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P20810

- ICAL_HUMAN

UniProt

P20810 - ICAL_HUMAN

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Protein

Calpastatin

Gene

CAST

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
  2. endopeptidase inhibitor activity Source: ProtInc
  3. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: GOC
  2. negative regulation of type B pancreatic cell apoptotic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI27.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpastatin
Alternative name(s):
Calpain inhibitor
Sperm BS-17 component
Gene namesi
Name:CAST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1515. CAST.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: BHF-UCL
  3. membrane Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708CalpastatinPRO_0000147632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501N6-acetyllysineBy similarity
Modified residuei133 – 1331Phosphoserine1 Publication
Modified residuei243 – 2431Phosphoserine1 Publication
Modified residuei364 – 3641Phosphoserine1 Publication
Modified residuei366 – 3661Phosphoserine1 Publication
Modified residuei373 – 3731Phosphoserine1 Publication
Modified residuei575 – 5751Phosphoserine1 Publication
Modified residuei577 – 5771Phosphoserine1 Publication

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP20810.
PaxDbiP20810.
PRIDEiP20810.

PTM databases

PhosphoSiteiP20810.

Expressioni

Gene expression databases

BgeeiP20810.
CleanExiHS_CAST.
ExpressionAtlasiP20810. baseline and differential.
GenevestigatoriP20810.

Organism-specific databases

HPAiCAB009491.
HPA036881.
HPA036882.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9Z3052EBI-1268770,EBI-9084208From a different organism.
NCK1P163332EBI-1268770,EBI-389883

Protein-protein interaction databases

BioGridi107281. 22 interactions.
IntActiP20810. 10 interactions.
STRINGi9606.ENSP00000379158.

Structurei

3D structure databases

DisProtiDP00196.
ProteinModelPortaliP20810.
SMRiP20810. Positions 156-240, 566-659.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati170 – 22253Inhibitory domain 1Add
BLAST
Repeati304 – 35653Inhibitory domain 2Add
BLAST
Repeati446 – 49954Inhibitory domain 3Add
BLAST
Repeati583 – 63654Inhibitory domain 4Add
BLAST

Domaini

Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG25116.
GeneTreeiENSGT00390000002993.
HOGENOMiHOG000082405.
HOVERGENiHBG000183.
InParanoidiP20810.
KOiK04281.
OMAiKSSSMNP.
OrthoDBiEOG77HDF0.
PhylomeDBiP20810.
TreeFamiTF332525.

Family and domain databases

InterProiIPR026998. Calpastatin.
IPR001259. Prot_inh_calpain.
[Graphical view]
PANTHERiPTHR10077. PTHR10077. 1 hit.
PfamiPF00748. Calpain_inhib. 4 hits.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P20810-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPTETKAIP VSQQMEGPHL PNKKKHKKQA VKTEPEKKSQ STKLSVVHEK
60 70 80 90 100
KSQEGKPKEH TEPKSLPKQA SDTGSNDAHN KKAVSRSAEQ QPSEKSTEPK
110 120 130 140 150
TKPQDMISAG GESVAGITAI SGKPGDKKKE KKSLTPAVPV ESKPDKPSGK
160 170 180 190 200
SGMDAALDDL IDTLGGPEET EEENTTYTGP EVSDPMSSTY IEELGKREVT
210 220 230 240 250
IPPKYRELLA KKEGITGPPA DSSKPIGPDD AIDALSSDFT CGSPTAAGKK
260 270 280 290 300
TEKEESTEVL KAQSAGTVRS AAPPQEKKRK VEKDTMSDQA LEALSASLGT
310 320 330 340 350
RQAEPELDLR SIKEVDEAKA KEEKLEKCGE DDETIPSEYR LKPATDKDGK
360 370 380 390 400
PLLPEPEEKP KPRSESELID ELSEDFDRSE CKEKPSKPTE KTEESKAAAP
410 420 430 440 450
APVSEAVCRT SMCSIQSAPP EPATLKGTVP DDAVEALADS LGKKEADPED
460 470 480 490 500
GKPVMDKVKE KAKEEDREKL GEKEETIPPD YRLEEVKDKD GKPLLPKESK
510 520 530 540 550
EQLPPMSEDF LLDALSEDFS GPQNASSLKF EDAKLAAAIS EVVSQTPAST
560 570 580 590 600
TQAGAPPRDT SQSDKDLDDA LDKLSDSLGQ RQPDPDENKP MEDKVKEKAK
610 620 630 640 650
AEHRDKLGER DDTIPPEYRH LLDDNGQDKP VKPPTKKSED SKKPADDQDP
660 670 680 690 700
IDALSGDLDS CPSTTETSQN TAKDKCKKAA SSSKAPKNGG KAKDSAKTTE

ETSKPKDD
Length:708
Mass (Da):76,573
Last modified:February 20, 2007 - v4
Checksum:i2DB0C14B860E89C7
GO
Isoform 2 (identifier: P20810-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-224: Missing.

Show »
Length:695
Mass (Da):75,304
Checksum:i9DBFF022F785D117
GO
Isoform 3 (identifier: P20810-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     212-224: Missing.

Show »
Length:590
Mass (Da):63,665
Checksum:iDB776EDB8EC13005
GO
Isoform 4 (identifier: P20810-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-30: Missing.
     44-62: Missing.

Show »
Length:667
Mass (Da):71,894
Checksum:i47831647A417E024
GO
Isoform 5 (identifier: P20810-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MNPTETKAIPVSQQMEGPHLPNKKKHKKQ → MSQPGQKPAA...SSSMNPTETK
     212-224: Missing.

Note: Contains a phosphoserine at position 11.

Show »
Length:756
Mass (Da):81,169
Checksum:i18BA3EAB0A9989D3
GO
Isoform 6 (identifier: P20810-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQPGQKPAA...SGATSKSSSM

Note: Contains a phosphoserine at position 11.

Show »
Length:791
Mass (Da):84,943
Checksum:iDC3DC0A4FC0F0825
GO
Isoform 7 (identifier: P20810-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQPGQKPAA...SGATSKSSSM
     44-62: Missing.

Note: Contains a phosphoserine at position 11.

Show »
Length:772
Mass (Da):82,771
Checksum:i1B147E0CE4CD15E9
GO
Isoform 8 (identifier: P20810-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-30: Missing.

Note: No experimental confirmation available.

Show »
Length:686
Mass (Da):74,067
Checksum:i3B383857507798D3
GO
Isoform 9 (identifier: P20810-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: MNPTETKAIP...QEGKPKEHTE → MSQPGQKPAA...EPEKKSQSTK

Note: Gene prediction based on EST data. Contains a phosphoserine at position 11.

Show »
Length:750
Mass (Da):80,265
Checksum:i41EF9956565188AD
GO

Sequence cautioni

The sequence AAH16066.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti467 – 4671R → L in AAC50136. 1 PublicationCurated
Sequence conflicti486 – 4883VKD → GKE in AAC50136. 1 PublicationCurated
Sequence conflicti543 – 5431V → L in AAC50136. 1 PublicationCurated
Sequence conflicti562 – 5621Missing in AAB60371. 1 PublicationCurated
Sequence conflicti651 – 6511I → V in AAD09102. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti380 – 3801E → K.
Corresponds to variant rs1643702 [ dbSNP | Ensembl ].
VAR_030741
Natural varianti408 – 4081C → S.4 Publications
Corresponds to variant rs754615 [ dbSNP | Ensembl ].
VAR_022686
Natural varianti537 – 5371A → V.
Corresponds to variant rs4948 [ dbSNP | Ensembl ].
VAR_030742
Natural varianti592 – 5921E → G.1 Publication
VAR_005298

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 105105Missing in isoform 3. 1 PublicationVSP_000741Add
BLAST
Alternative sequencei1 – 6262MNPTE…KEHTE → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSMNPTETKAVKTEPEKKS QSTK in isoform 9. CuratedVSP_047393Add
BLAST
Alternative sequencei1 – 2929MNPTE…KHKKQ → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSMNPTETK in isoform 5. 1 PublicationVSP_038037Add
BLAST
Alternative sequencei1 – 11M → MSQPGQKPAASPRPRRAAAA RRTHEHVSEKTSESPSKPGE KKGSDEKKAASLGSSQSSRT YAGGTASATKVSASSGATSK SSSM in isoform 6 and isoform 7. CuratedVSP_038038
Alternative sequencei9 – 3022Missing in isoform 4 and isoform 8. 3 PublicationsVSP_000742Add
BLAST
Alternative sequencei44 – 6219Missing in isoform 4 and isoform 7. 2 PublicationsVSP_000743Add
BLAST
Alternative sequencei212 – 22413Missing in isoform 2, isoform 3 and isoform 5. 2 PublicationsVSP_000744Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16217 mRNA. Translation: BAA03747.1.
D50827 mRNA. Translation: BAA09438.1.
AF327443 mRNA. Translation: AAG48151.1.
BT009783 mRNA. Translation: AAP88785.1.
AC008906 Genomic DNA. No translation available.
AC020900 Genomic DNA. No translation available.
AC104125 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW96068.1.
CH471084 Genomic DNA. Translation: EAW96071.1.
CH471084 Genomic DNA. Translation: EAW96075.1.
BC013579 mRNA. Translation: AAH13579.1.
BC016066 mRNA. Translation: AAH16066.1. Sequence problems.
AL832349 mRNA. No translation available.
M86258 mRNA. Translation: AAB59398.1.
M28230
, M28227, M28228, M28229 Genomic DNA. Translation: AAA52066.1.
M33328 mRNA. Translation: AAA52296.1.
U26724 mRNA. Translation: AAC50136.2.
S73329 mRNA. Translation: AAB32311.1.
U38525 mRNA. Translation: AAA80684.1.
U31345 mRNA. Translation: AAB60371.1.
U31346 mRNA. Translation: AAB60372.1.
AF095891 mRNA. Translation: AAD09102.1.
CCDSiCCDS4082.1. [P20810-8]
CCDS54882.1. [P20810-9]
CCDS54883.1. [P20810-2]
PIRiA38091.
RefSeqiNP_001035905.1. NM_001042440.3. [P20810-9]
NP_001177371.1. NM_001190442.1. [P20810-2]
NP_001271141.1. NM_001284212.1.
NP_775083.1. NM_173060.3. [P20810-8]
XP_006714759.1. XM_006714696.1. [P20810-6]
XP_006714763.1. XM_006714700.1. [P20810-7]
XP_006714766.1. XM_006714703.1. [P20810-5]
XP_006714770.1. XM_006714707.1. [P20810-1]
XP_006714771.1. XM_006714708.1. [P20810-2]
XP_006714774.1. XM_006714711.1. [P20810-4]
UniGeneiHs.436186.

Genome annotation databases

EnsembliENST00000309190; ENSP00000312523; ENSG00000153113. [P20810-8]
ENST00000338252; ENSP00000343421; ENSG00000153113. [P20810-2]
ENST00000341926; ENSP00000339914; ENSG00000153113. [P20810-1]
ENST00000395812; ENSP00000379157; ENSG00000153113. [P20810-9]
ENST00000395813; ENSP00000379158; ENSG00000153113. [P20810-1]
ENST00000508830; ENSP00000425721; ENSG00000153113. [P20810-6]
ENST00000510098; ENSP00000427195; ENSG00000153113.
GeneIDi831.
KEGGihsa:831.
UCSCiuc003klt.3. human. [P20810-2]
uc003klx.3. human.
uc003klz.1. human. [P20810-1]
uc003kma.2. human. [P20810-4]
uc003kmd.3. human.

Polymorphism databases

DMDMi126302556.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16217 mRNA. Translation: BAA03747.1 .
D50827 mRNA. Translation: BAA09438.1 .
AF327443 mRNA. Translation: AAG48151.1 .
BT009783 mRNA. Translation: AAP88785.1 .
AC008906 Genomic DNA. No translation available.
AC020900 Genomic DNA. No translation available.
AC104125 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW96068.1 .
CH471084 Genomic DNA. Translation: EAW96071.1 .
CH471084 Genomic DNA. Translation: EAW96075.1 .
BC013579 mRNA. Translation: AAH13579.1 .
BC016066 mRNA. Translation: AAH16066.1 . Sequence problems.
AL832349 mRNA. No translation available.
M86258 mRNA. Translation: AAB59398.1 .
M28230
, M28227 , M28228 , M28229 Genomic DNA. Translation: AAA52066.1 .
M33328 mRNA. Translation: AAA52296.1 .
U26724 mRNA. Translation: AAC50136.2 .
S73329 mRNA. Translation: AAB32311.1 .
U38525 mRNA. Translation: AAA80684.1 .
U31345 mRNA. Translation: AAB60371.1 .
U31346 mRNA. Translation: AAB60372.1 .
AF095891 mRNA. Translation: AAD09102.1 .
CCDSi CCDS4082.1. [P20810-8 ]
CCDS54882.1. [P20810-9 ]
CCDS54883.1. [P20810-2 ]
PIRi A38091.
RefSeqi NP_001035905.1. NM_001042440.3. [P20810-9 ]
NP_001177371.1. NM_001190442.1. [P20810-2 ]
NP_001271141.1. NM_001284212.1.
NP_775083.1. NM_173060.3. [P20810-8 ]
XP_006714759.1. XM_006714696.1. [P20810-6 ]
XP_006714763.1. XM_006714700.1. [P20810-7 ]
XP_006714766.1. XM_006714703.1. [P20810-5 ]
XP_006714770.1. XM_006714707.1. [P20810-1 ]
XP_006714771.1. XM_006714708.1. [P20810-2 ]
XP_006714774.1. XM_006714711.1. [P20810-4 ]
UniGenei Hs.436186.

3D structure databases

DisProti DP00196.
ProteinModelPortali P20810.
SMRi P20810. Positions 156-240, 566-659.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107281. 22 interactions.
IntActi P20810. 10 interactions.
STRINGi 9606.ENSP00000379158.

Protein family/group databases

MEROPSi I27.001.

PTM databases

PhosphoSitei P20810.

Polymorphism databases

DMDMi 126302556.

Proteomic databases

MaxQBi P20810.
PaxDbi P20810.
PRIDEi P20810.

Protocols and materials databases

DNASUi 831.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309190 ; ENSP00000312523 ; ENSG00000153113 . [P20810-8 ]
ENST00000338252 ; ENSP00000343421 ; ENSG00000153113 . [P20810-2 ]
ENST00000341926 ; ENSP00000339914 ; ENSG00000153113 . [P20810-1 ]
ENST00000395812 ; ENSP00000379157 ; ENSG00000153113 . [P20810-9 ]
ENST00000395813 ; ENSP00000379158 ; ENSG00000153113 . [P20810-1 ]
ENST00000508830 ; ENSP00000425721 ; ENSG00000153113 . [P20810-6 ]
ENST00000510098 ; ENSP00000427195 ; ENSG00000153113 .
GeneIDi 831.
KEGGi hsa:831.
UCSCi uc003klt.3. human. [P20810-2 ]
uc003klx.3. human.
uc003klz.1. human. [P20810-1 ]
uc003kma.2. human. [P20810-4 ]
uc003kmd.3. human.

Organism-specific databases

CTDi 831.
GeneCardsi GC05P095865.
HGNCi HGNC:1515. CAST.
HPAi CAB009491.
HPA036881.
HPA036882.
MIMi 114090. gene.
neXtProti NX_P20810.
PharmGKBi PA26098.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25116.
GeneTreei ENSGT00390000002993.
HOGENOMi HOG000082405.
HOVERGENi HBG000183.
InParanoidi P20810.
KOi K04281.
OMAi KSSSMNP.
OrthoDBi EOG77HDF0.
PhylomeDBi P20810.
TreeFami TF332525.

Miscellaneous databases

ChiTaRSi CAST. human.
GeneWikii Calpastatin.
GenomeRNAii 831.
NextBioi 3422.
PROi P20810.
SOURCEi Search...

Gene expression databases

Bgeei P20810.
CleanExi HS_CAST.
ExpressionAtlasi P20810. baseline and differential.
Genevestigatori P20810.

Family and domain databases

InterProi IPR026998. Calpastatin.
IPR001259. Prot_inh_calpain.
[Graphical view ]
PANTHERi PTHR10077. PTHR10077. 1 hit.
Pfami PF00748. Calpain_inhib. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of human calpastatin: sequence homology among human, pig, and rabbit calpastatins."
    Asada K., Ishino Y., Shimada M., Shimojo T., Endo M., Kimizuka F., Kato I., Maki M., Hatanaka M., Murachi T.
    J. Enzym. Inhib. 3:49-56(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-408 AND GLY-592.
  2. "Cloning and characterization of a novel isoform of calpastatin in human adult testis."
    Zhu H., Zhou Z.-M., Li J.-M., Zhu H., Cheng L.-J., Shan Y.-X., Yin L.-L., Sha J.H.
    Acta Pharmacol. Sin. 23:450-454(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Testis.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 6 AND 7).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-319 (ISOFORM 5).
    Tissue: Lung and Skin.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-479 (ISOFORM 8), VARIANT SER-408.
  8. "Molecular diversity in amino-terminal domains of human calpastatin by exon skipping."
    Lee W.J., Ma H., Takano E., Yang H.Q., Hatanaka M., Maki M.
    J. Biol. Chem. 267:8437-8442(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-283 (ISOFORM 1), ALTERNATIVE SPLICING.
    Tissue: Lung.
  9. "Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene."
    Maki M., Bagci H., Hamaguchi K., Ueda M., Murachi T., Hatanaka M.
    J. Biol. Chem. 264:18866-18869(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-317.
  10. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-283 (ISOFORMS 2/3).
  11. Wang L.F.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 153-708 (ISOFORMS 2/3), SEQUENCE REVISION, VARIANT SER-408.
  12. "Calpastatin gene in human testis."
    Wang L.F., Wei S.G., Miao S.Y., Liu Q.Y., Koide S.S.
    Biochem. Mol. Biol. Int. 33:245-252(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 523-708 (ISOFORMS 1/2/3/4).
    Tissue: Testis.
  13. "Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera."
    Despres N., Talbot G., Plouffe B., Boire G., Menard H.A.
    J. Clin. Invest. 95:1891-1896(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 425-708 (ISOFORMS 1/2/3/4).
    Tissue: Placenta.
  14. El-Amine M., Talbot G., Despres N., Asselin C., Boire G., Menard H.A.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-708 (ISOFORMS 1/2/3/4), VARIANT SER-408.
    Tissue: Placenta.
  15. "New calpastatin 3' UTR."
    Rochdi M.D., El-Amine M., Menard H.A.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 636-708 (ISOFORMS 1/2/3/4).
  16. "Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells."
    Adachi Y., Ishida-Takahashi A., Takahashi C., Takano E., Murachi T., Hatanaka M.
    J. Biol. Chem. 266:3968-3972(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  17. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-364; SER-366 AND SER-373, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133; SER-575 AND SER-577, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 (ISOFORMS 5; 6; 7 AND 9), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiICAL_HUMAN
AccessioniPrimary (citable) accession number: P20810
Secondary accession number(s): G5E946
, G5E9D3, O95360, Q05DE8, Q7Z4K0, Q96D08, Q9H1Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3