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P20722

- BMP6_MOUSE

UniProt

P20722 - BMP6_MOUSE

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Protein

Bone morphogenetic protein 6

Gene

Bmp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation.By similarity

GO - Molecular functioni

  1. BMP receptor binding Source: MGI
  2. protein heterodimerization activity Source: MGI

GO - Biological processi

  1. BMP signaling pathway Source: MGI
  2. cartilage development Source: UniProtKB-KW
  3. cell differentiation Source: MGI
  4. cellular response to mechanical stimulus Source: Ensembl
  5. endochondral ossification Source: MGI
  6. eye development Source: UniProtKB
  7. growth Source: InterPro
  8. immune response Source: Ensembl
  9. inflammatory response Source: UniProtKB
  10. kidney development Source: UniProtKB
  11. male genitalia development Source: MGI
  12. osteoblast differentiation Source: MGI
  13. positive regulation of aldosterone biosynthetic process Source: Ensembl
  14. positive regulation of aldosterone secretion Source: Ensembl
  15. positive regulation of bone mineralization Source: Ensembl
  16. positive regulation of chondrocyte differentiation Source: Ensembl
  17. positive regulation of endothelial cell differentiation Source: DFLAT
  18. positive regulation of endothelial cell proliferation Source: DFLAT
  19. positive regulation of neuron differentiation Source: MGI
  20. positive regulation of osteoblast differentiation Source: Ensembl
  21. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  22. response to activity Source: Ensembl
  23. response to glucocorticoid Source: Ensembl
  24. response to iron ion Source: Ensembl
  25. response to magnesium ion Source: Ensembl
  26. response to retinoic acid Source: Ensembl
  27. SMAD protein signal transduction Source: UniProtKB
  28. type B pancreatic cell development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 6
Short name:
BMP-6
Alternative name(s):
VG-1-related protein
Short name:
VGR-1
Gene namesi
Name:Bmp6
Synonyms:Bmp-6, Vgr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:88182. Bmp6.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
  3. membrane-bounded vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 371351Sequence AnalysisPRO_0000033872Add
BLAST
Chaini372 – 510139Bone morphogenetic protein 6PRO_0000033873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi409 ↔ 475By similarity
Disulfide bondi438 ↔ 507By similarity
Disulfide bondi442 ↔ 509By similarity
Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi474 – 474InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP20722.

Expressioni

Tissue specificityi

Expressed in the lung. Low levels seen in the kidney.

Gene expression databases

BgeeiP20722.
CleanExiMM_BMP6.
ExpressionAtlasiP20722. baseline and differential.
GenevestigatoriP20722.

Interactioni

Subunit structurei

Interacts with SOSTDC1.1 Publication

Protein-protein interaction databases

BioGridi198366. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP20722.
SMRiP20722. Positions 407-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG272883.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP20722.
KOiK16620.
OMAiWWGLLCS.
OrthoDBiEOG7J9VPQ.
PhylomeDBiP20722.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20722-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR
60 70 80 90 100
AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ
110 120 130 140 150
PPVLPPQQQQ QQQQQQTARE EPPPGRLKSA PLFMLDLYNA LSNDDEEDGA
160 170 180 190 200
SEGVGQEPGS HGGASSSQLR QPSPGAAHSL NRKSLLAPGP GGGASPLTSA
210 220 230 240 250
QDSAFLNDAD MVMSFVNLVE YDKEFSPHQR HHKEFKFNLS QIPEGEAVTA
260 270 280 290 300
AEFRVYKDCV VGSFKNQTFL ISIYQVLQEH QHRDSDLFLL DTRVVWASEE
310 320 330 340 350
GWLEFDITAT SNLWVVTPQH NMGLQLSVVT RDGLHVNPRA AGLVGRDGPY
360 370 380 390 400
DKQPFMVAFF KVSEVHVRTT RSASSRRRQQ SRNRSTQSQD VSRGSGSSDY
410 420 430 440 450
NGSELKTACK KHELYVSFQD LGWQDWIIAP KGYAANYCDG ECSFPLNAHM
460 470 480 490 500
NATNHAIVQT LVHLMNPEYV PKPCCAPTKL NAISVLYFDD NSNVILKKYR
510
NMVVRACGCH
Length:510
Mass (Da):56,432
Last modified:October 1, 1996 - v2
Checksum:i910B68531289FCD2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731K → M(PubMed:2734307)Curated
Sequence conflicti75 – 751E → K(PubMed:2734307)Curated
Sequence conflicti86 – 861L → P in AAA40548. (PubMed:2734307)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80992 mRNA. Translation: CAA56917.1.
U73520
, U73515, U73516, U73517, U73518, U73519 Genomic DNA. Translation: AAB18235.1.
BC138593 mRNA. Translation: AAI38594.1.
BC138595 mRNA. Translation: AAI38596.1.
J04566 mRNA. Translation: AAA40548.1.
CCDSiCCDS26462.1.
PIRiA54798.
RefSeqiNP_031582.1. NM_007556.2.
UniGeneiMm.385759.

Genome annotation databases

EnsembliENSMUST00000171970; ENSMUSP00000126999; ENSMUSG00000039004.
GeneIDi12161.
KEGGimmu:12161.
UCSCiuc007qdp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80992 mRNA. Translation: CAA56917.1 .
U73520
, U73515 , U73516 , U73517 , U73518 , U73519 Genomic DNA. Translation: AAB18235.1 .
BC138593 mRNA. Translation: AAI38594.1 .
BC138595 mRNA. Translation: AAI38596.1 .
J04566 mRNA. Translation: AAA40548.1 .
CCDSi CCDS26462.1.
PIRi A54798.
RefSeqi NP_031582.1. NM_007556.2.
UniGenei Mm.385759.

3D structure databases

ProteinModelPortali P20722.
SMRi P20722. Positions 407-510.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198366. 1 interaction.

Proteomic databases

PRIDEi P20722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000171970 ; ENSMUSP00000126999 ; ENSMUSG00000039004 .
GeneIDi 12161.
KEGGi mmu:12161.
UCSCi uc007qdp.1. mouse.

Organism-specific databases

CTDi 654.
MGIi MGI:88182. Bmp6.

Phylogenomic databases

eggNOGi NOG272883.
GeneTreei ENSGT00760000118883.
HOGENOMi HOG000249476.
HOVERGENi HBG004860.
InParanoidi P20722.
KOi K16620.
OMAi WWGLLCS.
OrthoDBi EOG7J9VPQ.
PhylomeDBi P20722.
TreeFami TF316134.

Miscellaneous databases

NextBioi 280511.
PROi P20722.
SOURCEi Search...

Gene expression databases

Bgeei P20722.
CleanExi MM_BMP6.
ExpressionAtlasi P20722. baseline and differential.
Genevestigatori P20722.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo."
    Gitelman S.E., Kobrin M.S., Ye J.Q., Lopez A.R., Lee A., Derynck R.
    J. Cell Biol. 126:1595-1609(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily."
    Lyons K., Graycar J.L., Lee A., Hashmi S., Lindquist P.B., Chen E.Y., Hogan B.L.M., Derynck R.
    Proc. Natl. Acad. Sci. U.S.A. 86:4554-4558(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-510.
  5. "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot."
    Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.
    Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SOSTDC1.

Entry informationi

Entry nameiBMP6_MOUSE
AccessioniPrimary (citable) accession number: P20722
Secondary accession number(s): B2RRV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3