P20764 (IGLL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immunoglobulin lambda-like polypeptide 1

Alternative name(s):
CD179 antigen-like family member B
Ig lambda-5
CD_antigen=CD179b

Gene names

Name:	Igll1
Synonyms:	Igl-5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Critical for B-cell development By similarity.
Subunit structure	Associates non-covalently with VPREB1 By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Selectively expressed in pre-B lymphocytes. Ref.3
Sequence similarities	Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 209	179	Immunoglobulin lambda-like polypeptide 1		PRO_0000153611
Regions
	Domain	110 – 204	95	Ig-like C1-type
	Region	93 – 104	12	J region (By similarity to lambda light-chain)
	Region	105 – 209	105	C region (By similarity to lambda light-chain)
Amino acid modifications
	Disulfide bond	131 ↔ 190		By similarity
	Disulfide bond	208		Interchain (with a heavy chain) By similarity
Experimental info
	Sequence conflict	124 – 129	6	ANKATL → PTRPHV in CAH68524. Ref.1
	Sequence conflict	128	1	T → Q in M30387. Ref.3
	Sequence conflict	188	1	Y → T in M30387. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P20764 [UniParc]. Last modified October 3, 2012. Version 3. Checksum: E0ADE721EAEB491E	FASTA	209	22,772
	10 20 30 40 50 60 MKLRVGQTLG TIPRQCEVLL LLLLLGLVDG VHHILSPSSA ERSRAVGPGA SVGSNRPSLW 70 80 90 100 110 120 ALPGRLLFQI IPRGAGPRCS PHRLPSKPQF WYVFGGGTQL TILGQPKSDP LVTLFLPSLK 130 140 150 160 170 180 NLQANKATLV CLVSEFYPGT LVVDWKVDGV PVTQGVETTQ PSKQTNNKYM VSSYLTLISD 190 200 QWMPHSRYSC RVTHEGNTVE KSVSPAECS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mapping and functional analysis of regulatory sequences in the mouse lambda5-VpreB1 domain." Minaee S., Farmer D., Georgiou A., Sabbattini P., Webster Z., Chow C.-M., Dillon N. Mol. Immunol. 42:1283-1292(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes." Sakaguchi N., Melchers F. Nature 324:579-582(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-209, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ852426 Genomic DNA. Translation: CAH68524.1. AC166832 Genomic DNA. No translation available. M30387 mRNA. No translation available.
IPI	IPI00122759. IPI01008536.
PIR	B26434.
RefSeq	NP_001177254.1. NM_001190325.1.
UniGene	Mm.184441.
3D structure databases
ProteinModelPortal	P20764.
SMR	P20764. Positions 39-206.
ModBase	Search...
Proteomic databases
PaxDb	P20764.
PRIDE	P20764.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000100136; ENSMUSP00000097713; ENSMUSG00000075370.
GeneID	16136.
KEGG	mmu:16136.
UCSC	uc007yje.1. mouse.
Organism-specific databases
CTD	3543.
MGI	MGI:96529. Igll1.
Phylogenomic databases
eggNOG	NOG46716.
GeneTree	ENSGT00530000063029.
HOGENOM	HOG000113013.
HOVERGEN	HBG039526.
InParanoid	P20764.
KO	K06554.
OMA	FWSEPQS.
Gene expression databases
CleanEx	MM_IGLL1.
Genevestigator	P20764.
GermOnline	ENSMUSG00000075370. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. [Graphical view]
SMART	SM00407. IGc1. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288923.
SOURCE	Search...

Entry information

Entry name

IGLL1_MOUSE

Accession

Primary (citable) accession number: P20764
Secondary accession number(s): E9QMX0, Q5W1K3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	October 3, 2012
Last modified:	May 1, 2013
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program