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P20693

- FCER2_MOUSE

UniProt

P20693 - FCER2_MOUSE

Protein

Low affinity immunoglobulin epsilon Fc receptor

Gene

Fcer2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi272 – 2721CalciumBy similarity
    Metal bindingi292 – 2921CalciumBy similarity
    Metal bindingi293 – 2931CalciumBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
    2. positive regulation of killing of cells of other organism Source: Ensembl
    3. positive regulation of nitric-oxide synthase activity Source: Ensembl
    4. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Calcium, IgE-binding protein, Lectin, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low affinity immunoglobulin epsilon Fc receptor
    Alternative name(s):
    Fc-epsilon-RII
    Lymphocyte IgE receptor
    CD_antigen: CD23
    Gene namesi
    Name:Fcer2
    Synonyms:Fcer2a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:95497. Fcer2a.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type II membrane protein By similarity. Cell membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Low affinity immunoglobulin epsilon Fc receptorPRO_0000046640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi17 – 171S-palmitoyl cysteineBy similarity
    Lipidationi18 – 181S-palmitoyl cysteineBy similarity
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi183 ↔ 311PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 197PROSITE-ProRule annotation
    Disulfide bondi214 ↔ 305PROSITE-ProRule annotation
    Disulfide bondi282 ↔ 296PROSITE-ProRule annotation

    Post-translational modificationi

    N- and O-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP20693.

    PTM databases

    PhosphoSiteiP20693.

    Expressioni

    Gene expression databases

    BgeeiP20693.
    GenevestigatoriP20693.

    Structurei

    Secondary structure

    1
    331
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi197 – 2004
    Helixi207 – 21610
    Helixi227 – 23711
    Beta strandi242 – 2476
    Beta strandi260 – 2623
    Beta strandi282 – 2854
    Beta strandi291 – 2944
    Beta strandi304 – 3074

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HLJmodel-A196-308[»]
    ProteinModelPortaliP20693.
    SMRiP20693. Positions 147-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini50 – 331282ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4926Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati71 – 9121Add
    BLAST
    Repeati92 – 11221Add
    BLAST
    Repeati113 – 13321Add
    BLAST
    Domaini185 – 298114C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235454.
    GeneTreeiENSGT00750000117265.
    HOGENOMiHOG000089951.
    HOVERGENiHBG051599.
    InParanoidiP20693.
    KOiK06468.
    OMAiKCYYFGE.
    OrthoDBiEOG7FV3QQ.
    PhylomeDBiP20693.
    TreeFamiTF333341.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P20693-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEENEYSGYW EPPRKRCCCA RRGTQLMLVG LLSTAMWAGL LALLLLWHWE    50
    TEKNLKQLGD TAIQNVSHVT KDLQKFQSNQ LAQKSQVVQM SQNLQELQAE 100
    QKQMKAQDSR LSQNLTGLQE DLRNAQSQNS KLSQNLNRLQ DDLVNIKSLG 150
    LNEKRTASDS LEKLQEEVAK LWIEILISKG TACNICPKNW LHFQQKCYYF 200
    GKGSKQWIQA RFACSDLQGR LVSIHSQKEQ DFLMQHINKK DSWIGLQDLN 250
    MEGEFVWSDG SPVGYSNWNP GEPNNGGQGE DCVMMRGSGQ WNDAFCRSYL 300
    DAWVCEQLAT CEISAPLASV TPTRPTPKSE P 331
    Length:331
    Mass (Da):37,648
    Last modified:February 1, 1991 - v1
    Checksum:iB8C6D65F34ACCDB2
    GO
    Isoform 2 (identifier: P20693-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: MEENEYS → MNSQNQ

    Show »
    Length:330
    Mass (Da):37,467
    Checksum:i61D2B82297CF8D79
    GO
    Isoform 3 (identifier: P20693-3) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: MEENEYS → MDTHHT

    Show »
    Length:330
    Mass (Da):37,487
    Checksum:i4DEDD630A27B80F7
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 77MEENEYS → MNSQNQ in isoform 2. 1 PublicationVSP_003058
    Alternative sequencei1 – 77MEENEYS → MDTHHT in isoform 3. 1 PublicationVSP_003059

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99371 mRNA. Translation: AAA74898.1.
    M34163 mRNA. Translation: AAA37603.1.
    X64223 mRNA. Translation: CAA45532.1.
    X64224 mRNA. Translation: CAA45533.1.
    CCDSiCCDS22071.1. [P20693-1]
    PIRiA43518. LNMSER.
    RefSeqiNP_001240666.1. NM_001253737.1. [P20693-2]
    NP_001240668.1. NM_001253739.1. [P20693-3]
    NP_001240672.1. NM_001253743.1.
    NP_001240674.1. NM_001253745.1.
    NP_001240675.1. NM_001253746.1.
    NP_001240676.1. NM_001253747.1.
    NP_038545.1. NM_013517.4. [P20693-1]
    UniGeneiMm.1233.

    Genome annotation databases

    EnsembliENSMUST00000005678; ENSMUSP00000005678; ENSMUSG00000005540. [P20693-1]
    GeneIDi14128.
    KEGGimmu:14128.
    UCSCiuc009ksl.1. mouse. [P20693-3]
    uc009ksm.1. mouse. [P20693-2]
    uc009ksn.1. mouse. [P20693-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    CD23

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99371 mRNA. Translation: AAA74898.1 .
    M34163 mRNA. Translation: AAA37603.1 .
    X64223 mRNA. Translation: CAA45532.1 .
    X64224 mRNA. Translation: CAA45533.1 .
    CCDSi CCDS22071.1. [P20693-1 ]
    PIRi A43518. LNMSER.
    RefSeqi NP_001240666.1. NM_001253737.1. [P20693-2 ]
    NP_001240668.1. NM_001253739.1. [P20693-3 ]
    NP_001240672.1. NM_001253743.1.
    NP_001240674.1. NM_001253745.1.
    NP_001240675.1. NM_001253746.1.
    NP_001240676.1. NM_001253747.1.
    NP_038545.1. NM_013517.4. [P20693-1 ]
    UniGenei Mm.1233.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HLJ model - A 196-308 [» ]
    ProteinModelPortali P20693.
    SMRi P20693. Positions 147-311.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P20693.

    Proteomic databases

    PRIDEi P20693.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005678 ; ENSMUSP00000005678 ; ENSMUSG00000005540 . [P20693-1 ]
    GeneIDi 14128.
    KEGGi mmu:14128.
    UCSCi uc009ksl.1. mouse. [P20693-3 ]
    uc009ksm.1. mouse. [P20693-2 ]
    uc009ksn.1. mouse. [P20693-1 ]

    Organism-specific databases

    CTDi 14128.
    MGIi MGI:95497. Fcer2a.

    Phylogenomic databases

    eggNOGi NOG235454.
    GeneTreei ENSGT00750000117265.
    HOGENOMi HOG000089951.
    HOVERGENi HBG051599.
    InParanoidi P20693.
    KOi K06468.
    OMAi KCYYFGE.
    OrthoDBi EOG7FV3QQ.
    PhylomeDBi P20693.
    TreeFami TF333341.

    Miscellaneous databases

    NextBioi 285218.
    PROi P20693.
    SOURCEi Search...

    Gene expression databases

    Bgeei P20693.
    Genevestigatori P20693.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular structure and expression of the murine lymphocyte low-affinity receptor for IgE (Fc epsilon RII)."
      Bettler B., Hofstetter H., Rao M., Yokoyama W.M., Kilchherr F., Conrad D.H.
      Proc. Natl. Acad. Sci. U.S.A. 86:7566-7570(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Isolation, characterization, and expression of cDNA clones encoding the mouse Fc receptor for IgE (Fc epsilon RII)1."
      Gollnick S.O., Trounstine M.L., Yamashita L.C., Kehry M.R., Moore K.W.
      J. Immunol. 144:1974-1982(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning of cDNAs for new subtypes of murine low-affinity Fc receptor for IgE (Fc epsilon RII/CD23)."
      Kondo H., Ichikawa Y., Nakamura K., Tsuchiya S.
      Int. Arch. Allergy Immunol. 105:38-48(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
      Strain: DBA/2.
    4. "Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23)."
      Padlan E.A., Helm B.A.
      Receptor 3:325-341(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF LECTIN DOMAIN.

    Entry informationi

    Entry nameiFCER2_MOUSE
    AccessioniPrimary (citable) accession number: P20693
    Secondary accession number(s): Q61556, Q61557
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3