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Protein

Immunoglobulin lambda-like polypeptide 1

Gene

Igll1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Critical for B-cell development.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda-like polypeptide 1
Alternative name(s):
CD179 antigen-like family member B
Ig lambda-5
CD_antigen: CD179b
Gene namesi
Name:Igll1
Synonyms:Igl-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:96529. Igll1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 209179Immunoglobulin lambda-like polypeptide 1PRO_0000153611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi131 ↔ 190PROSITE-ProRule annotation
Disulfide bondi208 – 208Interchain (with a heavy chain)PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP20764.
PRIDEiP20764.

Expressioni

Tissue specificityi

Selectively expressed in pre-B lymphocytes.1 Publication

Gene expression databases

CleanExiMM_IGLL1.
ExpressionAtlasiP20764. differential.

Interactioni

Subunit structurei

Associates non-covalently with VPREB1.By similarity

Protein-protein interaction databases

BioGridi200596. 3 interactions.
STRINGi10090.ENSMUSP00000097713.

Structurei

3D structure databases

ProteinModelPortaliP20764.
SMRiP20764. Positions 63-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 20495Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 10412J region (By similarity to lambda light-chain)Add
BLAST
Regioni105 – 209105C region (By similarity to lambda light-chain)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG46716.
GeneTreeiENSGT00730000110696.
HOGENOMiHOG000113013.
HOVERGENiHBG039526.
InParanoidiP20764.
KOiK06554.
OMAiGTIPRQC.
TreeFamiTF335549.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRVGQTLG TIPRQCEVLL LLLLLGLVDG VHHILSPSSA ERSRAVGPGA
60 70 80 90 100
SVGSNRPSLW ALPGRLLFQI IPRGAGPRCS PHRLPSKPQF WYVFGGGTQL
110 120 130 140 150
TILGQPKSDP LVTLFLPSLK NLQANKATLV CLVSEFYPGT LVVDWKVDGV
160 170 180 190 200
PVTQGVETTQ PSKQTNNKYM VSSYLTLISD QWMPHSRYSC RVTHEGNTVE

KSVSPAECS
Length:209
Mass (Da):22,772
Last modified:October 3, 2012 - v3
Checksum:iE0ADE721EAEB491E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1296ANKATL → PTRPHV in CAH68524 (PubMed:15950724).Curated
Sequence conflicti128 – 1281T → Q in M30387 (PubMed:3024017).Curated
Sequence conflicti188 – 1881Y → T in M30387 (PubMed:3024017).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ852426 Genomic DNA. Translation: CAH68524.1.
AC166832 Genomic DNA. No translation available.
M30387 mRNA. No translation available.
CCDSiCCDS49775.1.
PIRiB26434.
RefSeqiNP_001177254.1. NM_001190325.1.
UniGeneiMm.184441.

Genome annotation databases

EnsembliENSMUST00000100136; ENSMUSP00000097713; ENSMUSG00000075370.
GeneIDi16136.
KEGGimmu:16136.
UCSCiuc007yje.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ852426 Genomic DNA. Translation: CAH68524.1.
AC166832 Genomic DNA. No translation available.
M30387 mRNA. No translation available.
CCDSiCCDS49775.1.
PIRiB26434.
RefSeqiNP_001177254.1. NM_001190325.1.
UniGeneiMm.184441.

3D structure databases

ProteinModelPortaliP20764.
SMRiP20764. Positions 63-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200596. 3 interactions.
STRINGi10090.ENSMUSP00000097713.

Proteomic databases

PaxDbiP20764.
PRIDEiP20764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100136; ENSMUSP00000097713; ENSMUSG00000075370.
GeneIDi16136.
KEGGimmu:16136.
UCSCiuc007yje.1. mouse.

Organism-specific databases

CTDi3543.
MGIiMGI:96529. Igll1.

Phylogenomic databases

eggNOGiNOG46716.
GeneTreeiENSGT00730000110696.
HOGENOMiHOG000113013.
HOVERGENiHBG039526.
InParanoidiP20764.
KOiK06554.
OMAiGTIPRQC.
TreeFamiTF335549.

Miscellaneous databases

NextBioi288923.
PROiP20764.
SOURCEiSearch...

Gene expression databases

CleanExiMM_IGLL1.
ExpressionAtlasiP20764. differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping and functional analysis of regulatory sequences in the mouse lambda5-VpreB1 domain."
    Minaee S., Farmer D., Georgiou A., Sabbattini P., Webster Z., Chow C.-M., Dillon N.
    Mol. Immunol. 42:1283-1292(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes."
    Sakaguchi N., Melchers F.
    Nature 324:579-582(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-209, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIGLL1_MOUSE
AccessioniPrimary (citable) accession number: P20764
Secondary accession number(s): E9QMX0, Q5W1K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 3, 2012
Last modified: July 22, 2015
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.