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Protein

Homeobox protein Hox-A5

Gene

HOXA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi195 – 25460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. bronchiole development Source: Ensembl
  3. cell-cell signaling involved in mammary gland development Source: Ensembl
  4. cell migration Source: Ensembl
  5. embryonic skeletal system morphogenesis Source: Ensembl
  6. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  7. intestinal epithelial cell maturation Source: Ensembl
  8. lung alveolus development Source: Ensembl
  9. lung-associated mesenchyme development Source: Ensembl
  10. lung goblet cell differentiation Source: Ensembl
  11. mammary gland alveolus development Source: Ensembl
  12. mammary gland epithelial cell differentiation Source: Ensembl
  13. mesenchymal-epithelial cell signaling Source: Ensembl
  14. multicellular organism growth Source: Ensembl
  15. negative regulation of angiogenesis Source: UniProtKB
  16. negative regulation of erythrocyte differentiation Source: UniProtKB
  17. positive regulation of apoptotic process Source: UniProtKB
  18. positive regulation of myeloid cell differentiation Source: UniProtKB
  19. positive regulation of receptor biosynthetic process Source: UniProtKB
  20. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  21. regulation of mammary gland epithelial cell proliferation Source: Ensembl
  22. respiratory system process Source: Ensembl
  23. thyroid gland development Source: Ensembl
  24. trachea cartilage morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP20719.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A5
Alternative name(s):
Homeobox protein Hox-1C
Gene namesi
Name:HOXA5
Synonyms:HOX1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:5106. HOXA5.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Homeobox protein Hox-A5PRO_0000200057Add
BLAST

Proteomic databases

MaxQBiP20719.
PaxDbiP20719.
PRIDEiP20719.

PTM databases

PhosphoSiteiP20719.

Expressioni

Developmental stagei

Expressed during embryogenesis and in adult kidney.

Gene expression databases

BgeeiP20719.
CleanExiHS_HOXA5.
GenevestigatoriP20719.

Organism-specific databases

HPAiCAB032627.
HPA029319.

Interactioni

Protein-protein interaction databases

BioGridi109442. 17 interactions.
IntActiP20719. 1 interaction.
MINTiMINT-2801671.
STRINGi9606.ENSP00000222726.

Structurei

3D structure databases

ProteinModelPortaliP20719.
SMRiP20719. Positions 202-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 1816Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG236516.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP20719.
KOiK09305.
OMAiYRDSASM.
OrthoDBiEOG780RP4.
PhylomeDBiP20719.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20719-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN
60 70 80 90 100
GMDLSVGRSG SGHFGSGERA RSYAASASAA PAEPRYSQPA TSTHSPQPDP
110 120 130 140 150
LPCSAVAPSP GSDSHHGGKN SLSNSSGASA DAGSTHISSR EGVGTASGAE
160 170 180 190 200
EDAPASSEQA SAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART
210 220 230 240 250
AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW
260 270
KKDNKLKSMS MAAAGGAFRP
Length:270
Mass (Da):29,345
Last modified:September 27, 2004 - v2
Checksum:i2093BB73101AFCCC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141S → T in AAA58663. (PubMed:2568583)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26679 Genomic DNA. Translation: AAA58663.1.
BT009744 mRNA. Translation: AAP88746.1.
CR542256 mRNA. Translation: CAG47052.1.
AC004080 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24223.1.
CH471073 Genomic DNA. Translation: EAW93873.1.
BC013682 mRNA. Translation: AAH13682.1.
CCDSiCCDS5406.1.
PIRiA24777.
A32799. WJHU1C.
RefSeqiNP_061975.2. NM_019102.3.
UniGeneiHs.655218.

Genome annotation databases

EnsembliENST00000222726; ENSP00000222726; ENSG00000106004.
GeneIDi3202.
KEGGihsa:3202.
UCSCiuc003syn.2. human.

Polymorphism databases

DMDMi52788238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26679 Genomic DNA. Translation: AAA58663.1.
BT009744 mRNA. Translation: AAP88746.1.
CR542256 mRNA. Translation: CAG47052.1.
AC004080 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24223.1.
CH471073 Genomic DNA. Translation: EAW93873.1.
BC013682 mRNA. Translation: AAH13682.1.
CCDSiCCDS5406.1.
PIRiA24777.
A32799. WJHU1C.
RefSeqiNP_061975.2. NM_019102.3.
UniGeneiHs.655218.

3D structure databases

ProteinModelPortaliP20719.
SMRiP20719. Positions 202-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109442. 17 interactions.
IntActiP20719. 1 interaction.
MINTiMINT-2801671.
STRINGi9606.ENSP00000222726.

PTM databases

PhosphoSiteiP20719.

Polymorphism databases

DMDMi52788238.

Proteomic databases

MaxQBiP20719.
PaxDbiP20719.
PRIDEiP20719.

Protocols and materials databases

DNASUi3202.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222726; ENSP00000222726; ENSG00000106004.
GeneIDi3202.
KEGGihsa:3202.
UCSCiuc003syn.2. human.

Organism-specific databases

CTDi3202.
GeneCardsiGC07M027180.
H-InvDBHIX0201165.
HGNCiHGNC:5106. HOXA5.
HPAiCAB032627.
HPA029319.
MIMi142952. gene.
neXtProtiNX_P20719.
PharmGKBiPA29383.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG236516.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP20719.
KOiK09305.
OMAiYRDSASM.
OrthoDBiEOG780RP4.
PhylomeDBiP20719.
TreeFamiTF316310.

Enzyme and pathway databases

SignaLinkiP20719.

Miscellaneous databases

GeneWikiiHOXA5.
GenomeRNAii3202.
NextBioi12740.
PROiP20719.
SOURCEiSearch...

Gene expression databases

BgeeiP20719.
CleanExiHS_HOXA5.
GenevestigatoriP20719.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Remarkable intron and exon sequence conservation in human and mouse homeobox Hox 1.3 genes."
    Tournier-Lasserve E., Odenwald W.F., Garbern J., Trojanowski J., Lazzarini R.A.
    Mol. Cell. Biol. 9:2273-2278(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  8. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-260.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiHXA5_HUMAN
AccessioniPrimary (citable) accession number: P20719
Secondary accession number(s): A4D179, O43367, Q96CY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: September 27, 2004
Last modified: February 4, 2015
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.