Reviewed, UniProtKB/Swiss-Prot P20803 (ACP_ANAVA)

Names and origin

Protein names

Recommended name:
    Acyl carrier protein
      Short name=ACP

Gene names

Name:

acpP

Organism

Anabaena variabilis

Taxonomic identifier

1172 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	77 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Carrier of the growing fatty acid chain in fatty acid biosynthesis. HAMAP MF_01217
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01217
Subcellular location	Cytoplasm By similarity.
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group. HAMAP MF_01217
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	Phosphopantetheine
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: HAMAP cofactor binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – ›77	›76	Acyl carrier protein HAMAP MF_01217		PRO_0000180093
Amino acid modifications
	Modified residue	40	1	O-(pantetheine 4'-phosphoryl)serine By similarity
Experimental info
	Non-terminal residue	77	1

Sequences

	Sequence		Length	Mass (Da)
	P20803-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 283EF874186923F0	FASTA	77	8,496
	10 20 30 40 50 60 MSQSETFEKV KKIVIEQLSV ENPDTVTPEA SFANDLQADS LDTVELVMAL EEEFDIEIPD 70 EAAEKITTVQ AAVDXIN

References

[1]	"Purification and characterization of acyl carrier protein from two cyanobacteria species." Froehlich J.E., Poorman R., Reardon E., Barnum S.R., Jaworski J.G. Eur. J. Biochem. 193:817-825(1990) [PubMed: 2123456] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-77. Strain: PCC 6309 / ATCC 29211.

Cross-references

Sequence databases
PIR	S13819.
3D structure databases
HSSP	HSSP built from PDB template 1ACP based on UniProtKB P02901.
SMR	P20803. Positions 8-74.
ModBase	Search...
Family and domain databases
HAMAP	MF_01217. [Tree]
InterPro	IPR003231. Acyl_carrier. IPR009081. Acyl_carrier_prot-like. IPR006163. Phsphopanteth_bd. IPR006162. PPantetheine_attach_site. [Graphical view]
Pfam	PF00550. PP-binding. 1 hit. [Graphical view]
ProDom	PD000887. Acyl_carrier. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00517. acyl_carrier. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACP_ANAVA

Accession

Primary (citable) accession number: P20803

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	January 23, 2007
Last modified:	September 22, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)