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Protein

ATP-dependent DNA helicase uvsW

Gene

uvsW

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays important roles in recombination-dependent DNA repair and the reorganization of stalled replication forks during viral DNA synthesis.2 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi135 – 142ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase uvsW (EC:3.6.4.12)
Alternative name(s):
Dar protein
Gene namesi
Name:uvsW
Synonyms:dar
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi141K → R: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001649881 – 587ATP-dependent DNA helicase uvsWAdd BLAST587

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with gp32.1 Publication

Structurei

Secondary structure

1587
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Turni9 – 11Combined sources3
Beta strandi12 – 16Combined sources5
Helixi19 – 28Combined sources10
Beta strandi30 – 32Combined sources3
Turni34 – 37Combined sources4
Helixi40 – 43Combined sources4
Beta strandi49 – 54Combined sources6
Beta strandi59 – 61Combined sources3
Helixi62 – 67Combined sources6
Helixi68 – 74Combined sources7
Beta strandi79 – 81Combined sources3
Helixi83 – 86Combined sources4
Helixi93 – 101Combined sources9
Beta strandi105 – 107Combined sources3
Beta strandi110 – 112Combined sources3
Helixi116 – 128Combined sources13
Beta strandi129 – 133Combined sources5
Turni138 – 140Combined sources3
Helixi141 – 155Combined sources15
Beta strandi157 – 163Combined sources7
Helixi167 – 179Combined sources13
Helixi185 – 187Combined sources3
Beta strandi188 – 190Combined sources3
Helixi192 – 194Combined sources3
Helixi199 – 201Combined sources3
Beta strandi206 – 210Combined sources5
Helixi212 – 215Combined sources4
Helixi220 – 225Combined sources6
Beta strandi226 – 232Combined sources7
Helixi234 – 236Combined sources3
Helixi239 – 245Combined sources7
Turni246 – 248Combined sources3
Beta strandi254 – 258Combined sources5
Helixi262 – 264Combined sources3
Helixi269 – 276Combined sources8
Beta strandi278 – 280Combined sources3
Beta strandi298 – 305Combined sources8
Helixi308 – 314Combined sources7
Helixi319 – 327Combined sources9
Helixi330 – 344Combined sources15
Turni345 – 347Combined sources3
Beta strandi349 – 356Combined sources8
Helixi357 – 368Combined sources12
Beta strandi372 – 380Combined sources9
Helixi383 – 395Combined sources13
Beta strandi400 – 404Combined sources5
Helixi405 – 410Combined sources6
Beta strandi416 – 424Combined sources9
Helixi431 – 440Combined sources10
Beta strandi450 – 457Combined sources8
Beta strandi463 – 466Combined sources4
Helixi476 – 490Combined sources15
Beta strandi495 – 501Combined sources7
Beta strandi514 – 517Combined sources4
Helixi518 – 523Combined sources6
Helixi528 – 533Combined sources6
Helixi538 – 551Combined sources14
Turni552 – 554Combined sources3
Helixi560 – 578Combined sources19
Turni583 – 585Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RIFX-ray2.00A/B1-282[»]
2JPNNMR-A512-587[»]
2OCAX-ray2.70A1-502[»]
ProteinModelPortaliP20703
SMRiP20703
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20703

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 280Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST159
Domaini335 – 501Helicase C-terminalPROSITE-ProRule annotationAdd BLAST167

Phylogenomic databases

KOiK18959
OrthoDBiVOG090000CT

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.20.1280.210, 1 hit
InterProiView protein in InterPro
IPR020975 DNA-helicase_ATP-dep_UvsW
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038341 UvsW_sf
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
PF11637 UvsW, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

P20703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIKVHFHDF SHVRIDCEES TFHELRDFFS FEADGYRFNP RFRYGNWDGR
60 70 80 90 100
IRLLDYNRLL PFGLVGQIKK FCDNFGYKAW IDPQINEKEE LSRKDFDEWL
110 120 130 140 150
SKLEIYSGNK RIEPHWYQKD AVFEGLVNRR RILNLPTSAG KSLIQALLAR
160 170 180 190 200
YYLENYEGKI LIIVPTTALT TQMADDFVDY RLFSHAMIKK IGGGASKDDK
210 220 230 240 250
YKNDAPVVVG TWQTVVKQPK EWFSQFGMMM NDECHLATGK SISSIISGLN
260 270 280 290 300
NCMFKFGLSG SLRDGKANIM QYVGMFGEIF KPVTTSKLME DGQVTELKIN
310 320 330 340 350
SIFLRYPDEF TTKLKGKTYQ EEIKIITGLS KRNKWIAKLA IKLAQKDENA
360 370 380 390 400
FVMFKHVSHG KAIFDLIKNE YDKVYYVSGE VDTETRNIMK TLAENGKGII
410 420 430 440 450
IVASYGVFST GISVKNLHHV VLAHGVKSKI IVLQTIGRVL RKHGSKTIAT
460 470 480 490 500
VWDLIDSAGV KPKSANTKKK YVHLNYLLKH GIDRIQRYAD EKFNYVMKTV
510 520 530 540 550
NLISFGPLEK KMLLEFKQFL YEASIDEFMG KIASCQTLEG LEELEAYYKK
560 570 580
RVKETELKDT DDISVRDALA GKRAELEDSD DEVEESF
Length:587
Mass (Da):67,525
Last modified:February 1, 1995 - v2
Checksum:iD7FBD8CE1E38C7CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158101 Genomic DNA Translation: AAD42668.1
X56097 Genomic DNA Translation: CAA39576.1
X14869 Genomic DNA Translation: CAA33014.1
PIRiPQ0097 S10498
RefSeqiNP_049796.1, NC_000866.4

Genome annotation databases

GeneIDi1258733
KEGGivg:1258733

Similar proteinsi

Entry informationi

Entry nameiUVSW_BPT4
AccessioniPrimary (citable) accession number: P20703
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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