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P20764 (IGLL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin lambda-like polypeptide 1
Alternative name(s):
CD179 antigen-like family member B
Ig lambda-5
CD_antigen=CD179b
Gene names
Name:Igll1
Synonyms:Igl-5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Critical for B-cell development By similarity.

Subunit structure

Associates non-covalently with VPREB1 By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Selectively expressed in pre-B lymphocytes. Ref.3

Sequence similarities

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainImmunoglobulin domain
Signal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 209179Immunoglobulin lambda-like polypeptide 1
PRO_0000153611

Regions

Domain110 – 20495Ig-like C1-type
Region93 – 10412J region (By similarity to lambda light-chain)
Region105 – 209105C region (By similarity to lambda light-chain)

Amino acid modifications

Disulfide bond131 ↔ 190 By similarity
Disulfide bond208Interchain (with a heavy chain) By similarity

Experimental info

Sequence conflict124 – 1296ANKATL → PTRPHV in CAH68524. Ref.1
Sequence conflict1281T → Q in M30387. Ref.3
Sequence conflict1881Y → T in M30387. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P20764 [UniParc].

Last modified October 3, 2012. Version 3.
Checksum: E0ADE721EAEB491E

FASTA20922,772
        10         20         30         40         50         60 
MKLRVGQTLG TIPRQCEVLL LLLLLGLVDG VHHILSPSSA ERSRAVGPGA SVGSNRPSLW 

        70         80         90        100        110        120 
ALPGRLLFQI IPRGAGPRCS PHRLPSKPQF WYVFGGGTQL TILGQPKSDP LVTLFLPSLK 

       130        140        150        160        170        180 
NLQANKATLV CLVSEFYPGT LVVDWKVDGV PVTQGVETTQ PSKQTNNKYM VSSYLTLISD 

       190        200 
QWMPHSRYSC RVTHEGNTVE KSVSPAECS 

« Hide

References

« Hide 'large scale' references
[1]"Mapping and functional analysis of regulatory sequences in the mouse lambda5-VpreB1 domain."
Minaee S., Farmer D., Georgiou A., Sabbattini P., Webster Z., Chow C.-M., Dillon N.
Mol. Immunol. 42:1283-1292(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes."
Sakaguchi N., Melchers F.
Nature 324:579-582(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-209, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ852426 Genomic DNA. Translation: CAH68524.1.
AC166832 Genomic DNA. No translation available.
M30387 mRNA. No translation available.
PIRB26434.
RefSeqNP_001177254.1. NM_001190325.1.
UniGeneMm.184441.

3D structure databases

ProteinModelPortalP20764.
SMRP20764. Positions 63-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000097713.

Proteomic databases

PaxDbP20764.
PRIDEP20764.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000100136; ENSMUSP00000097713; ENSMUSG00000075370.
GeneID16136.
KEGGmmu:16136.

Organism-specific databases

CTD3543.
MGIMGI:96529. Igll1.

Phylogenomic databases

eggNOGNOG46716.
GeneTreeENSGT00730000110696.
HOGENOMHOG000113013.
HOVERGENHBG039526.
InParanoidP20764.
KOK06554.
OMATIPRQCE.
TreeFamTF335549.

Gene expression databases

CleanExMM_IGLL1.
GenevestigatorP20764.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288923.
PROP20764.
SOURCESearch...

Entry information

Entry nameIGLL1_MOUSE
AccessionPrimary (citable) accession number: P20764
Secondary accession number(s): E9QMX0, Q5W1K3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot