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P20720

- UD12_RAT

UniProt

P20720 - UD12_RAT

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Protein
UDP-glucuronosyltransferase 1-2
Gene
Ugt1a2, Ugt1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. liver development Source: RGD
  2. organ regeneration Source: RGD
  3. response to organic cyclic compound Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-2 (EC:2.4.1.17)
Short name:
UDPGT 1-2
Short name:
UGT1*2
Short name:
UGT1-02
Short name:
UGT1.2
Alternative name(s):
B2
Bilirubin-specific UDPGT
UDP-glucuronosyltransferase 1A2
Short name:
UGT1A2
Gene namesi
Name:Ugt1a2
Synonyms:Ugt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1549741. Ugt1a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei491 – 50717Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 533506UDP-glucuronosyltransferase 1-2
PRO_0000036013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi141 – 1411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi295 – 2951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP20720.

Expressioni

Gene expression databases

GenevestigatoriP20720.

Structurei

3D structure databases

ProteinModelPortaliP20720.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000220832.
HOVERGENiHBG004033.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: P20720-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDTGLCAPLR GLSGLLLLLC ALPWAEGGKV LVFPMEGSHW LSMRDVVREL    50
HARGHQAVVL APEVTVHMKG EDFFTLQTYA FPYTKEEYQR EILGNAKKGF 100
EPQHFVKTFF ETMASIKKFF DLYANSCAAL LHNKTLIQQL NSSSFDVVLT 150
DPVFPCGALL AKYLQIPAVF FLRSVPCGID YEATQCPKPS SYIPNLLTML 200
SDHMTFLQRV KNMLYPLTLK YICHLSITPY ESLASELLQR EMSLVEVLSH 250
ASVWLFRGDF VFDYPRPIMP NMVFIGGINC VIKKPLSQEF EAYVNASGEH 300
GIVVFSLGSM VSEIPEKKAM EIAEALGRIP QTLLWRYTGT RPSNLAKNTI 350
LVKWLPQNDL LGHPKARAFI THSGSHGIYE GICNGVPMVM MPLFGDQMDN 400
AKRMETRGAG VTLNVLEMTA DDLENALKTV INNKSYKENI MRLSSLHKDR 450
PIEPLDLAVF WVEYVMRHKG APHLRPAAHD LTWYQYHSLD VIGFLLAIVL 500
TVVFIVYKSC AYGCRKCFGG KGRVKKSHKS KTH 533
Length:533
Mass (Da):60,045
Last modified:November 1, 1997 - v2
Checksum:i5A9E974EF7EBAF5B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 32Missing1 Publication
Sequence conflicti177 – 1782CG → SP in BAA07261. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34007 mRNA. Translation: AAA42312.1.
D38066 Genomic DNA. Translation: BAA07261.1.
PIRiA35343.
UniGeneiRn.26489.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34007 mRNA. Translation: AAA42312.1 .
D38066 Genomic DNA. Translation: BAA07261.1 .
PIRi A35343.
UniGenei Rn.26489.

3D structure databases

ProteinModelPortali P20720.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEi P20720.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 1549741. Ugt1a2.

Phylogenomic databases

HOGENOMi HOG000220832.
HOVERGENi HBG004033.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 5301.

Gene expression databases

Genevestigatori P20720.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
    Sato H., Koiwai O., Tanabe K., Kashiwamata S.
    Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
    Emi Y., Ikushiro S., Iyanagi T.
    J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-288.
    Strain: Wistar.

Entry informationi

Entry nameiUD12_RAT
AccessioniPrimary (citable) accession number: P20720
Secondary accession number(s): Q64636
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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