P20809 (IL11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-11
Short name=IL-11

Alternative name(s):
Adipogenesis inhibitory factor
Short name=AGIF
INN=Oprelvekin

Gene names

Name:

IL11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
Subcellular location	Secreted.
Pharmaceutical use	Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.
Sequence similarities	Belongs to the IL-6 superfamily.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine Growth factor
Technical term	Complete proteome Pharmaceutical Reference proteome
Gene Ontology (GO)
Biological_process	B cell differentiation Non-traceable author statement Ref.1. Source: UniProtKB cell-cell signaling Inferred by curator Ref.1. Source: UniProtKB fat cell differentiation Non-traceable author statement Ref.2. Source: UniProtKB megakaryocyte differentiation Non-traceable author statement Ref.1. Source: UniProtKB negative regulation of hormone secretion Inferred from direct assay PubMed 7867561. Source: MGI platelet activation Non-traceable author statement. Source: UniProtKB positive regulation of MAPK cascade Inferred from direct assay PubMed 7508917. Source: MGI positive regulation of cell proliferation Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of peptidyl-serine phosphorylation Inferred from direct assay PubMed 7508917. Source: MGI positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay PubMed 7508917. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 7508917. Source: MGI
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular region Inferred by curator Ref.1. Source: UniProtKB extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	growth factor activity Inferred from direct assay Ref.1. Source: UniProtKB interleukin-11 receptor binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 199	178	Interleukin-11		PRO_0000015618
Natural variations
	Natural variant	108	1	V → M. Ref.4 Corresponds to variant rs4252576 [ dbSNP | Ensembl ].		VAR_016313
	Natural variant	112	1	R → H. Ref.4 Corresponds to variant rs4252548 [ dbSNP | Ensembl ].		VAR_016314
Experimental info
	Sequence conflict	175	1	H → L in AAH12506. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P20809 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: F292BF8B34F4096D	FASTA	199	21,429
	10 20 30 40 50 60 MNCVCRLVLV VLSLWPDTAV APGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL 70 80 90 100 110 120 RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK 130 140 150 160 170 180 TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG 190 LHLTLDWAVR GLLLLKTRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine." Paul S.R., Bennett F., Calvetti J.A., Kelleher K., Wood C.R., O'Hara R.M. Jr., Leary A.C., Sibley B.S., Clark S.C., Williams D.A., Yang Y.-C. Proc. Natl. Acad. Sci. U.S.A. 87:7512-7516(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11." Kawashima I., Ohsumi J., Mita-Honjo K., Shimoda-Takano K., Ishikawa H., Sakakibara S., Miyadai K., Takiguchi Y. FEBS Lett. 283:199-202(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow.
[3]	"Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)." McKinley D., Wu Q., Yang-Feng T., Yang Y.C. Genomics 13:814-819(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	SeattleSNPs variation discovery resource Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-108 AND HIS-112.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
+	Additional computationally mapped references.

Web resources

Neumega

Clinical information on Neumega

Wikipedia

Interleukin-11 entry

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	M57765 mRNA. Translation: AAA59132.1. X58377 mRNA. Translation: CAA41266.1. AY207429 Genomic DNA. Translation: AAO13493.1. BC012506 mRNA. Translation: AAH12506.1.
IPI	IPI00025820.
PIR	B38285. A42830.
RefSeq	NP_000632.1. NM_000641.3.
UniGene	Hs.467304.
3D structure databases
ProteinModelPortal	P20809.
SMR	P20809. Positions 35-195.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3775N.
IntAct	P20809. 1 interaction.
MINT	MINT-1470864.
STRING	9606.ENSP00000264563.
PTM databases
PhosphoSite	P20809.
Polymorphism databases
DMDM	124294.
Proteomic databases
PaxDb	P20809.
PRIDE	P20809.
Protocols and materials databases
DNASU	3589.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264563; ENSP00000264563; ENSG00000095752. ENST00000585513; ENSP00000467355; ENSG00000095752.
GeneID	3589.
KEGG	hsa:3589.
UCSC	uc002qks.1. human.
Organism-specific databases
CTD	3589.
GeneCards	GC19M055875.
HGNC	HGNC:5966. IL11.
MIM	147681. gene.
neXtProt	NX_P20809.
PharmGKB	PA29781.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72895.
HOGENOM	HOG000013057.
HOVERGEN	HBG003999.
InParanoid	P20809.
KO	K05417.
OMA	SLWPDRA.
OrthoDB	EOG495ZSZ.
PhylomeDB	P20809.
Enzyme and pathway databases
SignaLink	P20809.
Gene expression databases
ArrayExpress	P20809.
Bgee	P20809.
CleanEx	HS_IL11.
Genevestigator	P20809.
GermOnline	ENSG00000095752. Homo sapiens.
Family and domain databases
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR020438. Interleukin-11. IPR020412. Interleukin-11_mammalian. [Graphical view]
Pfam	PF07400. IL11. 1 hit. [Graphical view]
PRINTS	PR01943. INTLKN11MAML. PR01927. INTRLEUKIN11.
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00038. Oprelvekin.
GenomeRNAi	3589.
NextBio	14023.
SOURCE	Search...

Entry information

Entry name

IL11_HUMAN

Accession

Primary (citable) accession number: P20809
Secondary accession number(s): Q96EB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	May 29, 2013
This is version 131 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.