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P20800

- EDN2_HUMAN

UniProt

P20800 - EDN2_HUMAN

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Protein

Endothelin-2

Gene

EDN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei69 – 702Cleavage; by KEL

GO - Molecular functioni

  1. hormone activity Source: BHF-UCL

GO - Biological processi

  1. artery smooth muscle contraction Source: BHF-UCL
  2. calcium-mediated signaling Source: BHF-UCL
  3. cell surface receptor signaling pathway Source: BHF-UCL
  4. cytokine-mediated signaling pathway Source: BHF-UCL
  5. energy homeostasis Source: Ensembl
  6. hormonal regulation of the force of heart contraction Source: BHF-UCL
  7. inositol phosphate-mediated signaling Source: BHF-UCL
  8. lung alveolus development Source: Ensembl
  9. macrophage activation Source: BHF-UCL
  10. macrophage chemotaxis Source: BHF-UCL
  11. neutrophil chemotaxis Source: BHF-UCL
  12. positive regulation of cell proliferation Source: BHF-UCL
  13. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  14. positive regulation of heart rate Source: BHF-UCL
  15. positive regulation of leukocyte chemotaxis Source: BHF-UCL
  16. positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
  17. positive regulation of smooth muscle contraction Source: Ensembl
  18. positive regulation of the force of heart contraction by chemical signal Source: BHF-UCL
  19. prostaglandin biosynthetic process Source: BHF-UCL
  20. regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
  21. regulation of vasoconstriction Source: InterPro
  22. temperature homeostasis Source: Ensembl
  23. vasoconstriction Source: BHF-UCL
  24. vein smooth muscle contraction Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Gene namesi
Name:EDN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3177. EDN2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 4622PRO_0000008093Add
BLAST
Peptidei49 – 6921Endothelin-2PRO_0000008094Add
BLAST
Propeptidei70 – 178109PRO_0000008095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 63By similarity
Disulfide bondi51 ↔ 59By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP20800.
PRIDEiP20800.

Miscellaneous databases

PMAP-CutDBP20800.

Expressioni

Tissue specificityi

Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells.1 Publication

Gene expression databases

BgeeiP20800.
CleanExiHS_EDN2.
GenevestigatoriP20800.

Organism-specific databases

HPAiHPA028459.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361668.

Structurei

3D structure databases

ProteinModelPortaliP20800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 11116Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43933.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP20800.
KOiK16367.
OMAiEQTAPYG.
OrthoDBiEOG7F7WBX.
PhylomeDBiP20800.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20800-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS
60 70 80 90 100
CSSWLDKECV YFCHLDIIWV NTPEQTAPYG LGNPPRRRRR SLPRRCQCSS
110 120 130 140 150
ARDPACATFC LRRPWTEAGA VPSRKSPADV FQTGKTGATT GELLQRLRDI
160 170
STVKSLFAKR QQEAMREPRS THSRWRKR
Length:178
Mass (Da):19,960
Last modified:November 1, 1991 - v2
Checksum:i7711B2B6F075CFB4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti131 – 1311F → L.
Corresponds to variant rs5798 [ dbSNP | Ensembl ].
VAR_033914
Natural varianti168 – 1681P → L.1 Publication
Corresponds to variant rs11572371 [ dbSNP | Ensembl ].
VAR_018817

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55177 mRNA. Translation: CAA38962.1.
M65199 mRNA. Translation: AAA52404.1.
AY518541 Genomic DNA. Translation: AAR89914.1.
AL445933 Genomic DNA. Translation: CAI14535.1.
CH471059 Genomic DNA. Translation: EAX07175.1.
BC034393 mRNA. Translation: AAH34393.1.
M25550 Genomic DNA. Translation: AAA52340.1.
CCDSiCCDS462.1.
PIRiA39070.
RefSeqiNP_001947.1. NM_001956.3.
UniGeneiHs.1407.

Genome annotation databases

EnsembliENST00000372587; ENSP00000361668; ENSG00000127129.
GeneIDi1907.
KEGGihsa:1907.
UCSCiuc001cgx.3. human.

Polymorphism databases

DMDMi119615.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55177 mRNA. Translation: CAA38962.1 .
M65199 mRNA. Translation: AAA52404.1 .
AY518541 Genomic DNA. Translation: AAR89914.1 .
AL445933 Genomic DNA. Translation: CAI14535.1 .
CH471059 Genomic DNA. Translation: EAX07175.1 .
BC034393 mRNA. Translation: AAH34393.1 .
M25550 Genomic DNA. Translation: AAA52340.1 .
CCDSi CCDS462.1.
PIRi A39070.
RefSeqi NP_001947.1. NM_001956.3.
UniGenei Hs.1407.

3D structure databases

ProteinModelPortali P20800.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000361668.

Polymorphism databases

DMDMi 119615.

Proteomic databases

PaxDbi P20800.
PRIDEi P20800.

Protocols and materials databases

DNASUi 1907.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372587 ; ENSP00000361668 ; ENSG00000127129 .
GeneIDi 1907.
KEGGi hsa:1907.
UCSCi uc001cgx.3. human.

Organism-specific databases

CTDi 1907.
GeneCardsi GC01M041944.
HGNCi HGNC:3177. EDN2.
HPAi HPA028459.
MIMi 131241. gene.
neXtProti NX_P20800.
PharmGKBi PA27615.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43933.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
InParanoidi P20800.
KOi K16367.
OMAi EQTAPYG.
OrthoDBi EOG7F7WBX.
PhylomeDBi P20800.
TreeFami TF333184.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii Endothelin_2.
GenomeRNAii 1907.
NextBioi 7761.
PMAP-CutDB P20800.
PROi P20800.
SOURCEi Search...

Gene expression databases

Bgeei P20800.
CleanExi HS_EDN2.
Genevestigatori P20800.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view ]
PANTHERi PTHR13874:SF8. PTHR13874:SF8. 1 hit.
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization."
    Ohkubo S., Ogi K., Hosoya M., Matsumoto H., Suzuki N., Kimura C., Onda H., Fujino M.
    FEBS Lett. 274:136-140(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2."
    Bloch K.D., Hong C.C., Eddy R.L. Jr., Shows T.B., Quertermous T.
    Genomics 10:236-242(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Expression of endothelin-2 (ET-2) gene in a human renal adenocarcinoma cell line: purification and cDNA cloning of ET-2."
    Onda H., Ohkubo S., Kosaka T., Yasuhara T., Ogi K., Hosoya M., Matsumoto H., Suzuki N., Kitada C., Ishibashi Y., Kimura C., Kubo K., Fujino M.
    J. Cardiovasc. Pharmacol. 17:S39-S43(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. NIEHS SNPs program
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-168.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Kidney and Stomach.
  8. "The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."
    Inoue A., Yanagisawa M., Kimura S., Kasuya Y., Miyauchi T., Goto K., Masaki T.
    Proc. Natl. Acad. Sci. U.S.A. 86:2863-2867(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-73.
  9. "Proteolytic processing of big endothelin-3 by the kell blood group protein."
    Lee S., Lin M., Mele A., Cao Y., Farmar J., Russo D., Redman C.
    Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, CLEAVAGE BY KELL, IDENTIFICATION BY MASS SPECTROMETRY.
  10. "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
    Bourgeois C., Robert B., Rebourcet R., Mondon F., Mignot T.-M., Duc-Goiran P., Ferre F.
    J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiEDN2_HUMAN
AccessioniPrimary (citable) accession number: P20800
Secondary accession number(s): Q5T1R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 1, 1991
Last modified: October 29, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3