P20804 (ACP_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl carrier protein
Short name=ACP

Gene names

Name:	acpP
Synonyms:	acp
Ordered Locus Names:	ssl2084

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	77 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Carrier of the growing fatty acid chain in fatty acid biosynthesis. HAMAP MF_01217
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01217
Subcellular location	Cytoplasm By similarity HAMAP MF_01217.
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group. HAMAP MF_01217
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	Phosphopantetheine
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 77	77	Acyl carrier protein HAMAP MF_01217		PRO_0000180207
Amino acid modifications
	Modified residue	38	1	O-(pantetheine 4'-phosphoryl)serine By similarity
Experimental info
	Sequence conflict	2	1	N → D AA sequence Ref.2
	Sequence conflict	23	1	K → G AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P20804 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: FDDED4DBFD6EBD53	FASTA	77	8,590
	10 20 30 40 50 60 MNQEIFEKVK KIVVEQLEVD PDKVTPDATF AEDLGADSLD TVELVMALEE EFDIEIPDEV 70 AETIDTVGKA VEHIESK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[2]	"Purification and characterization of acyl carrier protein from two cyanobacteria species." Froehlich J.E., Poorman R., Reardon E., Barnum S.R., Jaworski J.G. Eur. J. Biochem. 193:817-825(1990) [PubMed: 2123456] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-61, NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-45. Strain: ATCC 27184.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA17312.1.
PIR	S77465.
RefSeq	NP_440632.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P20804.
SMR	P20804. Positions 3-77.
ModBase	Search...
Protein-protein interaction databases
IntAct	P20804. 2 interactions.
STRING	P20804.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	953935.
GenomeReviews	Gene locus ssl2084 in contig BA000022_GR.
KEGG	syn:ssl2084.
NMPDR	fig|1148.1.peg.733.
PATRIC	23838462. VBISynSp132158_0798.
Phylogenomic databases
eggNOG	COG0236.
HOGENOM	HBG755218.
OMA	DVQIPDE.
PhylomeDB	P20804.
ProtClustDB	PRK00982.
Enzyme and pathway databases
BioCyc	SSP1148:SSL2084-MONOMER.
Family and domain databases
HAMAP	MF_01217. Acyl_carrier. [Tree]
InterPro	IPR003231. Acyl_carrier. IPR009081. Acyl_carrier_prot-like. IPR006163. Phsphopanteth-bd. IPR006162. PPantetheine_attach_site. [Graphical view]
Gene3D	G3DSA:1.10.1200.10. ACP_like. 1 hit.
KO	K02078.
Pfam	PF00550. PP-binding. 1 hit. [Graphical view]
ProDom	PD000887. PD000887. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47336. ACP_like. 1 hit.
TIGRFAMs	TIGR00517. Acyl_carrier. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACP_SYNY3

Accession

Primary (citable) accession number: P20804
Secondary accession number(s): P73284

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program