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Protein

Interferon-related developmental regulator 1

Gene

Ifrd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probably participates in neurogenesis. Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF.

GO - Molecular functioni

GO - Biological processi

  • glial cell proliferation Source: RGD
  • muscle cell differentiation Source: RGD
  • neuroblast proliferation Source: RGD
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-related developmental regulator 1
Alternative name(s):
IRPR
Nerve growth factor-inducible protein PC4
Gene namesi
Name:Ifrd1
Synonyms:Pc4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2867. Ifrd1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001532881 – 449Interferon-related developmental regulator 1Add BLAST449

Proteomic databases

PaxDbiP20695.
PRIDEiP20695.

Expressioni

Tissue specificityi

Expressed at high levels in the embryonic brain in the period related to neuroblast proliferation and differentiation.

Developmental stagei

Activated at the onset of neuronal differentiation.

Inductioni

By nerve growth factor.

Interactioni

Subunit structurei

Interacts with PSIP1/LEDGF.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067730.

Structurei

3D structure databases

ProteinModelPortaliP20695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 21Poly-Gly9
Compositional biasi142 – 147Poly-Ala6

Sequence similaritiesi

Belongs to the IFRD family.Curated

Phylogenomic databases

eggNOGiKOG2842. Eukaryota.
ENOG410XSIZ. LUCA.
HOVERGENiHBG052089.
InParanoidiP20695.
PhylomeDBiP20695.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006921. Interferon-rel_develop_reg_C.
IPR007701. Interferon-rel_develop_reg_N.
[Graphical view]
PfamiPF05004. IFRD. 1 hit.
PF04836. IFRD_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

P20695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNKKRNAP HRGGGGGGGS GAATSAATTG GPHRTVQPFS DEDASIETMS
60 70 80 90 100
HCSGYSDPSS FAEDGPEVLD EEGTQEDLEY KLKGLIDLTL DKSAKTRQAA
110 120 130 140 150
LEGVKNALSS KVLYEFVLER RMTLTDSIER CLKKGKSDGQ RAAAALASVL
160 170 180 190 200
CIQLGPGLES EEILKTLGPI LKKIICDGTA SIQARQTCAT CFGVCCFIAT
210 220 230 240 250
DDITELYSTL ECLEGIFTKS YLKEKDTNVP CSTPNTVLHI SSLLAWTLLL
260 270 280 290 300
TICPISEVKK KLELHFHKLP SLLSCDDVNM RIAAGESLAL LFELARGMES
310 320 330 340 350
DFFYEDMDSL TQMLRALATD GNKHRAKVDK RKQRSVFRDV LRAVEERDFP
360 370 380 390 400
TETVKFGPER MYIDSWVKKH TYDTFKEALG SGMQYHLQTN EFLRNVFELG
410 420 430 440
PPVMLDAATL KTMKIPRFER HLYNSAAFKA RTKARSKCRD KRADVGEFF
Length:449
Mass (Da):49,783
Last modified:February 1, 1991 - v1
Checksum:iE1385CC622942219
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04511 mRNA. Translation: AAC28946.1.
PIRiA30303.
RefSeqiNP_062115.1. NM_019242.1.
UniGeneiRn.3723.

Genome annotation databases

GeneIDi29596.
KEGGirno:29596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04511 mRNA. Translation: AAC28946.1.
PIRiA30303.
RefSeqiNP_062115.1. NM_019242.1.
UniGeneiRn.3723.

3D structure databases

ProteinModelPortaliP20695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067730.

Proteomic databases

PaxDbiP20695.
PRIDEiP20695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29596.
KEGGirno:29596.

Organism-specific databases

CTDi3475.
RGDi2867. Ifrd1.

Phylogenomic databases

eggNOGiKOG2842. Eukaryota.
ENOG410XSIZ. LUCA.
HOVERGENiHBG052089.
InParanoidiP20695.
PhylomeDBiP20695.

Miscellaneous databases

PROiP20695.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006921. Interferon-rel_develop_reg_C.
IPR007701. Interferon-rel_develop_reg_N.
[Graphical view]
PfamiPF05004. IFRD. 1 hit.
PF04836. IFRD_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIFRD1_RAT
AccessioniPrimary (citable) accession number: P20695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.