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P20789 (NTR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotensin receptor type 1

Short name=NT-R-1
Short name=NTR1
Alternative name(s):
High-affinity levocabastine-insensitive neurotensin receptor
NTRH
Gene names
Name:Ntsr1
Synonyms:Ntsr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Neurotensin receptor type 1
PRO_0000069948

Regions

Topological domain1 – 6464Extracellular Potential
Transmembrane65 – 8723Helical; Name=1; Potential
Topological domain88 – 969Cytoplasmic Potential
Transmembrane97 – 12125Helical; Name=2; Potential
Topological domain122 – 14322Extracellular Potential
Transmembrane144 – 16522Helical; Name=3; Potential
Topological domain166 – 18823Cytoplasmic Potential
Transmembrane189 – 21022Helical; Name=4; Potential
Topological domain211 – 23525Extracellular Potential
Transmembrane236 – 26025Helical; Name=5; Potential
Topological domain261 – 30848Cytoplasmic Potential
Transmembrane309 – 33022Helical; Name=6; Potential
Topological domain331 – 34818Extracellular Potential
Transmembrane349 – 37224Helical; Name=7; Potential
Topological domain373 – 42452Cytoplasmic Potential

Amino acid modifications

Lipidation3881S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation421N-linked (GlcNAc...) Potential
Disulfide bond142 ↔ 225 By similarity

Secondary structure

............................. 424
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P20789 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: A9C2F7EAF8D9BCD3

FASTA42447,055
        10         20         30         40         50         60 
MHLNSSVPQG TPGEPDAQPF SGPQSEMEAT FLALSLSNGS GNTSESDTAG PNSDLDVNTD 

        70         80         90        100        110        120 
IYSKVLVTAI YLALFVVGTV GNSVTAFTLA RKKSLQSLQS TVHYHLGSLA LSDLLILLLA 

       130        140        150        160        170        180 
MPVELYNFIW VHHPWAFGDA GCRGYYFLRD ACTYATALNV ASLSVERYLA ICHPFKAKTL 

       190        200        210        220        230        240 
MSRSRTKKFI SAIWLASALL AIPMLFTMGL QNRSGDGTHP GGLVCTPIVD TATVKVVIQV 

       250        260        270        280        290        300 
NTFMSFLFPM LVISILNTVI ANKLTVMVHQ AAEQGRVCTV GTHNGLEHST FNMTIEPGRV 

       310        320        330        340        350        360 
QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF YMLTNALFYV 

       370        380        390        400        410        420 
SSAINPILYN LVSANFRQVF LSTLACLCPG WRHRRKKRPT FSRKPNSMSS NHAFSTSATR 


ETLY 

« Hide

References

[1]"Structure and functional expression of the cloned rat neurotensin receptor."
Tanaka K., Masu M., Nakanishi S.
Neuron 4:847-854(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRJH0164.
RefSeqNP_001102437.1. NM_001108967.1.
XP_006235850.1. XM_006235788.1.
UniGeneRn.200149.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZEVX-ray3.00A/B50-390[»]
4BUOX-ray2.75A/B50-390[»]
4BV0X-ray3.10A/B50-390[»]
4BWBX-ray3.57A/B50-390[»]
4GRVX-ray2.80A43-396[»]
ProteinModelPortalP20789.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59956N.
STRING10116.ENSRNOP00000035997.

Chemistry

BindingDBP20789.
ChEMBLCHEMBL3027.
GuidetoPHARMACOLOGY309.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP20789.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000039780; ENSRNOP00000035997; ENSRNOG00000028708.
GeneID366274.
KEGGrno:366274.
UCSCRGD:1306076. rat.

Organism-specific databases

CTD4923.
RGD1306076. Ntsr1.

Phylogenomic databases

eggNOGNOG303702.
GeneTreeENSGT00700000104470.
HOGENOMHOG000231271.
HOVERGENHBG098285.
InParanoidP20789.
KOK04211.
OMATVMVRQA.
OrthoDBEOG75F4DR.
TreeFamTF337167.

Gene expression databases

GenevestigatorP20789.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003985. NT1_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01480. NEUROTENSN1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio689103.
PROP20789.

Entry information

Entry nameNTR1_RAT
AccessionPrimary (citable) accession number: P20789
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 19, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries