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P20720 (UD12_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 1-2

Short name=UDPGT 1-2
Short name=UGT1*2
Short name=UGT1-02
Short name=UGT1.2
EC=2.4.1.17
Alternative name(s):
B2
Bilirubin-specific UDPGT
UDP-glucuronosyltransferase 1A2
Short name=UGT1A2
Gene names
Name:Ugt1a2
Synonyms:Ugt1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length533 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: P20720-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 533506UDP-glucuronosyltransferase 1-2
PRO_0000036013

Regions

Transmembrane491 – 50717Helical; Potential

Amino acid modifications

Glycosylation1331N-linked (GlcNAc...) Potential
Glycosylation1411N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2 – 32Missing Ref.1
Sequence conflict177 – 1782CG → SP in BAA07261. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 5A9E974EF7EBAF5B

FASTA53360,045
        10         20         30         40         50         60 
MDTGLCAPLR GLSGLLLLLC ALPWAEGGKV LVFPMEGSHW LSMRDVVREL HARGHQAVVL 

        70         80         90        100        110        120 
APEVTVHMKG EDFFTLQTYA FPYTKEEYQR EILGNAKKGF EPQHFVKTFF ETMASIKKFF 

       130        140        150        160        170        180 
DLYANSCAAL LHNKTLIQQL NSSSFDVVLT DPVFPCGALL AKYLQIPAVF FLRSVPCGID 

       190        200        210        220        230        240 
YEATQCPKPS SYIPNLLTML SDHMTFLQRV KNMLYPLTLK YICHLSITPY ESLASELLQR 

       250        260        270        280        290        300 
EMSLVEVLSH ASVWLFRGDF VFDYPRPIMP NMVFIGGINC VIKKPLSQEF EAYVNASGEH 

       310        320        330        340        350        360 
GIVVFSLGSM VSEIPEKKAM EIAEALGRIP QTLLWRYTGT RPSNLAKNTI LVKWLPQNDL 

       370        380        390        400        410        420 
LGHPKARAFI THSGSHGIYE GICNGVPMVM MPLFGDQMDN AKRMETRGAG VTLNVLEMTA 

       430        440        450        460        470        480 
DDLENALKTV INNKSYKENI MRLSSLHKDR PIEPLDLAVF WVEYVMRHKG APHLRPAAHD 

       490        500        510        520        530 
LTWYQYHSLD VIGFLLAIVL TVVFIVYKSC AYGCRKCFGG KGRVKKSHKS KTH 

« Hide

References

[1]"Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
Sato H., Koiwai O., Tanabe K., Kashiwamata S.
Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
Emi Y., Ikushiro S., Iyanagi T.
J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-288.
Strain: Wistar.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34007 mRNA. Translation: AAA42312.1.
D38066 Genomic DNA. Translation: BAA07261.1.
PIRA35343.
UniGeneRn.26489.

3D structure databases

ProteinModelPortalP20720.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEP20720.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD1549741. Ugt1a2.

Phylogenomic databases

HOGENOMHOG000220832.
HOVERGENHBG004033.

Enzyme and pathway databases

BRENDA2.4.1.17. 5301.

Gene expression databases

GenevestigatorP20720.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUD12_RAT
AccessionPrimary (citable) accession number: P20720
Secondary accession number(s): Q64636
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families