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P20782

- ACHE_MOUSE

UniProt

P20782 - ACHE_MOUSE

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Protein

Acetylcholine receptor subunit epsilon

Gene
Chrne, Acre
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: InterPro

GO - Biological processi

  1. cation transport Source: GOC
  2. regulation of membrane potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198593. Highly sodium permeable acetylcholine nicotinic receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit epsilon
Gene namesi
Name:Chrne
Synonyms:Acre
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:87894. Chrne.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 239219ExtracellularAdd
BLAST
Transmembranei240 – 26425Helical; Reviewed predictionAdd
BLAST
Topological domaini265 – 2728Cytoplasmic Reviewed prediction
Transmembranei273 – 29119Helical; Reviewed predictionAdd
BLAST
Topological domaini292 – 30615Extracellular Reviewed predictionAdd
BLAST
Transmembranei307 – 32822Helical; Reviewed predictionAdd
BLAST
Topological domaini329 – 456128Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei457 – 48024Helical; Reviewed predictionAdd
BLAST
Topological domaini481 – 49313Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. postsynaptic membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 493473Acetylcholine receptor subunit epsilonPRO_0000000330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi148 ↔ 162 By similarity
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20782.
PRIDEiP20782.

Expressioni

Gene expression databases

BgeeiP20782.
GenevestigatoriP20782.

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Structurei

3D structure databases

ProteinModelPortaliP20782.
SMRiP20782. Positions 22-337, 448-485.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291810.
GeneTreeiENSGT00750000117375.
HOGENOMiHOG000006757.
HOVERGENiHBG003756.
KOiK04817.
OrthoDBiEOG7H7925.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20782-1 [UniParc]FASTAAdd to Basket

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MAGALLGALL LLTLFGRSQG KNEELSLYHH LFDNYDPECR PVRRPEDTVT    50
ITLKVTLTNL ISLNEKEETL TTSVWIGIDW HDYRLNYSKD DFAGVGILRV 100
PSEHVWLPEI VLENNIDGQF GVAYDSNVLV YEGGYVSWLP PAIYRSTCAV 150
EVTYFPFDWQ NCSLIFRSQT YNAEEVEFIF AVDDDGNTIN KIDIDTAAFT 200
ENGEWAIDYC PGMIRRYEGG STEGPGETDV IYTLIIRRKP LFYVINIIVP 250
CVLISGLVLL AYFLPAQAGG QKCTVSINVL LAQTVFLFLI AQKIPETSLS 300
VPLLGRYLIF VMVVATLIVM NCVIVLNVSL RTPTTHATSP RLRQILLELL 350
PRLLGSSPPP EDPRTASPAR RASSVGILLR AEELILKKPR SELVFEGQRH 400
RHGTWTAALC QNLGAAAPEI RCCVDAVNFV AESTRDQEAT GEELSDWVRM 450
GKALDNVCFW AALVLFSVGS TLIFLGGYFN QVPDLPYPPC IQP 493
Length:493
Mass (Da):54,914
Last modified:February 1, 1991 - v1
Checksum:iF3E468644F3FB7DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04698 Genomic DNA. Translation: AAA37153.1.
X55718 mRNA. Translation: CAA39251.1.
CCDSiCCDS24956.1.
PIRiS13592. ACMSE.
RefSeqiNP_033733.1. NM_009603.1.
UniGeneiMm.4980.

Genome annotation databases

EnsembliENSMUST00000102556; ENSMUSP00000099616; ENSMUSG00000014609.
GeneIDi11448.
KEGGimmu:11448.
UCSCiuc007jvo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04698 Genomic DNA. Translation: AAA37153.1 .
X55718 mRNA. Translation: CAA39251.1 .
CCDSi CCDS24956.1.
PIRi S13592. ACMSE.
RefSeqi NP_033733.1. NM_009603.1.
UniGenei Mm.4980.

3D structure databases

ProteinModelPortali P20782.
SMRi P20782. Positions 22-337, 448-485.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 477.

Proteomic databases

PaxDbi P20782.
PRIDEi P20782.

Protocols and materials databases

DNASUi 11448.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102556 ; ENSMUSP00000099616 ; ENSMUSG00000014609 .
GeneIDi 11448.
KEGGi mmu:11448.
UCSCi uc007jvo.1. mouse.

Organism-specific databases

CTDi 1145.
MGIi MGI:87894. Chrne.

Phylogenomic databases

eggNOGi NOG291810.
GeneTreei ENSGT00750000117375.
HOGENOMi HOG000006757.
HOVERGENi HBG003756.
KOi K04817.
OrthoDBi EOG7H7925.
TreeFami TF315605.

Enzyme and pathway databases

Reactomei REACT_198593. Highly sodium permeable acetylcholine nicotinic receptors.

Miscellaneous databases

NextBioi 278760.
PROi P20782.
SOURCEi Search...

Gene expression databases

Bgeei P20782.
Genevestigatori P20782.

Family and domain databases

Gene3Di 1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of the beta and epsilon subunit genes of mouse muscle acetylcholine receptor."
    Buonanno A., Mudd J., Merlie J.P.
    J. Biol. Chem. 264:7611-7616(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of the epsilon-subunit of the mouse muscle nicotinic acetylcholine receptor."
    Gardner P.D.
    Nucleic Acids Res. 18:6714-6714(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiACHE_MOUSE
AccessioniPrimary (citable) accession number: P20782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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