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P20774

- MIME_HUMAN

UniProt

P20774 - MIME_HUMAN

Protein

Mimecan

Gene

OGN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. glycosaminoglycan metabolic process Source: Reactome
    3. keratan sulfate biosynthetic process Source: Reactome
    4. keratan sulfate catabolic process Source: Reactome
    5. keratan sulfate metabolic process Source: Reactome
    6. negative regulation of smooth muscle cell proliferation Source: UniProtKB
    7. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_121120. Keratan sulfate biosynthesis.
    REACT_121313. Keratan sulfate degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mimecan
    Alternative name(s):
    Osteoglycin
    Osteoinductive factor
    Short name:
    OIF
    Gene namesi
    Name:OGN
    Synonyms:OIF, SLRR3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:8126. OGN.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: BHF-UCL
    3. Golgi lumen Source: Reactome
    4. lysosomal lumen Source: Reactome
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31913.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 298278MimecanPRO_0000032760Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801O-linked (GalNAc...)1 Publication
    Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi255 ↔ 288By similarity
    Glycosylationi258 – 2581N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP20774.
    PaxDbiP20774.
    PeptideAtlasiP20774.
    PRIDEiP20774.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00025465.

    PTM databases

    PhosphoSiteiP20774.

    Miscellaneous databases

    PMAP-CutDBP20774.

    Expressioni

    Tissue specificityi

    Bone.

    Gene expression databases

    ArrayExpressiP20774.
    BgeeiP20774.
    CleanExiHS_OGN.
    GenevestigatoriP20774.

    Organism-specific databases

    HPAiHPA013132.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CRKP461082EBI-1753690,EBI-886

    Protein-protein interaction databases

    IntActiP20774. 3 interactions.
    MINTiMINT-4529844.
    STRINGi9606.ENSP00000262551.

    Structurei

    3D structure databases

    ProteinModelPortaliP20774.
    SMRiP20774. Positions 94-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati112 – 13120LRR 1Add
    BLAST
    Repeati132 – 15524LRR 2Add
    BLAST
    Repeati156 – 17924LRR 3Add
    BLAST
    Repeati180 – 19920LRR 4Add
    BLAST
    Repeati200 – 22526LRR 5Add
    BLAST
    Repeati226 – 24621LRR 6Add
    BLAST
    Repeati247 – 27731LRR 7Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi94 – 10613Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 7 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG318805.
    HOVERGENiHBG006850.
    InParanoidiP20774.
    KOiK08126.
    OMAiDTRYIRD.
    OrthoDBiEOG75TMD0.
    PhylomeDBiP20774.
    TreeFamiTF351924.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR027211. Mimecan.
    [Graphical view]
    PANTHERiPTHR24371:SF5. PTHR24371:SF5. 1 hit.
    PfamiPF13855. LRR_8. 1 hit.
    [Graphical view]
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTLQSTLLL LLLVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK    50
    YLDGKNIKEK ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL 100
    SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DIPNLRRLDF 150
    TGNLIEDIED GTFSKLSLLE ELSLAENQLL KLPVLPPKLT LFNAKYNKIK 200
    SRGIKANAFK KLNNLTFLYL DHNALESVPL NLPESLRVIH LQFNNIASIT 250
    DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF 298
    Length:298
    Mass (Da):33,922
    Last modified:February 1, 1991 - v1
    Checksum:iF4590785C3849F83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF192483
    , AF192478, AF192479, AF192480, AF192481, AF192482 Genomic DNA. Translation: AAF19364.1.
    AF202167 mRNA. Translation: AAF69109.1.
    AF100758 mRNA. Translation: AAD43022.1.
    AL110267 mRNA. Translation: CAB53706.1.
    CR533516 mRNA. Translation: CAG38547.1.
    AL137848 Genomic DNA. Translation: CAI16694.1.
    BC037273 mRNA. Translation: AAH37273.1.
    BC095443 mRNA. Translation: AAH95443.1.
    AF112465 Genomic DNA. Translation: AAD40453.1.
    AL133114 mRNA. Translation: CAB61417.2.
    CCDSiCCDS6695.1.
    PIRiB35272.
    RefSeqiNP_054776.1. NM_014057.3.
    NP_148935.1. NM_033014.2.
    UniGeneiHs.109439.

    Genome annotation databases

    EnsembliENST00000262551; ENSP00000262551; ENSG00000106809.
    ENST00000375561; ENSP00000364711; ENSG00000106809.
    GeneIDi4969.
    KEGGihsa:4969.
    UCSCiuc004asa.3. human.

    Polymorphism databases

    DMDMi129078.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF192483
    , AF192478 , AF192479 , AF192480 , AF192481 , AF192482 Genomic DNA. Translation: AAF19364.1 .
    AF202167 mRNA. Translation: AAF69109.1 .
    AF100758 mRNA. Translation: AAD43022.1 .
    AL110267 mRNA. Translation: CAB53706.1 .
    CR533516 mRNA. Translation: CAG38547.1 .
    AL137848 Genomic DNA. Translation: CAI16694.1 .
    BC037273 mRNA. Translation: AAH37273.1 .
    BC095443 mRNA. Translation: AAH95443.1 .
    AF112465 Genomic DNA. Translation: AAD40453.1 .
    AL133114 mRNA. Translation: CAB61417.2 .
    CCDSi CCDS6695.1.
    PIRi B35272.
    RefSeqi NP_054776.1. NM_014057.3.
    NP_148935.1. NM_033014.2.
    UniGenei Hs.109439.

    3D structure databases

    ProteinModelPortali P20774.
    SMRi P20774. Positions 94-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P20774. 3 interactions.
    MINTi MINT-4529844.
    STRINGi 9606.ENSP00000262551.

    PTM databases

    PhosphoSitei P20774.

    Polymorphism databases

    DMDMi 129078.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00025465.

    Proteomic databases

    MaxQBi P20774.
    PaxDbi P20774.
    PeptideAtlasi P20774.
    PRIDEi P20774.

    Protocols and materials databases

    DNASUi 4969.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262551 ; ENSP00000262551 ; ENSG00000106809 .
    ENST00000375561 ; ENSP00000364711 ; ENSG00000106809 .
    GeneIDi 4969.
    KEGGi hsa:4969.
    UCSCi uc004asa.3. human.

    Organism-specific databases

    CTDi 4969.
    GeneCardsi GC09M095146.
    HGNCi HGNC:8126. OGN.
    HPAi HPA013132.
    MIMi 602383. gene.
    neXtProti NX_P20774.
    PharmGKBi PA31913.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318805.
    HOVERGENi HBG006850.
    InParanoidi P20774.
    KOi K08126.
    OMAi DTRYIRD.
    OrthoDBi EOG75TMD0.
    PhylomeDBi P20774.
    TreeFami TF351924.

    Enzyme and pathway databases

    Reactomei REACT_121120. Keratan sulfate biosynthesis.
    REACT_121313. Keratan sulfate degradation.

    Miscellaneous databases

    GeneWikii OGN_(gene).
    GenomeRNAii 4969.
    NextBioi 19134.
    PMAP-CutDB P20774.
    PROi P20774.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20774.
    Bgeei P20774.
    CleanExi HS_OGN.
    Genevestigatori P20774.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR027211. Mimecan.
    [Graphical view ]
    PANTHERi PTHR24371:SF5. PTHR24371:SF5. 1 hit.
    Pfami PF13855. LRR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Grover J., Rodriguez E., Roughley P.J.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    9. "The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon."
      Tasheva E.S., Funderburgh M.L., McReynolds J., Funderburgh J.L., Conrad G.W.
      J. Biol. Chem. 274:18693-18701(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54.
    10. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-35.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-298.
      Tissue: Uterus.
    12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-258.
      Tissue: Liver.
    13. "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
      Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-80, STRUCTURE OF CARBOHYDRATES.
      Tissue: Cerebrospinal fluid.

    Entry informationi

    Entry nameiMIME_HUMAN
    AccessioniPrimary (citable) accession number: P20774
    Secondary accession number(s): Q6FIB0, Q9UF90, Q9UNK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3