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Protein

Protein-arginine deiminase type-2

Gene

Padi2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein-arginine deiminase activity Source: UniProtKB

GO - Biological processi

  • protein citrullination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BRENDAi3.5.3.15. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-2 (EC:3.5.3.15)
Alternative name(s):
Peptidylarginine deiminase II
Protein-arginine deiminase type II
Gene namesi
Name:Padi2
Synonyms:Pad2, Pdi, Pdi2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3288. Padi2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665Protein-arginine deiminase type-2PRO_0000220028Add
BLAST

Proteomic databases

PaxDbiP20717.
PRIDEiP20717.

PTM databases

iPTMnetiP20717.
PhosphoSiteiP20717.

Expressioni

Tissue specificityi

Spinal cord, submaxillary gland, cerebrum, cerebellum, and skeletal muscle.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010183.

Structurei

3D structure databases

ProteinModelPortaliP20717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F. Eukaryota.
ENOG410ZKF3. LUCA.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiP20717.
KOiK01481.
PhylomeDBiP20717.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

P20717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRERTVRLQ YGSRVEAVYV LGTQLWTDVY SAAPAGAKTF SLKHSEGVKV
60 70 80 90 100
EVVRDGEAEE VVTNGKQRWA LSPSTTLRLS MAQASTEASS DKVTVNYYEE
110 120 130 140 150
DGSAPIDQAG LFLTAIEISL DVDADRDGEV EKNNPKKASW TWGPEGQGAI
160 170 180 190 200
LLVNCDRDTP WLPKEDCSDE KVYSKQDLQD MSQMILRTKG PDRLPAGYEI
210 220 230 240 250
VLYISMSDSD KVGVFYVENP FFGQRYIHIL GRQKLYHVVK YTGGSAELLF
260 270 280 290 300
FVEGLRFPDE SFSGLVSIHV SLLEYMAEDI PLTPIFTDTV TFRIAPWIMT
310 320 330 340 350
PNILPPVSVF VCCMKDNYLF LKEVKNLVEK TNCELKVCFQ YMNRGDRWIQ
360 370 380 390 400
DEIEFGYIEA PHKGFPVVLD SPRDGNLKDF PIKQLLGPDF GYVTREPLFE
410 420 430 440 450
TVTSLDSFGN LEVSPPVTVN GKAYPLGRIL IGSSFPLSGG RRMTKVVRDF
460 470 480 490 500
LQAQQVQAPV ELYSDWLTVG HVDEFMTFVP IPGKKEFRLL MASTSACYQL
510 520 530 540 550
FREKQKEGHG EAIMFKGLGG MSSKRITINK ILSNESLTQE NQYFQRCLDW
560 570 580 590 600
NRDILKKELA LTEKDIIDLP ALFKMDEDRQ ARAFFPNMVN MIVLDKDLGI
610 620 630 640 650
PKPFGPQVEE ECCLETHVRG LLEPLGLACT FIDDISAYHK FLGEVHCGTN
660
VRRKPFTFKW WHMVP
Length:665
Mass (Da):75,356
Last modified:February 1, 1991 - v1
Checksum:i96C38C8ECD7A0799
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05022 mRNA. Translation: AAA41793.1.
D10459 Genomic DNA. Translation: BAA01253.1.
PIRiA34339. DIRTR1.
RefSeqiNP_058922.1. NM_017226.1.
UniGeneiRn.98523.

Genome annotation databases

GeneIDi29511.
KEGGirno:29511.
UCSCiRGD:3288. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05022 mRNA. Translation: AAA41793.1.
D10459 Genomic DNA. Translation: BAA01253.1.
PIRiA34339. DIRTR1.
RefSeqiNP_058922.1. NM_017226.1.
UniGeneiRn.98523.

3D structure databases

ProteinModelPortaliP20717.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010183.

PTM databases

iPTMnetiP20717.
PhosphoSiteiP20717.

Proteomic databases

PaxDbiP20717.
PRIDEiP20717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29511.
KEGGirno:29511.
UCSCiRGD:3288. rat.

Organism-specific databases

CTDi11240.
RGDi3288. Padi2.

Phylogenomic databases

eggNOGiENOG410IF3F. Eukaryota.
ENOG410ZKF3. LUCA.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiP20717.
KOiK01481.
PhylomeDBiP20717.

Enzyme and pathway databases

BRENDAi3.5.3.15. 5301.

Miscellaneous databases

PROiP20717.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPADI2_RAT
AccessioniPrimary (citable) accession number: P20717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.