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Protein

Ig gamma-2A chain C region

Gene

Igg-2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region
Gene namesi
Name:Igg-2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359626. Igg-2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153592‹1 – 322Ig gamma-2A chain C regionAdd BLAST›322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 82
Disulfide bondi102Interchain (with a heavy chain)
Disulfide bondi105Interchain (with a heavy chain)
Disulfide bondi107Interchain (with a heavy chain)
Disulfide bondi136 ↔ 196
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi242 ↔ 300

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20760.
PRIDEiP20760.

Expressioni

Gene expression databases

BgeeiENSRNOG00000043205.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP20760. 2 interactors.
STRINGi10116.ENSRNOP00000062949.

Structurei

Secondary structure

1322
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi115 – 118Combined sources4
Helixi122 – 125Combined sources4
Beta strandi128 – 130Combined sources3
Beta strandi133 – 141Combined sources9
Beta strandi142 – 144Combined sources3
Beta strandi149 – 156Combined sources8
Beta strandi163 – 169Combined sources7
Turni171 – 173Combined sources3
Beta strandi175 – 182Combined sources8
Helixi185 – 189Combined sources5
Beta strandi194 – 199Combined sources6
Beta strandi201 – 205Combined sources5
Beta strandi207 – 211Combined sources5
Beta strandi222 – 226Combined sources5
Helixi230 – 234Combined sources5
Beta strandi235 – 250Combined sources16
Beta strandi253 – 258Combined sources6
Beta strandi264 – 268Combined sources5
Beta strandi279 – 288Combined sources10
Helixi289 – 293Combined sources5
Beta strandi298 – 303Combined sources6
Helixi308 – 310Combined sources3
Beta strandi311 – 316Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FN4X-ray2.80B4-102[»]
1I1AX-ray2.80C/D98-322[»]
1I1CX-ray2.70A/B98-322[»]
ProteinModelPortaliP20760.
SMRiP20760.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20760.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 98Ig-like 1Add BLAST93
Domaini115 – 212Ig-like 2Add BLAST98
Domaini221 – 317Ig-like 3Add BLAST97

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
HOVERGENiHBG005814.
InParanoidiP20760.
PhylomeDBiP20760.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AETTAPSVYP LAPGTALKSN SMVTLGCLVK GYFPEPVTVT WNSGALSSGV
60 70 80 90 100
HTFPAVLQSG LYTLTSSVTV PSSTWSSQAV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
ECNPCGCTGS EVSSVFIFPP KTKDVLTITL TPKVTCVVVD ISQNDPEVRF
160 170 180 190 200
SWFIDDVEVH TAQTHAPEKQ SNSTLRSVSE LPIVHRDWLN GKTFKCKVNS
210 220 230 240 250
GAFPAPIEKS ISKPEGTPRG PQVYTMAPPK EEMTQSQVSI TCMVKGFYPP
260 270 280 290 300
DIYTEWKMNG QPQENYKNTP PTMDTDGSYF LYSKLNVKKE TWQQGNTFTC
310 320
SVLHEGLHNH HTEKSLSHSP GK
Length:322
Mass (Da):35,186
Last modified:February 1, 1991 - v1
Checksum:iE8EA136A9DE01EDB
GO

Sequence cautioni

The sequence AAA41376 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13804 Genomic DNA. Translation: AAA41376.1. Different initiation.
PIRiPS0019.
UniGeneiRn.106192.
Rn.10956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13804 Genomic DNA. Translation: AAA41376.1. Different initiation.
PIRiPS0019.
UniGeneiRn.106192.
Rn.10956.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FN4X-ray2.80B4-102[»]
1I1AX-ray2.80C/D98-322[»]
1I1CX-ray2.70A/B98-322[»]
ProteinModelPortaliP20760.
SMRiP20760.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP20760. 2 interactors.
STRINGi10116.ENSRNOP00000062949.

Protein family/group databases

IMGTiSearch...

Proteomic databases

PaxDbiP20760.
PRIDEiP20760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1359626. Igg-2a.

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
HOVERGENiHBG005814.
InParanoidiP20760.
PhylomeDBiP20760.

Miscellaneous databases

EvolutionaryTraceiP20760.
PROiP20760.

Gene expression databases

BgeeiENSRNOG00000043205.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGG2A_RAT
AccessioniPrimary (citable) accession number: P20760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.