Reviewed,
UniProtKB/Swiss-Prot P20806 (7LESS_DROVI)
Last modified
June 16, 2009.
Version 86.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Protein sevenless EC=2.7.10.1 | ||
| Gene names |
| ||
| Organism | Drosophila virilis (Fruit fly) | ||
| Taxonomic identifier | 7244 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila |
Protein attributes
| Sequence length | 2594 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Receptor for an extracellular signal required to instruct a cell to differentiate into a R7 photoreceptor. The ligand for Sev is the Boss (Bride of Sevenless) protein. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subcellular location | Cell membrane; Single-pass membrane protein Potential. |
| Domain | It is unclear whether the potential membrane spanning region near the N-terminus is present as a transmembrane domain in the native protein or serves as a cleaved signal sequence. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 7 fibronectin type-III domains. Contains 1 protein kinase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 2594 | 2594 | Protein sevenless | PRO_0000058929 | |||||
Regions | |||||||||
| Topological domain | 1 – 2139 | 2139 | Extracellular Potential | ||||||
| Transmembrane | 2140 – 2163 | 24 | Potential | ||||||
| Topological domain | 2164 – 2594 | 431 | Cytoplasmic Potential | ||||||
| Domain | 356 – 459 | 104 | Fibronectin type-III 1 | ||||||
| Domain | 464 – 555 | 92 | Fibronectin type-III 2 | ||||||
| Domain | 835 – 935 | 101 | Fibronectin type-III 3 | ||||||
| Domain | 1328 – 1421 | 94 | Fibronectin type-III 4 | ||||||
| Domain | 1706 – 1816 | 111 | Fibronectin type-III 5 | ||||||
| Domain | 1817 – 1916 | 100 | Fibronectin type-III 6 | ||||||
| Domain | 1917 – 2007 | 91 | Fibronectin type-III 7 | ||||||
| Domain | 2224 – 2495 | 272 | Protein kinase | ||||||
| Nucleotide binding | 2230 – 2238 | 9 | ATP By similarity | ||||||
| Compositional bias | 9 – 26 | 18 | Poly-Gln | ||||||
| Compositional bias | 2057 – 2063 | 7 | Poly-Arg | ||||||
Sites | |||||||||
| Active site | 2355 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 2257 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2391 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||
| Glycosylation | 77 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 401 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 508 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 532 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 641 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 667 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 778 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 797 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 874 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 980 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1257 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1344 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1382 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1577 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1587 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1665 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1752 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1776 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1824 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1908 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 1966 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 2088 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Comparison of the sevenless genes of Drosophila virilis and Drosophila melanogaster." Michael W.M., Bowtell D.D.L., Rubin G.M. Proc. Natl. Acad. Sci. U.S.A. 87:5351-5353(1990) [PubMed: 2115169] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| M34545, M34544, M34543 Genomic DNA. Translation: AAA28883.1. | |
| PIR | A35774. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1LUF based on UniProtKB Q62838. |
| ModBase | Search... |
Organism-specific databases | |
| FlyBase | FBgn0013140. Dvir\sev. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.1. 141708. |
Family and domain databases | |
| InterPro | IPR011042. 6-blade_b-propeller_TolB-like. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR000033. LDLR. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR002011. Recept_tyr_kinase-II_CS. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view] |
| Gene3D | G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 3 hits. G3DSA:2.60.40.30. FN_III-like. 3 hits. |
| Pfam | PF00041. fn3. 6 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view] |
| PRINTS | PR00109. TYRKINASE. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00060. FN3. 7 hits. SM00135. LY. 3 hits. SM00219. TyrKc. 1 hit. [Graphical view] |
| PROSITE | PS50853. FN3. 8 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | 7LESS_DROVI | ||||||||
| Accession | Primary (citable) accession number: P20806 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |
