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P20742

- PZP_HUMAN

UniProt

P20742 - PZP_HUMAN

Protein

Pregnancy zone protein

Gene

PZP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 4 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

    GO - Molecular functioni

    1. endopeptidase inhibitor activity Source: UniProtKB
    2. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. female pregnancy Source: UniProtKB
    2. negative regulation of endopeptidase activity Source: GOC

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI39.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pregnancy zone protein
    Alternative name(s):
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
    Gene namesi
    Name:PZP
    Synonyms:CPAMD6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:9750. PZP.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. extracellular region Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Add
    BLAST
    Chaini26 – 14821457Pregnancy zone proteinPRO_0000000063Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi406 – 4061N-linked (GlcNAc...)1 Publication
    Glycosylationi753 – 7531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi875 – 8751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi932 – 9321N-linked (GlcNAc...)1 Publication
    Cross-linki978 ↔ 981Isoglutamyl cysteine thioester (Cys-Gln)
    Glycosylationi997 – 9971N-linked (GlcNAc...)2 Publications
    Glycosylationi1430 – 14301N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Thioester bond

    Proteomic databases

    MaxQBiP20742.
    PaxDbiP20742.
    PRIDEiP20742.

    PTM databases

    PhosphoSiteiP20742.

    Expressioni

    Tissue specificityi

    Plasma. Prominent constituent of late-pregnancy sera.

    Gene expression databases

    ArrayExpressiP20742.
    BgeeiP20742.
    GenevestigatoriP20742.

    Organism-specific databases

    HPAiHPA041403.
    HPA041471.

    Interactioni

    Subunit structurei

    Homotetramer, which consists of two pairs of disulfide-linked chains.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000261336.

    Structurei

    3D structure databases

    ProteinModelPortaliP20742.
    SMRiP20742. Positions 126-226, 1346-1474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni685 – 73551Bait regionAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Bait region, Signal

    Phylogenomic databases

    eggNOGiCOG2373.
    HOGENOMiHOG000220939.
    HOVERGENiHBG000039.
    InParanoidiP20742.
    OMAiWIWELVA.
    OrthoDBiEOG7DJSKB.
    PhylomeDBiP20742.
    TreeFamiTF313285.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProiIPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    IPR010916. TonB_box_CS.
    [Graphical view]
    PfamiPF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P20742-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRKDRLLHLC LVLLLILLSA SDSNSTEPQY MVLVPSLLHT EAPKKGCVLL     50
    SHLNETVTVS ASLESGRENR SLFTDLVAEK DLFHCVSFTL PRISASSEVA 100
    FLSIQIKGPT QDFRKRNTVL VLNTQSLVFV QTDKPMYKPG QTVRFRVVSV 150
    DENFRPRNEL IPLIYLENPR RNRIAQWQSL KLEAGINQLS FPLSSEPIQG 200
    SYRVVVQTES GGRIQHPFTV EEFVLPKFEV KVQVPKIISI MDEKVNITVC 250
    GEYTYGKPVP GLATVSLCRK LSRVLNCDKQ EVCEEFSQQL NSNGCITQQV 300
    HTKMLQITNT GFEMKLRVEA RIREEGTDLE VTANRISEIT NIVSKLKFVK 350
    VDSHFRQGIP FFAQVLLVDG KGVPIPNKLF FISVNDANYY SNATTNEQGL 400
    AQFSINTTSI SVNKLFVRVF TVHPNLCFHY SWVAEDHQGA QHTANRVFSL 450
    SGSYIHLEPV AGTLPCGHTE TITAHYTLNR QAMGELSELS FHYLIMAKGV 500
    IVRSGTHTLP VESGDMKGSF ALSFPVESDV APIARMFIFA ILPDGEVVGD 550
    SEKFEIENCL ANKVDLSFSP AQSPPASHAH LQVAAAPQSL CALRAVDQSV 600
    LLMKPEAELS VSSVYNLLTV KDLTNFPDNV DQQEEEQGHC PRPFFIHNGA 650
    IYVPLSSNEA DIYSFLKGMG LKVFTNSKIR KPKSCSVIPS VSAGAVGQGY 700
    YGAGLGVVER PYVPQLGTYN VIPLNNEQSS GPVPETVRSY FPETWIWELV 750
    AVNSSGVAEV GVTVPDTITE WKAGAFCLSE DAGLGISSTA SLRAFQPFFV 800
    ELTMPYSVIR GEVFTLKATV LNYLPKCIRV SVQLKASPAF LASQNTKGEE 850
    SYCICGNERQ TLSWTVTPKT LGNVNFSVSA EAMQSLELCG NEVVEVPEIK 900
    RKDTVIKTLL VEAEGIEQEK TFSSMTCASG ANVSEQLSLK LPSNVVKESA 950
    RASFSVLGDI LGSAMQNIQN LLQMPYGCGE QNMVLFAPNI YVLNYLNETQ 1000
    QLTQEIKAKA VGYLITGYQR QLNYKHQDGS YSTFGERYGR NQGNTWLTAF 1050
    VLKTFAQARS YIFIDEAHIT QSLTWLSQMQ KDNGCFRSSG SLLNNAIKGG 1100
    VEDEATLSAY VTIALLEIPL PVTNPIVRNA LFCLESAWNV AKEGTHGSHV 1150
    YTKALLAYAF SLLGKQNQNR EILNSLDKEA VKEDNLVHWE RPQRPKAPVG 1200
    HLYQTQAPSA EVEMTSYVLL AYLTAQPAPT SGDLTSATNI VKWIMKQQNA 1250
    QGGFSSTQDT VVALHALSRY GAATFTRTEK TAQVTVQDSQ TFSTNFQVDN 1300
    NNLLLLQQIS LPELPGEYVI TVTGERCVYL QTSMKYNILP EKEDSPFALK 1350
    VQTVPQTCDG HKAHTSFQIS LTISYTGNRP ASNMVIVDVK MVSGFIPLKP 1400
    TVKMLERSSS VSRTEVSNNH VLIYVEQVTN QTLSFSFMVL QDIPVGDLKP 1450
    AIVKVYDYYE TDESVVAEYI APCSTDTEHG NV 1482
    Length:1,482
    Mass (Da):163,863
    Last modified:December 15, 2009 - v4
    Checksum:iFA89A47458C4A18B
    GO
    Isoform 2 (identifier: P20742-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-131: Missing.
         132-142: TDKPMYKPGQT → MSESYRRTTFP
         830-912: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,268
    Mass (Da):140,368
    Checksum:i8D3255FD5698667E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti753 – 7531N → Q AA sequence (PubMed:2476433)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti379 – 3791L → V.
    Corresponds to variant rs12230214 [ dbSNP | Ensembl ].
    VAR_034429
    Natural varianti691 – 6911V → M.1 Publication
    Corresponds to variant rs3213832 [ dbSNP | Ensembl ].
    VAR_021845
    Natural varianti813 – 8131V → A.
    Corresponds to variant rs2277413 [ dbSNP | Ensembl ].
    VAR_020005
    Natural varianti857 – 8571N → S.1 Publication
    Corresponds to variant rs3213831 [ dbSNP | Ensembl ].
    VAR_060733
    Natural varianti1003 – 10031T → M.
    Corresponds to variant rs57006764 [ dbSNP | Ensembl ].
    VAR_060982
    Natural varianti1128 – 11281R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036235
    Natural varianti1205 – 12051T → P.1 Publication
    Corresponds to variant rs2377741 [ dbSNP | Ensembl ].
    VAR_060734
    Natural varianti1443 – 14431I → N.
    Corresponds to variant rs10842971 [ dbSNP | Ensembl ].
    VAR_024358

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 131131Missing in isoform 2. 1 PublicationVSP_030862Add
    BLAST
    Alternative sequencei132 – 14211TDKPMYKPGQT → MSESYRRTTFP in isoform 2. 1 PublicationVSP_030863Add
    BLAST
    Alternative sequencei830 – 91283Missing in isoform 2. 1 PublicationVSP_030864Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54380 mRNA. Translation: CAA38255.1.
    AC010175 Genomic DNA. No translation available.
    BC111756 mRNA. Translation: AAI11757.1.
    X51541 Genomic DNA. Translation: CAA35919.1.
    M24416 Genomic DNA. Translation: AAA60234.1.
    CCDSiCCDS8600.1. [P20742-1]
    PIRiS13495.
    S29738.
    UniGeneiHs.707491.

    Genome annotation databases

    EnsembliENST00000261336; ENSP00000261336; ENSG00000126838. [P20742-1]
    UCSCiuc001qvl.3. human. [P20742-1]
    uc009zgl.3. human. [P20742-2]

    Polymorphism databases

    DMDMi281185515.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54380 mRNA. Translation: CAA38255.1 .
    AC010175 Genomic DNA. No translation available.
    BC111756 mRNA. Translation: AAI11757.1 .
    X51541 Genomic DNA. Translation: CAA35919.1 .
    M24416 Genomic DNA. Translation: AAA60234.1 .
    CCDSi CCDS8600.1. [P20742-1 ]
    PIRi S13495.
    S29738.
    UniGenei Hs.707491.

    3D structure databases

    ProteinModelPortali P20742.
    SMRi P20742. Positions 126-226, 1346-1474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000261336.

    Protein family/group databases

    MEROPSi I39.003.

    PTM databases

    PhosphoSitei P20742.

    Polymorphism databases

    DMDMi 281185515.

    Proteomic databases

    MaxQBi P20742.
    PaxDbi P20742.
    PRIDEi P20742.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261336 ; ENSP00000261336 ; ENSG00000126838 . [P20742-1 ]
    UCSCi uc001qvl.3. human. [P20742-1 ]
    uc009zgl.3. human. [P20742-2 ]

    Organism-specific databases

    GeneCardsi GC12M009301.
    H-InvDB HIX0036869.
    HGNCi HGNC:9750. PZP.
    HPAi HPA041403.
    HPA041471.
    MIMi 176420. gene.
    neXtProti NX_P20742.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2373.
    HOGENOMi HOG000220939.
    HOVERGENi HBG000039.
    InParanoidi P20742.
    OMAi WIWELVA.
    OrthoDBi EOG7DJSKB.
    PhylomeDBi P20742.
    TreeFami TF313285.

    Miscellaneous databases

    PROi P20742.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20742.
    Bgeei P20742.
    Genevestigatori P20742.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProi IPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    IPR010916. TonB_box_CS.
    [Graphical view ]
    Pfami PF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of pregnancy zone protein. Molecular cloning of a full-length PZP cDNA clone by the polymerase chain reaction."
      Devriendt K., van den Berghe H., Cassiman J.-J., Marynen P.
      Biochim. Biophys. Acta 1088:95-103(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-857.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-1205.
    4. "Alpha-macroglobulin domain structure studied by specific limited proteolysis."
      Thomsen N.K., Sottrup-Jensen L.
      Arch. Biochem. Biophys. 300:327-334(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-37; 222-230; 720-733; 896-902; 1003-1008; 1056-1061; 1184-1193; 1197-1224; 1277-1286 AND 1336-1344 (ISOFORM 1).
    5. "A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin."
      Marynen P., Devriendt K., van den Berghe H., Cassiman J.-J.
      FEBS Lett. 262:349-352(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 668-753, VARIANT MET-691.
      Tissue: Placenta.
    6. "The alpha-macroglobulin bait region. Sequence diversity and localization of cleavage sites for proteinases in five mammalian alpha-macroglobulins."
      Sottrup-Jensen L., Sand O., Kristensen L., Fey G.H.
      J. Biol. Chem. 264:15781-15789(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 670-759.
    7. "Characterization of human pregnancy zone protein. Comparison with human alpha 2-macroglobulin."
      Sand O., Folkersen J., Westergaard J.G., Sottrup-Jensen L.
      J. Biol. Chem. 260:15723-15735(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 974-983.
    8. "A cluster of alpha 2-macroglobulin-related genes (alpha 2 M) on human chromosome 12p: cloning of the pregnancy-zone protein gene and an alpha 2M pseudogene."
      Devriendt K., Zhang J., van Leuven F., van den Berghe H., Cassiman J.-J., Marynen P.
      Gene 81:325-334(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1259-1461.
    9. "Pregnancy zone protein, a proteinase-binding macroglobulin. Interactions with proteinases and methylamine."
      Christensen U., Simonsen M., Harrit N., Sottrup-Jensen L.
      Biochemistry 28:9324-9331(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PROTEINASES AND METHYLAMINE.
    10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-406; ASN-932; ASN-997 AND ASN-1430.
      Tissue: Plasma.
    11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-997.
      Tissue: Liver.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-1128.

    Entry informationi

    Entry nameiPZP_HUMAN
    AccessioniPrimary (citable) accession number: P20742
    Secondary accession number(s): A6ND27
    , Q15273, Q2NKL2, Q7M4N7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 134 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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