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Protein

Troponin C, skeletal muscle

Gene

Tnnc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi28 – 39121Add
BLAST
Calcium bindingi64 – 75122Add
BLAST
Calcium bindingi104 – 115123Add
BLAST
Calcium bindingi140 – 151124Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, skeletal muscle
Alternative name(s):
STNC
Gene namesi
Name:Tnnc2
Synonyms:Tncs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98780. Tnnc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 160159Troponin C, skeletal musclePRO_0000073704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP20801.
PaxDbiP20801.
PeptideAtlasiP20801.
PRIDEiP20801.

2D gel databases

SWISS-2DPAGEP20801.

PTM databases

iPTMnetiP20801.
PhosphoSiteiP20801.

Expressioni

Tissue specificityi

Fast skeletal muscle.

Gene expression databases

BgeeiP20801.
CleanExiMM_TNNC2.
GenevisibleiP20801. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204239. 1 interaction.
STRINGi10090.ENSMUSP00000099384.

Structurei

3D structure databases

ProteinModelPortaliP20801.
SMRiP20801. Positions 3-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 5036EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini51 – 8636EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini91 – 12636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini127 – 16034EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the troponin C family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP20801.
KOiK12042.
OMAiNADGMLD.
OrthoDBiEOG76X61W.
PhylomeDBiP20801.
TreeFamiTF318191.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT
60 70 80 90 100
PTKEELDAII EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF
110 120 130 140 150
RIFDRNADGY IDAEELAEIF RASGEHVTEE EIESLMKDGD KNNDGRIDFD
160
EFLKMMEGVQ
Length:160
Mass (Da):18,110
Last modified:January 23, 2007 - v2
Checksum:i9AE469E732A0F903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57590 Genomic DNA. Translation: AAA37642.1.
BC024390 mRNA. Translation: AAH24390.1.
CCDSiCCDS17056.1.
PIRiA38383.
RefSeqiNP_033420.1. NM_009394.2.
UniGeneiMm.1716.

Genome annotation databases

EnsembliENSMUST00000103095; ENSMUSP00000099384; ENSMUSG00000017300.
GeneIDi21925.
KEGGimmu:21925.
UCSCiuc008nvz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57590 Genomic DNA. Translation: AAA37642.1.
BC024390 mRNA. Translation: AAH24390.1.
CCDSiCCDS17056.1.
PIRiA38383.
RefSeqiNP_033420.1. NM_009394.2.
UniGeneiMm.1716.

3D structure databases

ProteinModelPortaliP20801.
SMRiP20801. Positions 3-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204239. 1 interaction.
STRINGi10090.ENSMUSP00000099384.

PTM databases

iPTMnetiP20801.
PhosphoSiteiP20801.

2D gel databases

SWISS-2DPAGEP20801.

Proteomic databases

MaxQBiP20801.
PaxDbiP20801.
PeptideAtlasiP20801.
PRIDEiP20801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103095; ENSMUSP00000099384; ENSMUSG00000017300.
GeneIDi21925.
KEGGimmu:21925.
UCSCiuc008nvz.1. mouse.

Organism-specific databases

CTDi7125.
MGIiMGI:98780. Tnnc2.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP20801.
KOiK12042.
OMAiNADGMLD.
OrthoDBiEOG76X61W.
PhylomeDBiP20801.
TreeFamiTF318191.

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Miscellaneous databases

ChiTaRSiTnnc2. mouse.
PROiP20801.
SOURCEiSearch...

Gene expression databases

BgeeiP20801.
CleanExiMM_TNNC2.
GenevisibleiP20801. MM.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The structure and regulation of expression of the murine fast skeletal troponin C gene. Identification of a developmentally regulated, muscle-specific transcriptional enhancer."
    Parmacek M.S., Bengur A.R., Vora A.J., Leiden J.M.
    J. Biol. Chem. 265:15970-15976(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue.

Entry informationi

Entry nameiTNNC2_MOUSE
AccessioniPrimary (citable) accession number: P20801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Skeletal muscle troponin C binds four calcium ions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.