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P20792

- DAF1_CAEEL

UniProt

P20792 - DAF1_CAEEL

Protein

Cell surface receptor daf-1

Gene

daf-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Controls the dauer/nondauer developmental decision in a range of environmental conditions.1 Publication

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei320 – 3201ATPPROSITE-ProRule annotation
    Active sitei423 – 4231Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi299 – 3079ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. receptor signaling protein serine/threonine kinase activity Source: InterPro
    4. transmembrane receptor protein serine/threonine kinase activity Source: InterPro

    GO - Biological processi

    1. dauer larval development Source: WormBase
    2. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
    3. regulation of pharyngeal pumping Source: WormBase

    Keywords - Molecular functioni

    Developmental protein, Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 1045.
    SignaLinkiP20792.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell surface receptor daf-1 (EC:2.7.11.30)
    Alternative name(s):
    Abnormal dauer formation protein 1
    Gene namesi
    Name:daf-1
    ORF Names:F29C4.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiF29C4.1a; CE17719; WBGene00000897; daf-1.
    F29C4.1b; CE31492; WBGene00000897; daf-1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi70 – 701G → R in allele p168; forms many dauer larvae. 1 Publication
    Mutagenesisi90 – 901C → Y in allele m138; forms many dauer larvae. 1 Publication
    Mutagenesisi105 – 1051E → A in allele m122; forms many dauer larvae; when associated with E-110. 1 Publication
    Mutagenesisi110 – 1101G → E in allele m122; forms many dauer larvae; when associated with A-105. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 669650Cell surface receptor daf-1PRO_0000024430Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP20792.
    PRIDEiP20792.

    Expressioni

    Tissue specificityi

    Head and ventral nerve cord from embryos to adults. Expressed in many sensory neurons. Subset of head neurons show coexpression with daf-4 when dauer/nondauer decision is made. Also expressed in non-neuronal cells: membraneous sheath surrounding the distal end of the intestine and in the distal tip cell of the gonad.1 Publication

    Developmental stagei

    All stages.1 Publication

    Interactioni

    Subunit structurei

    May interact with daf-4 to regulate dauer larva development.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    daf-21Q186882EBI-360236,EBI-313329

    Protein-protein interaction databases

    BioGridi41992. 2 interactions.
    IntActiP20792. 1 interaction.
    STRINGi6239.F29C4.1a.

    Structurei

    3D structure databases

    ProteinModelPortaliP20792.
    SMRiP20792. Positions 256-591.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 170151ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 669478CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini262 – 29231GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini293 – 593301Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00560000076906.
    HOGENOMiHOG000016460.
    InParanoidiP20792.
    OMAiDLTCAIG.
    OrthoDBiEOG7JHM5B.
    PhylomeDBiP20792.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: P20792-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRIRHVVFCL LALVYGAETS DDDLDERTNI FIRDKLIPAL KLAEVTKVNF    50
    TRLHLCHCSR EVGCNARTTG WVPGIEFLNE TDRSFYENTC YTDGSCYQSA 100
    RPSPEISHFG CMDEKSVTDE TEFHDTAAKV CTNNTKDPHA TVWICCDKGN 150
    FCANETIIHL APGPQQSSTW LILTILALLT FIVLLGIAIF LTRKSWEAKF 200
    DWYIRFKPKP GDPLRETENN VPMVTMGDGA GSSVPEVAPI EQQGSTMSTS 250
    AGNSFPPGIM PNNMKDMLDV LEETSGSGMG PTTLHKLTIG GQIRLTGRVG 300
    SGRFGNVSRG DYRGEAVAVK VFNALDEPAF HKETEIFETR MLRHPNVLRY 350
    IGSDRVDTGF VTELWLVTEY HPSGSLHDFL LENTVNIETY YNLMRSTASG 400
    LAFLHNQIGG SKESNKPAMA HRDIKSKNIM VKNDLTCAIG DLGLSLSKPE 450
    DAASDIIANE NYKCGTVRYL APEILNSTMQ FTVFESYQCA DVYSFSLVMW 500
    ETLCRCEDGD VLPREAATVI PYIEWTDRDP QDAQMFDVVC TRRLRPTENP 550
    LWKDHPEMKH IMEIIKTCWN GNPSARFTSY ICRKRMDERQ QLLLDKKAKA 600
    VAQTAGVTVQ DRKILGPQKP KDESPANGAP RIVQKEIDRE DEQENWRETA 650
    KTPNGHISSN DDSSRPLLG 669
    Length:669
    Mass (Da):75,006
    Last modified:February 1, 1991 - v1
    Checksum:i8BDD86C67C8F2A6A
    GO
    Isoform b (identifier: P20792-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         467-467: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:668
    Mass (Da):74,907
    Checksum:iEED85A548CE780B2
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei467 – 4671Missing in isoform b. CuratedVSP_007948

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32877 Genomic DNA. Translation: AAA28001.1.
    FO080227 Genomic DNA. Translation: CCD62175.1.
    FO080227 Genomic DNA. Translation: CCD62176.1.
    PIRiA35103.
    RefSeqiNP_001023159.1. NM_001027988.4. [P20792-1]
    NP_001023160.1. NM_001027989.3. [P20792-2]
    UniGeneiCel.5220.

    Genome annotation databases

    EnsemblMetazoaiF29C4.1a; F29C4.1a; WBGene00000897. [P20792-1]
    GeneIDi176829.
    KEGGicel:CELE_F29C4.1.
    UCSCiF29C4.1a. c. elegans. [P20792-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32877 Genomic DNA. Translation: AAA28001.1 .
    FO080227 Genomic DNA. Translation: CCD62175.1 .
    FO080227 Genomic DNA. Translation: CCD62176.1 .
    PIRi A35103.
    RefSeqi NP_001023159.1. NM_001027988.4. [P20792-1 ]
    NP_001023160.1. NM_001027989.3. [P20792-2 ]
    UniGenei Cel.5220.

    3D structure databases

    ProteinModelPortali P20792.
    SMRi P20792. Positions 256-591.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41992. 2 interactions.
    IntActi P20792. 1 interaction.
    STRINGi 6239.F29C4.1a.

    Proteomic databases

    PaxDbi P20792.
    PRIDEi P20792.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F29C4.1a ; F29C4.1a ; WBGene00000897 . [P20792-1 ]
    GeneIDi 176829.
    KEGGi cel:CELE_F29C4.1.
    UCSCi F29C4.1a. c. elegans. [P20792-1 ]

    Organism-specific databases

    CTDi 176829.
    WormBasei F29C4.1a ; CE17719 ; WBGene00000897 ; daf-1.
    F29C4.1b ; CE31492 ; WBGene00000897 ; daf-1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00560000076906.
    HOGENOMi HOG000016460.
    InParanoidi P20792.
    OMAi DLTCAIG.
    OrthoDBi EOG7JHM5B.
    PhylomeDBi P20792.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 1045.
    SignaLinki P20792.

    Miscellaneous databases

    NextBioi 894194.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase."
      Georgi L.L., Albert P.S., Riddle D.L.
      Cell 61:635-645(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.
    3. "A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development."
      Gunther C.V., Georgi L.L., Riddle D.L.
      Development 127:3337-3347(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF GLY-70; CYS-90; GLU-105 AND GLY-110.

    Entry informationi

    Entry nameiDAF1_CAEEL
    AccessioniPrimary (citable) accession number: P20792
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3