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P20723

- ETXD_STAAU

UniProt

P20723 - ETXD_STAAU

Protein

Enterotoxin type D

Gene

entD

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi212 – 2121Zinc
    Metal bindingi250 – 2501Zinc
    Metal bindingi252 – 2521Zinc

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Enterotoxin, Superantigen, Toxin

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enterotoxin type D
    Alternative name(s):
    SED
    Gene namesi
    Name:entD
    OrganismiStaphylococcus aureus
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Protein family/group databases

    Allergomei2142. Sta a SED.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Add
    BLAST
    Chaini26 – 258233Enterotoxin type DPRO_0000035612Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer; zinc-dependent.

    Structurei

    3D structure databases

    ProteinModelPortaliP20723.
    SMRiP20723. Positions 32-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.10.20.120. 1 hit.
    InterProiIPR008992. Enterotoxin.
    IPR006126. Staph/Strept_toxin_CS.
    IPR006173. Staph_tox_OB.
    IPR016091. SuperAg_toxin_C.
    IPR013307. Superantigen_bac.
    IPR006123. Toxin_b-grasp_Staph/Strep.
    IPR006177. Toxin_bac.
    [Graphical view]
    PfamiPF02876. Stap_Strp_tox_C. 1 hit.
    PF01123. Stap_Strp_toxin. 1 hit.
    [Graphical view]
    PRINTSiPR00279. BACTRLTOXIN.
    PR01898. SAGSUPRFAMLY.
    SUPFAMiSSF50203. SSF50203. 1 hit.
    SSF54334. SSF54334. 1 hit.
    PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
    PS00278. STAPH_STREP_TOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20723-1 [UniParc]FASTAAdd to Basket

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    MKKFNILIAL LFFTSLVISP LNVKANENID SVKEKELHKK SELSSTALNN    50
    MKHSYADKNP IIGENKSTGD QFLENTLLYK KFFTDLINFE DLLINFNSKE 100
    MAQHFKSKNV DVYPIRYSIN CYGGEIDRTA CTYGGVTPHE GNKLKERKKI 150
    PINLWINGVQ KEVSLDKVQT DKKNVTVQEL DAQARRYLQK DLKLYNNDTL 200
    GGKIQRGKIE FDSSDGSKVS YDLFDVKGDF PEKQLRIYSD NKTLSTEHLH 250
    IDIYLYEK 258
    Length:258
    Mass (Da):29,746
    Last modified:February 1, 1991 - v1
    Checksum:i4F7C6A28D42597FD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti114 – 1141P → A in strain: ATCC 23235.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28521 Genomic DNA. Translation: AAB06195.1.
    PIRiA33953.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28521 Genomic DNA. Translation: AAB06195.1 .
    PIRi A33953.

    3D structure databases

    ProteinModelPortali P20723.
    SMRi P20723. Positions 32-257.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 2142. Sta a SED.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    PROi P20723.

    Family and domain databases

    Gene3Di 3.10.20.120. 1 hit.
    InterProi IPR008992. Enterotoxin.
    IPR006126. Staph/Strept_toxin_CS.
    IPR006173. Staph_tox_OB.
    IPR016091. SuperAg_toxin_C.
    IPR013307. Superantigen_bac.
    IPR006123. Toxin_b-grasp_Staph/Strep.
    IPR006177. Toxin_bac.
    [Graphical view ]
    Pfami PF02876. Stap_Strp_tox_C. 1 hit.
    PF01123. Stap_Strp_toxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00279. BACTRLTOXIN.
    PR01898. SAGSUPRFAMLY.
    SUPFAMi SSF50203. SSF50203. 1 hit.
    SSF54334. SSF54334. 1 hit.
    PROSITEi PS00277. STAPH_STREP_TOXIN_1. 1 hit.
    PS00278. STAPH_STREP_TOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic and molecular analyses of the gene encoding staphylococcal enterotoxin D."
      Bayles K.W., Iandolo J.J.
      J. Bacteriol. 171:4799-4806(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The crystal structure of staphylococcal enterotoxin type D reveals Zn2+-mediated homodimerization."
      Sundstroem M., Abrahmsen L., Antonsson P., Mehindate K., Mourad W., Dohlsten M.
      EMBO J. 15:6832-6840(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
      Strain: ATCC 23235 / NCTC 10656.

    Entry informationi

    Entry nameiETXD_STAAU
    AccessioniPrimary (citable) accession number: P20723
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3