Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mimecan

Gene

OGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106809-MONOMER.
ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-2022857. Keratan sulfate degradation.
R-HSA-3656225. Defective CHST6 causes MCDC1.
R-HSA-3656243. Defective ST3GAL3 causes MCT12 and EIEE15.
R-HSA-3656244. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).

Names & Taxonomyi

Protein namesi
Recommended name:
Mimecan
Alternative name(s):
Osteoglycin
Osteoinductive factor
Short name:
OIF
Gene namesi
Name:OGN
Synonyms:OIF, SLRR3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8126. OGN.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: BHF-UCL
  • extracellular vesicle Source: UniProtKB
  • Golgi lumen Source: Reactome
  • lysosomal lumen Source: Reactome
  • proteinaceous extracellular matrix Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4969.
OpenTargetsiENSG00000106809.
PharmGKBiPA31913.

Polymorphism and mutation databases

BioMutaiOGN.
DMDMi129078.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000003276021 – 298MimecanAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80O-linked (GalNAc...)1 Publication1
Glycosylationi214N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi255 ↔ 288By similarity
Glycosylationi258N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP20774.
PaxDbiP20774.
PeptideAtlasiP20774.
PRIDEiP20774.

2D gel databases

REPRODUCTION-2DPAGEIPI00025465.

PTM databases

iPTMnetiP20774.
PhosphoSitePlusiP20774.
UniCarbKBiP20774.

Miscellaneous databases

PMAP-CutDBP20774.

Expressioni

Tissue specificityi

Bone.

Gene expression databases

BgeeiENSG00000106809.
CleanExiHS_OGN.
ExpressionAtlasiP20774. baseline and differential.
GenevisibleiP20774. HS.

Organism-specific databases

HPAiHPA013132.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRKP461082EBI-1753690,EBI-886

Protein-protein interaction databases

BioGridi111019. 7 interactors.
IntActiP20774. 3 interactors.
MINTiMINT-4529844.
STRINGi9606.ENSP00000262551.

Structurei

3D structure databases

ProteinModelPortaliP20774.
SMRiP20774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati112 – 131LRR 1Add BLAST20
Repeati132 – 155LRR 2Add BLAST24
Repeati156 – 179LRR 3Add BLAST24
Repeati180 – 199LRR 4Add BLAST20
Repeati200 – 225LRR 5Add BLAST26
Repeati226 – 246LRR 6Add BLAST21
Repeati247 – 277LRR 7Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi94 – 106Cys-richAdd BLAST13

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOVERGENiHBG006850.
InParanoidiP20774.
KOiK08126.
OMAiRMDEIRM.
OrthoDBiEOG091G0E49.
PhylomeDBiP20774.
TreeFamiTF351924.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24373:SF122. PTHR24373:SF122. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLQSTLLL LLLVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK
60 70 80 90 100
YLDGKNIKEK ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL
110 120 130 140 150
SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DIPNLRRLDF
160 170 180 190 200
TGNLIEDIED GTFSKLSLLE ELSLAENQLL KLPVLPPKLT LFNAKYNKIK
210 220 230 240 250
SRGIKANAFK KLNNLTFLYL DHNALESVPL NLPESLRVIH LQFNNIASIT
260 270 280 290
DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF
Length:298
Mass (Da):33,922
Last modified:February 1, 1991 - v1
Checksum:iF4590785C3849F83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192483
, AF192478, AF192479, AF192480, AF192481, AF192482 Genomic DNA. Translation: AAF19364.1.
AF202167 mRNA. Translation: AAF69109.1.
AF100758 mRNA. Translation: AAD43022.1.
AL110267 mRNA. Translation: CAB53706.1.
CR533516 mRNA. Translation: CAG38547.1.
AL137848 Genomic DNA. Translation: CAI16694.1.
BC037273 mRNA. Translation: AAH37273.1.
BC095443 mRNA. Translation: AAH95443.1.
AF112465 Genomic DNA. Translation: AAD40453.1.
AL133114 mRNA. Translation: CAB61417.2.
CCDSiCCDS6695.1.
PIRiB35272.
RefSeqiNP_054776.1. NM_014057.4.
NP_077727.3. NM_024416.4.
NP_148935.1. NM_033014.3.
UniGeneiHs.109439.
Hs.617761.

Genome annotation databases

EnsembliENST00000262551; ENSP00000262551; ENSG00000106809.
ENST00000375561; ENSP00000364711; ENSG00000106809.
GeneIDi4969.
KEGGihsa:4969.
UCSCiuc004asa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192483
, AF192478, AF192479, AF192480, AF192481, AF192482 Genomic DNA. Translation: AAF19364.1.
AF202167 mRNA. Translation: AAF69109.1.
AF100758 mRNA. Translation: AAD43022.1.
AL110267 mRNA. Translation: CAB53706.1.
CR533516 mRNA. Translation: CAG38547.1.
AL137848 Genomic DNA. Translation: CAI16694.1.
BC037273 mRNA. Translation: AAH37273.1.
BC095443 mRNA. Translation: AAH95443.1.
AF112465 Genomic DNA. Translation: AAD40453.1.
AL133114 mRNA. Translation: CAB61417.2.
CCDSiCCDS6695.1.
PIRiB35272.
RefSeqiNP_054776.1. NM_014057.4.
NP_077727.3. NM_024416.4.
NP_148935.1. NM_033014.3.
UniGeneiHs.109439.
Hs.617761.

3D structure databases

ProteinModelPortaliP20774.
SMRiP20774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111019. 7 interactors.
IntActiP20774. 3 interactors.
MINTiMINT-4529844.
STRINGi9606.ENSP00000262551.

PTM databases

iPTMnetiP20774.
PhosphoSitePlusiP20774.
UniCarbKBiP20774.

Polymorphism and mutation databases

BioMutaiOGN.
DMDMi129078.

2D gel databases

REPRODUCTION-2DPAGEIPI00025465.

Proteomic databases

MaxQBiP20774.
PaxDbiP20774.
PeptideAtlasiP20774.
PRIDEiP20774.

Protocols and materials databases

DNASUi4969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262551; ENSP00000262551; ENSG00000106809.
ENST00000375561; ENSP00000364711; ENSG00000106809.
GeneIDi4969.
KEGGihsa:4969.
UCSCiuc004asa.4. human.

Organism-specific databases

CTDi4969.
DisGeNETi4969.
GeneCardsiOGN.
HGNCiHGNC:8126. OGN.
HPAiHPA013132.
MIMi602383. gene.
neXtProtiNX_P20774.
OpenTargetsiENSG00000106809.
PharmGKBiPA31913.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOVERGENiHBG006850.
InParanoidiP20774.
KOiK08126.
OMAiRMDEIRM.
OrthoDBiEOG091G0E49.
PhylomeDBiP20774.
TreeFamiTF351924.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106809-MONOMER.
ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-2022857. Keratan sulfate degradation.
R-HSA-3656225. Defective CHST6 causes MCDC1.
R-HSA-3656243. Defective ST3GAL3 causes MCT12 and EIEE15.
R-HSA-3656244. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).

Miscellaneous databases

GeneWikiiOGN_(gene).
GenomeRNAii4969.
PMAP-CutDBP20774.
PROiP20774.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106809.
CleanExiHS_OGN.
ExpressionAtlasiP20774. baseline and differential.
GenevisibleiP20774. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24373:SF122. PTHR24373:SF122. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIME_HUMAN
AccessioniPrimary (citable) accession number: P20774
Secondary accession number(s): Q6FIB0, Q9UF90, Q9UNK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.