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Protein

Aromatic-L-amino-acid decarboxylase

Gene

DDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Catalytic activityi

L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

pyridoxal 5'-phosphate1 Publication

Pathwayi: dopamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dopamine from L-tyrosine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tyrosine 3-monooxygenase (TH)
  2. Aromatic-L-amino-acid decarboxylase (DDC)
This subpathway is part of the pathway dopamine biosynthesis, which is itself part of Catecholamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dopamine from L-tyrosine, the pathway dopamine biosynthesis and in Catecholamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82SubstrateBy similarity1
Binding sitei148Pyridoxal phosphate; via amide nitrogen1
Binding sitei149Pyridoxal phosphate1
Binding sitei192SubstrateBy similarity1
Binding sitei246Pyridoxal phosphate; via carbonyl oxygen1
Binding sitei300Pyridoxal phosphate1

GO - Molecular functioni

  • amino acid binding Source: Ensembl
  • aromatic-L-amino-acid decarboxylase activity Source: UniProtKB
  • enzyme binding Source: ParkinsonsUK-UCL
  • L-dopa decarboxylase activity Source: ParkinsonsUK-UCL
  • pyridoxal phosphate binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Catecholamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS05635-MONOMER.
ZFISH:HS05635-MONOMER.
BRENDAi4.1.1.28. 2681.
ReactomeiR-HSA-209905. Catecholamine biosynthesis.
R-HSA-209931. Serotonin and melatonin biosynthesis.
UniPathwayiUPA00747; UER00734.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic-L-amino-acid decarboxylase (EC:4.1.1.28)
Short name:
AADC
Alternative name(s):
DOPA decarboxylase
Short name:
DDC
Gene namesi
Name:DDC
Synonyms:AADC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:2719. DDC.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • synaptic vesicle Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Aromatic L-amino-acid decarboxylase deficiency (AADCD)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
See also OMIM:608643
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04613747P → H in AADCD. 1 PublicationCorresponds to variant rs780542462dbSNPEnsembl.1
Natural variantiVAR_04613891A → V in AADCD. 1 PublicationCorresponds to variant rs137853211dbSNPEnsembl.1
Natural variantiVAR_019309102G → S in AADCD. 2 PublicationsCorresponds to variant rs137853207dbSNPEnsembl.1
Natural variantiVAR_046139147S → R in AADCD. 1 PublicationCorresponds to variant rs137853210dbSNPEnsembl.1
Natural variantiVAR_046140250S → F in AADCD. 2 PublicationsCorresponds to variant rs137853208dbSNPEnsembl.1
Natural variantiVAR_046141275A → T in AADCD. 1 PublicationCorresponds to variant rs137853212dbSNPEnsembl.1
Natural variantiVAR_046142309F → L in AADCD. 1 PublicationCorresponds to variant rs137853209dbSNPEnsembl.1
Natural variantiVAR_046143347R → Q in AADCD. 1 PublicationCorresponds to variant rs201951824dbSNPEnsembl.1
Natural variantiVAR_046144408L → I in AADCD. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1644.
MalaCardsiDDC.
MIMi608643. phenotype.
OpenTargetsiENSG00000132437.
Orphaneti35708. Aromatic L-amino acid decarboxylase deficiency.
PharmGKBiPA140.

Chemistry databases

ChEMBLiCHEMBL1843.
DrugBankiDB00915. Amantadine.
DB00190. Carbidopa.
DB00260. Cycloserine.
DB06262. Droxidopa.
DB00875. Flupentixol.
DB00150. L-Tryptophan.
DB01235. Levodopa.
DB00968. Methyldopa.

Polymorphism and mutation databases

BioMutaiDDC.
DMDMi311033369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469391 – 480Aromatic-L-amino-acid decarboxylaseAdd BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei303N6-(pyridoxal phosphate)lysine1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP20711.
PaxDbiP20711.
PeptideAtlasiP20711.
PRIDEiP20711.

PTM databases

PhosphoSitePlusiP20711.

Expressioni

Gene expression databases

BgeeiENSG00000132437.
CleanExiHS_DDC.
ExpressionAtlasiP20711. baseline and differential.
GenevisibleiP20711. HS.

Organism-specific databases

HPAiHPA017742.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102752EBI-1632155,EBI-608057

GO - Molecular functioni

  • enzyme binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi108011. 3 interactors.
DIPiDIP-40563N.
IntActiP20711. 4 interactors.
STRINGi9606.ENSP00000350616.

Chemistry databases

BindingDBiP20711.

Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 22Combined sources20
Helixi24 – 26Combined sources3
Helixi39 – 41Combined sources3
Helixi53 – 63Combined sources11
Helixi65 – 67Combined sources3
Beta strandi78 – 80Combined sources3
Helixi86 – 98Combined sources13
Turni105 – 107Combined sources3
Helixi109 – 125Combined sources17
Helixi130 – 132Combined sources3
Beta strandi135 – 137Combined sources3
Beta strandi141 – 146Combined sources6
Helixi148 – 169Combined sources22
Helixi176 – 180Combined sources5
Beta strandi183 – 188Combined sources6
Helixi193 – 201Combined sources9
Beta strandi205 – 209Combined sources5
Helixi219 – 231Combined sources13
Beta strandi235 – 244Combined sources10
Turni246 – 248Combined sources3
Helixi254 – 263Combined sources10
Beta strandi267 – 271Combined sources5
Helixi275 – 280Combined sources6
Turni282 – 284Combined sources3
Helixi285 – 288Combined sources4
Helixi291 – 293Combined sources3
Beta strandi295 – 299Combined sources5
Helixi301 – 304Combined sources4
Beta strandi312 – 317Combined sources6
Helixi319 – 323Combined sources5
Helixi359 – 393Combined sources35
Beta strandi398 – 400Combined sources3
Beta strandi406 – 415Combined sources10
Helixi417 – 430Combined sources14
Beta strandi432 – 434Combined sources3
Beta strandi436 – 440Combined sources5
Beta strandi443 – 449Combined sources7
Helixi457 – 476Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RBFX-ray2.90A/B1-480[»]
3RBLX-ray3.24A/B1-480[»]
3RCHX-ray2.80A/B1-480[»]
ProteinModelPortaliP20711.
SMRiP20711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 1151Add BLAST58
Repeati118 – 1782Add BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 1782 X approximate tandem repeatsAdd BLAST121

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiP20711.
KOiK01593.
OMAiPICNKED.
OrthoDBiEOG091G03KI.
PhylomeDBiP20711.
TreeFamiTF313863.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20711-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNASEFRRRG KEMVDYMANY MEGIEGRQVY PDVEPGYLRP LIPAAAPQEP
60 70 80 90 100
DTFEDIINDV EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC
110 120 130 140 150
IGFSWAASPA CTELETVMMD WLGKMLELPK AFLNEKAGEG GGVIQGSASE
160 170 180 190 200
ATLVALLAAR TKVIHRLQAA SPELTQAAIM EKLVAYSSDQ AHSSVERAGL
210 220 230 240 250
IGGVKLKAIP SDGNFAMRAS ALQEALERDK AAGLIPFFMV ATLGTTTCCS
260 270 280 290 300
FDNLLEVGPI CNKEDIWLHV DAAYAGSAFI CPEFRHLLNG VEFADSFNFN
310 320 330 340 350
PHKWLLVNFD CSAMWVKKRT DLTGAFRLDP TYLKHSHQDS GLITDYRHWQ
360 370 380 390 400
IPLGRRFRSL KMWFVFRMYG VKGLQAYIRK HVQLSHEFES LVRQDPRFEI
410 420 430 440 450
CVEVILGLVC FRLKGSNKVN EALLQRINSA KKIHLVPCHL RDKFVLRFAI
460 470 480
CSRTVESAHV QRAWEHIKEL AADVLRAERE
Length:480
Mass (Da):53,926
Last modified:November 2, 2010 - v2
Checksum:i0A2CFF9A39BDE298
GO
Isoform 2 (identifier: P20711-2) [UniParc]FASTAAdd to basket
Also known as: alt-DDC

The sequence of this isoform differs from the canonical sequence as follows:
     316-338: VKKRTDLTGAFRLDPTYLKHSHQ → SRQPVRMLRLKKTCLVSAVVRRS
     339-480: Missing.

Note: High expression in kidney.
Show »
Length:338
Mass (Da):37,118
Checksum:i4197295F0675291A
GO
Isoform 3 (identifier: P20711-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-145: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:402
Mass (Da):45,479
Checksum:i04119E5E691B06A2
GO
Isoform 4 (identifier: P20711-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-238: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:387
Mass (Da):44,239
Checksum:iC9D8C9459140ADD4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49E → G in AAB59432 (PubMed:8510497).Curated1
Sequence conflicti155A → P in AAD40482 (PubMed:1540578).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01478817M → V.8 PublicationsCorresponds to variant rs6264dbSNPEnsembl.1
Natural variantiVAR_04613747P → H in AADCD. 1 PublicationCorresponds to variant rs780542462dbSNPEnsembl.1
Natural variantiVAR_01921461E → D.1 PublicationCorresponds to variant rs11575292dbSNPEnsembl.1
Natural variantiVAR_04613891A → V in AADCD. 1 PublicationCorresponds to variant rs137853211dbSNPEnsembl.1
Natural variantiVAR_019309102G → S in AADCD. 2 PublicationsCorresponds to variant rs137853207dbSNPEnsembl.1
Natural variantiVAR_046139147S → R in AADCD. 1 PublicationCorresponds to variant rs137853210dbSNPEnsembl.1
Natural variantiVAR_014789210P → L.2 PublicationsCorresponds to variant rs6262dbSNPEnsembl.1
Natural variantiVAR_014790217M → V.2 PublicationsCorresponds to variant rs6263dbSNPEnsembl.1
Natural variantiVAR_019215239M → I.1 PublicationCorresponds to variant rs11575377dbSNPEnsembl.1
Natural variantiVAR_019216239M → L.1 PublicationCorresponds to variant rs11575376dbSNPEnsembl.1
Natural variantiVAR_046140250S → F in AADCD. 2 PublicationsCorresponds to variant rs137853208dbSNPEnsembl.1
Natural variantiVAR_046141275A → T in AADCD. 1 PublicationCorresponds to variant rs137853212dbSNPEnsembl.1
Natural variantiVAR_046142309F → L in AADCD. 1 PublicationCorresponds to variant rs137853209dbSNPEnsembl.1
Natural variantiVAR_046143347R → Q in AADCD. 1 PublicationCorresponds to variant rs201951824dbSNPEnsembl.1
Natural variantiVAR_046144408L → I in AADCD. 1 Publication1
Natural variantiVAR_019217462R → Q.1 PublicationCorresponds to variant rs11575542dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04717568 – 145Missing in isoform 3. CuratedAdd BLAST78
Alternative sequenceiVSP_047176146 – 238Missing in isoform 4. CuratedAdd BLAST93
Alternative sequenceiVSP_046569316 – 338VKKRT…KHSHQ → SRQPVRMLRLKKTCLVSAVV RRS in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_046570339 – 480Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76180 mRNA. Translation: AAA58437.1.
M88700 mRNA. Translation: AAA20894.1.
M84592
, M84600, M84593, M84594, M84596, M84597, M84595, M84598, M84599, M84588, M84589, M84590, M84591 Genomic DNA. Translation: AAD40482.1.
AJ310724 mRNA. Translation: CAC84071.1.
AY526322 Genomic DNA. Translation: AAS00092.1.
AC018705 Genomic DNA. Translation: AAS01995.1.
BC000485 mRNA. Translation: AAH00485.1.
BC008366 mRNA. Translation: AAH08366.1.
AH005280 Genomic DNA. Translation: AAB59432.1.
S46516 Genomic DNA. Translation: AAB23675.1.
CCDSiCCDS5511.1. [P20711-1]
CCDS56485.1. [P20711-3]
CCDS56486.1. [P20711-4]
CCDS56487.1. [P20711-2]
PIRiA33663. DCHUA.
RefSeqiNP_000781.1. NM_000790.3.
NP_001076440.1. NM_001082971.1.
NP_001229815.1. NM_001242886.1.
NP_001229816.1. NM_001242887.1.
NP_001229817.1. NM_001242888.1.
NP_001229818.1. NM_001242889.1.
NP_001229819.1. NM_001242890.1.
UniGeneiHs.359698.

Genome annotation databases

EnsembliENST00000357936; ENSP00000350616; ENSG00000132437. [P20711-1]
ENST00000380984; ENSP00000370371; ENSG00000132437. [P20711-2]
ENST00000426377; ENSP00000395069; ENSG00000132437. [P20711-3]
ENST00000431062; ENSP00000399184; ENSG00000132437. [P20711-4]
ENST00000444124; ENSP00000403644; ENSG00000132437. [P20711-1]
ENST00000615193; ENSP00000484104; ENSG00000132437. [P20711-4]
GeneIDi1644.
KEGGihsa:1644.
UCSCiuc003tpf.5. human. [P20711-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Aromatic L-amino-acid decarboxylase entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76180 mRNA. Translation: AAA58437.1.
M88700 mRNA. Translation: AAA20894.1.
M84592
, M84600, M84593, M84594, M84596, M84597, M84595, M84598, M84599, M84588, M84589, M84590, M84591 Genomic DNA. Translation: AAD40482.1.
AJ310724 mRNA. Translation: CAC84071.1.
AY526322 Genomic DNA. Translation: AAS00092.1.
AC018705 Genomic DNA. Translation: AAS01995.1.
BC000485 mRNA. Translation: AAH00485.1.
BC008366 mRNA. Translation: AAH08366.1.
AH005280 Genomic DNA. Translation: AAB59432.1.
S46516 Genomic DNA. Translation: AAB23675.1.
CCDSiCCDS5511.1. [P20711-1]
CCDS56485.1. [P20711-3]
CCDS56486.1. [P20711-4]
CCDS56487.1. [P20711-2]
PIRiA33663. DCHUA.
RefSeqiNP_000781.1. NM_000790.3.
NP_001076440.1. NM_001082971.1.
NP_001229815.1. NM_001242886.1.
NP_001229816.1. NM_001242887.1.
NP_001229817.1. NM_001242888.1.
NP_001229818.1. NM_001242889.1.
NP_001229819.1. NM_001242890.1.
UniGeneiHs.359698.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RBFX-ray2.90A/B1-480[»]
3RBLX-ray3.24A/B1-480[»]
3RCHX-ray2.80A/B1-480[»]
ProteinModelPortaliP20711.
SMRiP20711.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108011. 3 interactors.
DIPiDIP-40563N.
IntActiP20711. 4 interactors.
STRINGi9606.ENSP00000350616.

Chemistry databases

BindingDBiP20711.
ChEMBLiCHEMBL1843.
DrugBankiDB00915. Amantadine.
DB00190. Carbidopa.
DB00260. Cycloserine.
DB06262. Droxidopa.
DB00875. Flupentixol.
DB00150. L-Tryptophan.
DB01235. Levodopa.
DB00968. Methyldopa.

PTM databases

PhosphoSitePlusiP20711.

Polymorphism and mutation databases

BioMutaiDDC.
DMDMi311033369.

Proteomic databases

MaxQBiP20711.
PaxDbiP20711.
PeptideAtlasiP20711.
PRIDEiP20711.

Protocols and materials databases

DNASUi1644.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357936; ENSP00000350616; ENSG00000132437. [P20711-1]
ENST00000380984; ENSP00000370371; ENSG00000132437. [P20711-2]
ENST00000426377; ENSP00000395069; ENSG00000132437. [P20711-3]
ENST00000431062; ENSP00000399184; ENSG00000132437. [P20711-4]
ENST00000444124; ENSP00000403644; ENSG00000132437. [P20711-1]
ENST00000615193; ENSP00000484104; ENSG00000132437. [P20711-4]
GeneIDi1644.
KEGGihsa:1644.
UCSCiuc003tpf.5. human. [P20711-1]

Organism-specific databases

CTDi1644.
DisGeNETi1644.
GeneCardsiDDC.
H-InvDBHIX0006684.
HGNCiHGNC:2719. DDC.
HPAiHPA017742.
MalaCardsiDDC.
MIMi107930. gene.
608643. phenotype.
neXtProtiNX_P20711.
OpenTargetsiENSG00000132437.
Orphaneti35708. Aromatic L-amino acid decarboxylase deficiency.
PharmGKBiPA140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiP20711.
KOiK01593.
OMAiPICNKED.
OrthoDBiEOG091G03KI.
PhylomeDBiP20711.
TreeFamiTF313863.

Enzyme and pathway databases

UniPathwayiUPA00747; UER00734.
BioCyciMetaCyc:HS05635-MONOMER.
ZFISH:HS05635-MONOMER.
BRENDAi4.1.1.28. 2681.
ReactomeiR-HSA-209905. Catecholamine biosynthesis.
R-HSA-209931. Serotonin and melatonin biosynthesis.

Miscellaneous databases

GenomeRNAii1644.
PROiP20711.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132437.
CleanExiHS_DDC.
ExpressionAtlasiP20711. baseline and differential.
GenevisibleiP20711. HS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDC_HUMAN
AccessioniPrimary (citable) accession number: P20711
Secondary accession number(s): C9IYA0
, E7ER62, E7EU95, Q16723, Q5W5T9, Q75MJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 174 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.