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P20783

- NTF3_HUMAN

UniProt

P20783 - NTF3_HUMAN

Protein

Neurotrophin-3

Gene

NTF3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Seems to promote the survival of visceral and proprioceptive sensory neurons.

    GO - Molecular functioni

    1. chemoattractant activity Source: BHF-UCL
    2. growth factor activity Source: BHF-UCL
    3. receptor binding Source: ProtInc

    GO - Biological processi

    1. activation of MAPK activity Source: BHF-UCL
    2. activation of protein kinase B activity Source: BHF-UCL
    3. activation of Ras GTPase activity Source: BHF-UCL
    4. axon guidance Source: Ensembl
    5. brain development Source: Ensembl
    6. cell-cell signaling Source: ProtInc
    7. enteric nervous system development Source: Ensembl
    8. epidermis development Source: Ensembl
    9. glial cell fate determination Source: Ensembl
    10. induction of positive chemotaxis Source: BHF-UCL
    11. mechanoreceptor differentiation Source: Ensembl
    12. myelination Source: Ensembl
    13. negative regulation of neuron apoptotic process Source: Ensembl
    14. negative regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
    15. nerve development Source: Ensembl
    16. nervous system development Source: ProtInc
    17. neuromuscular synaptic transmission Source: Ensembl
    18. peripheral nervous system development Source: Ensembl
    19. positive chemotaxis Source: GOC
    20. positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
    21. positive regulation of cell migration Source: BHF-UCL
    22. positive regulation of cell proliferation Source: BHF-UCL
    23. positive regulation of glial cell differentiation Source: Ensembl
    24. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
    25. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
    26. positive regulation of receptor internalization Source: BHF-UCL
    27. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    28. regulation of synaptic transmission Source: Ensembl
    29. signal transduction Source: ProtInc
    30. smooth muscle cell differentiation Source: Ensembl
    31. transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    SignaLinkiP20783.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotrophin-3
    Short name:
    NT-3
    Alternative name(s):
    HDNF
    Nerve growth factor 2
    Short name:
    NGF-2
    Neurotrophic factor
    Gene namesi
    Name:NTF3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:8023. NTF3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31806.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 138120PRO_0000019659Add
    BLAST
    Chaini139 – 257119Neurotrophin-3PRO_0000019660Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 217
    Disulfide bondi195 ↔ 246
    Disulfide bondi205 ↔ 248

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP20783.
    PRIDEiP20783.

    PTM databases

    PhosphoSiteiP20783.

    Miscellaneous databases

    PMAP-CutDBP20783.

    Expressioni

    Tissue specificityi

    Brain and peripheral tissues.

    Gene expression databases

    BgeeiP20783.
    CleanExiHS_NTF3.
    GenevestigatoriP20783.

    Organism-specific databases

    HPAiHPA032000.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BDNFP235601EBI-1025994,EBI-1026003

    Protein-protein interaction databases

    BioGridi110963. 5 interactions.
    DIPiDIP-346N.
    IntActiP20783. 1 interaction.
    MINTiMINT-188565.
    STRINGi9606.ENSP00000397297.

    Structurei

    Secondary structure

    1
    257
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi148 – 1525
    Beta strandi154 – 1596
    Beta strandi164 – 1674
    Beta strandi172 – 1754
    Beta strandi177 – 1793
    Turni181 – 1833
    Beta strandi190 – 1956
    Beta strandi200 – 2056
    Turni210 – 2123
    Beta strandi216 – 23318
    Beta strandi236 – 24914

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1B8KX-ray2.15A139-257[»]
    1BNDX-ray2.30B139-257[»]
    1NT3X-ray2.40A139-257[»]
    3BUKX-ray2.60A/B139-257[»]
    ProteinModelPortaliP20783.
    SMRiP20783. Positions 146-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP20783.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39844.
    HOGENOMiHOG000231516.
    HOVERGENiHBG006494.
    InParanoidiP20783.
    KOiK04356.
    OMAiYAEHKSH.
    OrthoDBiEOG7RBZ8Z.
    PhylomeDBiP20783.
    TreeFamiTF106463.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR015578. Neurotrophin-3.
    [Graphical view]
    PANTHERiPTHR11589. PTHR11589. 1 hit.
    PTHR11589:SF4. PTHR11589:SF4. 1 hit.
    PfamiPF00243. NGF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001789. NGF. 1 hit.
    PRINTSiPR01914. NEUROTROPHN3.
    PR00268. NGF.
    ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00140. NGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P20783-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK    50
    QMVDVKENYQ STLPKAEAPR EPERGGPAKS AFQPVIAMDT ELLRQQRRYN 100
    SPRVLLSDST PLEPPPLYLM EDYVGSPVVA NRTSRRKRYA EHKSHRGEYS 150
    VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEARP 200
    VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL 250
    SRKIGRT 257
    Length:257
    Mass (Da):29,355
    Last modified:February 1, 1991 - v1
    Checksum:i39A5BB3B28E25E03
    GO
    Isoform 2 (identifier: P20783-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MVTFATILQVNKVM

    Note: No experimental confirmation available.

    Show »
    Length:270
    Mass (Da):30,800
    Checksum:i43B3342B32424E97
    GO

    Polymorphismi

    Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti76 – 761G → E.2 Publications
    Corresponds to variant rs1805149 [ dbSNP | Ensembl ].
    VAR_012084

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MVTFATILQVNKVM in isoform 2. 1 PublicationVSP_043353

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53655 mRNA. Translation: CAA37703.1.
    M37763 Genomic DNA. Translation: AAA59953.1.
    M61180 Genomic DNA. Translation: AAA63231.1.
    AK293895 mRNA. Translation: BAH11621.1.
    CR541906 mRNA. Translation: CAG46704.1.
    CH471116 Genomic DNA. Translation: EAW88824.1.
    CH471116 Genomic DNA. Translation: EAW88825.1.
    BC069773 mRNA. Translation: AAH69773.1.
    BC107075 mRNA. Translation: AAI07076.1.
    CCDSiCCDS44806.1. [P20783-2]
    CCDS8538.1. [P20783-1]
    PIRiA36208. C40304.
    RefSeqiNP_001096124.1. NM_001102654.1. [P20783-2]
    NP_002518.1. NM_002527.4. [P20783-1]
    UniGeneiHs.99171.

    Genome annotation databases

    EnsembliENST00000331010; ENSP00000328738; ENSG00000185652. [P20783-1]
    ENST00000423158; ENSP00000397297; ENSG00000185652. [P20783-2]
    GeneIDi4908.
    KEGGihsa:4908.
    UCSCiuc001qnk.4. human. [P20783-2]
    uc001qnl.4. human. [P20783-1]

    Polymorphism databases

    DMDMi128581.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53655 mRNA. Translation: CAA37703.1 .
    M37763 Genomic DNA. Translation: AAA59953.1 .
    M61180 Genomic DNA. Translation: AAA63231.1 .
    AK293895 mRNA. Translation: BAH11621.1 .
    CR541906 mRNA. Translation: CAG46704.1 .
    CH471116 Genomic DNA. Translation: EAW88824.1 .
    CH471116 Genomic DNA. Translation: EAW88825.1 .
    BC069773 mRNA. Translation: AAH69773.1 .
    BC107075 mRNA. Translation: AAI07076.1 .
    CCDSi CCDS44806.1. [P20783-2 ]
    CCDS8538.1. [P20783-1 ]
    PIRi A36208. C40304.
    RefSeqi NP_001096124.1. NM_001102654.1. [P20783-2 ]
    NP_002518.1. NM_002527.4. [P20783-1 ]
    UniGenei Hs.99171.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1B8K X-ray 2.15 A 139-257 [» ]
    1BND X-ray 2.30 B 139-257 [» ]
    1NT3 X-ray 2.40 A 139-257 [» ]
    3BUK X-ray 2.60 A/B 139-257 [» ]
    ProteinModelPortali P20783.
    SMRi P20783. Positions 146-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110963. 5 interactions.
    DIPi DIP-346N.
    IntActi P20783. 1 interaction.
    MINTi MINT-188565.
    STRINGi 9606.ENSP00000397297.

    PTM databases

    PhosphoSitei P20783.

    Polymorphism databases

    DMDMi 128581.

    Proteomic databases

    PaxDbi P20783.
    PRIDEi P20783.

    Protocols and materials databases

    DNASUi 4908.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331010 ; ENSP00000328738 ; ENSG00000185652 . [P20783-1 ]
    ENST00000423158 ; ENSP00000397297 ; ENSG00000185652 . [P20783-2 ]
    GeneIDi 4908.
    KEGGi hsa:4908.
    UCSCi uc001qnk.4. human. [P20783-2 ]
    uc001qnl.4. human. [P20783-1 ]

    Organism-specific databases

    CTDi 4908.
    GeneCardsi GC12P005541.
    HGNCi HGNC:8023. NTF3.
    HPAi HPA032000.
    MIMi 162660. gene.
    neXtProti NX_P20783.
    PharmGKBi PA31806.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39844.
    HOGENOMi HOG000231516.
    HOVERGENi HBG006494.
    InParanoidi P20783.
    KOi K04356.
    OMAi YAEHKSH.
    OrthoDBi EOG7RBZ8Z.
    PhylomeDBi P20783.
    TreeFami TF106463.

    Enzyme and pathway databases

    SignaLinki P20783.

    Miscellaneous databases

    EvolutionaryTracei P20783.
    GeneWikii Neurotrophin-3.
    GenomeRNAii 4908.
    NextBioi 18887.
    PMAP-CutDB P20783.
    PROi P20783.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20783.
    CleanExi HS_NTF3.
    Genevestigatori P20783.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR015578. Neurotrophin-3.
    [Graphical view ]
    PANTHERi PTHR11589. PTHR11589. 1 hit.
    PTHR11589:SF4. PTHR11589:SF4. 1 hit.
    Pfami PF00243. NGF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001789. NGF. 1 hit.
    PRINTSi PR01914. NEUROTROPHN3.
    PR00268. NGF.
    ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00140. NGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a cDNA encoding a novel human neurotrophic factor."
      Kaisho Y., Yoshimura K., Nakahama K.
      FEBS Lett. 266:187-191(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Primary structure and biological activity of a novel human neurotrophic factor."
      Rosenthal A., Goeddel D.V., Nguyen T., Lewis M., Shih A., Laramee G.R., Nikolics K., Winslow J.W.
      Neuron 4:767-773(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    3. "Molecular cloning of a human gene that is a member of the nerve growth factor family."
      Jones K.R., Reichardt L.F.
      Proc. Natl. Acad. Sci. U.S.A. 87:8060-8064(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."
      Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.
      Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    9. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
      Hallboeoek F., Ibanez C.F., Persson H.
      Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 194-236.
      Tissue: Leukocyte.
    10. "Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer."
      Robinson R.C., Radziejewski C., Stuart D.I., Jones E.Y.
      Biochemistry 34:4139-4146(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
    11. "Association of neurotrophin-3 gene variant with severe forms of schizophrenia."
      Hattori M., Nanko S.
      Biochem. Biophys. Res. Commun. 209:513-518(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLU-76.
    12. "Failure to find associations of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia."
      Arinami T., Takekoshi K., Itokawa M., Hamaguchi H., Toru M.
      Psychiatr. Genet. 6:13-15(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLU-76.

    Entry informationi

    Entry nameiNTF3_HUMAN
    AccessioniPrimary (citable) accession number: P20783
    Secondary accession number(s): B7Z1T5, Q6FH50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 151 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3