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Protein

Bone morphogenetic protein 6

Gene

Bmp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation.By similarity

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: MGI
  • cartilage development Source: UniProtKB-KW
  • cell differentiation Source: MGI
  • cellular iron ion homeostasis Source: BHF-UCL
  • cellular response to BMP stimulus Source: MGI
  • cellular response to extracellular stimulus Source: BHF-UCL
  • cellular response to iron ion Source: BHF-UCL
  • cellular response to mechanical stimulus Source: Ensembl
  • endochondral ossification Source: MGI
  • eye development Source: UniProtKB
  • immune response Source: MGI
  • inflammatory response Source: UniProtKB
  • kidney development Source: UniProtKB
  • male genitalia development Source: MGI
  • multicellular organismal iron ion homeostasis Source: BHF-UCL
  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • osteoblast differentiation Source: MGI
  • positive regulation of aldosterone biosynthetic process Source: MGI
  • positive regulation of aldosterone secretion Source: Ensembl
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of chondrocyte differentiation Source: Ensembl
  • positive regulation of endothelial cell differentiation Source: DFLAT
  • positive regulation of endothelial cell proliferation Source: DFLAT
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of lipopolysaccharide-mediated signaling pathway Source: BHF-UCL
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • positive regulation of SMAD protein signal transduction Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • response to activity Source: Ensembl
  • response to glucocorticoid Source: Ensembl
  • response to magnesium ion Source: Ensembl
  • response to retinoic acid Source: Ensembl
  • SMAD protein signal transduction Source: BHF-UCL
  • type B pancreatic cell development Source: MGI

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 6
Short name:
BMP-6
Alternative name(s):
VG-1-related protein
Short name:
VGR-1
Gene namesi
Name:Bmp6
Synonyms:Bmp-6, Vgr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:88182 Bmp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003387221 – 371Sequence analysisAdd BLAST351
ChainiPRO_0000033873372 – 510Bone morphogenetic protein 6Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi409 ↔ 475By similarity
Disulfide bondi438 ↔ 507By similarity
Disulfide bondi442 ↔ 509By similarity
Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi474InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP20722
PaxDbiP20722
PRIDEiP20722

PTM databases

iPTMnetiP20722
PhosphoSitePlusiP20722

Expressioni

Tissue specificityi

Expressed in the lung. Low levels seen in the kidney.

Gene expression databases

BgeeiENSMUSG00000039004
CleanExiMM_BMP6
GenevisibleiP20722 MM

Interactioni

Subunit structurei

Interacts with SOSTDC1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198366, 1 interactor
STRINGi10090.ENSMUSP00000126999

Structurei

3D structure databases

ProteinModelPortaliP20722
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000249476
HOVERGENiHBG004860
InParanoidiP20722
KOiK16620
OMAiIYKDCVV
OrthoDBiEOG091G0C2J
PhylomeDBiP20722
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR
60 70 80 90 100
AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ
110 120 130 140 150
PPVLPPQQQQ QQQQQQTARE EPPPGRLKSA PLFMLDLYNA LSNDDEEDGA
160 170 180 190 200
SEGVGQEPGS HGGASSSQLR QPSPGAAHSL NRKSLLAPGP GGGASPLTSA
210 220 230 240 250
QDSAFLNDAD MVMSFVNLVE YDKEFSPHQR HHKEFKFNLS QIPEGEAVTA
260 270 280 290 300
AEFRVYKDCV VGSFKNQTFL ISIYQVLQEH QHRDSDLFLL DTRVVWASEE
310 320 330 340 350
GWLEFDITAT SNLWVVTPQH NMGLQLSVVT RDGLHVNPRA AGLVGRDGPY
360 370 380 390 400
DKQPFMVAFF KVSEVHVRTT RSASSRRRQQ SRNRSTQSQD VSRGSGSSDY
410 420 430 440 450
NGSELKTACK KHELYVSFQD LGWQDWIIAP KGYAANYCDG ECSFPLNAHM
460 470 480 490 500
NATNHAIVQT LVHLMNPEYV PKPCCAPTKL NAISVLYFDD NSNVILKKYR
510
NMVVRACGCH
Length:510
Mass (Da):56,432
Last modified:October 1, 1996 - v2
Checksum:i910B68531289FCD2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73K → M (PubMed:2734307).Curated1
Sequence conflicti75E → K (PubMed:2734307).Curated1
Sequence conflicti86L → P in AAA40548 (PubMed:2734307).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80992 mRNA Translation: CAA56917.1
U73520
, U73515, U73516, U73517, U73518, U73519 Genomic DNA Translation: AAB18235.1
BC138593 mRNA Translation: AAI38594.1
BC138595 mRNA Translation: AAI38596.1
J04566 mRNA Translation: AAA40548.1
CCDSiCCDS26462.1
PIRiA54798
RefSeqiNP_031582.1, NM_007556.3
UniGeneiMm.385759

Genome annotation databases

EnsembliENSMUST00000171970; ENSMUSP00000126999; ENSMUSG00000039004
GeneIDi12161
KEGGimmu:12161
UCSCiuc007qdp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBMP6_MOUSE
AccessioniPrimary (citable) accession number: P20722
Secondary accession number(s): B2RRV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health