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P20809 (IL11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-11

Short name=IL-11
Alternative name(s):
Adipogenesis inhibitory factor
Short name=AGIF
INN=Oprelvekin
Gene names
Name:IL11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.

Subcellular location

Secreted.

Pharmaceutical use

Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.

Sequence similarities

Belongs to the IL-6 superfamily.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionCytokine
Growth factor
   Technical termComplete proteome
Pharmaceutical
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Non-traceable author statement Ref.1. Source: UniProtKB

cell-cell signaling

Inferred by curator Ref.1. Source: UniProtKB

fat cell differentiation

Non-traceable author statement Ref.2. Source: UniProtKB

megakaryocyte differentiation

Non-traceable author statement Ref.1. Source: UniProtKB

negative regulation of hormone secretion

Inferred from direct assay PubMed 7867561. Source: MGI

positive regulation of MAPK cascade

Inferred from direct assay PubMed 7508917. Source: MGI

positive regulation of cell proliferation

Inferred from direct assay Ref.1. Source: UniProtKB

positive regulation of peptidyl-serine phosphorylation

Inferred from direct assay PubMed 7508917. Source: MGI

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 7508917. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 7508917. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred by curator Ref.1. Source: UniProtKB

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiongrowth factor activity

Inferred from direct assay Ref.1. Source: UniProtKB

interleukin-11 receptor binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P20809-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P20809-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 199178Interleukin-11
PRO_0000015618

Natural variations

Alternative sequence1 – 7979Missing in isoform 2.
VSP_046936
Natural variant1081V → M. Ref.4
Corresponds to variant rs4252576 [ dbSNP | Ensembl ].
VAR_016313
Natural variant1121R → H. Ref.4
Corresponds to variant rs4252548 [ dbSNP | Ensembl ].
VAR_016314

Experimental info

Sequence conflict1751H → L in AAH12506. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: F292BF8B34F4096D

FASTA19921,429
        10         20         30         40         50         60 
MNCVCRLVLV VLSLWPDTAV APGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL 

        70         80         90        100        110        120 
RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK 

       130        140        150        160        170        180 
TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG 

       190 
LHLTLDWAVR GLLLLKTRL 

« Hide

Isoform 2 [UniParc].

Checksum: 780FBDAA475370D2
Show »

FASTA12012,994

References

« Hide 'large scale' references
[1]"Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine."
Paul S.R., Bennett F., Calvetti J.A., Kelleher K., Wood C.R., O'Hara R.M. Jr., Leary A.C., Sibley B.S., Clark S.C., Williams D.A., Yang Y.-C.
Proc. Natl. Acad. Sci. U.S.A. 87:7512-7516(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11."
Kawashima I., Ohsumi J., Mita-Honjo K., Shimoda-Takano K., Ishikawa H., Sakakibara S., Miyadai K., Takiguchi Y.
FEBS Lett. 283:199-202(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Bone marrow.
[3]"Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)."
McKinley D., Wu Q., Yang-Feng T., Yang Y.C.
Genomics 13:814-819(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[4]SeattleSNPs variation discovery resource
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS MET-108 AND HIS-112.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Prostate.
+Additional computationally mapped references.

Web resources

Neumega

Clinical information on Neumega

Wikipedia

Interleukin-11 entry

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57765 mRNA. Translation: AAA59132.1.
X58377 mRNA. Translation: CAA41266.1.
AY207429 Genomic DNA. Translation: AAO13493.1.
AK298973 mRNA. Translation: BAG61067.1.
AC020922 Genomic DNA. No translation available.
BC012506 mRNA. Translation: AAH12506.1.
PIRB38285. A42830.
RefSeqNP_000632.1. NM_000641.3.
NP_001254647.1. NM_001267718.1.
UniGeneHs.467304.

3D structure databases

ProteinModelPortalP20809.
SMRP20809. Positions 37-195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109803. 1 interaction.
DIPDIP-3775N.
IntActP20809. 1 interaction.
MINTMINT-1470864.
STRING9606.ENSP00000264563.

Chemistry

DrugBankDB00038. Oprelvekin.

PTM databases

PhosphoSiteP20809.

Polymorphism databases

DMDM124294.

Proteomic databases

PaxDbP20809.
PRIDEP20809.

Protocols and materials databases

DNASU3589.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264563; ENSP00000264563; ENSG00000095752. [P20809-1]
ENST00000585513; ENSP00000467355; ENSG00000095752. [P20809-1]
ENST00000590625; ENSP00000465705; ENSG00000095752. [P20809-2]
GeneID3589.
KEGGhsa:3589.
UCSCuc002qks.2. human. [P20809-1]

Organism-specific databases

CTD3589.
GeneCardsGC19M055875.
HGNCHGNC:5966. IL11.
MIM147681. gene.
neXtProtNX_P20809.
PharmGKBPA29781.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72895.
HOGENOMHOG000013057.
HOVERGENHBG003999.
InParanoidP20809.
KOK05417.
OMAMNSVCCL.
OrthoDBEOG7W1569.
PhylomeDBP20809.
TreeFamTF337294.

Enzyme and pathway databases

SignaLinkP20809.

Gene expression databases

ArrayExpressP20809.
BgeeP20809.
CleanExHS_IL11.
GenevestigatorP20809.

Family and domain databases

InterProIPR009079. 4_helix_cytokine-like_core.
IPR020438. IL-11.
IPR020412. IL-11_mml.
[Graphical view]
PfamPF07400. IL11. 1 hit.
[Graphical view]
PRINTSPR01943. INTLKN11MAML.
PR01927. INTRLEUKIN11.
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

GeneWikiInterleukin_11.
GenomeRNAi3589.
NextBio14023.
PROP20809.
SOURCESearch...

Entry information

Entry nameIL11_HUMAN
AccessionPrimary (citable) accession number: P20809
Secondary accession number(s): B4DQV5, Q96EB4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 19, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM