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P20782

- ACHE_MOUSE

UniProt

P20782 - ACHE_MOUSE

Protein

Acetylcholine receptor subunit epsilon

Gene

Chrne

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: InterPro

    GO - Biological processi

    1. cation transport Source: GOC
    2. regulation of membrane potential Source: MGI

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198593. Highly sodium permeable acetylcholine nicotinic receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylcholine receptor subunit epsilon
    Gene namesi
    Name:Chrne
    Synonyms:Acre
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:87894. Chrne.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. postsynaptic membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 493473Acetylcholine receptor subunit epsilonPRO_0000000330Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi148 ↔ 162By similarity
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP20782.
    PRIDEiP20782.

    Expressioni

    Gene expression databases

    BgeeiP20782.
    GenevestigatoriP20782.

    Interactioni

    Subunit structurei

    Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

    Structurei

    3D structure databases

    ProteinModelPortaliP20782.
    SMRiP20782. Positions 22-337, 448-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 239219ExtracellularAdd
    BLAST
    Topological domaini265 – 2728CytoplasmicSequence Analysis
    Topological domaini292 – 30615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini329 – 456128CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini481 – 49313ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei240 – 26425HelicalSequence AnalysisAdd
    BLAST
    Transmembranei273 – 29119HelicalSequence AnalysisAdd
    BLAST
    Transmembranei307 – 32822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei457 – 48024HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291810.
    GeneTreeiENSGT00750000117375.
    HOGENOMiHOG000006757.
    HOVERGENiHBG003756.
    KOiK04817.
    OrthoDBiEOG7H7925.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20782-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGALLGALL LLTLFGRSQG KNEELSLYHH LFDNYDPECR PVRRPEDTVT    50
    ITLKVTLTNL ISLNEKEETL TTSVWIGIDW HDYRLNYSKD DFAGVGILRV 100
    PSEHVWLPEI VLENNIDGQF GVAYDSNVLV YEGGYVSWLP PAIYRSTCAV 150
    EVTYFPFDWQ NCSLIFRSQT YNAEEVEFIF AVDDDGNTIN KIDIDTAAFT 200
    ENGEWAIDYC PGMIRRYEGG STEGPGETDV IYTLIIRRKP LFYVINIIVP 250
    CVLISGLVLL AYFLPAQAGG QKCTVSINVL LAQTVFLFLI AQKIPETSLS 300
    VPLLGRYLIF VMVVATLIVM NCVIVLNVSL RTPTTHATSP RLRQILLELL 350
    PRLLGSSPPP EDPRTASPAR RASSVGILLR AEELILKKPR SELVFEGQRH 400
    RHGTWTAALC QNLGAAAPEI RCCVDAVNFV AESTRDQEAT GEELSDWVRM 450
    GKALDNVCFW AALVLFSVGS TLIFLGGYFN QVPDLPYPPC IQP 493
    Length:493
    Mass (Da):54,914
    Last modified:February 1, 1991 - v1
    Checksum:iF3E468644F3FB7DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04698 Genomic DNA. Translation: AAA37153.1.
    X55718 mRNA. Translation: CAA39251.1.
    CCDSiCCDS24956.1.
    PIRiS13592. ACMSE.
    RefSeqiNP_033733.1. NM_009603.1.
    UniGeneiMm.4980.

    Genome annotation databases

    EnsembliENSMUST00000102556; ENSMUSP00000099616; ENSMUSG00000014609.
    GeneIDi11448.
    KEGGimmu:11448.
    UCSCiuc007jvo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04698 Genomic DNA. Translation: AAA37153.1 .
    X55718 mRNA. Translation: CAA39251.1 .
    CCDSi CCDS24956.1.
    PIRi S13592. ACMSE.
    RefSeqi NP_033733.1. NM_009603.1.
    UniGenei Mm.4980.

    3D structure databases

    ProteinModelPortali P20782.
    SMRi P20782. Positions 22-337, 448-485.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 477.

    Proteomic databases

    PaxDbi P20782.
    PRIDEi P20782.

    Protocols and materials databases

    DNASUi 11448.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102556 ; ENSMUSP00000099616 ; ENSMUSG00000014609 .
    GeneIDi 11448.
    KEGGi mmu:11448.
    UCSCi uc007jvo.1. mouse.

    Organism-specific databases

    CTDi 1145.
    MGIi MGI:87894. Chrne.

    Phylogenomic databases

    eggNOGi NOG291810.
    GeneTreei ENSGT00750000117375.
    HOGENOMi HOG000006757.
    HOVERGENi HBG003756.
    KOi K04817.
    OrthoDBi EOG7H7925.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_198593. Highly sodium permeable acetylcholine nicotinic receptors.

    Miscellaneous databases

    NextBioi 278760.
    PROi P20782.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20782.
    Genevestigatori P20782.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the beta and epsilon subunit genes of mouse muscle acetylcholine receptor."
      Buonanno A., Mudd J., Merlie J.P.
      J. Biol. Chem. 264:7611-7616(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide sequence of the epsilon-subunit of the mouse muscle nicotinic acetylcholine receptor."
      Gardner P.D.
      Nucleic Acids Res. 18:6714-6714(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiACHE_MOUSE
    AccessioniPrimary (citable) accession number: P20782
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3