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P20719

- HXA5_HUMAN

UniProt

P20719 - HXA5_HUMAN

Protein

Homeobox protein Hox-A5

Gene

HOXA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (27 Sep 2004)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi195 – 25460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. bronchiole development Source: Ensembl
    3. cell-cell signaling involved in mammary gland development Source: Ensembl
    4. cell migration Source: Ensembl
    5. embryonic skeletal system morphogenesis Source: Ensembl
    6. epithelial tube branching involved in lung morphogenesis Source: Ensembl
    7. intestinal epithelial cell maturation Source: Ensembl
    8. lung alveolus development Source: Ensembl
    9. lung-associated mesenchyme development Source: Ensembl
    10. lung goblet cell differentiation Source: Ensembl
    11. mammary gland alveolus development Source: Ensembl
    12. mammary gland epithelial cell differentiation Source: Ensembl
    13. mesenchymal-epithelial cell signaling Source: Ensembl
    14. multicellular organism growth Source: Ensembl
    15. negative regulation of angiogenesis Source: UniProtKB
    16. negative regulation of erythrocyte differentiation Source: UniProtKB
    17. positive regulation of apoptotic process Source: UniProtKB
    18. positive regulation of myeloid cell differentiation Source: UniProtKB
    19. positive regulation of receptor biosynthetic process Source: UniProtKB
    20. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    21. regulation of mammary gland epithelial cell proliferation Source: Ensembl
    22. respiratory system process Source: Ensembl
    23. thyroid gland development Source: Ensembl
    24. trachea cartilage morphogenesis Source: Ensembl
    25. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP20719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A5
    Alternative name(s):
    Homeobox protein Hox-1C
    Gene namesi
    Name:HOXA5
    Synonyms:HOX1C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:5106. HOXA5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29383.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Homeobox protein Hox-A5PRO_0000200057Add
    BLAST

    Proteomic databases

    MaxQBiP20719.
    PaxDbiP20719.
    PRIDEiP20719.

    PTM databases

    PhosphoSiteiP20719.

    Expressioni

    Developmental stagei

    Expressed during embryogenesis and in adult kidney.

    Gene expression databases

    BgeeiP20719.
    CleanExiHS_HOXA5.
    GenevestigatoriP20719.

    Organism-specific databases

    HPAiCAB032627.
    HPA029319.

    Interactioni

    Protein-protein interaction databases

    BioGridi109442. 11 interactions.
    IntActiP20719. 1 interaction.
    MINTiMINT-2801671.
    STRINGi9606.ENSP00000222726.

    Structurei

    3D structure databases

    ProteinModelPortaliP20719.
    SMRiP20719. Positions 202-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi176 – 1816Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG236516.
    HOGENOMiHOG000231178.
    HOVERGENiHBG016849.
    InParanoidiP20719.
    KOiK09305.
    OMAiSVSEQYR.
    OrthoDBiEOG780RP4.
    PhylomeDBiP20719.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20719-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN    50
    GMDLSVGRSG SGHFGSGERA RSYAASASAA PAEPRYSQPA TSTHSPQPDP 100
    LPCSAVAPSP GSDSHHGGKN SLSNSSGASA DAGSTHISSR EGVGTASGAE 150
    EDAPASSEQA SAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART 200
    AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW 250
    KKDNKLKSMS MAAAGGAFRP 270
    Length:270
    Mass (Da):29,345
    Last modified:September 27, 2004 - v2
    Checksum:i2093BB73101AFCCC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141S → T in AAA58663. (PubMed:2568583)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26679 Genomic DNA. Translation: AAA58663.1.
    BT009744 mRNA. Translation: AAP88746.1.
    CR542256 mRNA. Translation: CAG47052.1.
    AC004080 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24223.1.
    CH471073 Genomic DNA. Translation: EAW93873.1.
    BC013682 mRNA. Translation: AAH13682.1.
    CCDSiCCDS5406.1.
    PIRiA24777.
    A32799. WJHU1C.
    RefSeqiNP_061975.2. NM_019102.3.
    UniGeneiHs.655218.

    Genome annotation databases

    EnsembliENST00000222726; ENSP00000222726; ENSG00000106004.
    GeneIDi3202.
    KEGGihsa:3202.
    UCSCiuc003syn.2. human.

    Polymorphism databases

    DMDMi52788238.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26679 Genomic DNA. Translation: AAA58663.1 .
    BT009744 mRNA. Translation: AAP88746.1 .
    CR542256 mRNA. Translation: CAG47052.1 .
    AC004080 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24223.1 .
    CH471073 Genomic DNA. Translation: EAW93873.1 .
    BC013682 mRNA. Translation: AAH13682.1 .
    CCDSi CCDS5406.1.
    PIRi A24777.
    A32799. WJHU1C.
    RefSeqi NP_061975.2. NM_019102.3.
    UniGenei Hs.655218.

    3D structure databases

    ProteinModelPortali P20719.
    SMRi P20719. Positions 202-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109442. 11 interactions.
    IntActi P20719. 1 interaction.
    MINTi MINT-2801671.
    STRINGi 9606.ENSP00000222726.

    PTM databases

    PhosphoSitei P20719.

    Polymorphism databases

    DMDMi 52788238.

    Proteomic databases

    MaxQBi P20719.
    PaxDbi P20719.
    PRIDEi P20719.

    Protocols and materials databases

    DNASUi 3202.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222726 ; ENSP00000222726 ; ENSG00000106004 .
    GeneIDi 3202.
    KEGGi hsa:3202.
    UCSCi uc003syn.2. human.

    Organism-specific databases

    CTDi 3202.
    GeneCardsi GC07M027180.
    H-InvDB HIX0201165.
    HGNCi HGNC:5106. HOXA5.
    HPAi CAB032627.
    HPA029319.
    MIMi 142952. gene.
    neXtProti NX_P20719.
    PharmGKBi PA29383.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG236516.
    HOGENOMi HOG000231178.
    HOVERGENi HBG016849.
    InParanoidi P20719.
    KOi K09305.
    OMAi SVSEQYR.
    OrthoDBi EOG780RP4.
    PhylomeDBi P20719.
    TreeFami TF316310.

    Enzyme and pathway databases

    SignaLinki P20719.

    Miscellaneous databases

    GeneWikii HOXA5.
    GenomeRNAii 3202.
    NextBioi 12740.
    PROi P20719.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20719.
    CleanExi HS_HOXA5.
    Genevestigatori P20719.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Remarkable intron and exon sequence conservation in human and mouse homeobox Hox 1.3 genes."
      Tournier-Lasserve E., Odenwald W.F., Garbern J., Trojanowski J., Lazzarini R.A.
      Mol. Cell. Biol. 9:2273-2278(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    8. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-260.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiHXA5_HUMAN
    AccessioniPrimary (citable) accession number: P20719
    Secondary accession number(s): A4D179, O43367, Q96CY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3