P20723 (ETXD_STAAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Enterotoxin type D

Alternative name(s):
SED

Gene names

Name:

entD

Organism

Staphylococcus aureus

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
Subunit structure	Homodimer; zinc-dependent.
Subcellular location	Secreted.
Sequence similarities	Belongs to the staphylococcal/streptococcal toxin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Enterotoxin Superantigen Toxin
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25
	Chain	26 – 258	233	Enterotoxin type D		PRO_0000035612
Sites
	Metal binding	212	1	Zinc
	Metal binding	250	1	Zinc
	Metal binding	252	1	Zinc
Natural variations
	Natural variant	114	1	P → A in strain: ATCC 23235.

Sequences

	Sequence		Length	Mass (Da)
	P20723 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 4F7C6A28D42597FD	FASTA	258	29,746
	10 20 30 40 50 60 MKKFNILIAL LFFTSLVISP LNVKANENID SVKEKELHKK SELSSTALNN MKHSYADKNP 70 80 90 100 110 120 IIGENKSTGD QFLENTLLYK KFFTDLINFE DLLINFNSKE MAQHFKSKNV DVYPIRYSIN 130 140 150 160 170 180 CYGGEIDRTA CTYGGVTPHE GNKLKERKKI PINLWINGVQ KEVSLDKVQT DKKNVTVQEL 190 200 210 220 230 240 DAQARRYLQK DLKLYNNDTL GGKIQRGKIE FDSSDGSKVS YDLFDVKGDF PEKQLRIYSD 250 NKTLSTEHLH IDIYLYEK

References

[1]	"Genetic and molecular analyses of the gene encoding staphylococcal enterotoxin D." Bayles K.W., Iandolo J.J. J. Bacteriol. 171:4799-4806(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The crystal structure of staphylococcal enterotoxin type D reveals Zn2+-mediated homodimerization." Sundstroem M., Abrahmsen L., Antonsson P., Mehindate K., Mourad W., Dohlsten M. EMBO J. 15:6832-6840(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS). Strain: ATCC 23235 / NCTC 10656.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M28521 Genomic DNA. Translation: AAB06195.1.
PIR	A33953.
3D structure databases
ProteinModelPortal	P20723.
SMR	P20723. Positions 32-257.
ModBase	Search...
Protein family/group databases
Allergome	2142. Sta a SED.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.10.20.120. 1 hit.
InterPro	IPR008992. Enterotoxin_bac. IPR006126. Staph/Strept_toxin_CS. IPR006173. Staph_tox_OB. IPR016091. SuperAg_toxin_C. IPR013307. Superantigen_bac. IPR006123. Toxin_b-grasp_Staph/Strep. IPR006177. Toxin_bac. [Graphical view]
Pfam	PF02876. Stap_Strp_tox_C. 1 hit. PF01123. Stap_Strp_toxin. 1 hit. [Graphical view]
PRINTS	PR00279. BACTRLTOXIN. PR01898. SAGSUPRFAMLY.
SUPFAM	SSF50203. Bact_endotox. 1 hit. SSF54334. Stap/Strep_toxin. 1 hit.
PROSITE	PS00277. STAPH_STREP_TOXIN_1. 1 hit. PS00278. STAPH_STREP_TOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ETXD_STAAU

Accession

Primary (citable) accession number: P20723

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program