P20722 (BMP6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 6
Short name=BMP-6

Alternative name(s):
VG-1-related protein
Short name=VGR-1

Gene names

Name:	Bmp6
Synonyms:	Bmp-6, Vgr1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces cartilage and bone formation By similarity.
Subunit structure	Interacts with SOSTDC1. Ref.5
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed in the lung. Low levels seen in the kidney.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Osteogenesis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from direct assay Ref.5PubMed 19852960. Source: MGI SMAD protein signal transduction Inferred from sequence or structural similarity. Source: UniProtKB cartilage development Inferred from electronic annotation. Source: UniProtKB-KW endochondral ossification Inferred from mutant phenotype PubMed 9664685. Source: MGI eye development Inferred from genetic interaction PubMed 16154126. Source: UniProtKB growth Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: Compara inflammatory response Inferred from expression pattern PubMed 12151307. Source: UniProtKB kidney development Inferred from genetic interaction PubMed 16154126. Source: UniProtKB male genitalia development Inferred from genetic interaction PubMed 9664685. Source: MGI osteoblast differentiation Inferred from genetic interaction PubMed 16109715. Source: MGI positive regulation of aldosterone biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell differentiation Inferred from direct assay PubMed 20406889. Source: DFLAT positive regulation of endothelial cell proliferation Inferred from direct assay PubMed 20406889. Source: DFLAT positive regulation of neuron differentiation Inferred from direct assay PubMed 9786991. Source: MGI positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to retinoic acid Inferred from electronic annotation. Source: Compara type B pancreatic cell development Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: UniProtKB-KW membrane-bounded vesicle Inferred from electronic annotation. Source: Compara
Molecular_function	BMP receptor binding Inferred from sequence orthology PubMed 7811286. Source: MGI protein heterodimerization activity Inferred from sequence orthology PubMed 7811286. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 371	351	Potential		PRO_0000033872
	Chain	372 – 510	139	Bone morphogenetic protein 6		PRO_0000033873
Amino acid modifications
	Glycosylation	238	1	N-linked (GlcNAc...) Potential
	Glycosylation	266	1	N-linked (GlcNAc...) Potential
	Glycosylation	383	1	N-linked (GlcNAc...) Potential
	Glycosylation	401	1	N-linked (GlcNAc...) Potential
	Glycosylation	451	1	N-linked (GlcNAc...) Potential
	Disulfide bond	409 ↔ 475		By similarity
	Disulfide bond	438 ↔ 507		By similarity
	Disulfide bond	442 ↔ 509		By similarity
	Disulfide bond	474		Interchain By similarity
Experimental info
	Sequence conflict	73	1	K → M Ref.4
	Sequence conflict	75	1	E → K Ref.4
	Sequence conflict	86	1	L → P in AAA40548. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P20722 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 910B68531289FCD2	FASTA	510	56,432
	10 20 30 40 50 60 MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR AEQPPPQSSS 70 80 90 100 110 120 SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ PPVLPPQQQQ QQQQQQTARE 130 140 150 160 170 180 EPPPGRLKSA PLFMLDLYNA LSNDDEEDGA SEGVGQEPGS HGGASSSQLR QPSPGAAHSL 190 200 210 220 230 240 NRKSLLAPGP GGGASPLTSA QDSAFLNDAD MVMSFVNLVE YDKEFSPHQR HHKEFKFNLS 250 260 270 280 290 300 QIPEGEAVTA AEFRVYKDCV VGSFKNQTFL ISIYQVLQEH QHRDSDLFLL DTRVVWASEE 310 320 330 340 350 360 GWLEFDITAT SNLWVVTPQH NMGLQLSVVT RDGLHVNPRA AGLVGRDGPY DKQPFMVAFF 370 380 390 400 410 420 KVSEVHVRTT RSASSRRRQQ SRNRSTQSQD VSRGSGSSDY NGSELKTACK KHELYVSFQD 430 440 450 460 470 480 LGWQDWIIAP KGYAANYCDG ECSFPLNAHM NATNHAIVQT LVHLMNPEYV PKPCCAPTKL 490 500 510 NAISVLYFDD NSNVILKKYR NMVVRACGCH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo." Gitelman S.E., Kobrin M.S., Ye J.Q., Lopez A.R., Lee A., Derynck R. J. Cell Biol. 126:1595-1609(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
[2]	"Structure and sequence of the mouse Bmp6 gene." Gitelman S.E., Kobrin M.S., Lee A., Fet V., Lyons K., Hogan B.L.M., Derynck R. Mamm. Genome 8:212-214(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily." Lyons K., Graycar J.L., Lee A., Hashmi S., Lindquist P.B., Chen E.Y., Hogan B.L.M., Derynck R. Proc. Natl. Acad. Sci. U.S.A. 86:4554-4558(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-510.
[5]	"Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot." Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N. Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SOSTDC1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80992 mRNA. Translation: CAA56917.1. U73520 , U73515, U73516, U73517, U73518, U73519 Genomic DNA. Translation: AAB18235.1. BC138593 mRNA. Translation: AAI38594.1. BC138595 mRNA. Translation: AAI38596.1. J04566 mRNA. Translation: AAA40548.1.
IPI	IPI00122582.
PIR	A54798.
RefSeq	NP_031582.1. NM_007556.2.
UniGene	Mm.385759.
3D structure databases
ProteinModelPortal	P20722.
SMR	P20722. Positions 407-510.
ModBase	Search...
Proteomic databases
PRIDE	P20722.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000171970; ENSMUSP00000126999; ENSMUSG00000039004.
GeneID	12161.
KEGG	mmu:12161.
UCSC	uc007qdp.1. mouse.
Organism-specific databases
CTD	654.
MGI	MGI:88182. Bmp6.
Phylogenomic databases
eggNOG	NOG272883.
GeneTree	ENSGT00620000087601.
HOGENOM	HOG000249476.
HOVERGEN	HBG004860.
InParanoid	B2RRV6.
KO	K16620.
OMA	WWGLLCS.
OrthoDB	EOG4GB76H.
Gene expression databases
ArrayExpress	P20722.
Bgee	P20722.
CleanEx	MM_BMP6.
Genevestigator	P20722.
GermOnline	ENSMUSG00000039004. Mus musculus.
Family and domain databases
InterPro	IPR002405. Inhibin_asu. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PRINTS	PR00669. INHIBINA.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280511.
SOURCE	Search...

Entry information

Entry name

BMP6_MOUSE

Accession

Primary (citable) accession number: P20722
Secondary accession number(s): B2RRV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program