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P20806 (7LESS_DROVI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein sevenless
EC=2.7.10.1
Gene names
Name:sev
OrganismDrosophila virilis (Fruit fly)
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

Protein attributes

Sequence length2594 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Receptor for an extracellular signal required to instruct a cell to differentiate into a R7 photoreceptor. The ligand for Sev is the Boss (Bride of Sevenless) protein.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Cell membrane; Single-pass membrane protein Potential.

Domain

It is unclear whether the potential membrane spanning region near the N-terminus is present as a transmembrane domain in the native protein or serves as a cleaved signal sequence.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Contains 8 fibronectin type-III domains.

Contains 1 LDL-receptor class B repeat.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 25942594Protein sevenless
PRO_0000058929

Regions

Topological domain1 – 21412141Extracellular Potential
Transmembrane2142 – 216221Helical; Potential
Topological domain2163 – 2594432Cytoplasmic Potential
Domain358 – 459102Fibronectin type-III 1
Domain465 – 55591Fibronectin type-III 2
Domain838 – 93396Fibronectin type-III 3
Repeat1024 – 106643LDL-receptor class B
Domain1227 – 131791Fibronectin type-III 4
Domain1322 – 1423102Fibronectin type-III 5
Domain1819 – 191799Fibronectin type-III 6
Domain1922 – 200887Fibronectin type-III 7
Domain2012 – 2128117Fibronectin type-III 8
Domain2224 – 2495272Protein kinase
Nucleotide binding2230 – 22389ATP By similarity
Compositional bias9 – 2618Poly-Gln
Compositional bias2057 – 20637Poly-Arg

Sites

Active site23551Proton acceptor By similarity
Binding site22571ATP By similarity

Amino acid modifications

Modified residue23911Phosphotyrosine; by autocatalysis By similarity
Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential
Glycosylation5081N-linked (GlcNAc...) Potential
Glycosylation5321N-linked (GlcNAc...) Potential
Glycosylation6411N-linked (GlcNAc...) Potential
Glycosylation6671N-linked (GlcNAc...) Potential
Glycosylation7781N-linked (GlcNAc...) Potential
Glycosylation7971N-linked (GlcNAc...) Potential
Glycosylation8741N-linked (GlcNAc...) Potential
Glycosylation9801N-linked (GlcNAc...) Potential
Glycosylation12571N-linked (GlcNAc...) Potential
Glycosylation13441N-linked (GlcNAc...) Potential
Glycosylation13821N-linked (GlcNAc...) Potential
Glycosylation15771N-linked (GlcNAc...) Potential
Glycosylation15871N-linked (GlcNAc...) Potential
Glycosylation16651N-linked (GlcNAc...) Potential
Glycosylation17521N-linked (GlcNAc...) Potential
Glycosylation17761N-linked (GlcNAc...) Potential
Glycosylation18241N-linked (GlcNAc...) Potential
Glycosylation19081N-linked (GlcNAc...) Potential
Glycosylation19661N-linked (GlcNAc...) Potential
Glycosylation20881N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P20806 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 77D8A356CBAD0BBD

FASTA2,594289,133
        10         20         30         40         50         60 
MFWREDAAQQ QQQQQQQQQQ QQQQQQPPHP PKRLSFSFNV KIAVNVNTKM STTHINQERS 

        70         80         90        100        110        120 
KQQTTTGSRS RSRSNSNSSV SCKGDGDRRV RRHTTRLVGL RQQLLHLGRQ LNPGQFLVTG 

       130        140        150        160        170        180 
HGGISTILIA NLLLLLLLSL CCNVCCRSHI EPDQNLTPTT TSPAAVAVVP MLLPLAQTHM 

       190        200        210        220        230        240 
RPQLDSDVVE KVAVWTKHVG AAPPSIAEGI AISSVVRMPP SIQTPTETVR RQEQQRQQQQ 

       250        260        270        280        290        300 
QQQEAAAAAA ADAAIDERIV LERVTRDCVQ RCIVEEDLFL DEFGIKCEKA DNSDKCYKTR 

       310        320        330        340        350        360 
CNKGCAQWYR ALKEIEPCQE ACASTQFYPY DMPCIGACET AQRDYWHMQR LAMARLVETT 

       370        380        390        400        410        420 
QPQLLEMTDE SSTLTIKWAM QFPENYLASR PFNIQYQQVD NQSEPEWHNL ADYDCDEYYV 

       430        440        450        460        470        480 
CEILEALVPY TRYKFRFELP FGESSEDVLY SPATPVYETP MEGAPISAPI IVALLALDEH 

       490        500        510        520        530        540 
HVFVHWRPGR YSNAPIEGYR VLLTSAGNTS REQLLPAQRT SCIFAQLQPL TNYTVALTMI 

       550        560        570        580        590        600 
NKQGEGPSTV VSIVTKSPLE PQQLQSVLLA SEHSIIWQSL EPAGETRLLY TSEPAAISDF 

       610        620        630        640        650        660 
TFSQREQRLW LLDELGQLHS QLLDETTTSA ARRLRLELPS NGSSQWTPRK LSLDWLQRRL 

       670        680        690        700        710        720 
YIAAQANSSD GAEGGFELFS SNLEGGDVQM AGVQLGLVVE QLELDALNGW LFWCDADSLW 

       730        740        750        760        770        780 
RLDLSSKQQL RLTQPAGAPG RFMLEPQRWL LHVLLPQENQ LLELSYDGGH KHALALSNDS 

       790        800        810        820        830        840 
WRGFAWSSDQ AQLLLANETQ LQLLDGQTLV PLANWSPDGG CCALLPLERR RQPLSLEPPA 

       850        860        870        880        890        900 
PRELRALLGA QGAHITWQPP AANPYQTATA AARNFSYELE VLDVASQSAY NIRNIRVPHF 

       910        920        930        940        950        960 
GLERLQADNL YQLRVRANNA AGRAGVWTAP LATRTWPLGD HRLRWATQRG SLYTTNELGG 

       970        980        990       1000       1010       1020 
QLQPLPVQLA SSPGPLALVN ASVAYYVSGR EQSLHCVNLL QPQLSCTDER LEHVGAVAYD 

      1030       1040       1050       1060       1070       1080 
WRGGLLYWTD LARDCVQRLD PFSGERELLP IFGARHLALD SAQGHLYYSS SAHLARRSLS 

      1090       1100       1110       1120       1130       1140 
ALSTHQPELE YYHVNGLAGQ ISGFCLDLPQ RHIYWLVAGN SALHLYRTAL SAGGSQAAVP 

      1150       1160       1170       1180       1190       1200 
LQLLTTLPAA DALPHTLQHL APLGALLWLA ADGRGAHLLR LAAQLETDTD TMRLLPEGLV 

      1210       1220       1230       1240       1250       1260 
EPLSAVQLLE RSAGPPPPPP DEGVRPLAVP PDSVHIDEGG HWNDFRVRWQ PAASGGNHSV 

      1270       1280       1290       1300       1310       1320 
CYKLLLEHGS ERLITLELLT PFARITQLAQ APLGLRISIT PHTAWRAGST TRVQLDTPVA 

      1330       1340       1350       1360       1370       1380 
APTQPRRLRV FVERQAAPLQ LAPNVSALLR WDVPEEHAGS QSLQYRISCW RGSELHSELL 

      1390       1400       1410       1420       1430       1440 
LNQSTLEARV EHLQPEETYR FQVQAHVAAT GLAAGATSHA LHVSPEVQSV PRLLYANAEH 

      1450       1460       1470       1480       1490       1500 
IGELDLDTGH RKQLVHTASP VEHLVVLQGE QRLLWVNEHV ELLSHVPGKA PAKLARMRAE 

      1510       1520       1530       1540       1550       1560 
VLALTVDWVQ RIVYWAELDA ADGGCVIYSL DLCRFDGRIL QGERLWSTPR GQLLRDLVAL 

      1570       1580       1590       1600       1610       1620 
PHARQLVWLQ HDLDSRNATL QGRSLANGSA LTFEGVTLPL WRLFEGSQEP LAETLNLVDH 

      1630       1640       1650       1660       1670       1680 
LGRLCVYHVA RQLCTSSALR AQLNLLNDDI GQLAQDPGYL YALRNGSVRA YGRRRQQLEF 

      1690       1700       1710       1720       1730       1740 
LLELQPDEVR LLRAYNYQAY PSRRCLLLPT TAAALESTPS SCEETQCSLQ LPALSAAPDC 

      1750       1760       1770       1780       1790       1800 
PLPVPGLNYQ LNLSSSSRSA QLELRSLHSA AGLTLNISQL QPYQAYELRA QVGSYYQQQL 

      1810       1820       1830       1840       1850       1860 
GQEPLQLPVL TLHTAAATPS APRNFSGRAL SPSELELSWL APLELRSASV YYTLHWQLQL 

      1870       1880       1890       1900       1910       1920 
EDTEEQSQEQ PAQEQRVETA GVQRLTGLQP ARLYQVWLQA HATPSKYNSS GRLLIRSYAP 

      1930       1940       1950       1960       1970       1980 
LPPLQLIELN AYGMTLAWPG TPDALSSLTL ECQSLREQLQ FNVAGNHTQM RLAPLQPKTR 

      1990       2000       2010       2020       2030       2040 
YSCRLALAYA ATPGAPIYFG PSHEYETLGD APSAPGRPQL EHIAGEIFRV SWTPALDNGS 

      2050       2060       2070       2080       2090       2100 
PILLYNLEAL QARRTNRRRR RRRETTLSLL PWAEEPLVIE DQWLDFCNTT ELSCIVRELH 

      2110       2120       2130       2140       2150       2160 
TRRLLLFRVR ARNRPHGWGP YSEDSERIAE PFVSPEKRGS LVLAIIAPAA IVSSCVLALV 

      2170       2180       2190       2200       2210       2220 
LVRKLQKRRH RAKKLLQQSR PSIWSNLSAL QTQQQLLAAR SRTFSMSLSD ADIALLPQIN 

      2230       2240       2250       2260       2270       2280 
WNRLTLLRFL GSGAFGEVYE GQLQAEDEAQ PQRVAIKSLR KGASEFAELL QEAQLMSNFK 

      2290       2300       2310       2320       2330       2340 
HENIVCLIGI CCDTDSISLI MEHMEAGDLL SYLRAARPSS QEALSKLQLP ELLSMCLDVA 

      2350       2360       2370       2380       2390       2400 
NGCSYMEDMH FVHRDLACRN CLVSDGAAIG GRRIVKIGDF GLARDIYKSD YYRKEGEGLL 

      2410       2420       2430       2440       2450       2460 
PVRWMALESL VDGLFSTQSD VWAFGVLCWE IFTLGQQPYA ARNNFEVLAH VKEGGRLQQP 

      2470       2480       2490       2500       2510       2520 
ERCPEKLYAL LLQCWRSEPW ERPSFKRCLS TLQALSSDLR RTEMLATDET PLVSALCAFK 

      2530       2540       2550       2560       2570       2580 
PDAKVRFDDA PQRLTLHLDA KDTVSTTDAD TTGSPTTPTA PTTPTTTTST IAVVSTAPSS 

      2590 
ENGQLYANEG ISGL

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References

[1]"Comparison of the sevenless genes of Drosophila virilis and Drosophila melanogaster."
Michael W.M., Bowtell D.D.L., Rubin G.M.
Proc. Natl. Acad. Sci. U.S.A. 87:5351-5353(1990) [PubMed: 2115169] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M34545, M34544, M34543 Genomic DNA. Translation: AAA28883.1.
PIRA35774.

3D structure databases

ProteinModelPortalP20806.
ModBaseSearch...

Protein-protein interaction databases

STRINGP20806.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0013140. Dvir\sev.

Phylogenomic databases

GeneTreeEMGT00050000002732.
InParanoidP20806.
OrthoDBEOG44MW6S.

Enzyme and pathway databases

BRENDA2.7.10.1. 2005.

Family and domain databases

InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000033. LDLR_classB_rpt.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
Gene3DG3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 3 hits.
G3DSA:2.60.40.10. Ig-like_fold. 5 hits.
PfamPF00041. fn3. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SMARTSM00060. FN3. 7 hits.
SM00135. LY. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 6 hits.
SSF56112. Kinase_like. 1 hit.
PROSITEPS50853. FN3. 8 hits.
PS51120. LDLRB. False negative.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name7LESS_DROVI
AccessionPrimary (citable) accession number: P20806
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 16, 2011
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents