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P20723 (ETXD_STAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enterotoxin type D
Alternative name(s):
SED
Gene names
Name:entD
OrganismStaphylococcus aureus
Taxonomic identifier1280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Subunit structure

Homodimer; zinc-dependent.

Subcellular location

Secreted.

Sequence similarities

Belongs to the staphylococcal/streptococcal toxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionEnterotoxin
Superantigen
Toxin
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525
Chain26 – 258233Enterotoxin type D
PRO_0000035612

Sites

Metal binding2121Zinc
Metal binding2501Zinc
Metal binding2521Zinc

Natural variations

Natural variant1141P → A in strain: ATCC 23235.

Sequences

Sequence LengthMass (Da)Tools
P20723 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 4F7C6A28D42597FD

FASTA25829,746
        10         20         30         40         50         60 
MKKFNILIAL LFFTSLVISP LNVKANENID SVKEKELHKK SELSSTALNN MKHSYADKNP 

        70         80         90        100        110        120 
IIGENKSTGD QFLENTLLYK KFFTDLINFE DLLINFNSKE MAQHFKSKNV DVYPIRYSIN 

       130        140        150        160        170        180 
CYGGEIDRTA CTYGGVTPHE GNKLKERKKI PINLWINGVQ KEVSLDKVQT DKKNVTVQEL 

       190        200        210        220        230        240 
DAQARRYLQK DLKLYNNDTL GGKIQRGKIE FDSSDGSKVS YDLFDVKGDF PEKQLRIYSD 

       250 
NKTLSTEHLH IDIYLYEK 

« Hide

References

[1]"Genetic and molecular analyses of the gene encoding staphylococcal enterotoxin D."
Bayles K.W., Iandolo J.J.
J. Bacteriol. 171:4799-4806(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The crystal structure of staphylococcal enterotoxin type D reveals Zn2+-mediated homodimerization."
Sundstroem M., Abrahmsen L., Antonsson P., Mehindate K., Mourad W., Dohlsten M.
EMBO J. 15:6832-6840(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
Strain: ATCC 23235 / NCTC 10656.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M28521 Genomic DNA. Translation: AAB06195.1.
PIRA33953.

3D structure databases

ProteinModelPortalP20723.
SMRP20723. Positions 32-257.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome2142. Sta a SED.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.10.20.120. 1 hit.
InterProIPR008992. Enterotoxin_bac.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP20723.

Entry information

Entry nameETXD_STAAU
AccessionPrimary (citable) accession number: P20723
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 16, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families