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P20723

- ETXD_STAAU

UniProt

P20723 - ETXD_STAAU

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Protein

Enterotoxin type D

Gene
entD
Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi212 – 2121Zinc
Metal bindingi250 – 2501Zinc
Metal bindingi252 – 2521Zinc

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type D
Alternative name(s):
SED
Gene namesi
Name:entD
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2142. Sta a SED.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 258233Enterotoxin type DPRO_0000035612Add
BLAST

Interactioni

Subunit structurei

Homodimer; zinc-dependent.

Structurei

3D structure databases

ProteinModelPortaliP20723.
SMRiP20723. Positions 32-257.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20723-1 [UniParc]FASTAAdd to Basket

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MKKFNILIAL LFFTSLVISP LNVKANENID SVKEKELHKK SELSSTALNN    50
MKHSYADKNP IIGENKSTGD QFLENTLLYK KFFTDLINFE DLLINFNSKE 100
MAQHFKSKNV DVYPIRYSIN CYGGEIDRTA CTYGGVTPHE GNKLKERKKI 150
PINLWINGVQ KEVSLDKVQT DKKNVTVQEL DAQARRYLQK DLKLYNNDTL 200
GGKIQRGKIE FDSSDGSKVS YDLFDVKGDF PEKQLRIYSD NKTLSTEHLH 250
IDIYLYEK 258
Length:258
Mass (Da):29,746
Last modified:February 1, 1991 - v1
Checksum:i4F7C6A28D42597FD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti114 – 1141P → A in strain: ATCC 23235.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28521 Genomic DNA. Translation: AAB06195.1.
PIRiA33953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28521 Genomic DNA. Translation: AAB06195.1 .
PIRi A33953.

3D structure databases

ProteinModelPortali P20723.
SMRi P20723. Positions 32-257.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 2142. Sta a SED.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

PROi P20723.

Family and domain databases

Gene3Di 3.10.20.120. 1 hit.
InterProi IPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view ]
Pfami PF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view ]
PRINTSi PR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMi SSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEi PS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic and molecular analyses of the gene encoding staphylococcal enterotoxin D."
    Bayles K.W., Iandolo J.J.
    J. Bacteriol. 171:4799-4806(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The crystal structure of staphylococcal enterotoxin type D reveals Zn2+-mediated homodimerization."
    Sundstroem M., Abrahmsen L., Antonsson P., Mehindate K., Mourad W., Dohlsten M.
    EMBO J. 15:6832-6840(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
    Strain: ATCC 23235 / NCTC 10656.

Entry informationi

Entry nameiETXD_STAAU
AccessioniPrimary (citable) accession number: P20723
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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