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P20774

- MIME_HUMAN

UniProt

P20774 - MIME_HUMAN

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Protein

Mimecan

Gene

OGN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. glycosaminoglycan metabolic process Source: Reactome
  3. keratan sulfate biosynthetic process Source: Reactome
  4. keratan sulfate catabolic process Source: Reactome
  5. keratan sulfate metabolic process Source: Reactome
  6. negative regulation of smooth muscle cell proliferation Source: UniProtKB
  7. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_121120. Keratan sulfate biosynthesis.
REACT_121313. Keratan sulfate degradation.
REACT_267635. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).
REACT_267713. Defective CHST6 causes MCDC1.

Names & Taxonomyi

Protein namesi
Recommended name:
Mimecan
Alternative name(s):
Osteoglycin
Osteoinductive factor
Short name:
OIF
Gene namesi
Name:OGN
Synonyms:OIF, SLRR3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:8126. OGN.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: BHF-UCL
  3. extracellular vesicular exosome Source: UniProtKB
  4. Golgi lumen Source: Reactome
  5. lysosomal lumen Source: Reactome
  6. proteinaceous extracellular matrix Source: UniProtKB-KW
  7. vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31913.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 298278MimecanPRO_0000032760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801O-linked (GalNAc...)1 Publication
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi255 ↔ 288By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP20774.
PaxDbiP20774.
PeptideAtlasiP20774.
PRIDEiP20774.

2D gel databases

REPRODUCTION-2DPAGEIPI00025465.

PTM databases

PhosphoSiteiP20774.

Miscellaneous databases

PMAP-CutDBP20774.

Expressioni

Tissue specificityi

Bone.

Gene expression databases

BgeeiP20774.
CleanExiHS_OGN.
ExpressionAtlasiP20774. baseline and differential.
GenevestigatoriP20774.

Organism-specific databases

HPAiHPA013132.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRKP461082EBI-1753690,EBI-886

Protein-protein interaction databases

BioGridi111019. 7 interactions.
IntActiP20774. 3 interactions.
MINTiMINT-4529844.
STRINGi9606.ENSP00000262551.

Structurei

3D structure databases

ProteinModelPortaliP20774.
SMRiP20774. Positions 80-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati112 – 13120LRR 1Add
BLAST
Repeati132 – 15524LRR 2Add
BLAST
Repeati156 – 17924LRR 3Add
BLAST
Repeati180 – 19920LRR 4Add
BLAST
Repeati200 – 22526LRR 5Add
BLAST
Repeati226 – 24621LRR 6Add
BLAST
Repeati247 – 27731LRR 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi94 – 10613Cys-richAdd
BLAST

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG318805.
GeneTreeiENSGT00730000110781.
HOVERGENiHBG006850.
InParanoidiP20774.
KOiK08126.
OMAiDTRYIRD.
OrthoDBiEOG75TMD0.
PhylomeDBiP20774.
TreeFamiTF351924.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24371:SF5. PTHR24371:SF5. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20774-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTLQSTLLL LLLVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK
60 70 80 90 100
YLDGKNIKEK ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL
110 120 130 140 150
SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DIPNLRRLDF
160 170 180 190 200
TGNLIEDIED GTFSKLSLLE ELSLAENQLL KLPVLPPKLT LFNAKYNKIK
210 220 230 240 250
SRGIKANAFK KLNNLTFLYL DHNALESVPL NLPESLRVIH LQFNNIASIT
260 270 280 290
DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF
Length:298
Mass (Da):33,922
Last modified:February 1, 1991 - v1
Checksum:iF4590785C3849F83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192483
, AF192478, AF192479, AF192480, AF192481, AF192482 Genomic DNA. Translation: AAF19364.1.
AF202167 mRNA. Translation: AAF69109.1.
AF100758 mRNA. Translation: AAD43022.1.
AL110267 mRNA. Translation: CAB53706.1.
CR533516 mRNA. Translation: CAG38547.1.
AL137848 Genomic DNA. Translation: CAI16694.1.
BC037273 mRNA. Translation: AAH37273.1.
BC095443 mRNA. Translation: AAH95443.1.
AF112465 Genomic DNA. Translation: AAD40453.1.
AL133114 mRNA. Translation: CAB61417.2.
CCDSiCCDS6695.1.
PIRiB35272.
RefSeqiNP_054776.1. NM_014057.3.
NP_148935.1. NM_033014.2.
UniGeneiHs.109439.

Genome annotation databases

EnsembliENST00000262551; ENSP00000262551; ENSG00000106809.
ENST00000375561; ENSP00000364711; ENSG00000106809.
GeneIDi4969.
KEGGihsa:4969.
UCSCiuc004asa.3. human.

Polymorphism databases

DMDMi129078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192483
, AF192478 , AF192479 , AF192480 , AF192481 , AF192482 Genomic DNA. Translation: AAF19364.1 .
AF202167 mRNA. Translation: AAF69109.1 .
AF100758 mRNA. Translation: AAD43022.1 .
AL110267 mRNA. Translation: CAB53706.1 .
CR533516 mRNA. Translation: CAG38547.1 .
AL137848 Genomic DNA. Translation: CAI16694.1 .
BC037273 mRNA. Translation: AAH37273.1 .
BC095443 mRNA. Translation: AAH95443.1 .
AF112465 Genomic DNA. Translation: AAD40453.1 .
AL133114 mRNA. Translation: CAB61417.2 .
CCDSi CCDS6695.1.
PIRi B35272.
RefSeqi NP_054776.1. NM_014057.3.
NP_148935.1. NM_033014.2.
UniGenei Hs.109439.

3D structure databases

ProteinModelPortali P20774.
SMRi P20774. Positions 80-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111019. 7 interactions.
IntActi P20774. 3 interactions.
MINTi MINT-4529844.
STRINGi 9606.ENSP00000262551.

PTM databases

PhosphoSitei P20774.

Polymorphism databases

DMDMi 129078.

2D gel databases

REPRODUCTION-2DPAGE IPI00025465.

Proteomic databases

MaxQBi P20774.
PaxDbi P20774.
PeptideAtlasi P20774.
PRIDEi P20774.

Protocols and materials databases

DNASUi 4969.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262551 ; ENSP00000262551 ; ENSG00000106809 .
ENST00000375561 ; ENSP00000364711 ; ENSG00000106809 .
GeneIDi 4969.
KEGGi hsa:4969.
UCSCi uc004asa.3. human.

Organism-specific databases

CTDi 4969.
GeneCardsi GC09M095146.
HGNCi HGNC:8126. OGN.
HPAi HPA013132.
MIMi 602383. gene.
neXtProti NX_P20774.
PharmGKBi PA31913.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG318805.
GeneTreei ENSGT00730000110781.
HOVERGENi HBG006850.
InParanoidi P20774.
KOi K08126.
OMAi DTRYIRD.
OrthoDBi EOG75TMD0.
PhylomeDBi P20774.
TreeFami TF351924.

Enzyme and pathway databases

Reactomei REACT_121120. Keratan sulfate biosynthesis.
REACT_121313. Keratan sulfate degradation.
REACT_267635. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).
REACT_267713. Defective CHST6 causes MCDC1.

Miscellaneous databases

GeneWikii OGN_(gene).
GenomeRNAii 4969.
NextBioi 19134.
PMAP-CutDB P20774.
PROi P20774.
SOURCEi Search...

Gene expression databases

Bgeei P20774.
CleanExi HS_OGN.
ExpressionAtlasi P20774. baseline and differential.
Genevestigatori P20774.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR027211. Mimecan.
[Graphical view ]
PANTHERi PTHR24371:SF5. PTHR24371:SF5. 1 hit.
Pfami PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Grover J., Rodriguez E., Roughley P.J.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  9. "The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon."
    Tasheva E.S., Funderburgh M.L., McReynolds J., Funderburgh J.L., Conrad G.W.
    J. Biol. Chem. 274:18693-18701(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54.
  10. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-35.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-298.
    Tissue: Uterus.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-258.
    Tissue: Liver.
  13. "Enrichment of glycopeptides for glycan structure and attachment site identification."
    Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
    Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-80, STRUCTURE OF CARBOHYDRATES.
    Tissue: Cerebrospinal fluid.

Entry informationi

Entry nameiMIME_HUMAN
AccessioniPrimary (citable) accession number: P20774
Secondary accession number(s): Q6FIB0, Q9UF90, Q9UNK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 26, 2014
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3