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Protein

Ig gamma-2B chain C region

Gene

Igh-1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-166663. Initial triggering of complement.
R-RNO-173623. Classical antibody-mediated complement activation.
R-RNO-2029481. FCGR activation.
R-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-2029485. Role of phospholipids in phagocytosis.
R-RNO-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2B chain C region
Alternative name(s):
Immunoglobulin heavy chain 1a
Gene namesi
Name:Igh-1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1305720. Igh-1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153593‹1 – 333Ig gamma-2B chain C regionAdd BLAST›333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi15Interchain (with a light chain)PROSITE-ProRule annotation
Disulfide bondi27 ↔ 80PROSITE-ProRule annotation
Disulfide bondi106Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi109Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi112Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi115Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi147 ↔ 207PROSITE-ProRule annotation
Disulfide bondi253 ↔ 311PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP20761.
PRIDEiP20761.

Expressioni

Gene expression databases

BgeeiENSRNOG00000048402.
GenevisibleiP20761. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP20761. 1 interactor.
STRINGi10116.ENSRNOP00000044037.

Structurei

Secondary structure

1333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 11Combined sources4
Beta strandi21 – 35Combined sources15
Beta strandi38 – 41Combined sources4
Helixi42 – 44Combined sources3
Beta strandi56 – 58Combined sources3
Beta strandi61 – 72Combined sources12
Turni73 – 75Combined sources3
Beta strandi79 – 84Combined sources6
Helixi85 – 87Combined sources3
Beta strandi89 – 94Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BFOX-ray2.60B/D/F/H1-95[»]
1C5DX-ray2.40B/H1-98[»]
2ARJX-ray2.88B/H1-98[»]
3B9KX-ray2.70D/H1-96[»]
ProteinModelPortaliP20761.
SMRiP20761.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20761.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 96Ig-like 1Add BLAST91
Domaini124 – 223Ig-like 2Add BLAST100
Domaini232 – 328Ig-like 3Add BLAST97

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
GeneTreeiENSGT00530000063726.
HOGENOMiHOG000168559.
HOVERGENiHBG005814.
InParanoidiP20761.
OMAiCSVVHEG.
OrthoDBiEOG091G0D3U.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 3 hits.
SMARTiView protein in SMART
SM00407. IGc1. 3 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

P20761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AQTTAPSVYP LAPGCGDTTS STVTLGCLVK GYFPEPVTVT WNSGALSSDV
60 70 80 90 100
HTFPAVLQSG LYTLTSSVTS STWPSQTVTC NVAHPASSTK VDKKVERRNG
110 120 130 140 150
GIGHKCPTCP TCHKCPVPEL LGGPSVFIFP PKPKDILLIS QNAKVTCVVV
160 170 180 190 200
DVSEEEPDVQ FSWFVNNVEV HTAQTQPREE QYNSTFRVVS ALPIQHQDWM
210 220 230 240 250
SGKEFKCKVN NKALPSPIEK TISKPKGLVR KPQVYVMGPP TEQLTEQTVS
260 270 280 290 300
LTCLTSGFLP NDIGVEWTSN GHIEKNYKNT EPVMDSDGSF FMYSKLNVER
310 320 330
SRWDSRAPFV CSVVHEGLHN HHVEKSISRP PGK
Length:333
Mass (Da):36,497
Last modified:February 1, 1991 - v1
Checksum:i55F8B64D48D460A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

PIRiPS0018.
UniGeneiRn.2255.

Genome annotation databases

EnsembliENSRNOT00000045874; ENSRNOP00000044037; ENSRNOG00000048402.

Similar proteinsi

Entry informationi

Entry nameiIGG2B_RAT
AccessioniPrimary (citable) accession number: P20761
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references