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Protein

Ig gamma-2A chain C region

Gene

Igg-2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region
Gene namesi
Name:Igg-2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359626. Igg-2a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 322›322Ig gamma-2A chain C regionPRO_0000153592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 82
Disulfide bondi102 – 102Interchain (with a heavy chain)
Disulfide bondi105 – 105Interchain (with a heavy chain)
Disulfide bondi107 – 107Interchain (with a heavy chain)
Disulfide bondi136 ↔ 196
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi242 ↔ 300

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20760.
PRIDEiP20760.

Interactioni

Protein-protein interaction databases

IntActiP20760. 2 interactions.
STRINGi10116.ENSRNOP00000062949.

Structurei

Secondary structure

1
322
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi115 – 1184Combined sources
Helixi122 – 1254Combined sources
Beta strandi128 – 1303Combined sources
Beta strandi133 – 1419Combined sources
Beta strandi142 – 1443Combined sources
Beta strandi149 – 1568Combined sources
Beta strandi163 – 1697Combined sources
Turni171 – 1733Combined sources
Beta strandi175 – 1828Combined sources
Helixi185 – 1895Combined sources
Beta strandi194 – 1996Combined sources
Beta strandi201 – 2055Combined sources
Beta strandi207 – 2115Combined sources
Beta strandi222 – 2265Combined sources
Helixi230 – 2345Combined sources
Beta strandi235 – 25016Combined sources
Beta strandi253 – 2586Combined sources
Beta strandi264 – 2685Combined sources
Beta strandi279 – 28810Combined sources
Helixi289 – 2935Combined sources
Beta strandi298 – 3036Combined sources
Helixi308 – 3103Combined sources
Beta strandi311 – 3166Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FN4X-ray2.80B4-102[»]
1I1AX-ray2.80C/D98-322[»]
1I1CX-ray2.70A/B98-322[»]
ProteinModelPortaliP20760.
SMRiP20760. Positions 1-318.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20760.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 9893Ig-like 1Add
BLAST
Domaini115 – 21298Ig-like 2Add
BLAST
Domaini221 – 31797Ig-like 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
HOVERGENiHBG005814.
InParanoidiP20760.
PhylomeDBiP20760.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AETTAPSVYP LAPGTALKSN SMVTLGCLVK GYFPEPVTVT WNSGALSSGV
60 70 80 90 100
HTFPAVLQSG LYTLTSSVTV PSSTWSSQAV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
ECNPCGCTGS EVSSVFIFPP KTKDVLTITL TPKVTCVVVD ISQNDPEVRF
160 170 180 190 200
SWFIDDVEVH TAQTHAPEKQ SNSTLRSVSE LPIVHRDWLN GKTFKCKVNS
210 220 230 240 250
GAFPAPIEKS ISKPEGTPRG PQVYTMAPPK EEMTQSQVSI TCMVKGFYPP
260 270 280 290 300
DIYTEWKMNG QPQENYKNTP PTMDTDGSYF LYSKLNVKKE TWQQGNTFTC
310 320
SVLHEGLHNH HTEKSLSHSP GK
Length:322
Mass (Da):35,186
Last modified:February 1, 1991 - v1
Checksum:iE8EA136A9DE01EDB
GO

Sequence cautioni

The sequence AAA41376.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13804 Genomic DNA. Translation: AAA41376.1. Different initiation.
PIRiPS0019.
UniGeneiRn.106192.
Rn.10956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13804 Genomic DNA. Translation: AAA41376.1. Different initiation.
PIRiPS0019.
UniGeneiRn.106192.
Rn.10956.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FN4X-ray2.80B4-102[»]
1I1AX-ray2.80C/D98-322[»]
1I1CX-ray2.70A/B98-322[»]
ProteinModelPortaliP20760.
SMRiP20760. Positions 1-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP20760. 2 interactions.
STRINGi10116.ENSRNOP00000062949.

Protein family/group databases

IMGTiSearch...

Proteomic databases

PaxDbiP20760.
PRIDEiP20760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1359626. Igg-2a.

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
HOVERGENiHBG005814.
InParanoidiP20760.
PhylomeDBiP20760.

Miscellaneous databases

EvolutionaryTraceiP20760.
PROiP20760.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of the rat immunoglobulin gamma heavy-chain gene family."
    Brueggemann M.
    Gene 74:473-482(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes."
    Bruggemann M., Free J., Diamond A., Howard J., Cobbold S., Waldmann H.
    Proc. Natl. Acad. Sci. U.S.A. 83:6075-6079(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-322.

Entry informationi

Entry nameiIGG2A_RAT
AccessioniPrimary (citable) accession number: P20760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.