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Protein

Homeobox protein Hox-A5

Gene

HOXA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 254HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP20719.
SIGNORiP20719.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A5
Alternative name(s):
Homeobox protein Hox-1C
Gene namesi
Name:HOXA5
Synonyms:HOX1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:5106. HOXA5.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3202.
OpenTargetsiENSG00000106004.
PharmGKBiPA29383.

Polymorphism and mutation databases

BioMutaiHOXA5.
DMDMi52788238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000571 – 270Homeobox protein Hox-A5Add BLAST270

Proteomic databases

MaxQBiP20719.
PaxDbiP20719.
PeptideAtlasiP20719.
PRIDEiP20719.

PTM databases

iPTMnetiP20719.
PhosphoSitePlusiP20719.

Expressioni

Developmental stagei

Expressed during embryogenesis and in adult kidney.

Gene expression databases

BgeeiENSG00000106004.
CleanExiHS_HOXA5.
GenevisibleiP20719. HS.

Organism-specific databases

HPAiHPA029319.

Interactioni

Protein-protein interaction databases

BioGridi109442. 36 interactors.
IntActiP20719. 6 interactors.
MINTiMINT-2801671.
STRINGi9606.ENSP00000222726.

Structurei

3D structure databases

ProteinModelPortaliP20719.
SMRiP20719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi176 – 181Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP20719.
KOiK09305.
OMAiLKSMNMA.
OrthoDBiEOG091G09XD.
PhylomeDBiP20719.
TreeFamiTF316310.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P20719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN
60 70 80 90 100
GMDLSVGRSG SGHFGSGERA RSYAASASAA PAEPRYSQPA TSTHSPQPDP
110 120 130 140 150
LPCSAVAPSP GSDSHHGGKN SLSNSSGASA DAGSTHISSR EGVGTASGAE
160 170 180 190 200
EDAPASSEQA SAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART
210 220 230 240 250
AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW
260 270
KKDNKLKSMS MAAAGGAFRP
Length:270
Mass (Da):29,345
Last modified:September 27, 2004 - v2
Checksum:i2093BB73101AFCCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114S → T in AAA58663 (PubMed:2568583).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26679 Genomic DNA. Translation: AAA58663.1.
BT009744 mRNA. Translation: AAP88746.1.
CR542256 mRNA. Translation: CAG47052.1.
AC004080 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24223.1.
CH471073 Genomic DNA. Translation: EAW93873.1.
BC013682 mRNA. Translation: AAH13682.1.
CCDSiCCDS5406.1.
PIRiA24777.
A32799. WJHU1C.
RefSeqiNP_061975.2. NM_019102.3.
UniGeneiHs.655218.

Genome annotation databases

EnsembliENST00000222726; ENSP00000222726; ENSG00000106004.
GeneIDi3202.
KEGGihsa:3202.
UCSCiuc003syn.2. human.

Similar proteinsi

Entry informationi

Entry nameiHXA5_HUMAN
AccessioniPrimary (citable) accession number: P20719
Secondary accession number(s): A4D179, O43367, Q96CY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: September 27, 2004
Last modified: August 30, 2017
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families