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P20774 (MIME_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mimecan
Alternative name(s):
Osteoglycin
Osteoinductive factor
Short name=OIF
Gene names
Name:OGN
Synonyms:OIF, SLRR3A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Bone.

Post-translational modification

N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

Contains 7 LRR (leucine-rich) repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CRKP461082EBI-1753690,EBI-886

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.10
Chain21 – 298278Mimecan
PRO_0000032760

Regions

Repeat112 – 13120LRR 1
Repeat132 – 15524LRR 2
Repeat156 – 17924LRR 3
Repeat180 – 19920LRR 4
Repeat200 – 22526LRR 5
Repeat226 – 24621LRR 6
Repeat247 – 27731LRR 7
Compositional bias94 – 10613Cys-rich

Amino acid modifications

Glycosylation801O-linked (GalNAc...) Ref.13
Glycosylation2141N-linked (GlcNAc...) Potential
Glycosylation2581N-linked (GlcNAc...) Ref.12
Disulfide bond255 ↔ 288 By similarity

Sequences

Sequence LengthMass (Da)Tools
P20774 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: F4590785C3849F83

FASTA29833,922
        10         20         30         40         50         60 
MKTLQSTLLL LLLVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK YLDGKNIKEK 

        70         80         90        100        110        120 
ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL SGSVYCEEVD IDAVPPLPKE 

       130        140        150        160        170        180 
SAYLYARFNK IKKLTAKDFA DIPNLRRLDF TGNLIEDIED GTFSKLSLLE ELSLAENQLL 

       190        200        210        220        230        240 
KLPVLPPKLT LFNAKYNKIK SRGIKANAFK KLNNLTFLYL DHNALESVPL NLPESLRVIH 

       250        260        270        280        290 
LQFNNIASIT DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel bone-forming compound: osteoinductive factor."
Madisen L., Neubauer M., Plowman G., Rosen D.M., Segarini P.R., Dasch J.R., Thompson A.Y., Ziman J., Bentz H., Purchio A.F.
DNA Cell Biol. 9:303-309(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Grover J., Rodriguez E., Roughley P.J.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Mutations in KERA, encoding keratocan, cause cornea plana."
Pellegata N.S., Dieguez-Lucena J.L., Joensuu T., Lau S., Montgomery K.T., Krahe R., Kivelae T., Kucherlapati R., Forsius H., de la Chapelle A.
Nat. Genet. 25:91-95(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[5]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[9]"The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon."
Tasheva E.S., Funderburgh M.L., McReynolds J., Funderburgh J.L., Conrad G.W.
J. Biol. Chem. 274:18693-18701(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54.
[10]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-35.
[11]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-298.
Tissue: Uterus.
[12]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-258.
Tissue: Liver.
[13]"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-80, STRUCTURE OF CARBOHYDRATES.
Tissue: Cerebrospinal fluid.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF192483 expand/collapse EMBL AC list , AF192478, AF192479, AF192480, AF192481, AF192482 Genomic DNA. Translation: AAF19364.1.
AF202167 mRNA. Translation: AAF69109.1.
AF100758 mRNA. Translation: AAD43022.1.
AL110267 mRNA. Translation: CAB53706.1.
CR533516 mRNA. Translation: CAG38547.1.
AL137848 Genomic DNA. Translation: CAI16694.1.
BC037273 mRNA. Translation: AAH37273.1.
BC095443 mRNA. Translation: AAH95443.1.
AF112465 Genomic DNA. Translation: AAD40453.1.
AL133114 mRNA. Translation: CAB61417.2.
PIRB35272.
RefSeqNP_054776.1. NM_014057.3.
NP_148935.1. NM_033014.2.
UniGeneHs.109439.

3D structure databases

ProteinModelPortalP20774.
SMRP20774. Positions 94-290.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP20774. 3 interactions.
MINTMINT-4529844.
STRING9606.ENSP00000262551.

PTM databases

PhosphoSiteP20774.

Polymorphism databases

DMDM129078.

2D gel databases

REPRODUCTION-2DPAGEIPI00025465.

Proteomic databases

PaxDbP20774.
PeptideAtlasP20774.
PRIDEP20774.

Protocols and materials databases

DNASU4969.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262551; ENSP00000262551; ENSG00000106809.
ENST00000375561; ENSP00000364711; ENSG00000106809.
GeneID4969.
KEGGhsa:4969.
UCSCuc004asa.3. human.

Organism-specific databases

CTD4969.
GeneCardsGC09M095146.
HGNCHGNC:8126. OGN.
HPAHPA013132.
MIM602383. gene.
neXtProtNX_P20774.
PharmGKBPA31913.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG318805.
HOVERGENHBG006850.
InParanoidP20774.
KOK08126.
OMADTRYIRD.
OrthoDBEOG75TMD0.
PhylomeDBP20774.
TreeFamTF351924.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.

Gene expression databases

ArrayExpressP20774.
BgeeP20774.
CleanExHS_OGN.
GenevestigatorP20774.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR027211. Mimecan.
[Graphical view]
PANTHERPTHR24371:SF5. PTHR24371:SF5. 1 hit.
SMARTSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOGN_(gene).
GenomeRNAi4969.
NextBio19134.
PMAP-CutDBP20774.
PROP20774.
SOURCESearch...

Entry information

Entry nameMIME_HUMAN
AccessionPrimary (citable) accession number: P20774
Secondary accession number(s): Q6FIB0, Q9UF90, Q9UNK5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 16, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM