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P20693

- FCER2_MOUSE

UniProt

P20693 - FCER2_MOUSE

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Protein
Low affinity immunoglobulin epsilon Fc receptor
Gene
Fcer2, Fcer2a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi272 – 2721Calcium By similarity
Metal bindingi292 – 2921Calcium By similarity
Metal bindingi293 – 2931Calcium By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
  2. positive regulation of killing of cells of other organism Source: Ensembl
  3. positive regulation of nitric-oxide synthase activity Source: Ensembl
  4. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Calcium, IgE-binding protein, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin epsilon Fc receptor
Alternative name(s):
Fc-epsilon-RII
Lymphocyte IgE receptor
CD_antigen: CD23
Gene namesi
Name:Fcer2
Synonyms:Fcer2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:95497. Fcer2a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei24 – 4926Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini50 – 331282Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Low affinity immunoglobulin epsilon Fc receptor
PRO_0000046640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi17 – 171S-palmitoyl cysteine By similarity
Lipidationi18 – 181S-palmitoyl cysteine By similarity
Glycosylationi65 – 651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi183 ↔ 311 By similarity
Disulfide bondi186 ↔ 197 By similarity
Disulfide bondi214 ↔ 305 By similarity
Disulfide bondi282 ↔ 296 By similarity

Post-translational modificationi

N- and O-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP20693.

PTM databases

PhosphoSiteiP20693.

Expressioni

Gene expression databases

BgeeiP20693.
GenevestigatoriP20693.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi197 – 2004
Helixi207 – 21610
Helixi227 – 23711
Beta strandi242 – 2476
Beta strandi260 – 2623
Beta strandi282 – 2854
Beta strandi291 – 2944
Beta strandi304 – 3074

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HLJmodel-A196-308[»]
ProteinModelPortaliP20693.
SMRiP20693. Positions 147-311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati71 – 9121
Add
BLAST
Repeati92 – 11221
Add
BLAST
Repeati113 – 13321
Add
BLAST
Domaini185 – 298114C-type lectin
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235454.
GeneTreeiENSGT00750000117265.
HOGENOMiHOG000089951.
HOVERGENiHBG051599.
InParanoidiP20693.
KOiK06468.
OMAiKCYYFGE.
OrthoDBiEOG7FV3QQ.
PhylomeDBiP20693.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P20693-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEENEYSGYW EPPRKRCCCA RRGTQLMLVG LLSTAMWAGL LALLLLWHWE    50
TEKNLKQLGD TAIQNVSHVT KDLQKFQSNQ LAQKSQVVQM SQNLQELQAE 100
QKQMKAQDSR LSQNLTGLQE DLRNAQSQNS KLSQNLNRLQ DDLVNIKSLG 150
LNEKRTASDS LEKLQEEVAK LWIEILISKG TACNICPKNW LHFQQKCYYF 200
GKGSKQWIQA RFACSDLQGR LVSIHSQKEQ DFLMQHINKK DSWIGLQDLN 250
MEGEFVWSDG SPVGYSNWNP GEPNNGGQGE DCVMMRGSGQ WNDAFCRSYL 300
DAWVCEQLAT CEISAPLASV TPTRPTPKSE P 331
Length:331
Mass (Da):37,648
Last modified:February 1, 1991 - v1
Checksum:iB8C6D65F34ACCDB2
GO
Isoform 2 (identifier: P20693-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEENEYS → MNSQNQ

Show »
Length:330
Mass (Da):37,467
Checksum:i61D2B82297CF8D79
GO
Isoform 3 (identifier: P20693-3) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEENEYS → MDTHHT

Show »
Length:330
Mass (Da):37,487
Checksum:i4DEDD630A27B80F7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77MEENEYS → MNSQNQ in isoform 2.
VSP_003058
Alternative sequencei1 – 77MEENEYS → MDTHHT in isoform 3.
VSP_003059

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M99371 mRNA. Translation: AAA74898.1.
M34163 mRNA. Translation: AAA37603.1.
X64223 mRNA. Translation: CAA45532.1.
X64224 mRNA. Translation: CAA45533.1.
CCDSiCCDS22071.1. [P20693-1]
PIRiA43518. LNMSER.
RefSeqiNP_001240666.1. NM_001253737.1. [P20693-2]
NP_001240668.1. NM_001253739.1. [P20693-3]
NP_001240672.1. NM_001253743.1.
NP_001240674.1. NM_001253745.1.
NP_001240675.1. NM_001253746.1.
NP_001240676.1. NM_001253747.1.
NP_038545.1. NM_013517.4. [P20693-1]
UniGeneiMm.1233.

Genome annotation databases

EnsembliENSMUST00000005678; ENSMUSP00000005678; ENSMUSG00000005540. [P20693-1]
GeneIDi14128.
KEGGimmu:14128.
UCSCiuc009ksl.1. mouse. [P20693-3]
uc009ksm.1. mouse. [P20693-2]
uc009ksn.1. mouse. [P20693-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD23

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M99371 mRNA. Translation: AAA74898.1 .
M34163 mRNA. Translation: AAA37603.1 .
X64223 mRNA. Translation: CAA45532.1 .
X64224 mRNA. Translation: CAA45533.1 .
CCDSi CCDS22071.1. [P20693-1 ]
PIRi A43518. LNMSER.
RefSeqi NP_001240666.1. NM_001253737.1. [P20693-2 ]
NP_001240668.1. NM_001253739.1. [P20693-3 ]
NP_001240672.1. NM_001253743.1.
NP_001240674.1. NM_001253745.1.
NP_001240675.1. NM_001253746.1.
NP_001240676.1. NM_001253747.1.
NP_038545.1. NM_013517.4. [P20693-1 ]
UniGenei Mm.1233.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1HLJ model - A 196-308 [» ]
ProteinModelPortali P20693.
SMRi P20693. Positions 147-311.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P20693.

Proteomic databases

PRIDEi P20693.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005678 ; ENSMUSP00000005678 ; ENSMUSG00000005540 . [P20693-1 ]
GeneIDi 14128.
KEGGi mmu:14128.
UCSCi uc009ksl.1. mouse. [P20693-3 ]
uc009ksm.1. mouse. [P20693-2 ]
uc009ksn.1. mouse. [P20693-1 ]

Organism-specific databases

CTDi 14128.
MGIi MGI:95497. Fcer2a.

Phylogenomic databases

eggNOGi NOG235454.
GeneTreei ENSGT00750000117265.
HOGENOMi HOG000089951.
HOVERGENi HBG051599.
InParanoidi P20693.
KOi K06468.
OMAi KCYYFGE.
OrthoDBi EOG7FV3QQ.
PhylomeDBi P20693.
TreeFami TF333341.

Miscellaneous databases

NextBioi 285218.
PROi P20693.
SOURCEi Search...

Gene expression databases

Bgeei P20693.
Genevestigatori P20693.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular structure and expression of the murine lymphocyte low-affinity receptor for IgE (Fc epsilon RII)."
    Bettler B., Hofstetter H., Rao M., Yokoyama W.M., Kilchherr F., Conrad D.H.
    Proc. Natl. Acad. Sci. U.S.A. 86:7566-7570(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Isolation, characterization, and expression of cDNA clones encoding the mouse Fc receptor for IgE (Fc epsilon RII)1."
    Gollnick S.O., Trounstine M.L., Yamashita L.C., Kehry M.R., Moore K.W.
    J. Immunol. 144:1974-1982(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning of cDNAs for new subtypes of murine low-affinity Fc receptor for IgE (Fc epsilon RII/CD23)."
    Kondo H., Ichikawa Y., Nakamura K., Tsuchiya S.
    Int. Arch. Allergy Immunol. 105:38-48(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
    Strain: DBA/2.
  4. "Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23)."
    Padlan E.A., Helm B.A.
    Receptor 3:325-341(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF LECTIN DOMAIN.

Entry informationi

Entry nameiFCER2_MOUSE
AccessioniPrimary (citable) accession number: P20693
Secondary accession number(s): Q61556, Q61557
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi