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Protein

Ig gamma-1 chain C region

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-166663. Initial triggering of complement.
R-RNO-173623. Classical antibody-mediated complement activation.
R-RNO-2029481. FCGR activation.
R-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-2029485. Role of phospholipids in phagocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-1 chain C region
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 326›326Ig gamma-1 chain C regionPRO_0000153591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 82PROSITE-ProRule annotation
Disulfide bondi102 – 102Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi106 – 106Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi109 – 109Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi111 – 111Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi140 ↔ 200PROSITE-ProRule annotation
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi246 ↔ 304PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20759.
PRIDEiP20759.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030332.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-1537485.
STRINGi10116.ENSRNOP00000006975.

Structurei

Secondary structure

1
326
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi119 – 1224
Helixi126 – 1305
Beta strandi137 – 1448
Beta strandi155 – 1584
Beta strandi172 – 1754
Beta strandi178 – 1869
Helixi189 – 1935
Beta strandi198 – 2025
Beta strandi205 – 2095
Beta strandi211 – 2155
Beta strandi226 – 2305
Turni234 – 2385
Beta strandi239 – 25416
Beta strandi256 – 2627
Beta strandi270 – 2723
Beta strandi283 – 29210
Helixi293 – 2975
Beta strandi302 – 3087
Beta strandi316 – 3205

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LK3X-ray1.91H/I1-100[»]
2FRTmodel-E118-322[»]
ProteinModelPortaliP20759.
SMRiP20759. Positions 1-322.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20759.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9797CH1Add
BLAST
Regioni98 – 11215HingeAdd
BLAST
Regioni113 – 219107CH2Add
BLAST
Regioni220 – 326107CH3Add
BLAST

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
GeneTreeiENSGT00530000063726.
HOGENOMiHOG000168559.
HOVERGENiHBG005814.
InParanoidiP20759.
OrthoDBiEOG091G0D3U.
PhylomeDBiP20759.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AETTAPSVYP LAPGTALKSN SMVTLGCLVK GYFPEPVTVT WNSGALSSGV
60 70 80 90 100
HTFPAVLQSG LYTLTSSVTV PSSTWPSQTV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
NCGGDCKPCI CTGSEVSSVF IFPPKPKDVL TITLTPKVTC VVVDISQDDP
160 170 180 190 200
EVHFSWFVDD VEVHTAQTRP PEEQFNSTFR SVSELPILHQ DWLNGRTFRC
210 220 230 240 250
KVTSAAFPSP IEKTISKPEG RTQVPHVYTM SPTKEEMTQN EVSITCMVKG
260 270 280 290 300
FYPPDIYVEW QMNGQPQENY KNTPPTMDTD GSYFLYSKLN VKKEKWQQGN
310 320
TFTCSVLHEG LHNHHTEKSL SHSPGK
Length:326
Mass (Da):35,946
Last modified:February 1, 1991 - v1
Checksum:i013BAB45EF49B9DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

PIRiPS0017.
UniGeneiRn.10956.

Genome annotation databases

EnsembliENSRNOT00000006975; ENSRNOP00000006975; ENSRNOG00000030332.

Cross-referencesi

Sequence databases

PIRiPS0017.
UniGeneiRn.10956.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LK3X-ray1.91H/I1-100[»]
2FRTmodel-E118-322[»]
ProteinModelPortaliP20759.
SMRiP20759. Positions 1-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1537485.
STRINGi10116.ENSRNOP00000006975.

Proteomic databases

PaxDbiP20759.
PRIDEiP20759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006975; ENSRNOP00000006975; ENSRNOG00000030332.

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
GeneTreeiENSGT00530000063726.
HOGENOMiHOG000168559.
HOVERGENiHBG005814.
InParanoidiP20759.
OrthoDBiEOG091G0D3U.
PhylomeDBiP20759.

Enzyme and pathway databases

ReactomeiR-RNO-166663. Initial triggering of complement.
R-RNO-173623. Classical antibody-mediated complement activation.
R-RNO-2029481. FCGR activation.
R-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-2029485. Role of phospholipids in phagocytosis.

Miscellaneous databases

EvolutionaryTraceiP20759.

Gene expression databases

BgeeiENSRNOG00000030332.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGHG1_RAT
AccessioniPrimary (citable) accession number: P20759
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.