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P20810 (ICAL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calpastatin
Alternative name(s):
Calpain inhibitor
Sperm BS-17 component
Gene names
Name:CAST
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length708 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

Domain

Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site By similarity.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the protease inhibitor I27 (calpastatin) family. [View classification]

Sequence caution

The sequence AAH16066.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Q9Z3052EBI-1268770,EBI-9084208From a different organism.
NCK1P163332EBI-1268770,EBI-389883

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P20810-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P20810-2)

The sequence of this isoform differs from the canonical sequence as follows:
     212-224: Missing.
Isoform 3 (identifier: P20810-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     212-224: Missing.
Isoform 4 (identifier: P20810-4)

The sequence of this isoform differs from the canonical sequence as follows:
     9-30: Missing.
     44-62: Missing.
Isoform 5 (identifier: P20810-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MNPTETKAIPVSQQMEGPHLPNKKKHKKQ → MSQPGQKPAA...SSSMNPTETK
     212-224: Missing.
Note: Contains a phosphoserine at position 11.
Isoform 6 (identifier: P20810-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQPGQKPAA...SGATSKSSSM
Note: Contains a phosphoserine at position 11.
Isoform 7 (identifier: P20810-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQPGQKPAA...SGATSKSSSM
     44-62: Missing.
Note: Contains a phosphoserine at position 11.
Isoform 8 (identifier: P20810-8)

The sequence of this isoform differs from the canonical sequence as follows:
     9-30: Missing.
Note: No experimental confirmation available.
Isoform 9 (identifier: P20810-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: MNPTETKAIP...QEGKPKEHTE → MSQPGQKPAA...EPEKKSQSTK
Note: Gene prediction based on EST data. Contains a phosphoserine at position 11.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 708708Calpastatin
PRO_0000147632

Regions

Repeat170 – 22253Inhibitory domain 1
Repeat304 – 35653Inhibitory domain 2
Repeat446 – 49954Inhibitory domain 3
Repeat583 – 63654Inhibitory domain 4

Amino acid modifications

Modified residue501N6-acetyllysine By similarity
Modified residue1331Phosphoserine Ref.20
Modified residue2431Phosphoserine Ref.18
Modified residue3641Phosphoserine Ref.18
Modified residue3661Phosphoserine Ref.18
Modified residue3731Phosphoserine Ref.18
Modified residue5751Phosphoserine Ref.20
Modified residue5771Phosphoserine Ref.20

Natural variations

Alternative sequence1 – 105105Missing in isoform 3.
VSP_000741
Alternative sequence1 – 6262MNPTE…KEHTE → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSMNPTETKAVKTEPEKKS QSTK in isoform 9.
VSP_047393
Alternative sequence1 – 2929MNPTE…KHKKQ → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSMNPTETK in isoform 5.
VSP_038037
Alternative sequence11M → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSM in isoform 6 and isoform 7.
VSP_038038
Alternative sequence9 – 3022Missing in isoform 4 and isoform 8.
VSP_000742
Alternative sequence44 – 6219Missing in isoform 4 and isoform 7.
VSP_000743
Alternative sequence212 – 22413Missing in isoform 2, isoform 3 and isoform 5.
VSP_000744
Natural variant3801E → K.
Corresponds to variant rs1643702 [ dbSNP | Ensembl ].
VAR_030741
Natural variant4081C → S. Ref.1 Ref.7 Ref.11 Ref.14
Corresponds to variant rs754615 [ dbSNP | Ensembl ].
VAR_022686
Natural variant5371A → V.
Corresponds to variant rs4948 [ dbSNP | Ensembl ].
VAR_030742
Natural variant5921E → G. Ref.1
VAR_005298

Experimental info

Sequence conflict4671R → L in AAC50136. Ref.11
Sequence conflict486 – 4883VKD → GKE in AAC50136. Ref.11
Sequence conflict5431V → L in AAC50136. Ref.11
Sequence conflict5621Missing in AAB60371. Ref.14
Sequence conflict6511I → V in AAD09102. Ref.15

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 4.
Checksum: 2DB0C14B860E89C7

FASTA70876,573
        10         20         30         40         50         60 
MNPTETKAIP VSQQMEGPHL PNKKKHKKQA VKTEPEKKSQ STKLSVVHEK KSQEGKPKEH 

        70         80         90        100        110        120 
TEPKSLPKQA SDTGSNDAHN KKAVSRSAEQ QPSEKSTEPK TKPQDMISAG GESVAGITAI 

       130        140        150        160        170        180 
SGKPGDKKKE KKSLTPAVPV ESKPDKPSGK SGMDAALDDL IDTLGGPEET EEENTTYTGP 

       190        200        210        220        230        240 
EVSDPMSSTY IEELGKREVT IPPKYRELLA KKEGITGPPA DSSKPIGPDD AIDALSSDFT 

       250        260        270        280        290        300 
CGSPTAAGKK TEKEESTEVL KAQSAGTVRS AAPPQEKKRK VEKDTMSDQA LEALSASLGT 

       310        320        330        340        350        360 
RQAEPELDLR SIKEVDEAKA KEEKLEKCGE DDETIPSEYR LKPATDKDGK PLLPEPEEKP 

       370        380        390        400        410        420 
KPRSESELID ELSEDFDRSE CKEKPSKPTE KTEESKAAAP APVSEAVCRT SMCSIQSAPP 

       430        440        450        460        470        480 
EPATLKGTVP DDAVEALADS LGKKEADPED GKPVMDKVKE KAKEEDREKL GEKEETIPPD 

       490        500        510        520        530        540 
YRLEEVKDKD GKPLLPKESK EQLPPMSEDF LLDALSEDFS GPQNASSLKF EDAKLAAAIS 

       550        560        570        580        590        600 
EVVSQTPAST TQAGAPPRDT SQSDKDLDDA LDKLSDSLGQ RQPDPDENKP MEDKVKEKAK 

       610        620        630        640        650        660 
AEHRDKLGER DDTIPPEYRH LLDDNGQDKP VKPPTKKSED SKKPADDQDP IDALSGDLDS 

       670        680        690        700 
CPSTTETSQN TAKDKCKKAA SSSKAPKNGG KAKDSAKTTE ETSKPKDD 

« Hide

Isoform 2 [UniParc].

Checksum: 9DBFF022F785D117
Show »

FASTA69575,304
Isoform 3 [UniParc].

Checksum: DB776EDB8EC13005
Show »

FASTA59063,665
Isoform 4 [UniParc].

Checksum: 47831647A417E024
Show »

FASTA66771,894
Isoform 5 [UniParc].

Checksum: 18BA3EAB0A9989D3
Show »

FASTA75681,169
Isoform 6 [UniParc].

Checksum: DC3DC0A4FC0F0825
Show »

FASTA79184,943
Isoform 7 [UniParc].

Checksum: 1B147E0CE4CD15E9
Show »

FASTA77282,771
Isoform 8 [UniParc].

Checksum: 3B383857507798D3
Show »

FASTA68674,067
Isoform 9 [UniParc].

Checksum: 41EF9956565188AD
Show »

FASTA75080,265

References

« Hide 'large scale' references
[1]"cDNA cloning of human calpastatin: sequence homology among human, pig, and rabbit calpastatins."
Asada K., Ishino Y., Shimada M., Shimojo T., Endo M., Kimizuka F., Kato I., Maki M., Hatanaka M., Murachi T.
J. Enzym. Inhib. 3:49-56(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-408 AND GLY-592.
[2]"Cloning and characterization of a novel isoform of calpastatin in human adult testis."
Zhu H., Zhou Z.-M., Li J.-M., Zhu H., Cheng L.-J., Shan Y.-X., Yin L.-L., Sha J.H.
Acta Pharmacol. Sin. 23:450-454(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
Tissue: Testis.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[4]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 6 AND 7).
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-319 (ISOFORM 5).
Tissue: Lung and Skin.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-479 (ISOFORM 8), VARIANT SER-408.
[8]"Molecular diversity in amino-terminal domains of human calpastatin by exon skipping."
Lee W.J., Ma H., Takano E., Yang H.Q., Hatanaka M., Maki M.
J. Biol. Chem. 267:8437-8442(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-283 (ISOFORM 1), ALTERNATIVE SPLICING.
Tissue: Lung.
[9]"Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene."
Maki M., Bagci H., Hamaguchi K., Ueda M., Murachi T., Hatanaka M.
J. Biol. Chem. 264:18866-18869(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-317.
[10]"Characterization of a functional domain of human calpastatin."
Uemori T., Shimojo T., Asada K., Asano T., Kimizuka F., Kato I., Maki M., Hatanaka M., Murachi T., Hanzawa H., Arata Y.
Biochem. Biophys. Res. Commun. 166:1485-1493(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-283 (ISOFORMS 2/3).
[11]Wang L.F.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 153-708 (ISOFORMS 2/3), SEQUENCE REVISION, VARIANT SER-408.
[12]"Calpastatin gene in human testis."
Wang L.F., Wei S.G., Miao S.Y., Liu Q.Y., Koide S.S.
Biochem. Mol. Biol. Int. 33:245-252(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 523-708 (ISOFORMS 1/2/3/4).
Tissue: Testis.
[13]"Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera."
Despres N., Talbot G., Plouffe B., Boire G., Menard H.A.
J. Clin. Invest. 95:1891-1896(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 425-708 (ISOFORMS 1/2/3/4).
Tissue: Placenta.
[14]El-Amine M., Talbot G., Despres N., Asselin C., Boire G., Menard H.A.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-708 (ISOFORMS 1/2/3/4), VARIANT SER-408.
Tissue: Placenta.
[15]"New calpastatin 3' UTR."
Rochdi M.D., El-Amine M., Menard H.A.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 636-708 (ISOFORMS 1/2/3/4).
[16]"Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells."
Adachi Y., Ishida-Takahashi A., Takahashi C., Takano E., Murachi T., Hatanaka M.
J. Biol. Chem. 266:3968-3972(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION.
[17]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[18]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-364; SER-366 AND SER-373, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[19]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[20]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133; SER-575 AND SER-577, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 (ISOFORMS 5; 6; 7 AND 9), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[21]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16217 mRNA. Translation: BAA03747.1.
D50827 mRNA. Translation: BAA09438.1.
AF327443 mRNA. Translation: AAG48151.1.
BT009783 mRNA. Translation: AAP88785.1.
AC008906 Genomic DNA. No translation available.
AC020900 Genomic DNA. No translation available.
AC104125 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW96068.1.
CH471084 Genomic DNA. Translation: EAW96071.1.
CH471084 Genomic DNA. Translation: EAW96075.1.
BC013579 mRNA. Translation: AAH13579.1.
BC016066 mRNA. Translation: AAH16066.1. Sequence problems.
AL832349 mRNA. No translation available.
M86258 mRNA. Translation: AAB59398.1.
M28230 expand/collapse EMBL AC list , M28227, M28228, M28229 Genomic DNA. Translation: AAA52066.1.
M33328 mRNA. Translation: AAA52296.1.
U26724 mRNA. Translation: AAC50136.2.
S73329 mRNA. Translation: AAB32311.1.
U38525 mRNA. Translation: AAA80684.1.
U31345 mRNA. Translation: AAB60371.1.
U31346 mRNA. Translation: AAB60372.1.
AF095891 mRNA. Translation: AAD09102.1.
CCDSCCDS4082.1. [P20810-8]
CCDS54882.1. [P20810-9]
CCDS54883.1. [P20810-2]
PIRA38091.
RefSeqNP_001035905.1. NM_001042440.3. [P20810-9]
NP_001177371.1. NM_001190442.1. [P20810-2]
NP_001271141.1. NM_001284212.1.
NP_775083.1. NM_173060.3. [P20810-8]
XP_006714759.1. XM_006714696.1. [P20810-6]
XP_006714763.1. XM_006714700.1. [P20810-7]
XP_006714766.1. XM_006714703.1. [P20810-5]
XP_006714770.1. XM_006714707.1. [P20810-1]
XP_006714771.1. XM_006714708.1. [P20810-2]
XP_006714774.1. XM_006714711.1. [P20810-4]
UniGeneHs.436186.

3D structure databases

DisProtDP00196.
ProteinModelPortalP20810.
SMRP20810. Positions 156-240, 566-659.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107281. 20 interactions.
IntActP20810. 10 interactions.
STRING9606.ENSP00000379158.

Protein family/group databases

MEROPSI27.001.

PTM databases

PhosphoSiteP20810.

Polymorphism databases

DMDM126302556.

Proteomic databases

MaxQBP20810.
PaxDbP20810.
PRIDEP20810.

Protocols and materials databases

DNASU831.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309190; ENSP00000312523; ENSG00000153113. [P20810-8]
ENST00000325674; ENSP00000320319; ENSG00000153113. [P20810-5]
ENST00000338252; ENSP00000343421; ENSG00000153113. [P20810-2]
ENST00000341926; ENSP00000339914; ENSG00000153113. [P20810-1]
ENST00000359176; ENSP00000352098; ENSG00000153113. [P20810-7]
ENST00000395812; ENSP00000379157; ENSG00000153113. [P20810-9]
ENST00000395813; ENSP00000379158; ENSG00000153113. [P20810-6]
ENST00000508830; ENSP00000425721; ENSG00000153113. [P20810-6]
ENST00000510098; ENSP00000427195; ENSG00000153113.
GeneID831.
KEGGhsa:831.
UCSCuc003klt.3. human. [P20810-2]
uc003klx.3. human.
uc003klz.1. human. [P20810-1]
uc003kma.2. human. [P20810-4]
uc003kmd.3. human.

Organism-specific databases

CTD831.
GeneCardsGC05P095865.
HGNCHGNC:1515. CAST.
HPACAB009491.
HPA036881.
HPA036882.
MIM114090. gene.
neXtProtNX_P20810.
PharmGKBPA26098.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25116.
HOGENOMHOG000082405.
HOVERGENHBG000183.
InParanoidP20810.
KOK04281.
OMAKSSSMNP.
OrthoDBEOG77HDF0.
PhylomeDBP20810.
TreeFamTF332525.

Gene expression databases

ArrayExpressP20810.
BgeeP20810.
CleanExHS_CAST.
GenevestigatorP20810.

Family and domain databases

InterProIPR026998. Calpastatin.
IPR001259. Prot_inh_calpain.
[Graphical view]
PANTHERPTHR10077. PTHR10077. 1 hit.
PfamPF00748. Calpain_inhib. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCAST. human.
GeneWikiCalpastatin.
GenomeRNAi831.
NextBio3422.
PROP20810.
SOURCESearch...

Entry information

Entry nameICAL_HUMAN
AccessionPrimary (citable) accession number: P20810
Secondary accession number(s): G5E946 expand/collapse secondary AC list , G5E9D3, O95360, Q05DE8, Q7Z4K0, Q96D08, Q9H1Z5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 140 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM