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Protein

Neurotrophin-3

Gene

NTF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  • chemoattractant activity Source: BHF-UCL
  • growth factor activity Source: BHF-UCL
  • neurotrophin p75 receptor binding Source: GO_Central
  • receptor binding Source: ProtInc

GO - Biological processi

  • activation of GTPase activity Source: BHF-UCL
  • activation of MAPK activity Source: BHF-UCL
  • activation of protein kinase B activity Source: BHF-UCL
  • cell-cell signaling Source: ProtInc
  • induction of positive chemotaxis Source: BHF-UCL
  • negative regulation of neuron apoptotic process Source: GO_Central
  • negative regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • nervous system development Source: ProtInc
  • neuron projection morphogenesis Source: GO_Central
  • positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  • positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • positive regulation of receptor internalization Source: BHF-UCL
  • regulation of apoptotic process Source: MGI
  • regulation of neuron differentiation Source: GO_Central
  • signal transduction Source: ProtInc
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

SignaLinkiP20783.
SIGNORiP20783.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:NTF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:8023. NTF3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4908.
OpenTargetsiENSG00000185652.
PharmGKBiPA31806.

Polymorphism and mutation databases

BioMutaiNTF3.
DMDMi128581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001965919 – 138Add BLAST120
ChainiPRO_0000019660139 – 257Neurotrophin-3Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi152 ↔ 217
Disulfide bondi195 ↔ 246
Disulfide bondi205 ↔ 248

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiP20783.
PaxDbiP20783.
PRIDEiP20783.

PTM databases

iPTMnetiP20783.
PhosphoSitePlusiP20783.

Miscellaneous databases

PMAP-CutDBP20783.

Expressioni

Tissue specificityi

Brain and peripheral tissues.

Gene expression databases

BgeeiENSG00000185652.
CleanExiHS_NTF3.
GenevisibleiP20783. HS.

Organism-specific databases

HPAiHPA032000.
HPA032001.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-1025994,EBI-10172134

GO - Molecular functioni

  • growth factor activity Source: BHF-UCL
  • neurotrophin p75 receptor binding Source: GO_Central
  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi110963. 11 interactors.
DIPiDIP-346N.
IntActiP20783. 3 interactors.
MINTiMINT-188565.
STRINGi9606.ENSP00000397297.

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi148 – 152Combined sources5
Beta strandi154 – 159Combined sources6
Beta strandi164 – 167Combined sources4
Beta strandi172 – 175Combined sources4
Beta strandi177 – 179Combined sources3
Turni181 – 183Combined sources3
Beta strandi190 – 195Combined sources6
Beta strandi200 – 205Combined sources6
Turni210 – 212Combined sources3
Beta strandi216 – 233Combined sources18
Beta strandi236 – 249Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8KX-ray2.15A139-257[»]
1BNDX-ray2.30B139-257[»]
1NT3X-ray2.40A139-257[»]
3BUKX-ray2.60A/B139-257[»]
ProteinModelPortaliP20783.
SMRiP20783.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20783.

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHMM. Eukaryota.
ENOG410XRRK. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP20783.
KOiK04356.
OMAiEFQPMIA.
OrthoDBiEOG091G0GHL.
PhylomeDBiP20783.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20783-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPR EPERGGPAKS AFQPVIAMDT ELLRQQRRYN
110 120 130 140 150
SPRVLLSDST PLEPPPLYLM EDYVGSPVVA NRTSRRKRYA EHKSHRGEYS
160 170 180 190 200
VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEARP
210 220 230 240 250
VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL

SRKIGRT
Length:257
Mass (Da):29,355
Last modified:February 1, 1991 - v1
Checksum:i39A5BB3B28E25E03
GO
Isoform 2 (identifier: P20783-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVTFATILQVNKVM

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):30,800
Checksum:i43B3342B32424E97
GO

Polymorphismi

Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01208476G → E.2 PublicationsCorresponds to variant rs1805149dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0433531M → MVTFATILQVNKVM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53655 mRNA. Translation: CAA37703.1.
M37763 Genomic DNA. Translation: AAA59953.1.
M61180 Genomic DNA. Translation: AAA63231.1.
AK293895 mRNA. Translation: BAH11621.1.
CR541906 mRNA. Translation: CAG46704.1.
CH471116 Genomic DNA. Translation: EAW88824.1.
CH471116 Genomic DNA. Translation: EAW88825.1.
BC069773 mRNA. Translation: AAH69773.1.
BC107075 mRNA. Translation: AAI07076.1.
CCDSiCCDS44806.1. [P20783-2]
CCDS8538.1. [P20783-1]
PIRiA36208. C40304.
RefSeqiNP_001096124.1. NM_001102654.1. [P20783-2]
NP_002518.1. NM_002527.4. [P20783-1]
XP_011519265.1. XM_011520963.2. [P20783-1]
UniGeneiHs.99171.

Genome annotation databases

EnsembliENST00000331010; ENSP00000328738; ENSG00000185652. [P20783-1]
ENST00000423158; ENSP00000397297; ENSG00000185652. [P20783-2]
GeneIDi4908.
KEGGihsa:4908.
UCSCiuc001qnk.5. human. [P20783-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53655 mRNA. Translation: CAA37703.1.
M37763 Genomic DNA. Translation: AAA59953.1.
M61180 Genomic DNA. Translation: AAA63231.1.
AK293895 mRNA. Translation: BAH11621.1.
CR541906 mRNA. Translation: CAG46704.1.
CH471116 Genomic DNA. Translation: EAW88824.1.
CH471116 Genomic DNA. Translation: EAW88825.1.
BC069773 mRNA. Translation: AAH69773.1.
BC107075 mRNA. Translation: AAI07076.1.
CCDSiCCDS44806.1. [P20783-2]
CCDS8538.1. [P20783-1]
PIRiA36208. C40304.
RefSeqiNP_001096124.1. NM_001102654.1. [P20783-2]
NP_002518.1. NM_002527.4. [P20783-1]
XP_011519265.1. XM_011520963.2. [P20783-1]
UniGeneiHs.99171.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8KX-ray2.15A139-257[»]
1BNDX-ray2.30B139-257[»]
1NT3X-ray2.40A139-257[»]
3BUKX-ray2.60A/B139-257[»]
ProteinModelPortaliP20783.
SMRiP20783.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110963. 11 interactors.
DIPiDIP-346N.
IntActiP20783. 3 interactors.
MINTiMINT-188565.
STRINGi9606.ENSP00000397297.

PTM databases

iPTMnetiP20783.
PhosphoSitePlusiP20783.

Polymorphism and mutation databases

BioMutaiNTF3.
DMDMi128581.

Proteomic databases

EPDiP20783.
PaxDbiP20783.
PRIDEiP20783.

Protocols and materials databases

DNASUi4908.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331010; ENSP00000328738; ENSG00000185652. [P20783-1]
ENST00000423158; ENSP00000397297; ENSG00000185652. [P20783-2]
GeneIDi4908.
KEGGihsa:4908.
UCSCiuc001qnk.5. human. [P20783-1]

Organism-specific databases

CTDi4908.
DisGeNETi4908.
GeneCardsiNTF3.
HGNCiHGNC:8023. NTF3.
HPAiHPA032000.
HPA032001.
MIMi162660. gene.
neXtProtiNX_P20783.
OpenTargetsiENSG00000185652.
PharmGKBiPA31806.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHMM. Eukaryota.
ENOG410XRRK. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP20783.
KOiK04356.
OMAiEFQPMIA.
OrthoDBiEOG091G0GHL.
PhylomeDBiP20783.
TreeFamiTF106463.

Enzyme and pathway databases

SignaLinkiP20783.
SIGNORiP20783.

Miscellaneous databases

EvolutionaryTraceiP20783.
GeneWikiiNeurotrophin-3.
GenomeRNAii4908.
PMAP-CutDBP20783.
PROiP20783.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185652.
CleanExiHS_NTF3.
GenevisibleiP20783. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTF3_HUMAN
AccessioniPrimary (citable) accession number: P20783
Secondary accession number(s): B7Z1T5, Q6FH50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.