P20699 (ACEA_HELAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Isocitrate lyase Short name=ICL Short name=Isocitrase Short name=Isocitratase EC=4.1.3.1
Organism	Helianthus annuus (Common sunflower)
Taxonomic identifier	4232 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae alliance › Heliantheae › Helianthus

Protein attributes

Sequence length	58 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in storage lipid mobilization during the growth of higher plant seedling.
Catalytic activity	Isocitrate = succinate + glyoxylate.
Pathway	Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.
Subunit structure	Homotetramer.
Subcellular location	Glyoxysome.
Sequence similarities	Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
Biological process	Glyoxylate bypass Tricarboxylic acid cycle
Cellular component	Glyoxysome Peroxisome
Molecular function	Lyase
Gene Ontology (GO)
Biological_process	glyoxylate cycle Inferred from electronic annotation. Source: UniProtKB-UniPathway tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	glyoxysome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	isocitrate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›58	›58	Isocitrate lyase		PRO_0000068807
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	58	1

Sequences

	Sequence		Length	Mass (Da)
	P20699 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: EFB03982D8B1089A	FASTA	58	6,513
	10 20 30 40 50 TRGMLAYVEK IQREERKHGV DTLAHQKWSG ANYYDRVLRT VQGGMTSTAA MGKGVTEE

References

[1]	"Regulation of isocitrate lyase gene expression in sunflower." Allen R.D., Trelease R.N., Thomas T.L. Plant Physiol. 86:527-532(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Giant grey stripe. Tissue: Seedling.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L37751 mRNA. Translation: AAA56819.1.
PIR	JA0155.
3D structure databases
ProteinModelPortal	P20699.
SMR	P20699. Positions 1-44.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00703; UER00719.
Family and domain databases
Gene3D	3.20.20.60. 1 hit.
InterPro	IPR006254. Isocitrate_lyase. IPR000918. Isocitrate_lyase/Pmutase. IPR015813. Pyrv/PenolPyrv_Kinase. [Graphical view]
PANTHER	PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfam	PF00463. ICL. 1 hit. [Graphical view]
SUPFAM	SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
PROSITE	PS00161. ISOCITRATE_LYASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACEA_HELAN

Accession

Primary (citable) accession number: P20699

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	March 6, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program