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P20810

- ICAL_HUMAN

UniProt

P20810 - ICAL_HUMAN

Protein

Calpastatin

Gene

CAST

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 4 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
    2. endopeptidase inhibitor activity Source: ProtInc
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: GOC
    2. negative regulation of type B pancreatic cell apoptotic process Source: BHF-UCL

    Keywords - Molecular functioni

    Protease inhibitor, Thiol protease inhibitor

    Protein family/group databases

    MEROPSiI27.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpastatin
    Alternative name(s):
    Calpain inhibitor
    Sperm BS-17 component
    Gene namesi
    Name:CAST
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:1515. CAST.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: BHF-UCL
    3. membrane Source: BHF-UCL

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26098.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 708708CalpastatinPRO_0000147632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei50 – 501N6-acetyllysineBy similarity
    Modified residuei133 – 1331Phosphoserine2 Publications
    Modified residuei243 – 2431Phosphoserine2 Publications
    Modified residuei364 – 3641Phosphoserine2 Publications
    Modified residuei366 – 3661Phosphoserine2 Publications
    Modified residuei373 – 3731Phosphoserine2 Publications
    Modified residuei575 – 5751Phosphoserine2 Publications
    Modified residuei577 – 5771Phosphoserine2 Publications

    Post-translational modificationi

    The N-terminus is blocked.

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP20810.
    PaxDbiP20810.
    PRIDEiP20810.

    PTM databases

    PhosphoSiteiP20810.

    Expressioni

    Gene expression databases

    ArrayExpressiP20810.
    BgeeiP20810.
    CleanExiHS_CAST.
    GenevestigatoriP20810.

    Organism-specific databases

    HPAiCAB009491.
    HPA036881.
    HPA036882.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q9Z3052EBI-1268770,EBI-9084208From a different organism.
    NCK1P163332EBI-1268770,EBI-389883

    Protein-protein interaction databases

    BioGridi107281. 20 interactions.
    IntActiP20810. 10 interactions.
    STRINGi9606.ENSP00000379158.

    Structurei

    3D structure databases

    DisProtiDP00196.
    ProteinModelPortaliP20810.
    SMRiP20810. Positions 156-240, 566-659.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati170 – 22253Inhibitory domain 1Add
    BLAST
    Repeati304 – 35653Inhibitory domain 2Add
    BLAST
    Repeati446 – 49954Inhibitory domain 3Add
    BLAST
    Repeati583 – 63654Inhibitory domain 4Add
    BLAST

    Domaini

    Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG25116.
    HOGENOMiHOG000082405.
    HOVERGENiHBG000183.
    InParanoidiP20810.
    KOiK04281.
    OMAiKSSSMNP.
    OrthoDBiEOG77HDF0.
    PhylomeDBiP20810.
    TreeFamiTF332525.

    Family and domain databases

    InterProiIPR026998. Calpastatin.
    IPR001259. Prot_inh_calpain.
    [Graphical view]
    PANTHERiPTHR10077. PTHR10077. 1 hit.
    PfamiPF00748. Calpain_inhib. 4 hits.
    [Graphical view]

    Sequences (9)i

    Sequence statusi: Complete.

    This entry describes 9 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P20810-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNPTETKAIP VSQQMEGPHL PNKKKHKKQA VKTEPEKKSQ STKLSVVHEK    50
    KSQEGKPKEH TEPKSLPKQA SDTGSNDAHN KKAVSRSAEQ QPSEKSTEPK 100
    TKPQDMISAG GESVAGITAI SGKPGDKKKE KKSLTPAVPV ESKPDKPSGK 150
    SGMDAALDDL IDTLGGPEET EEENTTYTGP EVSDPMSSTY IEELGKREVT 200
    IPPKYRELLA KKEGITGPPA DSSKPIGPDD AIDALSSDFT CGSPTAAGKK 250
    TEKEESTEVL KAQSAGTVRS AAPPQEKKRK VEKDTMSDQA LEALSASLGT 300
    RQAEPELDLR SIKEVDEAKA KEEKLEKCGE DDETIPSEYR LKPATDKDGK 350
    PLLPEPEEKP KPRSESELID ELSEDFDRSE CKEKPSKPTE KTEESKAAAP 400
    APVSEAVCRT SMCSIQSAPP EPATLKGTVP DDAVEALADS LGKKEADPED 450
    GKPVMDKVKE KAKEEDREKL GEKEETIPPD YRLEEVKDKD GKPLLPKESK 500
    EQLPPMSEDF LLDALSEDFS GPQNASSLKF EDAKLAAAIS EVVSQTPAST 550
    TQAGAPPRDT SQSDKDLDDA LDKLSDSLGQ RQPDPDENKP MEDKVKEKAK 600
    AEHRDKLGER DDTIPPEYRH LLDDNGQDKP VKPPTKKSED SKKPADDQDP 650
    IDALSGDLDS CPSTTETSQN TAKDKCKKAA SSSKAPKNGG KAKDSAKTTE 700
    ETSKPKDD 708
    Length:708
    Mass (Da):76,573
    Last modified:February 20, 2007 - v4
    Checksum:i2DB0C14B860E89C7
    GO
    Isoform 2 (identifier: P20810-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         212-224: Missing.

    Show »
    Length:695
    Mass (Da):75,304
    Checksum:i9DBFF022F785D117
    GO
    Isoform 3 (identifier: P20810-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-105: Missing.
         212-224: Missing.

    Show »
    Length:590
    Mass (Da):63,665
    Checksum:iDB776EDB8EC13005
    GO
    Isoform 4 (identifier: P20810-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         9-30: Missing.
         44-62: Missing.

    Show »
    Length:667
    Mass (Da):71,894
    Checksum:i47831647A417E024
    GO
    Isoform 5 (identifier: P20810-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: MNPTETKAIPVSQQMEGPHLPNKKKHKKQ → MSQPGQKPAA...SSSMNPTETK
         212-224: Missing.

    Note: Contains a phosphoserine at position 11.

    Show »
    Length:756
    Mass (Da):81,169
    Checksum:i18BA3EAB0A9989D3
    GO
    Isoform 6 (identifier: P20810-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MSQPGQKPAA...SGATSKSSSM

    Note: Contains a phosphoserine at position 11.

    Show »
    Length:791
    Mass (Da):84,943
    Checksum:iDC3DC0A4FC0F0825
    GO
    Isoform 7 (identifier: P20810-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MSQPGQKPAA...SGATSKSSSM
         44-62: Missing.

    Note: Contains a phosphoserine at position 11.

    Show »
    Length:772
    Mass (Da):82,771
    Checksum:i1B147E0CE4CD15E9
    GO
    Isoform 8 (identifier: P20810-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         9-30: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:686
    Mass (Da):74,067
    Checksum:i3B383857507798D3
    GO
    Isoform 9 (identifier: P20810-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-62: MNPTETKAIP...QEGKPKEHTE → MSQPGQKPAA...EPEKKSQSTK

    Note: Gene prediction based on EST data. Contains a phosphoserine at position 11.

    Show »
    Length:750
    Mass (Da):80,265
    Checksum:i41EF9956565188AD
    GO

    Sequence cautioni

    The sequence AAH16066.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti467 – 4671R → L in AAC50136. 1 PublicationCurated
    Sequence conflicti486 – 4883VKD → GKE in AAC50136. 1 PublicationCurated
    Sequence conflicti543 – 5431V → L in AAC50136. 1 PublicationCurated
    Sequence conflicti562 – 5621Missing in AAB60371. 1 PublicationCurated
    Sequence conflicti651 – 6511I → V in AAD09102. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti380 – 3801E → K.
    Corresponds to variant rs1643702 [ dbSNP | Ensembl ].
    VAR_030741
    Natural varianti408 – 4081C → S.4 Publications
    Corresponds to variant rs754615 [ dbSNP | Ensembl ].
    VAR_022686
    Natural varianti537 – 5371A → V.
    Corresponds to variant rs4948 [ dbSNP | Ensembl ].
    VAR_030742
    Natural varianti592 – 5921E → G.1 Publication
    VAR_005298

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 105105Missing in isoform 3. 1 PublicationVSP_000741Add
    BLAST
    Alternative sequencei1 – 6262MNPTE…KEHTE → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSMNPTETKAVKTEPEKKS QSTK in isoform 9. CuratedVSP_047393Add
    BLAST
    Alternative sequencei1 – 2929MNPTE…KHKKQ → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSMNPTETK in isoform 5. 1 PublicationVSP_038037Add
    BLAST
    Alternative sequencei1 – 11M → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSM in isoform 6 and isoform 7. CuratedVSP_038038
    Alternative sequencei9 – 3022Missing in isoform 4 and isoform 8. 3 PublicationsVSP_000742Add
    BLAST
    Alternative sequencei44 – 6219Missing in isoform 4 and isoform 7. 2 PublicationsVSP_000743Add
    BLAST
    Alternative sequencei212 – 22413Missing in isoform 2, isoform 3 and isoform 5. 2 PublicationsVSP_000744Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16217 mRNA. Translation: BAA03747.1.
    D50827 mRNA. Translation: BAA09438.1.
    AF327443 mRNA. Translation: AAG48151.1.
    BT009783 mRNA. Translation: AAP88785.1.
    AC008906 Genomic DNA. No translation available.
    AC020900 Genomic DNA. No translation available.
    AC104125 Genomic DNA. No translation available.
    CH471084 Genomic DNA. Translation: EAW96068.1.
    CH471084 Genomic DNA. Translation: EAW96071.1.
    CH471084 Genomic DNA. Translation: EAW96075.1.
    BC013579 mRNA. Translation: AAH13579.1.
    BC016066 mRNA. Translation: AAH16066.1. Sequence problems.
    AL832349 mRNA. No translation available.
    M86258 mRNA. Translation: AAB59398.1.
    M28230
    , M28227, M28228, M28229 Genomic DNA. Translation: AAA52066.1.
    M33328 mRNA. Translation: AAA52296.1.
    U26724 mRNA. Translation: AAC50136.2.
    S73329 mRNA. Translation: AAB32311.1.
    U38525 mRNA. Translation: AAA80684.1.
    U31345 mRNA. Translation: AAB60371.1.
    U31346 mRNA. Translation: AAB60372.1.
    AF095891 mRNA. Translation: AAD09102.1.
    CCDSiCCDS4082.1. [P20810-8]
    CCDS54882.1. [P20810-9]
    CCDS54883.1. [P20810-2]
    PIRiA38091.
    RefSeqiNP_001035905.1. NM_001042440.3. [P20810-9]
    NP_001177371.1. NM_001190442.1. [P20810-2]
    NP_001271141.1. NM_001284212.1.
    NP_775083.1. NM_173060.3. [P20810-8]
    XP_006714759.1. XM_006714696.1. [P20810-6]
    XP_006714763.1. XM_006714700.1. [P20810-7]
    XP_006714766.1. XM_006714703.1. [P20810-5]
    XP_006714770.1. XM_006714707.1. [P20810-1]
    XP_006714771.1. XM_006714708.1. [P20810-2]
    XP_006714774.1. XM_006714711.1. [P20810-4]
    UniGeneiHs.436186.

    Genome annotation databases

    EnsembliENST00000309190; ENSP00000312523; ENSG00000153113. [P20810-8]
    ENST00000325674; ENSP00000320319; ENSG00000153113. [P20810-5]
    ENST00000338252; ENSP00000343421; ENSG00000153113. [P20810-2]
    ENST00000341926; ENSP00000339914; ENSG00000153113. [P20810-1]
    ENST00000395812; ENSP00000379157; ENSG00000153113. [P20810-9]
    ENST00000395813; ENSP00000379158; ENSG00000153113. [P20810-6]
    ENST00000508830; ENSP00000425721; ENSG00000153113. [P20810-6]
    ENST00000510098; ENSP00000427195; ENSG00000153113.
    GeneIDi831.
    KEGGihsa:831.
    UCSCiuc003klt.3. human. [P20810-2]
    uc003klx.3. human.
    uc003klz.1. human. [P20810-1]
    uc003kma.2. human. [P20810-4]
    uc003kmd.3. human.

    Polymorphism databases

    DMDMi126302556.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16217 mRNA. Translation: BAA03747.1 .
    D50827 mRNA. Translation: BAA09438.1 .
    AF327443 mRNA. Translation: AAG48151.1 .
    BT009783 mRNA. Translation: AAP88785.1 .
    AC008906 Genomic DNA. No translation available.
    AC020900 Genomic DNA. No translation available.
    AC104125 Genomic DNA. No translation available.
    CH471084 Genomic DNA. Translation: EAW96068.1 .
    CH471084 Genomic DNA. Translation: EAW96071.1 .
    CH471084 Genomic DNA. Translation: EAW96075.1 .
    BC013579 mRNA. Translation: AAH13579.1 .
    BC016066 mRNA. Translation: AAH16066.1 . Sequence problems.
    AL832349 mRNA. No translation available.
    M86258 mRNA. Translation: AAB59398.1 .
    M28230
    , M28227 , M28228 , M28229 Genomic DNA. Translation: AAA52066.1 .
    M33328 mRNA. Translation: AAA52296.1 .
    U26724 mRNA. Translation: AAC50136.2 .
    S73329 mRNA. Translation: AAB32311.1 .
    U38525 mRNA. Translation: AAA80684.1 .
    U31345 mRNA. Translation: AAB60371.1 .
    U31346 mRNA. Translation: AAB60372.1 .
    AF095891 mRNA. Translation: AAD09102.1 .
    CCDSi CCDS4082.1. [P20810-8 ]
    CCDS54882.1. [P20810-9 ]
    CCDS54883.1. [P20810-2 ]
    PIRi A38091.
    RefSeqi NP_001035905.1. NM_001042440.3. [P20810-9 ]
    NP_001177371.1. NM_001190442.1. [P20810-2 ]
    NP_001271141.1. NM_001284212.1.
    NP_775083.1. NM_173060.3. [P20810-8 ]
    XP_006714759.1. XM_006714696.1. [P20810-6 ]
    XP_006714763.1. XM_006714700.1. [P20810-7 ]
    XP_006714766.1. XM_006714703.1. [P20810-5 ]
    XP_006714770.1. XM_006714707.1. [P20810-1 ]
    XP_006714771.1. XM_006714708.1. [P20810-2 ]
    XP_006714774.1. XM_006714711.1. [P20810-4 ]
    UniGenei Hs.436186.

    3D structure databases

    DisProti DP00196.
    ProteinModelPortali P20810.
    SMRi P20810. Positions 156-240, 566-659.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107281. 20 interactions.
    IntActi P20810. 10 interactions.
    STRINGi 9606.ENSP00000379158.

    Protein family/group databases

    MEROPSi I27.001.

    PTM databases

    PhosphoSitei P20810.

    Polymorphism databases

    DMDMi 126302556.

    Proteomic databases

    MaxQBi P20810.
    PaxDbi P20810.
    PRIDEi P20810.

    Protocols and materials databases

    DNASUi 831.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309190 ; ENSP00000312523 ; ENSG00000153113 . [P20810-8 ]
    ENST00000325674 ; ENSP00000320319 ; ENSG00000153113 . [P20810-5 ]
    ENST00000338252 ; ENSP00000343421 ; ENSG00000153113 . [P20810-2 ]
    ENST00000341926 ; ENSP00000339914 ; ENSG00000153113 . [P20810-1 ]
    ENST00000395812 ; ENSP00000379157 ; ENSG00000153113 . [P20810-9 ]
    ENST00000395813 ; ENSP00000379158 ; ENSG00000153113 . [P20810-6 ]
    ENST00000508830 ; ENSP00000425721 ; ENSG00000153113 . [P20810-6 ]
    ENST00000510098 ; ENSP00000427195 ; ENSG00000153113 .
    GeneIDi 831.
    KEGGi hsa:831.
    UCSCi uc003klt.3. human. [P20810-2 ]
    uc003klx.3. human.
    uc003klz.1. human. [P20810-1 ]
    uc003kma.2. human. [P20810-4 ]
    uc003kmd.3. human.

    Organism-specific databases

    CTDi 831.
    GeneCardsi GC05P095865.
    HGNCi HGNC:1515. CAST.
    HPAi CAB009491.
    HPA036881.
    HPA036882.
    MIMi 114090. gene.
    neXtProti NX_P20810.
    PharmGKBi PA26098.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25116.
    HOGENOMi HOG000082405.
    HOVERGENi HBG000183.
    InParanoidi P20810.
    KOi K04281.
    OMAi KSSSMNP.
    OrthoDBi EOG77HDF0.
    PhylomeDBi P20810.
    TreeFami TF332525.

    Miscellaneous databases

    ChiTaRSi CAST. human.
    GeneWikii Calpastatin.
    GenomeRNAii 831.
    NextBioi 3422.
    PROi P20810.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20810.
    Bgeei P20810.
    CleanExi HS_CAST.
    Genevestigatori P20810.

    Family and domain databases

    InterProi IPR026998. Calpastatin.
    IPR001259. Prot_inh_calpain.
    [Graphical view ]
    PANTHERi PTHR10077. PTHR10077. 1 hit.
    Pfami PF00748. Calpain_inhib. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of human calpastatin: sequence homology among human, pig, and rabbit calpastatins."
      Asada K., Ishino Y., Shimada M., Shimojo T., Endo M., Kimizuka F., Kato I., Maki M., Hatanaka M., Murachi T.
      J. Enzym. Inhib. 3:49-56(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-408 AND GLY-592.
    2. "Cloning and characterization of a novel isoform of calpastatin in human adult testis."
      Zhu H., Zhou Z.-M., Li J.-M., Zhu H., Cheng L.-J., Shan Y.-X., Yin L.-L., Sha J.H.
      Acta Pharmacol. Sin. 23:450-454(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Testis.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 6 AND 7).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-319 (ISOFORM 5).
      Tissue: Lung and Skin.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-479 (ISOFORM 8), VARIANT SER-408.
    8. "Molecular diversity in amino-terminal domains of human calpastatin by exon skipping."
      Lee W.J., Ma H., Takano E., Yang H.Q., Hatanaka M., Maki M.
      J. Biol. Chem. 267:8437-8442(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-283 (ISOFORM 1), ALTERNATIVE SPLICING.
      Tissue: Lung.
    9. "Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene."
      Maki M., Bagci H., Hamaguchi K., Ueda M., Murachi T., Hatanaka M.
      J. Biol. Chem. 264:18866-18869(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-317.
    10. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-283 (ISOFORMS 2/3).
    11. Wang L.F.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 153-708 (ISOFORMS 2/3), SEQUENCE REVISION, VARIANT SER-408.
    12. "Calpastatin gene in human testis."
      Wang L.F., Wei S.G., Miao S.Y., Liu Q.Y., Koide S.S.
      Biochem. Mol. Biol. Int. 33:245-252(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 523-708 (ISOFORMS 1/2/3/4).
      Tissue: Testis.
    13. "Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera."
      Despres N., Talbot G., Plouffe B., Boire G., Menard H.A.
      J. Clin. Invest. 95:1891-1896(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 425-708 (ISOFORMS 1/2/3/4).
      Tissue: Placenta.
    14. El-Amine M., Talbot G., Despres N., Asselin C., Boire G., Menard H.A.
      Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-708 (ISOFORMS 1/2/3/4), VARIANT SER-408.
      Tissue: Placenta.
    15. "New calpastatin 3' UTR."
      Rochdi M.D., El-Amine M., Menard H.A.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 636-708 (ISOFORMS 1/2/3/4).
    16. "Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells."
      Adachi Y., Ishida-Takahashi A., Takahashi C., Takano E., Murachi T., Hatanaka M.
      J. Biol. Chem. 266:3968-3972(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    17. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-364; SER-366 AND SER-373, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133; SER-575 AND SER-577, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 (ISOFORMS 5; 6; 7 AND 9), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiICAL_HUMAN
    AccessioniPrimary (citable) accession number: P20810
    Secondary accession number(s): G5E946
    , G5E9D3, O95360, Q05DE8, Q7Z4K0, Q96D08, Q9H1Z5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 141 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3