Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P20720

- UD12_RAT

UniProt

P20720 - UD12_RAT

Protein

UDP-glucuronosyltransferase 1-2

Gene

Ugt1a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. liver development Source: RGD
    2. organ regeneration Source: RGD
    3. response to organic cyclic compound Source: RGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 5301.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-2 (EC:2.4.1.17)
    Short name:
    UDPGT 1-2
    Short name:
    UGT1*2
    Short name:
    UGT1-02
    Short name:
    UGT1.2
    Alternative name(s):
    B2
    Bilirubin-specific UDPGT
    UDP-glucuronosyltransferase 1A2
    Short name:
    UGT1A2
    Gene namesi
    Name:Ugt1a2
    Synonyms:Ugt1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1549741. Ugt1a2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 533506UDP-glucuronosyltransferase 1-2PRO_0000036013Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP20720.

    Expressioni

    Gene expression databases

    GenevestigatoriP20720.

    Structurei

    3D structure databases

    ProteinModelPortaliP20720.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei491 – 50717HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000220832.
    HOVERGENiHBG004033.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

    Isoform 1 (identifier: P20720-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDTGLCAPLR GLSGLLLLLC ALPWAEGGKV LVFPMEGSHW LSMRDVVREL    50
    HARGHQAVVL APEVTVHMKG EDFFTLQTYA FPYTKEEYQR EILGNAKKGF 100
    EPQHFVKTFF ETMASIKKFF DLYANSCAAL LHNKTLIQQL NSSSFDVVLT 150
    DPVFPCGALL AKYLQIPAVF FLRSVPCGID YEATQCPKPS SYIPNLLTML 200
    SDHMTFLQRV KNMLYPLTLK YICHLSITPY ESLASELLQR EMSLVEVLSH 250
    ASVWLFRGDF VFDYPRPIMP NMVFIGGINC VIKKPLSQEF EAYVNASGEH 300
    GIVVFSLGSM VSEIPEKKAM EIAEALGRIP QTLLWRYTGT RPSNLAKNTI 350
    LVKWLPQNDL LGHPKARAFI THSGSHGIYE GICNGVPMVM MPLFGDQMDN 400
    AKRMETRGAG VTLNVLEMTA DDLENALKTV INNKSYKENI MRLSSLHKDR 450
    PIEPLDLAVF WVEYVMRHKG APHLRPAAHD LTWYQYHSLD VIGFLLAIVL 500
    TVVFIVYKSC AYGCRKCFGG KGRVKKSHKS KTH 533
    Length:533
    Mass (Da):60,045
    Last modified:November 1, 1997 - v2
    Checksum:i5A9E974EF7EBAF5B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 32Missing(PubMed:2112380)Curated
    Sequence conflicti177 – 1782CG → SP in BAA07261. (PubMed:7608130)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34007 mRNA. Translation: AAA42312.1.
    D38066 Genomic DNA. Translation: BAA07261.1.
    PIRiA35343.
    UniGeneiRn.26489.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34007 mRNA. Translation: AAA42312.1 .
    D38066 Genomic DNA. Translation: BAA07261.1 .
    PIRi A35343.
    UniGenei Rn.26489.

    3D structure databases

    ProteinModelPortali P20720.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PRIDEi P20720.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 1549741. Ugt1a2.

    Phylogenomic databases

    HOGENOMi HOG000220832.
    HOVERGENi HBG004033.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 5301.

    Gene expression databases

    Genevestigatori P20720.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
      Sato H., Koiwai O., Tanabe K., Kashiwamata S.
      Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
      Emi Y., Ikushiro S., Iyanagi T.
      J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-288.
      Strain: Wistar.

    Entry informationi

    Entry nameiUD12_RAT
    AccessioniPrimary (citable) accession number: P20720
    Secondary accession number(s): Q64636
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3