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P20764

- IGLL1_MOUSE

UniProt

P20764 - IGLL1_MOUSE

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Protein
Immunoglobulin lambda-like polypeptide 1
Gene
Igll1, Igl-5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Critical for B-cell development By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda-like polypeptide 1
Alternative name(s):
CD179 antigen-like family member B
Ig lambda-5
CD_antigen: CD179b
Gene namesi
Name:Igll1
Synonyms:Igl-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:96529. Igll1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 209179Immunoglobulin lambda-like polypeptide 1
PRO_0000153611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi131 ↔ 190 By similarity
Disulfide bondi208 – 208Interchain (with a heavy chain) By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP20764.
PRIDEiP20764.

Expressioni

Tissue specificityi

Selectively expressed in pre-B lymphocytes.1 Publication

Gene expression databases

CleanExiMM_IGLL1.
GenevestigatoriP20764.

Interactioni

Subunit structurei

Associates non-covalently with VPREB1 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097713.

Structurei

3D structure databases

ProteinModelPortaliP20764.
SMRiP20764. Positions 63-206.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 20495Ig-like C1-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 10412J region (By similarity to lambda light-chain)
Add
BLAST
Regioni105 – 209105C region (By similarity to lambda light-chain)
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG46716.
GeneTreeiENSGT00730000110696.
HOGENOMiHOG000113013.
HOVERGENiHBG039526.
InParanoidiP20764.
KOiK06554.
OMAiYTIANSP.
TreeFamiTF335549.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20764-1 [UniParc]FASTAAdd to Basket

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MKLRVGQTLG TIPRQCEVLL LLLLLGLVDG VHHILSPSSA ERSRAVGPGA    50
SVGSNRPSLW ALPGRLLFQI IPRGAGPRCS PHRLPSKPQF WYVFGGGTQL 100
TILGQPKSDP LVTLFLPSLK NLQANKATLV CLVSEFYPGT LVVDWKVDGV 150
PVTQGVETTQ PSKQTNNKYM VSSYLTLISD QWMPHSRYSC RVTHEGNTVE 200
KSVSPAECS 209
Length:209
Mass (Da):22,772
Last modified:October 3, 2012 - v3
Checksum:iE0ADE721EAEB491E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1296ANKATL → PTRPHV in CAH68524. 1 Publication
Sequence conflicti128 – 1281T → Q in M30387. 1 Publication
Sequence conflicti188 – 1881Y → T in M30387. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ852426 Genomic DNA. Translation: CAH68524.1.
AC166832 Genomic DNA. No translation available.
M30387 mRNA. No translation available.
CCDSiCCDS49775.1.
PIRiB26434.
RefSeqiNP_001177254.1. NM_001190325.1.
UniGeneiMm.184441.

Genome annotation databases

EnsembliENSMUST00000100136; ENSMUSP00000097713; ENSMUSG00000075370.
GeneIDi16136.
KEGGimmu:16136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ852426 Genomic DNA. Translation: CAH68524.1 .
AC166832 Genomic DNA. No translation available.
M30387 mRNA. No translation available.
CCDSi CCDS49775.1.
PIRi B26434.
RefSeqi NP_001177254.1. NM_001190325.1.
UniGenei Mm.184441.

3D structure databases

ProteinModelPortali P20764.
SMRi P20764. Positions 63-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000097713.

Proteomic databases

PaxDbi P20764.
PRIDEi P20764.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000100136 ; ENSMUSP00000097713 ; ENSMUSG00000075370 .
GeneIDi 16136.
KEGGi mmu:16136.

Organism-specific databases

CTDi 3543.
MGIi MGI:96529. Igll1.

Phylogenomic databases

eggNOGi NOG46716.
GeneTreei ENSGT00730000110696.
HOGENOMi HOG000113013.
HOVERGENi HBG039526.
InParanoidi P20764.
KOi K06554.
OMAi YTIANSP.
TreeFami TF335549.

Miscellaneous databases

NextBioi 288923.
PROi P20764.
SOURCEi Search...

Gene expression databases

CleanExi MM_IGLL1.
Genevestigatori P20764.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping and functional analysis of regulatory sequences in the mouse lambda5-VpreB1 domain."
    Minaee S., Farmer D., Georgiou A., Sabbattini P., Webster Z., Chow C.-M., Dillon N.
    Mol. Immunol. 42:1283-1292(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes."
    Sakaguchi N., Melchers F.
    Nature 324:579-582(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-209, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIGLL1_MOUSE
AccessioniPrimary (citable) accession number: P20764
Secondary accession number(s): E9QMX0, Q5W1K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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