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P20783

- NTF3_HUMAN

UniProt

P20783 - NTF3_HUMAN

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Protein

Neurotrophin-3

Gene
NTF3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  1. chemoattractant activity Source: BHF-UCL
  2. growth factor activity Source: BHF-UCL
  3. receptor binding Source: ProtInc

GO - Biological processi

  1. activation of MAPK activity Source: BHF-UCL
  2. activation of protein kinase B activity Source: BHF-UCL
  3. activation of Ras GTPase activity Source: BHF-UCL
  4. axon guidance Source: Ensembl
  5. brain development Source: Ensembl
  6. cell-cell signaling Source: ProtInc
  7. enteric nervous system development Source: Ensembl
  8. epidermis development Source: Ensembl
  9. glial cell fate determination Source: Ensembl
  10. induction of positive chemotaxis Source: BHF-UCL
  11. mechanoreceptor differentiation Source: Ensembl
  12. myelination Source: Ensembl
  13. negative regulation of neuron apoptotic process Source: Ensembl
  14. negative regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  15. nerve development Source: Ensembl
  16. nervous system development Source: ProtInc
  17. neuromuscular synaptic transmission Source: Ensembl
  18. peripheral nervous system development Source: Ensembl
  19. positive chemotaxis Source: GOC
  20. positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
  21. positive regulation of cell migration Source: BHF-UCL
  22. positive regulation of cell proliferation Source: BHF-UCL
  23. positive regulation of glial cell differentiation Source: Ensembl
  24. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  25. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  26. positive regulation of receptor internalization Source: BHF-UCL
  27. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  28. regulation of synaptic transmission Source: Ensembl
  29. signal transduction Source: ProtInc
  30. smooth muscle cell differentiation Source: Ensembl
  31. transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

SignaLinkiP20783.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:NTF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:8023. NTF3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Propeptidei19 – 138120PRO_0000019659Add
BLAST
Chaini139 – 257119Neurotrophin-3PRO_0000019660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi152 ↔ 217
Disulfide bondi195 ↔ 246
Disulfide bondi205 ↔ 248

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20783.
PRIDEiP20783.

PTM databases

PhosphoSiteiP20783.

Miscellaneous databases

PMAP-CutDBP20783.

Expressioni

Tissue specificityi

Brain and peripheral tissues.

Gene expression databases

BgeeiP20783.
CleanExiHS_NTF3.
GenevestigatoriP20783.

Organism-specific databases

HPAiHPA032000.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BDNFP235601EBI-1025994,EBI-1026003

Protein-protein interaction databases

BioGridi110963. 5 interactions.
DIPiDIP-346N.
IntActiP20783. 1 interaction.
MINTiMINT-188565.
STRINGi9606.ENSP00000397297.

Structurei

Secondary structure

1
257
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi148 – 1525
Beta strandi154 – 1596
Beta strandi164 – 1674
Beta strandi172 – 1754
Beta strandi177 – 1793
Turni181 – 1833
Beta strandi190 – 1956
Beta strandi200 – 2056
Turni210 – 2123
Beta strandi216 – 23318
Beta strandi236 – 24914

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B8KX-ray2.15A139-257[»]
1BNDX-ray2.30B139-257[»]
1NT3X-ray2.40A139-257[»]
3BUKX-ray2.60A/B139-257[»]
ProteinModelPortaliP20783.
SMRiP20783. Positions 146-253.

Miscellaneous databases

EvolutionaryTraceiP20783.

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39844.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP20783.
KOiK04356.
OMAiYAEHKSH.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiP20783.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P20783-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK    50
QMVDVKENYQ STLPKAEAPR EPERGGPAKS AFQPVIAMDT ELLRQQRRYN 100
SPRVLLSDST PLEPPPLYLM EDYVGSPVVA NRTSRRKRYA EHKSHRGEYS 150
VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEARP 200
VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL 250
SRKIGRT 257
Length:257
Mass (Da):29,355
Last modified:February 1, 1991 - v1
Checksum:i39A5BB3B28E25E03
GO
Isoform 2 (identifier: P20783-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVTFATILQVNKVM

Note: No experimental confirmation available.

Show »
Length:270
Mass (Da):30,800
Checksum:i43B3342B32424E97
GO

Polymorphismi

Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761G → E.2 Publications
Corresponds to variant rs1805149 [ dbSNP | Ensembl ].
VAR_012084

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MVTFATILQVNKVM in isoform 2. VSP_043353

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53655 mRNA. Translation: CAA37703.1.
M37763 Genomic DNA. Translation: AAA59953.1.
M61180 Genomic DNA. Translation: AAA63231.1.
AK293895 mRNA. Translation: BAH11621.1.
CR541906 mRNA. Translation: CAG46704.1.
CH471116 Genomic DNA. Translation: EAW88824.1.
CH471116 Genomic DNA. Translation: EAW88825.1.
BC069773 mRNA. Translation: AAH69773.1.
BC107075 mRNA. Translation: AAI07076.1.
CCDSiCCDS44806.1. [P20783-2]
CCDS8538.1. [P20783-1]
PIRiA36208. C40304.
RefSeqiNP_001096124.1. NM_001102654.1. [P20783-2]
NP_002518.1. NM_002527.4. [P20783-1]
UniGeneiHs.99171.

Genome annotation databases

EnsembliENST00000331010; ENSP00000328738; ENSG00000185652. [P20783-1]
ENST00000423158; ENSP00000397297; ENSG00000185652. [P20783-2]
GeneIDi4908.
KEGGihsa:4908.
UCSCiuc001qnk.4. human. [P20783-2]
uc001qnl.4. human. [P20783-1]

Polymorphism databases

DMDMi128581.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53655 mRNA. Translation: CAA37703.1 .
M37763 Genomic DNA. Translation: AAA59953.1 .
M61180 Genomic DNA. Translation: AAA63231.1 .
AK293895 mRNA. Translation: BAH11621.1 .
CR541906 mRNA. Translation: CAG46704.1 .
CH471116 Genomic DNA. Translation: EAW88824.1 .
CH471116 Genomic DNA. Translation: EAW88825.1 .
BC069773 mRNA. Translation: AAH69773.1 .
BC107075 mRNA. Translation: AAI07076.1 .
CCDSi CCDS44806.1. [P20783-2 ]
CCDS8538.1. [P20783-1 ]
PIRi A36208. C40304.
RefSeqi NP_001096124.1. NM_001102654.1. [P20783-2 ]
NP_002518.1. NM_002527.4. [P20783-1 ]
UniGenei Hs.99171.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1B8K X-ray 2.15 A 139-257 [» ]
1BND X-ray 2.30 B 139-257 [» ]
1NT3 X-ray 2.40 A 139-257 [» ]
3BUK X-ray 2.60 A/B 139-257 [» ]
ProteinModelPortali P20783.
SMRi P20783. Positions 146-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110963. 5 interactions.
DIPi DIP-346N.
IntActi P20783. 1 interaction.
MINTi MINT-188565.
STRINGi 9606.ENSP00000397297.

PTM databases

PhosphoSitei P20783.

Polymorphism databases

DMDMi 128581.

Proteomic databases

PaxDbi P20783.
PRIDEi P20783.

Protocols and materials databases

DNASUi 4908.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331010 ; ENSP00000328738 ; ENSG00000185652 . [P20783-1 ]
ENST00000423158 ; ENSP00000397297 ; ENSG00000185652 . [P20783-2 ]
GeneIDi 4908.
KEGGi hsa:4908.
UCSCi uc001qnk.4. human. [P20783-2 ]
uc001qnl.4. human. [P20783-1 ]

Organism-specific databases

CTDi 4908.
GeneCardsi GC12P005541.
HGNCi HGNC:8023. NTF3.
HPAi HPA032000.
MIMi 162660. gene.
neXtProti NX_P20783.
PharmGKBi PA31806.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39844.
HOGENOMi HOG000231516.
HOVERGENi HBG006494.
InParanoidi P20783.
KOi K04356.
OMAi YAEHKSH.
OrthoDBi EOG7RBZ8Z.
PhylomeDBi P20783.
TreeFami TF106463.

Enzyme and pathway databases

SignaLinki P20783.

Miscellaneous databases

EvolutionaryTracei P20783.
GeneWikii Neurotrophin-3.
GenomeRNAii 4908.
NextBioi 18887.
PMAP-CutDB P20783.
PROi P20783.
SOURCEi Search...

Gene expression databases

Bgeei P20783.
CleanExi HS_NTF3.
Genevestigatori P20783.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a cDNA encoding a novel human neurotrophic factor."
    Kaisho Y., Yoshimura K., Nakahama K.
    FEBS Lett. 266:187-191(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Primary structure and biological activity of a novel human neurotrophic factor."
    Rosenthal A., Goeddel D.V., Nguyen T., Lewis M., Shih A., Laramee G.R., Nikolics K., Winslow J.W.
    Neuron 4:767-773(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  3. "Molecular cloning of a human gene that is a member of the nerve growth factor family."
    Jones K.R., Reichardt L.F.
    Proc. Natl. Acad. Sci. U.S.A. 87:8060-8064(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."
    Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.
    Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  9. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
    Hallboeoek F., Ibanez C.F., Persson H.
    Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 194-236.
    Tissue: Leukocyte.
  10. "Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer."
    Robinson R.C., Radziejewski C., Stuart D.I., Jones E.Y.
    Biochemistry 34:4139-4146(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  11. "Association of neurotrophin-3 gene variant with severe forms of schizophrenia."
    Hattori M., Nanko S.
    Biochem. Biophys. Res. Commun. 209:513-518(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLU-76.
  12. "Failure to find associations of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia."
    Arinami T., Takekoshi K., Itokawa M., Hamaguchi H., Toru M.
    Psychiatr. Genet. 6:13-15(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLU-76.

Entry informationi

Entry nameiNTF3_HUMAN
AccessioniPrimary (citable) accession number: P20783
Secondary accession number(s): B7Z1T5, Q6FH50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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