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Protein

Pregnancy zone protein

Gene

PZP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

GO - Molecular functioni

  • endopeptidase inhibitor activity Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • female pregnancy Source: UniProtKB

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI39.003

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy zone protein
Alternative name(s):
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
Gene namesi
Name:PZP
Synonyms:CPAMD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000126838.9
HGNCiHGNC:9750 PZP
MIMi176420 gene
neXtProtiNX_P20742

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5858
OpenTargetsiENSG00000126838

Polymorphism and mutation databases

DMDMi281185515

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000000006326 – 1482Pregnancy zone proteinAdd BLAST1457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi392N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi406N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi753N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi875N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi932N-linked (GlcNAc...) asparagine1 Publication1
Cross-linki978 ↔ 981Isoglutamyl cysteine thioester (Cys-Gln)
Glycosylationi997N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi1430N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Thioester bond

Proteomic databases

MaxQBiP20742
PaxDbiP20742
PeptideAtlasiP20742
PRIDEiP20742

PTM databases

iPTMnetiP20742
PhosphoSitePlusiP20742

Expressioni

Tissue specificityi

Plasma. Prominent constituent of late-pregnancy sera.

Gene expression databases

BgeeiENSG00000126838
ExpressionAtlasiP20742 baseline and differential
GenevisibleiP20742 HS

Organism-specific databases

HPAiHPA041403
HPA041471

Interactioni

Subunit structurei

Homotetramer, which consists of two pairs of disulfide-linked chains.

Protein-protein interaction databases

BioGridi111796, 7 interactors
IntActiP20742, 2 interactors
STRINGi9606.ENSP00000261336

Structurei

3D structure databases

ProteinModelPortaliP20742
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni685 – 735Bait regionAdd BLAST51

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiENOG410IMYI Eukaryota
COG2373 LUCA
GeneTreeiENSGT00760000118982
HOGENOMiHOG000220939
HOVERGENiHBG000039
InParanoidiP20742
OMAiKVQVPKI
OrthoDBiEOG091G00F5
PhylomeDBiP20742
TreeFamiTF313285

Family and domain databases

Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011626 A2M_comp
IPR002890 A2M_N
IPR011625 A2M_N_2
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR019565 MacrogloblnA2_thiol-ester-bond
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR010916 TonB_box_CS
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07678 A2M_comp, 1 hit
PF01835 A2M_N, 1 hit
PF07703 A2M_N_2, 1 hit
PF07677 A2M_recep, 1 hit
PF10569 Thiol-ester_cl, 1 hit
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20742-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRKDRLLHLC LVLLLILLSA SDSNSTEPQY MVLVPSLLHT EAPKKGCVLL
60 70 80 90 100
SHLNETVTVS ASLESGRENR SLFTDLVAEK DLFHCVSFTL PRISASSEVA
110 120 130 140 150
FLSIQIKGPT QDFRKRNTVL VLNTQSLVFV QTDKPMYKPG QTVRFRVVSV
160 170 180 190 200
DENFRPRNEL IPLIYLENPR RNRIAQWQSL KLEAGINQLS FPLSSEPIQG
210 220 230 240 250
SYRVVVQTES GGRIQHPFTV EEFVLPKFEV KVQVPKIISI MDEKVNITVC
260 270 280 290 300
GEYTYGKPVP GLATVSLCRK LSRVLNCDKQ EVCEEFSQQL NSNGCITQQV
310 320 330 340 350
HTKMLQITNT GFEMKLRVEA RIREEGTDLE VTANRISEIT NIVSKLKFVK
360 370 380 390 400
VDSHFRQGIP FFAQVLLVDG KGVPIPNKLF FISVNDANYY SNATTNEQGL
410 420 430 440 450
AQFSINTTSI SVNKLFVRVF TVHPNLCFHY SWVAEDHQGA QHTANRVFSL
460 470 480 490 500
SGSYIHLEPV AGTLPCGHTE TITAHYTLNR QAMGELSELS FHYLIMAKGV
510 520 530 540 550
IVRSGTHTLP VESGDMKGSF ALSFPVESDV APIARMFIFA ILPDGEVVGD
560 570 580 590 600
SEKFEIENCL ANKVDLSFSP AQSPPASHAH LQVAAAPQSL CALRAVDQSV
610 620 630 640 650
LLMKPEAELS VSSVYNLLTV KDLTNFPDNV DQQEEEQGHC PRPFFIHNGA
660 670 680 690 700
IYVPLSSNEA DIYSFLKGMG LKVFTNSKIR KPKSCSVIPS VSAGAVGQGY
710 720 730 740 750
YGAGLGVVER PYVPQLGTYN VIPLNNEQSS GPVPETVRSY FPETWIWELV
760 770 780 790 800
AVNSSGVAEV GVTVPDTITE WKAGAFCLSE DAGLGISSTA SLRAFQPFFV
810 820 830 840 850
ELTMPYSVIR GEVFTLKATV LNYLPKCIRV SVQLKASPAF LASQNTKGEE
860 870 880 890 900
SYCICGNERQ TLSWTVTPKT LGNVNFSVSA EAMQSLELCG NEVVEVPEIK
910 920 930 940 950
RKDTVIKTLL VEAEGIEQEK TFSSMTCASG ANVSEQLSLK LPSNVVKESA
960 970 980 990 1000
RASFSVLGDI LGSAMQNIQN LLQMPYGCGE QNMVLFAPNI YVLNYLNETQ
1010 1020 1030 1040 1050
QLTQEIKAKA VGYLITGYQR QLNYKHQDGS YSTFGERYGR NQGNTWLTAF
1060 1070 1080 1090 1100
VLKTFAQARS YIFIDEAHIT QSLTWLSQMQ KDNGCFRSSG SLLNNAIKGG
1110 1120 1130 1140 1150
VEDEATLSAY VTIALLEIPL PVTNPIVRNA LFCLESAWNV AKEGTHGSHV
1160 1170 1180 1190 1200
YTKALLAYAF SLLGKQNQNR EILNSLDKEA VKEDNLVHWE RPQRPKAPVG
1210 1220 1230 1240 1250
HLYQTQAPSA EVEMTSYVLL AYLTAQPAPT SGDLTSATNI VKWIMKQQNA
1260 1270 1280 1290 1300
QGGFSSTQDT VVALHALSRY GAATFTRTEK TAQVTVQDSQ TFSTNFQVDN
1310 1320 1330 1340 1350
NNLLLLQQIS LPELPGEYVI TVTGERCVYL QTSMKYNILP EKEDSPFALK
1360 1370 1380 1390 1400
VQTVPQTCDG HKAHTSFQIS LTISYTGNRP ASNMVIVDVK MVSGFIPLKP
1410 1420 1430 1440 1450
TVKMLERSSS VSRTEVSNNH VLIYVEQVTN QTLSFSFMVL QDIPVGDLKP
1460 1470 1480
AIVKVYDYYE TDESVVAEYI APCSTDTEHG NV
Length:1,482
Mass (Da):163,863
Last modified:December 15, 2009 - v4
Checksum:iFA89A47458C4A18B
GO
Isoform 2 (identifier: P20742-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     132-142: TDKPMYKPGQT → MSESYRRTTFP
     830-912: Missing.

Note: No experimental confirmation available.
Show »
Length:1,268
Mass (Da):140,368
Checksum:i8D3255FD5698667E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti753N → Q AA sequence (PubMed:2476433).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034429379L → V. Corresponds to variant dbSNP:rs12230214Ensembl.1
Natural variantiVAR_021845691V → M1 PublicationCorresponds to variant dbSNP:rs3213832Ensembl.1
Natural variantiVAR_020005813V → A. Corresponds to variant dbSNP:rs2277413Ensembl.1
Natural variantiVAR_060733857N → S1 PublicationCorresponds to variant dbSNP:rs3213831Ensembl.1
Natural variantiVAR_0609821003T → M. Corresponds to variant dbSNP:rs57006764Ensembl.1
Natural variantiVAR_0362351128R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200477595Ensembl.1
Natural variantiVAR_0607341205T → P1 PublicationCorresponds to variant dbSNP:rs2377741Ensembl.1
Natural variantiVAR_0243581443I → N. Corresponds to variant dbSNP:rs10842971Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0308621 – 131Missing in isoform 2. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_030863132 – 142TDKPMYKPGQT → MSESYRRTTFP in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_030864830 – 912Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54380 mRNA Translation: CAA38255.1
AC010175 Genomic DNA No translation available.
BC111756 mRNA Translation: AAI11757.1
X51541 Genomic DNA Translation: CAA35919.1
M24416 Genomic DNA Translation: AAA60234.1
CCDSiCCDS8600.1 [P20742-1]
PIRiS13495
S29738
UniGeneiHs.707491

Genome annotation databases

EnsembliENST00000261336; ENSP00000261336; ENSG00000126838 [P20742-1]
UCSCiuc001qvl.3 human [P20742-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPZP_HUMAN
AccessioniPrimary (citable) accession number: P20742
Secondary accession number(s): A6ND27
, Q15273, Q2NKL2, Q7M4N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 15, 2009
Last modified: April 25, 2018
This is version 162 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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