ID   HXA5_HUMAN              Reviewed;         270 AA.
AC   P20719; A4D179; O43367; Q96CY6;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   24-JAN-2024, entry version 203.
DE   RecName: Full=Homeobox protein Hox-A5;
DE   AltName: Full=Homeobox protein Hox-1C;
GN   Name=HOXA5; Synonyms=HOX1C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2568583; DOI=10.1128/mcb.9.5.2273-2278.1989;
RA   Tournier-Lasserve E., Odenwald W.F., Garbern J., Trojanowski J.,
RA   Lazzarini R.A.;
RT   "Remarkable intron and exon sequence conservation in human and mouse
RT   homeobox Hox 1.3 genes.";
RL   Mol. Cell. Biol. 9:2273-2278(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA   Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA   LaBaer J.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-260.
RX   PubMed=2576652; DOI=10.1139/g89-133;
RA   Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA   Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT   "Organization of human class I homeobox genes.";
RL   Genome 31:745-756(1989).
RN   [9]
RP   INTERACTION WITH PBX1.
RX   PubMed=7791786; DOI=10.1128/mcb.15.7.3786;
RA   Lu Q., Knoepfler P.S., Scheele J., Wright D.D., Kamps M.P.;
RT   "Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the
RT   products of multiple murine Hox genes, some of which are themselves
RT   oncogenes.";
RL   Mol. Cell. Biol. 15:3786-3795(1995).
RN   [10]
RP   INTERACTION WITH PBX1.
RX   PubMed=9191052; DOI=10.1038/sj.onc.1201097;
RA   Knoepfler P.S., Kamps M.P.;
RT   "The highest affinity DNA element bound by Pbx complexes in t(1;19)
RT   leukemic cells fails to mediate cooperative DNA-binding or cooperative
RT   transactivation by E2a-Pbx1 and class I Hox proteins - evidence for
RT   selective targetting of E2a-Pbx1 to a subset of Pbx-recognition elements.";
RL   Oncogene 14:2521-2531(1997).
RN   [11]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Also binds to its
CC       own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
CC   -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC       PBX1. {ECO:0000269|PubMed:7791786, ECO:0000269|PubMed:9191052}.
CC   -!- INTERACTION:
CC       P20719; Q92870-2: APBB2; NbExp=3; IntAct=EBI-8470697, EBI-21535880;
CC       P20719; P56545-3: CTBP2; NbExp=5; IntAct=EBI-8470697, EBI-10171902;
CC       P20719; Q92997: DVL3; NbExp=3; IntAct=EBI-8470697, EBI-739789;
CC       P20719; P42858: HTT; NbExp=9; IntAct=EBI-8470697, EBI-466029;
CC       P20719; P40425: PBX2; NbExp=5; IntAct=EBI-8470697, EBI-348489;
CC       P20719; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-8470697, EBI-79165;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis and in adult
CC       kidney.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; M26679; AAA58663.1; -; Genomic_DNA.
DR   EMBL; BT009744; AAP88746.1; -; mRNA.
DR   EMBL; CR542256; CAG47052.1; -; mRNA.
DR   EMBL; AC004080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH236948; EAL24223.1; -; Genomic_DNA.
DR   EMBL; CH471073; EAW93873.1; -; Genomic_DNA.
DR   EMBL; BC013682; AAH13682.1; -; mRNA.
DR   CCDS; CCDS5406.1; -.
DR   PIR; A24777; A24777.
DR   PIR; A32799; WJHU1C.
DR   RefSeq; NP_061975.2; NM_019102.3.
DR   AlphaFoldDB; P20719; -.
DR   SMR; P20719; -.
DR   BioGRID; 109442; 84.
DR   IntAct; P20719; 32.
DR   MINT; P20719; -.
DR   STRING; 9606.ENSP00000222726; -.
DR   GlyGen; P20719; 2 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; P20719; -.
DR   PhosphoSitePlus; P20719; -.
DR   BioMuta; HOXA5; -.
DR   DMDM; 52788238; -.
DR   EPD; P20719; -.
DR   jPOST; P20719; -.
DR   MassIVE; P20719; -.
DR   MaxQB; P20719; -.
DR   PaxDb; 9606-ENSP00000222726; -.
DR   PeptideAtlas; P20719; -.
DR   ProteomicsDB; 53780; -.
DR   Pumba; P20719; -.
DR   Antibodypedia; 25931; 504 antibodies from 33 providers.
DR   DNASU; 3202; -.
DR   Ensembl; ENST00000222726.4; ENSP00000222726.3; ENSG00000106004.5.
DR   GeneID; 3202; -.
DR   KEGG; hsa:3202; -.
DR   MANE-Select; ENST00000222726.4; ENSP00000222726.3; NM_019102.4; NP_061975.2.
DR   UCSC; uc003syn.2; human.
DR   AGR; HGNC:5106; -.
DR   CTD; 3202; -.
DR   DisGeNET; 3202; -.
DR   GeneCards; HOXA5; -.
DR   HGNC; HGNC:5106; HOXA5.
DR   HPA; ENSG00000106004; Tissue enhanced (adrenal gland, epididymis, fallopian tube).
DR   MIM; 142952; gene.
DR   neXtProt; NX_P20719; -.
DR   OpenTargets; ENSG00000106004; -.
DR   PharmGKB; PA29383; -.
DR   VEuPathDB; HostDB:ENSG00000106004; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000159894; -.
DR   HOGENOM; CLU_061398_2_0_1; -.
DR   InParanoid; P20719; -.
DR   OMA; HNYGEHN; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P20719; -.
DR   TreeFam; TF316310; -.
DR   PathwayCommons; P20719; -.
DR   SignaLink; P20719; -.
DR   SIGNOR; P20719; -.
DR   BioGRID-ORCS; 3202; 20 hits in 1175 CRISPR screens.
DR   GeneWiki; HOXA5; -.
DR   GenomeRNAi; 3202; -.
DR   Pharos; P20719; Tbio.
DR   PRO; PR:P20719; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; P20719; Protein.
DR   Bgee; ENSG00000106004; Expressed in adrenal tissue and 147 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0060435; P:bronchiole development; IEA:Ensembl.
DR   GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR   GO; GO:0060764; P:cell-cell signaling involved in mammary gland development; IEA:Ensembl.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR   GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Ensembl.
DR   GO; GO:0060574; P:intestinal epithelial cell maturation; IEA:Ensembl.
DR   GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR   GO; GO:0060480; P:lung goblet cell differentiation; IEA:Ensembl.
DR   GO; GO:0060484; P:lung-associated mesenchyme development; IEA:Ensembl.
DR   GO; GO:0060749; P:mammary gland alveolus development; IEA:Ensembl.
DR   GO; GO:0060644; P:mammary gland epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0060638; P:mesenchymal-epithelial cell signaling; IEA:Ensembl.
DR   GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IMP:UniProtKB.
DR   GO; GO:0045647; P:negative regulation of erythrocyte differentiation; IDA:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
DR   GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IDA:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR   GO; GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0003016; P:respiratory system process; IEA:Ensembl.
DR   GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR   GO; GO:0060535; P:trachea cartilage morphogenesis; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF10; HOMEOBOX PROTEIN HOX-A5; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P20719; HS.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..270
FT                   /note="Homeobox protein Hox-A5"
FT                   /id="PRO_0000200057"
FT   DNA_BIND        195..254
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          75..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           176..181
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        85..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..166
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        114
FT                   /note="S -> T (in Ref. 1; AAA58663)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   270 AA;  29345 MW;  2093BB73101AFCCC CRC64;
     MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG
     SGHFGSGERA RSYAASASAA PAEPRYSQPA TSTHSPQPDP LPCSAVAPSP GSDSHHGGKN
     SLSNSSGASA DAGSTHISSR EGVGTASGAE EDAPASSEQA SAQSEPSPAP PAQPQIYPWM
     RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK
     IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP
//