Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P20809

- IL11_HUMAN

UniProt

P20809 - IL11_HUMAN

Protein

Interleukin-11

Gene

IL11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.

    GO - Molecular functioni

    1. growth factor activity Source: UniProtKB
    2. interleukin-11 receptor binding Source: UniProtKB

    GO - Biological processi

    1. B cell differentiation Source: UniProtKB
    2. cell-cell signaling Source: UniProtKB
    3. fat cell differentiation Source: UniProtKB
    4. megakaryocyte differentiation Source: UniProtKB
    5. negative regulation of hormone secretion Source: MGI
    6. positive regulation of cell proliferation Source: UniProtKB
    7. positive regulation of MAPK cascade Source: MGI
    8. positive regulation of peptidyl-serine phosphorylation Source: MGI
    9. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
    10. positive regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Enzyme and pathway databases

    SignaLinkiP20809.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-11
    Short name:
    IL-11
    Alternative name(s):
    Adipogenesis inhibitory factor
    Short name:
    AGIF
    INN: Oprelvekin
    Gene namesi
    Name:IL11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:5966. IL11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular region Source: UniProtKB
    3. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.

    Organism-specific databases

    PharmGKBiPA29781.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 199178Interleukin-11PRO_0000015618Add
    BLAST

    Proteomic databases

    PaxDbiP20809.
    PRIDEiP20809.

    PTM databases

    PhosphoSiteiP20809.

    Expressioni

    Gene expression databases

    ArrayExpressiP20809.
    BgeeiP20809.
    CleanExiHS_IL11.
    GenevestigatoriP20809.

    Interactioni

    Protein-protein interaction databases

    BioGridi109803. 1 interaction.
    DIPiDIP-3775N.
    IntActiP20809. 1 interaction.
    MINTiMINT-1470864.
    STRINGi9606.ENSP00000264563.

    Structurei

    3D structure databases

    ProteinModelPortaliP20809.
    SMRiP20809. Positions 37-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-6 superfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72895.
    HOGENOMiHOG000013057.
    HOVERGENiHBG003999.
    InParanoidiP20809.
    KOiK05417.
    OMAiMNSVCCL.
    OrthoDBiEOG7W1569.
    PhylomeDBiP20809.
    TreeFamiTF337294.

    Family and domain databases

    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR020438. IL-11.
    IPR020412. IL-11_mml.
    [Graphical view]
    PfamiPF07400. IL11. 1 hit.
    [Graphical view]
    PRINTSiPR01943. INTLKN11MAML.
    PR01927. INTRLEUKIN11.
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P20809-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNCVCRLVLV VLSLWPDTAV APGPPPGPPR VSPDPRAELD STVLLTRSLL    50
    ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD 100
    LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP 150
    QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL 199
    Length:199
    Mass (Da):21,429
    Last modified:February 1, 1991 - v1
    Checksum:iF292BF8B34F4096D
    GO
    Isoform 2 (identifier: P20809-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.

    Show »
    Length:120
    Mass (Da):12,994
    Checksum:i780FBDAA475370D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751H → L in AAH12506. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081V → M.1 Publication
    Corresponds to variant rs4252576 [ dbSNP | Ensembl ].
    VAR_016313
    Natural varianti112 – 1121R → H.1 Publication
    Corresponds to variant rs4252548 [ dbSNP | Ensembl ].
    VAR_016314

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7979Missing in isoform 2. 1 PublicationVSP_046936Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57765 mRNA. Translation: AAA59132.1.
    X58377 mRNA. Translation: CAA41266.1.
    AY207429 Genomic DNA. Translation: AAO13493.1.
    AK298973 mRNA. Translation: BAG61067.1.
    AC020922 Genomic DNA. No translation available.
    BC012506 mRNA. Translation: AAH12506.1.
    CCDSiCCDS12923.1. [P20809-1]
    CCDS59423.1. [P20809-2]
    PIRiA42830. B38285.
    RefSeqiNP_000632.1. NM_000641.3. [P20809-1]
    NP_001254647.1. NM_001267718.1. [P20809-2]
    UniGeneiHs.467304.

    Genome annotation databases

    EnsembliENST00000264563; ENSP00000264563; ENSG00000095752. [P20809-1]
    ENST00000585513; ENSP00000467355; ENSG00000095752. [P20809-1]
    ENST00000590625; ENSP00000465705; ENSG00000095752. [P20809-2]
    GeneIDi3589.
    KEGGihsa:3589.
    UCSCiuc002qks.2. human. [P20809-1]

    Polymorphism databases

    DMDMi124294.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Neumega

    Clinical information on Neumega

    Wikipedia

    Interleukin-11 entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57765 mRNA. Translation: AAA59132.1 .
    X58377 mRNA. Translation: CAA41266.1 .
    AY207429 Genomic DNA. Translation: AAO13493.1 .
    AK298973 mRNA. Translation: BAG61067.1 .
    AC020922 Genomic DNA. No translation available.
    BC012506 mRNA. Translation: AAH12506.1 .
    CCDSi CCDS12923.1. [P20809-1 ]
    CCDS59423.1. [P20809-2 ]
    PIRi A42830. B38285.
    RefSeqi NP_000632.1. NM_000641.3. [P20809-1 ]
    NP_001254647.1. NM_001267718.1. [P20809-2 ]
    UniGenei Hs.467304.

    3D structure databases

    ProteinModelPortali P20809.
    SMRi P20809. Positions 37-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109803. 1 interaction.
    DIPi DIP-3775N.
    IntActi P20809. 1 interaction.
    MINTi MINT-1470864.
    STRINGi 9606.ENSP00000264563.

    Chemistry

    DrugBanki DB00038. Oprelvekin.

    PTM databases

    PhosphoSitei P20809.

    Polymorphism databases

    DMDMi 124294.

    Proteomic databases

    PaxDbi P20809.
    PRIDEi P20809.

    Protocols and materials databases

    DNASUi 3589.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264563 ; ENSP00000264563 ; ENSG00000095752 . [P20809-1 ]
    ENST00000585513 ; ENSP00000467355 ; ENSG00000095752 . [P20809-1 ]
    ENST00000590625 ; ENSP00000465705 ; ENSG00000095752 . [P20809-2 ]
    GeneIDi 3589.
    KEGGi hsa:3589.
    UCSCi uc002qks.2. human. [P20809-1 ]

    Organism-specific databases

    CTDi 3589.
    GeneCardsi GC19M055875.
    HGNCi HGNC:5966. IL11.
    MIMi 147681. gene.
    neXtProti NX_P20809.
    PharmGKBi PA29781.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72895.
    HOGENOMi HOG000013057.
    HOVERGENi HBG003999.
    InParanoidi P20809.
    KOi K05417.
    OMAi MNSVCCL.
    OrthoDBi EOG7W1569.
    PhylomeDBi P20809.
    TreeFami TF337294.

    Enzyme and pathway databases

    SignaLinki P20809.

    Miscellaneous databases

    GeneWikii Interleukin_11.
    GenomeRNAii 3589.
    NextBioi 14023.
    PROi P20809.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20809.
    Bgeei P20809.
    CleanExi HS_IL11.
    Genevestigatori P20809.

    Family and domain databases

    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR020438. IL-11.
    IPR020412. IL-11_mml.
    [Graphical view ]
    Pfami PF07400. IL11. 1 hit.
    [Graphical view ]
    PRINTSi PR01943. INTLKN11MAML.
    PR01927. INTRLEUKIN11.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine."
      Paul S.R., Bennett F., Calvetti J.A., Kelleher K., Wood C.R., O'Hara R.M. Jr., Leary A.C., Sibley B.S., Clark S.C., Williams D.A., Yang Y.-C.
      Proc. Natl. Acad. Sci. U.S.A. 87:7512-7516(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11."
      Kawashima I., Ohsumi J., Mita-Honjo K., Shimoda-Takano K., Ishikawa H., Sakakibara S., Miyadai K., Takiguchi Y.
      FEBS Lett. 283:199-202(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    3. "Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)."
      McKinley D., Wu Q., Yang-Feng T., Yang Y.C.
      Genomics 13:814-819(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    4. SeattleSNPs variation discovery resource
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS MET-108 AND HIS-112.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Prostate.

    Entry informationi

    Entry nameiIL11_HUMAN
    AccessioniPrimary (citable) accession number: P20809
    Secondary accession number(s): B4DQV5, Q96EB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 143 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3