Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P20764

- IGLL1_MOUSE

UniProt

P20764 - IGLL1_MOUSE

Protein

Immunoglobulin lambda-like polypeptide 1

Gene

Igll1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (03 Oct 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Critical for B-cell development.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin lambda-like polypeptide 1
    Alternative name(s):
    CD179 antigen-like family member B
    Ig lambda-5
    CD_antigen: CD179b
    Gene namesi
    Name:Igll1
    Synonyms:Igl-5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:96529. Igll1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 209179Immunoglobulin lambda-like polypeptide 1PRO_0000153611Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi131 ↔ 190PROSITE-ProRule annotation
    Disulfide bondi208 – 208Interchain (with a heavy chain)PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP20764.
    PRIDEiP20764.

    Expressioni

    Tissue specificityi

    Selectively expressed in pre-B lymphocytes.1 Publication

    Gene expression databases

    CleanExiMM_IGLL1.
    GenevestigatoriP20764.

    Interactioni

    Subunit structurei

    Associates non-covalently with VPREB1.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000097713.

    Structurei

    3D structure databases

    ProteinModelPortaliP20764.
    SMRiP20764. Positions 63-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini110 – 20495Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 10412J region (By similarity to lambda light-chain)Add
    BLAST
    Regioni105 – 209105C region (By similarity to lambda light-chain)Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG46716.
    GeneTreeiENSGT00730000110696.
    HOGENOMiHOG000113013.
    HOVERGENiHBG039526.
    InParanoidiP20764.
    KOiK06554.
    OMAiYTIANSP.
    TreeFamiTF335549.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20764-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLRVGQTLG TIPRQCEVLL LLLLLGLVDG VHHILSPSSA ERSRAVGPGA    50
    SVGSNRPSLW ALPGRLLFQI IPRGAGPRCS PHRLPSKPQF WYVFGGGTQL 100
    TILGQPKSDP LVTLFLPSLK NLQANKATLV CLVSEFYPGT LVVDWKVDGV 150
    PVTQGVETTQ PSKQTNNKYM VSSYLTLISD QWMPHSRYSC RVTHEGNTVE 200
    KSVSPAECS 209
    Length:209
    Mass (Da):22,772
    Last modified:October 3, 2012 - v3
    Checksum:iE0ADE721EAEB491E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1296ANKATL → PTRPHV in CAH68524. (PubMed:15950724)Curated
    Sequence conflicti128 – 1281T → Q in M30387. (PubMed:3024017)Curated
    Sequence conflicti188 – 1881Y → T in M30387. (PubMed:3024017)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ852426 Genomic DNA. Translation: CAH68524.1.
    AC166832 Genomic DNA. No translation available.
    M30387 mRNA. No translation available.
    CCDSiCCDS49775.1.
    PIRiB26434.
    RefSeqiNP_001177254.1. NM_001190325.1.
    UniGeneiMm.184441.

    Genome annotation databases

    EnsembliENSMUST00000100136; ENSMUSP00000097713; ENSMUSG00000075370.
    GeneIDi16136.
    KEGGimmu:16136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ852426 Genomic DNA. Translation: CAH68524.1 .
    AC166832 Genomic DNA. No translation available.
    M30387 mRNA. No translation available.
    CCDSi CCDS49775.1.
    PIRi B26434.
    RefSeqi NP_001177254.1. NM_001190325.1.
    UniGenei Mm.184441.

    3D structure databases

    ProteinModelPortali P20764.
    SMRi P20764. Positions 63-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000097713.

    Proteomic databases

    PaxDbi P20764.
    PRIDEi P20764.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000100136 ; ENSMUSP00000097713 ; ENSMUSG00000075370 .
    GeneIDi 16136.
    KEGGi mmu:16136.

    Organism-specific databases

    CTDi 3543.
    MGIi MGI:96529. Igll1.

    Phylogenomic databases

    eggNOGi NOG46716.
    GeneTreei ENSGT00730000110696.
    HOGENOMi HOG000113013.
    HOVERGENi HBG039526.
    InParanoidi P20764.
    KOi K06554.
    OMAi YTIANSP.
    TreeFami TF335549.

    Miscellaneous databases

    NextBioi 288923.
    PROi P20764.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_IGLL1.
    Genevestigatori P20764.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping and functional analysis of regulatory sequences in the mouse lambda5-VpreB1 domain."
      Minaee S., Farmer D., Georgiou A., Sabbattini P., Webster Z., Chow C.-M., Dillon N.
      Mol. Immunol. 42:1283-1292(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes."
      Sakaguchi N., Melchers F.
      Nature 324:579-582(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-209, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiIGLL1_MOUSE
    AccessioniPrimary (citable) accession number: P20764
    Secondary accession number(s): E9QMX0, Q5W1K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3