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Protein

Ig gamma-1 chain C region

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-166663. Initial triggering of complement.
R-RNO-173623. Classical antibody-mediated complement activation.
R-RNO-2029481. FCGR activation.
R-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-2029485. Role of phospholipids in phagocytosis.
R-RNO-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-1 chain C region
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153591‹1 – 326Ig gamma-1 chain C regionAdd BLAST›326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 82PROSITE-ProRule annotation
Disulfide bondi102Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi106Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi109Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi111Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi140 ↔ 200PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi246 ↔ 304PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20759.
PRIDEiP20759.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030332.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-1537485.
STRINGi10116.ENSRNOP00000006975.

Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Beta strandi21 – 35Combined sources15
Beta strandi38 – 41Combined sources4
Helixi42 – 44Combined sources3
Beta strandi50 – 52Combined sources3
Beta strandi56 – 58Combined sources3
Beta strandi61 – 71Combined sources11
Helixi72 – 74Combined sources3
Turni75 – 77Combined sources3
Beta strandi81 – 86Combined sources6
Helixi87 – 89Combined sources3
Beta strandi91 – 96Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LK3X-ray1.91H/I1-100[»]
2FRTmodel-E118-322[»]
ProteinModelPortaliP20759.
SMRiP20759.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20759.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 97CH1Add BLAST97
Regioni98 – 112HingeAdd BLAST15
Regioni113 – 219CH2Add BLAST107
Regioni220 – 326CH3Add BLAST107

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
GeneTreeiENSGT00530000063726.
HOGENOMiHOG000168559.
HOVERGENiHBG005814.
InParanoidiP20759.
OrthoDBiEOG091G0D3U.
PhylomeDBiP20759.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 3 hits.
SMARTiView protein in SMART
SM00407. IGc1. 2 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.

Sequencei

Sequence statusi: Complete.

P20759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AETTAPSVYP LAPGTALKSN SMVTLGCLVK GYFPEPVTVT WNSGALSSGV
60 70 80 90 100
HTFPAVLQSG LYTLTSSVTV PSSTWPSQTV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
NCGGDCKPCI CTGSEVSSVF IFPPKPKDVL TITLTPKVTC VVVDISQDDP
160 170 180 190 200
EVHFSWFVDD VEVHTAQTRP PEEQFNSTFR SVSELPILHQ DWLNGRTFRC
210 220 230 240 250
KVTSAAFPSP IEKTISKPEG RTQVPHVYTM SPTKEEMTQN EVSITCMVKG
260 270 280 290 300
FYPPDIYVEW QMNGQPQENY KNTPPTMDTD GSYFLYSKLN VKKEKWQQGN
310 320
TFTCSVLHEG LHNHHTEKSL SHSPGK
Length:326
Mass (Da):35,946
Last modified:February 1, 1991 - v1
Checksum:i013BAB45EF49B9DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

PIRiPS0017.
UniGeneiRn.10956.

Genome annotation databases

EnsembliENSRNOT00000006975; ENSRNOP00000006975; ENSRNOG00000030332.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIGHG1_RAT
AccessioniPrimary (citable) accession number: P20759
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 7, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references