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P20707

- ODO1_AZOVI

UniProt

P20707 - ODO1_AZOVI

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
sucA, odhA
Organism
Azotobacter vinelandii
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

SABIO-RKP20707.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Synonyms:odhA
OrganismiAzotobacter vinelandii
Taxonomic identifieri354 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9439432-oxoglutarate dehydrogenase E1 component
PRO_0000162186Add
BLAST

Proteomic databases

PRIDEiP20707.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP20707.
SMRiP20707. Positions 90-943.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

P20707-1 [UniParc]FASTAAdd to Basket

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MQDSVMQRMW NSAHLSGGNA AYVEELYELY LHDPNAVPEE WRTYFEKLPA    50
EAGTSTDVPH APVRDQFVLL AKNQRRAQPV ATSSVSTEHE KKQVEVLRLI 100
QAYRTRGHQA SQLDPLGLWQ RTAPSDLSIT HYGLTNADLD TPFRTGELYI 150
GKEEATLREI LQALQETYCR TIGAEFTHIV DSEQRNWFAQ RLESVRGRPV 200
YSKEAKSHLL ERLSAAEGLE KYLGTKYPGT KRFGLEGGES LVPVVDEIIQ 250
RSGSYGTKEV VIGMAHRGRL NLLVNALGKN PRDLFDEFEG KHLVELGSGD 300
VKYHQGFSSN VMTSGGEVHL AMAFNPSHLE IVSPVVEGSV RARQDRRVDA 350
TGEKVVPISI HGDSAFAGQG VVMETFQMSQ IRGYKTGGTI HIVVNNQVGF 400
TTSNPVDTRS TEYCTDPAKM IQAPVLHVNG DDPEAVLFVT QLAVDYRMQF 450
KRDVVIDLVC YRRRGHNEAD EPSGTQPLMY QKIAKQPTTR ELYADALVKE 500
GSLSQEEVQA KVDEYRTALD NGQHVLKSLV KEPNTELFVD WTPYLGHAWT 550
ARHDTSFELK TLQELNAKLL QIPEGFVVQR QVAKILEDRG RMGVGAMPIN 600
WGCAETLAYA TLLKEGHPVR ITGQDVGRGT FSHRHAALHN QKDASRYIPL 650
QNLYEGQPKF ELYDSFLSEE AVLAFEYGYA TTTPNALVIW EASSGDFANG 700
AQVVIDQFIS SGETKWGALC GLTMLLPHGY EGQGPEHSSA RLERYLQLCA 750
EQNIQVCVPT TPAQVYHMLR RQVIRPLRKP LVALTPKSLL RHKSAISTLE 800
DLALGSFHPV LPEVDSLDPK KVERLVLCSG KVYYDLLDKR HAEGREDIAI 850
VRIEQLYPFP EEELAEVMAP YTNLKHVVWC QEEPMNQGAW YCSQHHMRRV 900
ASAHKKELFL QYAGREASAA PACGYASMHA EQQEKLLQDA FTV 943
Length:943
Mass (Da):105,688
Last modified:February 1, 1991 - v1
Checksum:iD3F35356D454E2A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52433 Genomic DNA. Translation: CAA36680.1.
X52432 Genomic DNA. Translation: CAA36677.1.
PIRiS07776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52433 Genomic DNA. Translation: CAA36680.1 .
X52432 Genomic DNA. Translation: CAA36677.1 .
PIRi S07776.

3D structure databases

ProteinModelPortali P20707.
SMRi P20707. Positions 90-943.
ModBasei Search...

Proteomic databases

PRIDEi P20707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P20707.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The 2-oxoglutarate dehydrogenase complex from Azotobacter vinelandii. 1. Molecular cloning and sequence analysis of the gene encoding the 2-oxoglutarate dehydrogenase component."
    Schulze E., Westphal A.H., Hanemaaijer R., de Kok A.
    Eur. J. Biochem. 187:229-234(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The 2-oxoglutarate dehydrogenase complex from Azotobacter vinelandii. 2. Molecular cloning and sequence analysis of the gene encoding the succinyltransferase component."
    Westphal A.H., de Kok A.
    Eur. J. Biochem. 187:235-239(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 909-943.

Entry informationi

Entry nameiODO1_AZOVI
AccessioniPrimary (citable) accession number: P20707
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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