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Protein

Interleukin-11

Gene

IL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.By similarity2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei168 – 1681Important for interaction with IL6ST and for the stimulation of cell proliferationBy similarity

GO - Molecular functioni

  1. growth factor activity Source: UniProtKB
  2. interleukin-11 receptor binding Source: UniProtKB

GO - Biological processi

  1. B cell differentiation Source: UniProtKB
  2. cell-cell signaling Source: UniProtKB
  3. fat cell differentiation Source: UniProtKB
  4. megakaryocyte differentiation Source: UniProtKB
  5. negative regulation of hormone secretion Source: MGI
  6. positive regulation of cell proliferation Source: UniProtKB
  7. positive regulation of MAPK cascade Source: MGI
  8. positive regulation of peptidyl-serine phosphorylation Source: MGI
  9. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  10. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

SignaLinkiP20809.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-11
Short name:
IL-11
Alternative name(s):
Adipogenesis inhibitory factor1 Publication
Short name:
AGIF1 Publication
INN: Oprelvekin
Gene namesi
Name:IL11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:5966. IL11.

Subcellular locationi

  1. Secreted 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular region Source: UniProtKB
  3. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi182 – 1821H → V: Increases affinity for IL11RA and stimulation of cell proliferation. 1 Publication
Mutagenesisi186 – 1861D → A: Strongly increases affinity for IL11RA and stimulation of cell proliferation. 1 Publication
Mutagenesisi186 – 1861D → V: Increases affinity for IL11RA and stimulation of cell proliferation. 1 Publication

Organism-specific databases

PharmGKBiPA29781.

Polymorphism and mutation databases

BioMutaiIL11.
DMDMi124294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 199178Interleukin-11PRO_0000015618Add
BLAST

Proteomic databases

PaxDbiP20809.
PRIDEiP20809.

PTM databases

PhosphoSiteiP20809.

Expressioni

Gene expression databases

BgeeiP20809.
CleanExiHS_IL11.
ExpressionAtlasiP20809. baseline and differential.
GenevestigatoriP20809.

Interactioni

Subunit structurei

Interacts with IL6ST and either IL11RA1 or IL11RA2, giving rise to a multimeric signaling complex.1 Publication1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA11P43364-23EBI-751694,EBI-10178634

Protein-protein interaction databases

BioGridi109803. 1 interaction.
DIPiDIP-3775N.
IntActiP20809. 1 interaction.
MINTiMINT-1470864.
STRINGi9606.ENSP00000264563.

Structurei

Secondary structure

1
199
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 6329Combined sources
Turni87 – 893Combined sources
Helixi90 – 11425Combined sources
Helixi117 – 1226Combined sources
Helixi123 – 14624Combined sources
Helixi167 – 19731Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4MHLX-ray2.09A23-199[»]
ProteinModelPortaliP20809.
SMRiP20809. Positions 34-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 1909Important for interaction with IL11RA and for the stimulation of cell proliferationCurated

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72895.
GeneTreeiENSGT00390000007165.
HOGENOMiHOG000013057.
HOVERGENiHBG003999.
InParanoidiP20809.
KOiK05417.
OMAiMNSVCCL.
OrthoDBiEOG7W1569.
PhylomeDBiP20809.
TreeFamiTF337294.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020438. IL-11.
IPR020412. IL-11_mml.
[Graphical view]
PfamiPF07400. IL11. 1 hit.
[Graphical view]
PRINTSiPR01943. INTLKN11MAML.
PR01927. INTRLEUKIN11.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20809-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNCVCRLVLV VLSLWPDTAV APGPPPGPPR VSPDPRAELD STVLLTRSLL
60 70 80 90 100
ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD
110 120 130 140 150
LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP
160 170 180 190
QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Length:199
Mass (Da):21,429
Last modified:February 1, 1991 - v1
Checksum:iF292BF8B34F4096D
GO
Isoform 2 (identifier: P20809-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:120
Mass (Da):12,994
Checksum:i780FBDAA475370D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751H → L in AAH12506 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081V → M.1 Publication
Corresponds to variant rs4252576 [ dbSNP | Ensembl ].
VAR_016313
Natural varianti112 – 1121R → H.1 Publication
Corresponds to variant rs4252548 [ dbSNP | Ensembl ].
VAR_016314

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979Missing in isoform 2. 1 PublicationVSP_046936Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57765 mRNA. Translation: AAA59132.1.
X58377 mRNA. Translation: CAA41266.1.
AY207429 Genomic DNA. Translation: AAO13493.1.
AK298973 mRNA. Translation: BAG61067.1.
AC020922 Genomic DNA. No translation available.
BC012506 mRNA. Translation: AAH12506.1.
CCDSiCCDS12923.1. [P20809-1]
CCDS59423.1. [P20809-2]
PIRiA42830. B38285.
RefSeqiNP_000632.1. NM_000641.3. [P20809-1]
NP_001254647.1. NM_001267718.1. [P20809-2]
UniGeneiHs.467304.

Genome annotation databases

EnsembliENST00000264563; ENSP00000264563; ENSG00000095752. [P20809-1]
ENST00000585513; ENSP00000467355; ENSG00000095752. [P20809-1]
ENST00000590625; ENSP00000465705; ENSG00000095752. [P20809-2]
GeneIDi3589.
KEGGihsa:3589.
UCSCiuc002qks.2. human. [P20809-1]

Polymorphism and mutation databases

BioMutaiIL11.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Neumega

Clinical information on Neumega

Wikipedia

Interleukin-11 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57765 mRNA. Translation: AAA59132.1.
X58377 mRNA. Translation: CAA41266.1.
AY207429 Genomic DNA. Translation: AAO13493.1.
AK298973 mRNA. Translation: BAG61067.1.
AC020922 Genomic DNA. No translation available.
BC012506 mRNA. Translation: AAH12506.1.
CCDSiCCDS12923.1. [P20809-1]
CCDS59423.1. [P20809-2]
PIRiA42830. B38285.
RefSeqiNP_000632.1. NM_000641.3. [P20809-1]
NP_001254647.1. NM_001267718.1. [P20809-2]
UniGeneiHs.467304.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4MHLX-ray2.09A23-199[»]
ProteinModelPortaliP20809.
SMRiP20809. Positions 34-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109803. 1 interaction.
DIPiDIP-3775N.
IntActiP20809. 1 interaction.
MINTiMINT-1470864.
STRINGi9606.ENSP00000264563.

PTM databases

PhosphoSiteiP20809.

Polymorphism and mutation databases

BioMutaiIL11.
DMDMi124294.

Proteomic databases

PaxDbiP20809.
PRIDEiP20809.

Protocols and materials databases

DNASUi3589.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264563; ENSP00000264563; ENSG00000095752. [P20809-1]
ENST00000585513; ENSP00000467355; ENSG00000095752. [P20809-1]
ENST00000590625; ENSP00000465705; ENSG00000095752. [P20809-2]
GeneIDi3589.
KEGGihsa:3589.
UCSCiuc002qks.2. human. [P20809-1]

Organism-specific databases

CTDi3589.
GeneCardsiGC19M055875.
HGNCiHGNC:5966. IL11.
MIMi147681. gene.
neXtProtiNX_P20809.
PharmGKBiPA29781.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG72895.
GeneTreeiENSGT00390000007165.
HOGENOMiHOG000013057.
HOVERGENiHBG003999.
InParanoidiP20809.
KOiK05417.
OMAiMNSVCCL.
OrthoDBiEOG7W1569.
PhylomeDBiP20809.
TreeFamiTF337294.

Enzyme and pathway databases

SignaLinkiP20809.

Miscellaneous databases

ChiTaRSiIL11. human.
GeneWikiiInterleukin_11.
GenomeRNAii3589.
NextBioi14023.
PROiP20809.
SOURCEiSearch...

Gene expression databases

BgeeiP20809.
CleanExiHS_IL11.
ExpressionAtlasiP20809. baseline and differential.
GenevestigatoriP20809.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020438. IL-11.
IPR020412. IL-11_mml.
[Graphical view]
PfamiPF07400. IL11. 1 hit.
[Graphical view]
PRINTSiPR01943. INTLKN11MAML.
PR01927. INTRLEUKIN11.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine."
    Paul S.R., Bennett F., Calvetti J.A., Kelleher K., Wood C.R., O'Hara R.M. Jr., Leary A.C., Sibley B.S., Clark S.C., Williams D.A., Yang Y.-C.
    Proc. Natl. Acad. Sci. U.S.A. 87:7512-7516(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
  2. "Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11."
    Kawashima I., Ohsumi J., Mita-Honjo K., Shimoda-Takano K., Ishikawa H., Sakakibara S., Miyadai K., Takiguchi Y.
    FEBS Lett. 283:199-202(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    Tissue: Bone marrow.
  3. "Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)."
    McKinley D., Wu Q., Yang-Feng T., Yang Y.C.
    Genomics 13:814-819(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. SeattleSNPs variation discovery resource
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS MET-108 AND HIS-112.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  8. Cited for: FUNCTION, SUBUNIT, MUTAGENESIS OF HIS-182 AND ASP-186.
  9. "The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6."
    Putoczki T.L., Dobson R.C., Griffin M.D.W.
    Acta Crystallogr. D 70:2277-2285(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) OF 23-199.

Entry informationi

Entry nameiIL11_HUMAN
AccessioniPrimary (citable) accession number: P20809
Secondary accession number(s): B4DQV5, Q96EB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 29, 2015
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.