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P20722 (BMP6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 6

Short name=BMP-6
Alternative name(s):
VG-1-related protein
Short name=VGR-1
Gene names
Name:Bmp6
Synonyms:Bmp-6, Vgr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces cartilage and bone formation By similarity.

Subunit structure

Interacts with SOSTDC1. Ref.5

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed in the lung. Low levels seen in the kidney.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
Osteogenesis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay Ref.5PubMed 19852960. Source: MGI

SMAD protein signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

cartilage development

Inferred from electronic annotation. Source: UniProtKB-KW

cell differentiation

Inferred from mutant phenotype PubMed 14623245. Source: MGI

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

endochondral ossification

Inferred from mutant phenotype PubMed 9664685. Source: MGI

eye development

Inferred from genetic interaction PubMed 16154126. Source: UniProtKB

growth

Inferred from electronic annotation. Source: InterPro

immune response

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from expression pattern PubMed 12151307. Source: UniProtKB

kidney development

Inferred from genetic interaction PubMed 16154126. Source: UniProtKB

male genitalia development

Inferred from genetic interaction PubMed 9664685. Source: MGI

osteoblast differentiation

Inferred from genetic interaction PubMed 16109715. Source: MGI

positive regulation of aldosterone biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of aldosterone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of bone mineralization

Inferred from electronic annotation. Source: Ensembl

positive regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell differentiation

Inferred from direct assay PubMed 20406889. Source: DFLAT

positive regulation of endothelial cell proliferation

Inferred from direct assay PubMed 20406889. Source: DFLAT

positive regulation of neuron differentiation

Inferred from direct assay PubMed 9786991. Source: MGI

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

response to activity

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to iron ion

Inferred from electronic annotation. Source: Ensembl

response to magnesium ion

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

type B pancreatic cell development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

membrane-bounded vesicle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionBMP receptor binding

Inferred from sequence orthology PubMed 7811286. Source: MGI

protein binding

Inferred from physical interaction PubMed 12897139PubMed 14660436. Source: MGI

protein heterodimerization activity

Inferred from sequence orthology PubMed 7811286. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 371351 Potential
PRO_0000033872
Chain372 – 510139Bone morphogenetic protein 6
PRO_0000033873

Amino acid modifications

Glycosylation2381N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Glycosylation3831N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential
Disulfide bond409 ↔ 475 By similarity
Disulfide bond438 ↔ 507 By similarity
Disulfide bond442 ↔ 509 By similarity
Disulfide bond474Interchain By similarity

Experimental info

Sequence conflict731K → M Ref.4
Sequence conflict751E → K Ref.4
Sequence conflict861L → P in AAA40548. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P20722 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 910B68531289FCD2

FASTA51056,432
        10         20         30         40         50         60 
MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR AEQPPPQSSS 

        70         80         90        100        110        120 
SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ PPVLPPQQQQ QQQQQQTARE 

       130        140        150        160        170        180 
EPPPGRLKSA PLFMLDLYNA LSNDDEEDGA SEGVGQEPGS HGGASSSQLR QPSPGAAHSL 

       190        200        210        220        230        240 
NRKSLLAPGP GGGASPLTSA QDSAFLNDAD MVMSFVNLVE YDKEFSPHQR HHKEFKFNLS 

       250        260        270        280        290        300 
QIPEGEAVTA AEFRVYKDCV VGSFKNQTFL ISIYQVLQEH QHRDSDLFLL DTRVVWASEE 

       310        320        330        340        350        360 
GWLEFDITAT SNLWVVTPQH NMGLQLSVVT RDGLHVNPRA AGLVGRDGPY DKQPFMVAFF 

       370        380        390        400        410        420 
KVSEVHVRTT RSASSRRRQQ SRNRSTQSQD VSRGSGSSDY NGSELKTACK KHELYVSFQD 

       430        440        450        460        470        480 
LGWQDWIIAP KGYAANYCDG ECSFPLNAHM NATNHAIVQT LVHLMNPEYV PKPCCAPTKL 

       490        500        510 
NAISVLYFDD NSNVILKKYR NMVVRACGCH 

« Hide

References

« Hide 'large scale' references
[1]"Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo."
Gitelman S.E., Kobrin M.S., Ye J.Q., Lopez A.R., Lee A., Derynck R.
J. Cell Biol. 126:1595-1609(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"Structure and sequence of the mouse Bmp6 gene."
Gitelman S.E., Kobrin M.S., Lee A., Fet V., Lyons K., Hogan B.L.M., Derynck R.
Mamm. Genome 8:212-214(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily."
Lyons K., Graycar J.L., Lee A., Hashmi S., Lindquist P.B., Chen E.Y., Hogan B.L.M., Derynck R.
Proc. Natl. Acad. Sci. U.S.A. 86:4554-4558(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-510.
[5]"Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot."
Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.
Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SOSTDC1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X80992 mRNA. Translation: CAA56917.1.
U73520 expand/collapse EMBL AC list , U73515, U73516, U73517, U73518, U73519 Genomic DNA. Translation: AAB18235.1.
BC138593 mRNA. Translation: AAI38594.1.
BC138595 mRNA. Translation: AAI38596.1.
J04566 mRNA. Translation: AAA40548.1.
CCDSCCDS26462.1.
PIRA54798.
RefSeqNP_031582.1. NM_007556.2.
UniGeneMm.385759.

3D structure databases

ProteinModelPortalP20722.
SMRP20722. Positions 407-510.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198366. 1 interaction.

Proteomic databases

PRIDEP20722.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000171970; ENSMUSP00000126999; ENSMUSG00000039004.
GeneID12161.
KEGGmmu:12161.
UCSCuc007qdp.1. mouse.

Organism-specific databases

CTD654.
MGIMGI:88182. Bmp6.

Phylogenomic databases

eggNOGNOG272883.
GeneTreeENSGT00730000110505.
HOGENOMHOG000249476.
HOVERGENHBG004860.
InParanoidB2RRV6.
KOK16620.
OMAWWGLLCS.
OrthoDBEOG7J9VPQ.
PhylomeDBP20722.
TreeFamTF316134.

Gene expression databases

ArrayExpressP20722.
BgeeP20722.
CleanExMM_BMP6.
GenevestigatorP20722.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280511.
PROP20722.
SOURCESearch...

Entry information

Entry nameBMP6_MOUSE
AccessionPrimary (citable) accession number: P20722
Secondary accession number(s): B2RRV6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot