##gff-version 3 P20809 UniProtKB Signal peptide 1 21 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P20809 UniProtKB Chain 22 199 . . . ID=PRO_0000015618;Note=Interleukin-11 P20809 UniProtKB Region 182 190 . . . Note=Important for interaction with IL11RA and for the stimulation of cell proliferation;Ontology_term=ECO:0000305;evidence=ECO:0000305 P20809 UniProtKB Site 168 168 . . . Note=Important for interaction with IL6ST and for the stimulation of cell proliferation;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P47873 P20809 UniProtKB Alternative sequence 1 79 . . . ID=VSP_046936;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P20809 UniProtKB Natural variant 108 108 . . . ID=VAR_016313;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs4252576 P20809 UniProtKB Natural variant 112 112 . . . ID=VAR_016314;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4;Dbxref=dbSNP:rs4252548 P20809 UniProtKB Mutagenesis 182 182 . . . Note=Increases affinity for IL11RA and stimulation of cell proliferation. H->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12919066;Dbxref=PMID:12919066 P20809 UniProtKB Mutagenesis 186 186 . . . Note=Strongly increases affinity for IL11RA and stimulation of cell proliferation. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12919066;Dbxref=PMID:12919066 P20809 UniProtKB Mutagenesis 186 186 . . . Note=Increases affinity for IL11RA and stimulation of cell proliferation. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12919066;Dbxref=PMID:12919066 P20809 UniProtKB Sequence conflict 175 175 . . . Note=H->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P20809 UniProtKB Helix 35 63 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O4O P20809 UniProtKB Helix 87 89 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O4O P20809 UniProtKB Helix 90 114 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O4O P20809 UniProtKB Helix 117 122 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O4O P20809 UniProtKB Helix 125 146 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O4O P20809 UniProtKB Helix 167 196 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O4O