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Protein

B-cell lymphoma 3 protein

Gene

BCL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).By similarity1 Publication

GO - Molecular functioni

  • DNA binding Source: Ensembl
  • protein binding, bridging Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: Ensembl
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • antimicrobial humoral response Source: Ensembl
  • cellular response to DNA damage stimulus Source: UniProtKB
  • defense response to bacterium Source: Ensembl
  • defense response to protozoan Source: Ensembl
  • DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  • extracellular matrix organization Source: Ensembl
  • follicular dendritic cell differentiation Source: Ensembl
  • germinal center formation Source: Ensembl
  • humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  • I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
  • maintenance of protein location in nucleus Source: UniProtKB
  • marginal zone B cell differentiation Source: Ensembl
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of interleukin-8 biosynthetic process Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of tumor necrosis factor biosynthetic process Source: Ensembl
  • positive regulation of interferon-gamma production Source: Ensembl
  • positive regulation of interleukin-10 biosynthetic process Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of translation Source: UniProtKB
  • protein import into nucleus, translocation Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • regulation of DNA binding Source: UniProtKB
  • regulation of NF-kappaB import into nucleus Source: UniProtKB
  • response to UV-C Source: UniProtKB
  • response to virus Source: UniProtKB
  • spleen development Source: Ensembl
  • T-helper 1 type immune response Source: Ensembl
  • T-helper 2 cell differentiation Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069399-MONOMER.
SIGNORiP20749.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma 3 protein
Short name:
BCL-3
Alternative name(s):
Proto-oncogene BCL3
Gene namesi
Name:BCL3
Synonyms:BCL4, D19S37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:998. BCL3.

Subcellular locationi

GO - Cellular componenti

  • Bcl3/NF-kappaB2 complex Source: UniProtKB
  • Bcl3-Bcl10 complex Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • intercellular bridge Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi602.
OpenTargetsiENSG00000069399.
PharmGKBiPA25310.

Polymorphism and mutation databases

BioMutaiBCL3.
DMDMi294862410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669761 – 454B-cell lymphoma 3 proteinAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1
Modified residuei374PhosphoserineCombined sources1
Modified residuei402Phosphoserine; by GSK31 Publication1
Modified residuei406Phosphoserine; by GSK31 Publication1

Post-translational modificationi

Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity).By similarity
Activated by phosphorylation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP20749.
PaxDbiP20749.
PeptideAtlasiP20749.
PRIDEiP20749.

PTM databases

iPTMnetiP20749.
PhosphoSitePlusiP20749.

Expressioni

Gene expression databases

BgeeiENSG00000069399.
CleanExiHS_BCL3.
ExpressionAtlasiP20749. baseline and differential.
GenevisibleiP20749. HS.

Organism-specific databases

HPAiCAB002051.
HPA047514.

Interactioni

Subunit structurei

Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL10O959993EBI-958997,EBI-958922
CTBP2P565452EBI-958997,EBI-741533
LCKP062393EBI-958997,EBI-1348

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107074. 39 interactors.
IntActiP20749. 11 interactors.
MINTiMINT-105740.
STRINGi9606.ENSP00000164227.

Structurei

Secondary structure

1454
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi138 – 144Combined sources7
Helixi148 – 160Combined sources13
Helixi175 – 181Combined sources7
Helixi185 – 193Combined sources9
Helixi208 – 214Combined sources7
Helixi218 – 227Combined sources10
Helixi245 – 252Combined sources8
Helixi255 – 263Combined sources9
Turni273 – 275Combined sources3
Helixi279 – 285Combined sources7
Helixi289 – 297Combined sources9
Helixi312 – 319Combined sources8
Helixi322 – 330Combined sources9
Turni345 – 348Combined sources4
Helixi352 – 358Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K1AX-ray1.86A127-367[»]
1K1BX-ray1.90A127-367[»]
ProteinModelPortaliP20749.
SMRiP20749.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20749.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati134 – 163ANK 1Add BLAST30
Repeati171 – 200ANK 2Add BLAST30
Repeati204 – 235ANK 3Add BLAST32
Repeati241 – 270ANK 4Add BLAST30
Repeati275 – 304ANK 5Add BLAST30
Repeati308 – 337ANK 6Add BLAST30
Repeati338 – 367ANK 7Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 120Pro-richAdd BLAST112
Compositional biasi365 – 454Pro/Ser-richAdd BLAST90

Sequence similaritiesi

Contains 7 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074527.
HOGENOMiHOG000095189.
HOVERGENiHBG108320.
InParanoidiP20749.
KOiK09258.
OMAiPLYPMMC.
OrthoDBiEOG091G092R.
PhylomeDBiP20749.
TreeFamiTF320166.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA
60 70 80 90 100
AGLVVPLDPL RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP
110 120 130 140 150
FPLVNLPTPL YPMMCPMEHP LSADIAMATR ADEDGDTPLH IAVVQGNLPA
160 170 180 190 200
VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV ITTLPSVVRL LVTAGASPMA
210 220 230 240 250
LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY DGLTALHVAV
260 270 280 290 300
NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA
310 320 330 340 350
NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR
360 370 380 390 400
SRRVIDILRG KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS
410 420 430 440 450
SSPSQSPPRD PPGFPMAPPN FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA

PGGS
Length:454
Mass (Da):47,584
Last modified:April 20, 2010 - v2
Checksum:i385F5320DB72C0E0
GO

Sequence cautioni

The sequence AAA51815 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA51816 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH64993 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31731 Genomic DNA. Translation: AAA51816.1. Different initiation.
M31732 mRNA. Translation: AAA51815.1. Different initiation.
AC092066 Genomic DNA. No translation available.
BC064993 mRNA. Translation: AAH64993.1. Different initiation.
AH006679 Genomic DNA. Translation: AAC51348.1.
CCDSiCCDS12642.2.
PIRiA34794.
RefSeqiNP_005169.2. NM_005178.4.
UniGeneiHs.31210.

Genome annotation databases

EnsembliENST00000164227; ENSP00000164227; ENSG00000069399.
GeneIDi602.
KEGGihsa:602.
UCSCiuc010xxe.3. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31731 Genomic DNA. Translation: AAA51816.1. Different initiation.
M31732 mRNA. Translation: AAA51815.1. Different initiation.
AC092066 Genomic DNA. No translation available.
BC064993 mRNA. Translation: AAH64993.1. Different initiation.
AH006679 Genomic DNA. Translation: AAC51348.1.
CCDSiCCDS12642.2.
PIRiA34794.
RefSeqiNP_005169.2. NM_005178.4.
UniGeneiHs.31210.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K1AX-ray1.86A127-367[»]
1K1BX-ray1.90A127-367[»]
ProteinModelPortaliP20749.
SMRiP20749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107074. 39 interactors.
IntActiP20749. 11 interactors.
MINTiMINT-105740.
STRINGi9606.ENSP00000164227.

PTM databases

iPTMnetiP20749.
PhosphoSitePlusiP20749.

Polymorphism and mutation databases

BioMutaiBCL3.
DMDMi294862410.

Proteomic databases

MaxQBiP20749.
PaxDbiP20749.
PeptideAtlasiP20749.
PRIDEiP20749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000164227; ENSP00000164227; ENSG00000069399.
GeneIDi602.
KEGGihsa:602.
UCSCiuc010xxe.3. human.

Organism-specific databases

CTDi602.
DisGeNETi602.
GeneCardsiBCL3.
HGNCiHGNC:998. BCL3.
HPAiCAB002051.
HPA047514.
MIMi109560. gene.
neXtProtiNX_P20749.
OpenTargetsiENSG00000069399.
PharmGKBiPA25310.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074527.
HOGENOMiHOG000095189.
HOVERGENiHBG108320.
InParanoidiP20749.
KOiK09258.
OMAiPLYPMMC.
OrthoDBiEOG091G092R.
PhylomeDBiP20749.
TreeFamiTF320166.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069399-MONOMER.
SIGNORiP20749.

Miscellaneous databases

EvolutionaryTraceiP20749.
GeneWikiiBCL3.
GenomeRNAii602.
PROiP20749.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069399.
CleanExiHS_BCL3.
ExpressionAtlasiP20749. baseline and differential.
GenevisibleiP20749. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCL3_HUMAN
AccessioniPrimary (citable) accession number: P20749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.