum:iB29C93684805FE0B
GO

Sequence cautioni

The sequence AAH16066 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti467R → L in AAC50136 (Ref. 12) Curated1
Sequence conflicti486 – 488VKD → GKE in AAC50136 (Ref. 12) Curated3
Sequence conflicti543V → L in AAC50136 (Ref. 12) Curated1
Sequence conflicti562Missing in AAB60371 (Ref. 15) Curated1
Sequence conflicti651I → V in AAD09102 (Ref. 16) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030741380E → K.Corresponds to variant rs1643702dbSNPEnsembl.1
Natural variantiVAR_022686408C → S.4 PublicationsCorresponds to variant rs754615dbSNPEnsembl.1
Natural variantiVAR_030742537A → V.Corresponds to variant rs4948dbSNPEnsembl.1
Natural variantiVAR_005298592E → G.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0007411 – 105Missing in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_0473931 – 62MNPTE…KEHTE → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSMNPTETKAVKTEPEKKS QSTK in isoform 9. CuratedAdd BLAST62
Alternative sequenceiVSP_0380371 – 29MNPTE…KHKKQ → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSMNPTETK in isoform 5 and isoform 10. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_0380381M → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSM in isoform 6 and isoform 7. Curated1
Alternative sequenceiVSP_0007429 – 30Missing in isoform 4 and isoform 8. 3 PublicationsAdd BLAST22
Alternative sequenceiVSP_00074344 – 62Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_000744212 – 224Missing in isoform 2, isoform 3 and isoform 5. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16217 mRNA. Translation: BAA03747.1.
D50827 mRNA. Translation: BAA09438.1.
AF327443 mRNA. Translation: AAG48151.1.
BT009783 mRNA. Translation: AAP88785.1.
AK296919 mRNA. Translation: BAH12454.1.
AC008906 Genomic DNA. No translation available.
AC020900 Genomic DNA. No translation available.
AC104125 Genomic DNA. No translation available.
KC877037 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW96068.1.
CH471084 Genomic DNA. Translation: EAW96071.1.
CH471084 Genomic DNA. Translation: EAW96075.1.
BC013579 mRNA. Translation: AAH13579.1.
BC016066 mRNA. Translation: AAH16066.1. Sequence problems.
AL832349 mRNA. No translation available.
M86258 mRNA. Translation: AAB59398.1.
M28230
, M28227, M28228, M28229 Genomic DNA. Translation: AAA52066.1.
M33328 mRNA. Translation: AAA52296.1.
U26724 mRNA. Translation: AAC50136.2.
S73329 mRNA. Translation: AAB32311.1.
U38525 mRNA. Translation: AAA80684.1.
U31345 mRNA. Translation: AAB60371.1.
U31346 mRNA. Translation: AAB60372.1.
AF095891 mRNA. Translation: AAD09102.1.
CCDSiCCDS4082.1. [P20810-8]
CCDS54882.1. [P20810-9]
CCDS54883.1. [P20810-2]
PIRiA38091.
RefSeqiNP_001035905.1. NM_001042440.4. [P20810-9]
NP_001035906.1. NM_001042441.2.
NP_001035907.1. NM_001042442.2.
NP_001035908.1. NM_001042443.2.
NP_001035909.1. NM_001042444.2.
NP_001271141.1. NM_001284212.3.
NP_001317560.1. NM_001330631.1.
NP_001741.4. NM_001750.6.
NP_775083.1. NM_173060.4. [P20810-8]
XP_006714759.1. XM_006714696.3. [P20810-6]
XP_006714764.1. XM_006714701.3. [P20810-10]
XP_006714766.1. XM_006714703.3. [P20810-5]
XP_006714767.1. XM_006714704.3.
XP_016865402.1. XM_017009913.1. [P20810-7]
UniGeneiHs.436186.

Genome annotation databases

EnsembliENST00000309190; ENSP00000312523; ENSG00000153113. [P20810-8]
ENST00000338252; ENSP00000343421; ENSG00000153113. [P20810-2]
ENST00000341926; ENSP00000339914; ENSG00000153113. [P20810-1]
ENST00000395812; ENSP00000379157; ENSG00000153113. [P20810-9]
ENST00000395813; ENSP00000379158; ENSG00000153113. [P20810-1]
ENST00000508830; ENSP00000425721; ENSG00000153113. [P20810-6]
ENST00000510756; ENSP00000422176; ENSG00000153113. [P20810-10]
GeneIDi831.
KEGGihsa:831.
UCSCiuc003klt.4. human. [P20810-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16217 mRNA. Translation: BAA03747.1.
D50827 mRNA. Translation: BAA09438.1.
AF327443 mRNA. Translation: AAG48151.1.
BT009783 mRNA. Translation: AAP88785.1.
AK296919 mRNA. Translation: BAH12454.1.
AC008906 Genomic DNA. No translation available.
AC020900 Genomic DNA. No translation available.
AC104125 Genomic DNA. No translation available.
KC877037 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW96068.1.
CH471084 Genomic DNA. Translation: EAW96071.1.
CH471084 Genomic DNA. Translation: EAW96075.1.
BC013579 mRNA. Translation: AAH13579.1.
BC016066 mRNA. Translation: AAH16066.1. Sequence problems.
AL832349 mRNA. No translation available.
M86258 mRNA. Translation: AAB59398.1.
M28230
, M28227, M28228, M28229 Genomic DNA. Translation: AAA52066.1.
M33328 mRNA. Translation: AAA52296.1.
U26724 mRNA. Translation: AAC50136.2.
S73329 mRNA. Translation: AAB32311.1.
U38525 mRNA. Translation: AAA80684.1.
U31345 mRNA. Translation: AAB60371.1.
U31346 mRNA. Translation: AAB60372.1.
AF095891 mRNA. Translation: AAD09102.1.
CCDSiCCDS4082.1. [P20810-8]
CCDS54882.1. [P20810-9]
CCDS54883.1. [P20810-2]
PIRiA38091.
RefSeqiNP_001035905.1. NM_001042440.4. [P20810-9]
NP_001035906.1. NM_001042441.2.
NP_001035907.1. NM_001042442.2.
NP_001035908.1. NM_001042443.2.
NP_001035909.1. NM_001042444.2.
NP_001271141.1. NM_001284212.3.
NP_001317560.1. NM_001330631.1.
NP_001741.4. NM_001750.6.
NP_775083.1. NM_173060.4. [P20810-8]
XP_006714759.1. XM_006714696.3. [P20810-6]
XP_006714764.1. XM_006714701.3. [P20810-10]
XP_006714766.1. XM_006714703.3. [P20810-5]
XP_006714767.1. XM_006714704.3.
XP_016865402.1. XM_017009913.1. [P20810-7]
UniGeneiHs.436186.

3D structure databases

DisProtiDP00196.
ProteinModelPortaliP20810.
SMRiP20810.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107281. 30 interactors.
IntActiP20810. 13 interactors.

Protein family/group databases

MEROPSiI27.001.

PTM databases

iPTMnetiP20810.
PhosphoSitePlusiP20810.

Polymorphism and mutation databases

BioMutaiCAST.
DMDMi126302556.

Proteomic databases

MaxQBiP20810.
PeptideAtlasiP20810.
PRIDEiP20810.
TopDownProteomicsiP20810-5. [P20810-5]

Protocols and materials databases

DNASUi831.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309190; ENSP00000312523; ENSG00000153113. [P20810-8]
ENST00000338252; ENSP00000343421; ENSG00000153113. [P20810-2]
ENST00000341926; ENSP00000339914; ENSG00000153113. [P20810-1]
ENST00000395812; ENSP00000379157; ENSG00000153113. [P20810-9]
ENST00000395813; ENSP00000379158; ENSG00000153113. [P20810-1]
ENST00000508830; ENSP00000425721; ENSG00000153113. [P20810-6]
ENST00000510756; ENSP00000422176; ENSG00000153113. [P20810-10]
GeneIDi831.
KEGGihsa:831.
UCSCiuc003klt.4. human. [P20810-1]

Organism-specific databases

CTDi831.
DisGeNETi831.
GeneCardsiCAST.
HGNCiHGNC:1515. CAST.
HPAiCAB009491.
HPA036881.
HPA036882.
MIMi114090. gene.
616295. phenotype.
neXtProtiNX_P20810.
OpenTargetsiENSG00000153113.
PharmGKBiPA26098.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000002993.
HOGENOMiHOG000082405.
HOVERGENiHBG000183.
InParanoidiP20810.
KOiK04281.
OMAiKSSSMNP.
OrthoDBiEOG091G0553.
PhylomeDBiP20810.
TreeFamiTF332525.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153113-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.

Miscellaneous databases

ChiTaRSiCAST. human.
GeneWikiiCalpastatin.
GenomeRNAii831.
PROiP20810.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153113.
CleanExiHS_CAST.
ExpressionAtlasiP20810. baseline and differential.
GenevisibleiP20810. HS.

Family and domain databases

InterProiIPR026998. Calpastatin.
IPR001259. Prot_inh_calpain.
[Graphical view]
PANTHERiPTHR10077. PTHR10077. 1 hit.
PfamiPF00748. Calpain_inhib. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiICAL_HUMAN
AccessioniPrimary (citable) accession number: P20810
Secondary accession number(s): B7Z468
, G5E946, G5E9D3, O95360, Q05DE8, Q7Z4K0, Q96D08, Q9H1Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 162 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.