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P20722

- BMP6_MOUSE

UniProt

P20722 - BMP6_MOUSE

Protein

Bone morphogenetic protein 6

Gene

Bmp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation.By similarity

    GO - Molecular functioni

    1. BMP receptor binding Source: MGI
    2. protein binding Source: MGI
    3. protein heterodimerization activity Source: MGI

    GO - Biological processi

    1. BMP signaling pathway Source: MGI
    2. cartilage development Source: UniProtKB-KW
    3. cell differentiation Source: MGI
    4. cellular response to mechanical stimulus Source: Ensembl
    5. endochondral ossification Source: MGI
    6. eye development Source: UniProtKB
    7. growth Source: InterPro
    8. immune response Source: Ensembl
    9. inflammatory response Source: UniProtKB
    10. kidney development Source: UniProtKB
    11. male genitalia development Source: MGI
    12. osteoblast differentiation Source: MGI
    13. positive regulation of aldosterone biosynthetic process Source: Ensembl
    14. positive regulation of aldosterone secretion Source: Ensembl
    15. positive regulation of bone mineralization Source: Ensembl
    16. positive regulation of chondrocyte differentiation Source: Ensembl
    17. positive regulation of endothelial cell differentiation Source: DFLAT
    18. positive regulation of endothelial cell proliferation Source: DFLAT
    19. positive regulation of neuron differentiation Source: MGI
    20. positive regulation of osteoblast differentiation Source: Ensembl
    21. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    22. response to activity Source: Ensembl
    23. response to glucocorticoid Source: Ensembl
    24. response to iron ion Source: Ensembl
    25. response to magnesium ion Source: Ensembl
    26. response to retinoic acid Source: Ensembl
    27. SMAD protein signal transduction Source: UniProtKB
    28. type B pancreatic cell development Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 6
    Short name:
    BMP-6
    Alternative name(s):
    VG-1-related protein
    Short name:
    VGR-1
    Gene namesi
    Name:Bmp6
    Synonyms:Bmp-6, Vgr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:88182. Bmp6.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: UniProtKB-KW
    3. membrane-bounded vesicle Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 371351Sequence AnalysisPRO_0000033872Add
    BLAST
    Chaini372 – 510139Bone morphogenetic protein 6PRO_0000033873Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi409 ↔ 475By similarity
    Disulfide bondi438 ↔ 507By similarity
    Disulfide bondi442 ↔ 509By similarity
    Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi474 – 474InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP20722.

    Expressioni

    Tissue specificityi

    Expressed in the lung. Low levels seen in the kidney.

    Gene expression databases

    ArrayExpressiP20722.
    BgeeiP20722.
    CleanExiMM_BMP6.
    GenevestigatoriP20722.

    Interactioni

    Subunit structurei

    Interacts with SOSTDC1.1 Publication

    Protein-protein interaction databases

    BioGridi198366. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP20722.
    SMRiP20722. Positions 407-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG272883.
    GeneTreeiENSGT00730000110505.
    HOGENOMiHOG000249476.
    HOVERGENiHBG004860.
    InParanoidiB2RRV6.
    KOiK16620.
    OMAiWWGLLCS.
    OrthoDBiEOG7J9VPQ.
    PhylomeDBiP20722.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20722-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR    50
    AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ 100
    PPVLPPQQQQ QQQQQQTARE EPPPGRLKSA PLFMLDLYNA LSNDDEEDGA 150
    SEGVGQEPGS HGGASSSQLR QPSPGAAHSL NRKSLLAPGP GGGASPLTSA 200
    QDSAFLNDAD MVMSFVNLVE YDKEFSPHQR HHKEFKFNLS QIPEGEAVTA 250
    AEFRVYKDCV VGSFKNQTFL ISIYQVLQEH QHRDSDLFLL DTRVVWASEE 300
    GWLEFDITAT SNLWVVTPQH NMGLQLSVVT RDGLHVNPRA AGLVGRDGPY 350
    DKQPFMVAFF KVSEVHVRTT RSASSRRRQQ SRNRSTQSQD VSRGSGSSDY 400
    NGSELKTACK KHELYVSFQD LGWQDWIIAP KGYAANYCDG ECSFPLNAHM 450
    NATNHAIVQT LVHLMNPEYV PKPCCAPTKL NAISVLYFDD NSNVILKKYR 500
    NMVVRACGCH 510
    Length:510
    Mass (Da):56,432
    Last modified:October 1, 1996 - v2
    Checksum:i910B68531289FCD2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731K → M(PubMed:2734307)Curated
    Sequence conflicti75 – 751E → K(PubMed:2734307)Curated
    Sequence conflicti86 – 861L → P in AAA40548. (PubMed:2734307)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80992 mRNA. Translation: CAA56917.1.
    U73520
    , U73515, U73516, U73517, U73518, U73519 Genomic DNA. Translation: AAB18235.1.
    BC138593 mRNA. Translation: AAI38594.1.
    BC138595 mRNA. Translation: AAI38596.1.
    J04566 mRNA. Translation: AAA40548.1.
    CCDSiCCDS26462.1.
    PIRiA54798.
    RefSeqiNP_031582.1. NM_007556.2.
    UniGeneiMm.385759.

    Genome annotation databases

    EnsembliENSMUST00000171970; ENSMUSP00000126999; ENSMUSG00000039004.
    GeneIDi12161.
    KEGGimmu:12161.
    UCSCiuc007qdp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80992 mRNA. Translation: CAA56917.1 .
    U73520
    , U73515 , U73516 , U73517 , U73518 , U73519 Genomic DNA. Translation: AAB18235.1 .
    BC138593 mRNA. Translation: AAI38594.1 .
    BC138595 mRNA. Translation: AAI38596.1 .
    J04566 mRNA. Translation: AAA40548.1 .
    CCDSi CCDS26462.1.
    PIRi A54798.
    RefSeqi NP_031582.1. NM_007556.2.
    UniGenei Mm.385759.

    3D structure databases

    ProteinModelPortali P20722.
    SMRi P20722. Positions 407-510.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198366. 1 interaction.

    Proteomic databases

    PRIDEi P20722.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000171970 ; ENSMUSP00000126999 ; ENSMUSG00000039004 .
    GeneIDi 12161.
    KEGGi mmu:12161.
    UCSCi uc007qdp.1. mouse.

    Organism-specific databases

    CTDi 654.
    MGIi MGI:88182. Bmp6.

    Phylogenomic databases

    eggNOGi NOG272883.
    GeneTreei ENSGT00730000110505.
    HOGENOMi HOG000249476.
    HOVERGENi HBG004860.
    InParanoidi B2RRV6.
    KOi K16620.
    OMAi WWGLLCS.
    OrthoDBi EOG7J9VPQ.
    PhylomeDBi P20722.
    TreeFami TF316134.

    Miscellaneous databases

    NextBioi 280511.
    PROi P20722.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20722.
    Bgeei P20722.
    CleanExi MM_BMP6.
    Genevestigatori P20722.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo."
      Gitelman S.E., Kobrin M.S., Ye J.Q., Lopez A.R., Lee A., Derynck R.
      J. Cell Biol. 126:1595-1609(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily."
      Lyons K., Graycar J.L., Lee A., Hashmi S., Lindquist P.B., Chen E.Y., Hogan B.L.M., Derynck R.
      Proc. Natl. Acad. Sci. U.S.A. 86:4554-4558(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-510.
    5. "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot."
      Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.
      Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SOSTDC1.

    Entry informationi

    Entry nameiBMP6_MOUSE
    AccessioniPrimary (citable) accession number: P20722
    Secondary accession number(s): B2RRV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3