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P20789

- NTR1_RAT

UniProt

P20789 - NTR1_RAT

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Protein

Neurotensin receptor type 1

Gene
Ntsr1, Ntsr
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. G-protein coupled neurotensin receptor activity Source: UniProtKB

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. neuropeptide signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 1
Short name:
NT-R-1
Short name:
NTR1
Alternative name(s):
High-affinity levocabastine-insensitive neurotensin receptor
NTRH
Gene namesi
Name:Ntsr1
Synonyms:Ntsr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1306076. Ntsr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464Extracellular Reviewed predictionAdd
BLAST
Transmembranei65 – 8723Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini88 – 969Cytoplasmic Reviewed prediction
Transmembranei97 – 12125Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini122 – 14322Extracellular Reviewed predictionAdd
BLAST
Transmembranei144 – 16522Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini166 – 18823Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei189 – 21022Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini211 – 23525Extracellular Reviewed predictionAdd
BLAST
Transmembranei236 – 26025Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini261 – 30848Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei309 – 33022Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini331 – 34818Extracellular Reviewed predictionAdd
BLAST
Transmembranei349 – 37224Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini373 – 42452Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Neurotensin receptor type 1PRO_0000069948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi38 – 381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi142 ↔ 2252 Publications
Lipidationi388 – 3881S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiP20789.

Expressioni

Gene expression databases

GenevestigatoriP20789.

Interactioni

Protein-protein interaction databases

DIPiDIP-59956N.
STRINGi10116.ENSRNOP00000035997.

Structurei

Secondary structure

1
424
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi53 – 553
Helixi61 – 9030
Helixi99 – 11820
Helixi120 – 12910
Helixi138 – 17235
Helixi174 – 1785
Helixi183 – 20119
Helixi204 – 2074
Beta strandi208 – 2125
Beta strandi214 – 2174
Helixi220 – 2223
Beta strandi223 – 2275
Helixi231 – 24515
Helixi247 – 26923
Helixi298 – 33336
Turni336 – 3383
Helixi341 – 37232
Helixi374 – 38310

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZEVX-ray3.00A/B50-390[»]
4BUOX-ray2.75A/B50-390[»]
4BV0X-ray3.10A/B50-390[»]
4BWBX-ray3.57A/B50-390[»]
4GRVX-ray2.80A43-268[»]
A300-396[»]
ProteinModelPortaliP20789.

Family & Domainsi

Domaini

The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembranes TM6 and TM7.1 Publication

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303702.
GeneTreeiENSGT00700000104470.
HOGENOMiHOG000231271.
HOVERGENiHBG098285.
InParanoidiP20789.
KOiK04211.
OMAiTVMVRQA.
OrthoDBiEOG75F4DR.
PhylomeDBiP20789.
TreeFamiTF337167.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003985. NT1_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01480. NEUROTENSN1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20789-1 [UniParc]FASTAAdd to Basket

« Hide

MHLNSSVPQG TPGEPDAQPF SGPQSEMEAT FLALSLSNGS GNTSESDTAG    50
PNSDLDVNTD IYSKVLVTAI YLALFVVGTV GNSVTAFTLA RKKSLQSLQS 100
TVHYHLGSLA LSDLLILLLA MPVELYNFIW VHHPWAFGDA GCRGYYFLRD 150
ACTYATALNV ASLSVERYLA ICHPFKAKTL MSRSRTKKFI SAIWLASALL 200
AIPMLFTMGL QNRSGDGTHP GGLVCTPIVD TATVKVVIQV NTFMSFLFPM 250
LVISILNTVI ANKLTVMVHQ AAEQGRVCTV GTHNGLEHST FNMTIEPGRV 300
QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF 350
YMLTNALFYV SSAINPILYN LVSANFRQVF LSTLACLCPG WRHRRKKRPT 400
FSRKPNSMSS NHAFSTSATR ETLY 424
Length:424
Mass (Da):47,055
Last modified:February 1, 1991 - v1
Checksum:iA9C2F7EAF8D9BCD3
GO

Sequence databases

PIRiJH0164.
RefSeqiNP_001102437.1. NM_001108967.1.
XP_006235850.1. XM_006235788.1.
UniGeneiRn.200149.

Genome annotation databases

EnsembliENSRNOT00000039780; ENSRNOP00000035997; ENSRNOG00000028708.
GeneIDi366274.
KEGGirno:366274.
UCSCiRGD:1306076. rat.

Cross-referencesi

Sequence databases

PIRi JH0164.
RefSeqi NP_001102437.1. NM_001108967.1.
XP_006235850.1. XM_006235788.1.
UniGenei Rn.200149.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZEV X-ray 3.00 A/B 50-390 [» ]
4BUO X-ray 2.75 A/B 50-390 [» ]
4BV0 X-ray 3.10 A/B 50-390 [» ]
4BWB X-ray 3.57 A/B 50-390 [» ]
4GRV X-ray 2.80 A 43-268 [» ]
A 300-396 [» ]
ProteinModelPortali P20789.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59956N.
STRINGi 10116.ENSRNOP00000035997.

Chemistry

BindingDBi P20789.
ChEMBLi CHEMBL3027.
GuidetoPHARMACOLOGYi 309.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P20789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000039780 ; ENSRNOP00000035997 ; ENSRNOG00000028708 .
GeneIDi 366274.
KEGGi rno:366274.
UCSCi RGD:1306076. rat.

Organism-specific databases

CTDi 4923.
RGDi 1306076. Ntsr1.

Phylogenomic databases

eggNOGi NOG303702.
GeneTreei ENSGT00700000104470.
HOGENOMi HOG000231271.
HOVERGENi HBG098285.
InParanoidi P20789.
KOi K04211.
OMAi TVMVRQA.
OrthoDBi EOG75F4DR.
PhylomeDBi P20789.
TreeFami TF337167.

Miscellaneous databases

NextBioi 689103.
PROi P20789.

Gene expression databases

Genevestigatori P20789.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003985. NT1_rcpt.
IPR003984. NT_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01480. NEUROTENSN1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and functional expression of the cloned rat neurotensin receptor."
    Tanaka K., Masu M., Nakanishi S.
    Neuron 4:847-854(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 43-396 IN COMPLEX WITH NEUROTENSIN FRAGMENT, LIGAND BINDING DOMAIN, DISULFIDE BOND.
  3. "Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli."
    Egloff P., Hillenbrand M., Klenk C., Batyuk A., Heine P., Balada S., Schlinkmann K.M., Scott D.J., Schutz M., Pluckthun A.
    Proc. Natl. Acad. Sci. U.S.A. 111:E655-E662(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 50-390, DISULFIDE BOND.

Entry informationi

Entry nameiNTR1_RAT
AccessioniPrimary (citable) accession number: P20789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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