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Protein

UDP-glucuronosyltransferase 1-2

Gene

Ugt1a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: GO_Central

GO - Biological processi

  1. cellular response to hormone stimulus Source: GO_Central
  2. flavonoid biosynthetic process Source: GO_Central
  3. flavonoid glucuronidation Source: GO_Central
  4. liver development Source: RGD
  5. organ regeneration Source: RGD
  6. response to organic cyclic compound Source: RGD
  7. xenobiotic glucuronidation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-2 (EC:2.4.1.17)
Short name:
UDPGT 1-2
Short name:
UGT1*2
Short name:
UGT1-02
Short name:
UGT1.2
Alternative name(s):
B2
Bilirubin-specific UDPGT
UDP-glucuronosyltransferase 1A2
Short name:
UGT1A2
Gene namesi
Name:Ugt1a2
Synonyms:Ugt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1549741. Ugt1a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei491 – 50717HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: GO_Central
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 533506UDP-glucuronosyltransferase 1-2PRO_0000036013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP20720.

Expressioni

Gene expression databases

GenevestigatoriP20720.

Structurei

3D structure databases

ProteinModelPortaliP20720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiP20720.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: P20720-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTGLCAPLR GLSGLLLLLC ALPWAEGGKV LVFPMEGSHW LSMRDVVREL
60 70 80 90 100
HARGHQAVVL APEVTVHMKG EDFFTLQTYA FPYTKEEYQR EILGNAKKGF
110 120 130 140 150
EPQHFVKTFF ETMASIKKFF DLYANSCAAL LHNKTLIQQL NSSSFDVVLT
160 170 180 190 200
DPVFPCGALL AKYLQIPAVF FLRSVPCGID YEATQCPKPS SYIPNLLTML
210 220 230 240 250
SDHMTFLQRV KNMLYPLTLK YICHLSITPY ESLASELLQR EMSLVEVLSH
260 270 280 290 300
ASVWLFRGDF VFDYPRPIMP NMVFIGGINC VIKKPLSQEF EAYVNASGEH
310 320 330 340 350
GIVVFSLGSM VSEIPEKKAM EIAEALGRIP QTLLWRYTGT RPSNLAKNTI
360 370 380 390 400
LVKWLPQNDL LGHPKARAFI THSGSHGIYE GICNGVPMVM MPLFGDQMDN
410 420 430 440 450
AKRMETRGAG VTLNVLEMTA DDLENALKTV INNKSYKENI MRLSSLHKDR
460 470 480 490 500
PIEPLDLAVF WVEYVMRHKG APHLRPAAHD LTWYQYHSLD VIGFLLAIVL
510 520 530
TVVFIVYKSC AYGCRKCFGG KGRVKKSHKS KTH
Length:533
Mass (Da):60,045
Last modified:November 1, 1997 - v2
Checksum:i5A9E974EF7EBAF5B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 32Missing (PubMed:2112380).Curated
Sequence conflicti177 – 1782CG → SP in BAA07261 (PubMed:7608130).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34007 mRNA. Translation: AAA42312.1.
D38066 Genomic DNA. Translation: BAA07261.1.
PIRiA35343.
UniGeneiRn.26489.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34007 mRNA. Translation: AAA42312.1.
D38066 Genomic DNA. Translation: BAA07261.1.
PIRiA35343.
UniGeneiRn.26489.

3D structure databases

ProteinModelPortaliP20720.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEiP20720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1549741. Ugt1a2.

Phylogenomic databases

HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiP20720.

Enzyme and pathway databases

BRENDAi2.4.1.17. 5301.

Miscellaneous databases

PROiP20720.

Gene expression databases

GenevestigatoriP20720.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript."
    Sato H., Koiwai O., Tanabe K., Kashiwamata S.
    Biochem. Biophys. Res. Commun. 169:260-264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
    Emi Y., Ikushiro S., Iyanagi T.
    J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-288.
    Strain: Wistar.

Entry informationi

Entry nameiUD12_RAT
AccessioniPrimary (citable) accession number: P20720
Secondary accession number(s): Q64636
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 1, 1997
Last modified: April 29, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.