##gff-version 3 P20794 UniProtKB Chain 1 623 . . . ID=PRO_0000086284;Note=Serine/threonine-protein kinase MAK P20794 UniProtKB Domain 4 284 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P20794 UniProtKB Region 328 396 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P20794 UniProtKB Region 416 469 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P20794 UniProtKB Compositional bias 333 393 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P20794 UniProtKB Compositional bias 416 439 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P20794 UniProtKB Compositional bias 445 469 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P20794 UniProtKB Active site 125 125 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 P20794 UniProtKB Binding site 10 18 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P20794 UniProtKB Binding site 33 33 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P20794 UniProtKB Modified residue 157 157 . . . Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21986944;Dbxref=PMID:21986944 P20794 UniProtKB Modified residue 159 159 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21986944;Dbxref=PMID:21986944 P20794 UniProtKB Alternative sequence 532 532 . . . ID=VSP_042470;Note=In isoform 2. A->AEESIIKPIEKLSCNETFPEKLEDPQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:21825139,ECO:0000303|PubMed:21835304;Dbxref=PMID:21825139,PMID:21835304 P20794 UniProtKB Alternative sequence 533 572 . . . ID=VSP_042471;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:21697133;Dbxref=PMID:21697133 P20794 UniProtKB Natural variant 13 13 . . . ID=VAR_066988;Note=In RP62%3B results in a complete loss of kinase activity compared to wild-type. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21835304;Dbxref=dbSNP:rs387906647,PMID:21835304 P20794 UniProtKB Natural variant 27 27 . . . ID=VAR_066989;Note=In RP62. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21835304;Dbxref=dbSNP:rs754916169,PMID:21835304 P20794 UniProtKB Natural variant 130 130 . . . ID=VAR_066990;Note=In RP62%3B results in a complete loss of kinase activity compared to wild-type. N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21835304;Dbxref=dbSNP:rs387906646,PMID:21835304 P20794 UniProtKB Natural variant 166 166 . . . ID=VAR_066991;Note=In RP62. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21835304;Dbxref=dbSNP:rs387906648,PMID:21835304 P20794 UniProtKB Natural variant 181 181 . . . ID=VAR_066992;Note=In RP62. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21835304;Dbxref=dbSNP:rs750559316,PMID:21835304 P20794 UniProtKB Natural variant 189 189 . . . ID=VAR_042006;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56215624,PMID:17344846 P20794 UniProtKB Natural variant 272 272 . . . ID=VAR_042007;Note=In a breast infiltrating ductal carcinoma sample%3B somatic mutation. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 P20794 UniProtKB Natural variant 325 325 . . . ID=VAR_066993;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21835304;Dbxref=dbSNP:rs371971492,PMID:21835304 P20794 UniProtKB Natural variant 329 329 . . . ID=VAR_053932;Note=D->E;Dbxref=dbSNP:rs17579447 P20794 UniProtKB Natural variant 384 384 . . . ID=VAR_042008;Note=N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55773478,PMID:17344846 P20794 UniProtKB Natural variant 520 520 . . . ID=VAR_042009;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs567083,PMID:17344846 P20794 UniProtKB Natural variant 550 550 . . . ID=VAR_042010;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56217305,PMID:17344846 P20794 UniProtKB Mutagenesis 33 33 . . . Note=Abolishes autophosphorylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12084720;Dbxref=PMID:12084720 P20794 UniProtKB Mutagenesis 157 157 . . . Note=Abolishes autophosphorylation and impairs kinase activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21986944;Dbxref=PMID:21986944 P20794 UniProtKB Mutagenesis 159 159 . . . Note=Abolishes autophosphorylation and impairs kinase activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21986944;Dbxref=PMID:21986944