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Protein

Low affinity immunoglobulin epsilon Fc receptor

Gene

Fcer2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi272 – 2721CalciumBy similarity
Metal bindingi292 – 2921CalciumBy similarity
Metal bindingi293 – 2931CalciumBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
  2. positive regulation of killing of cells of other organism Source: MGI
  3. positive regulation of nitric-oxide synthase activity Source: MGI
  4. positive regulation of nitric-oxide synthase biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Calcium, IgE-binding protein, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin epsilon Fc receptor
Alternative name(s):
Fc-epsilon-RII
Lymphocyte IgE receptor
CD_antigen: CD23
Gene namesi
Name:Fcer2
Synonyms:Fcer2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:95497. Fcer2a.

Subcellular locationi

Cell membrane By similarity; Single-pass type II membrane protein By similarity. Cell membrane By similarity; Lipid-anchor By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 4926Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini50 – 331282ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Low affinity immunoglobulin epsilon Fc receptorPRO_0000046640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi17 – 171S-palmitoyl cysteineBy similarity
Lipidationi18 – 181S-palmitoyl cysteineBy similarity
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi183 ↔ 311PROSITE-ProRule annotation
Disulfide bondi186 ↔ 197PROSITE-ProRule annotation
Disulfide bondi214 ↔ 305PROSITE-ProRule annotation
Disulfide bondi282 ↔ 296PROSITE-ProRule annotation

Post-translational modificationi

N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP20693.

PTM databases

PhosphoSiteiP20693.

Expressioni

Gene expression databases

BgeeiP20693.
GenevestigatoriP20693.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HLJmodel-A196-308[»]
ProteinModelPortaliP20693.
SMRiP20693. Positions 147-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati71 – 9121Add
BLAST
Repeati92 – 11221Add
BLAST
Repeati113 – 13321Add
BLAST
Domaini185 – 298114C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235454.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000089951.
HOVERGENiHBG051599.
InParanoidiP20693.
KOiK06468.
OMAiKCYYFGE.
OrthoDBiEOG7FV3QQ.
PhylomeDBiP20693.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20693-1) [UniParc]FASTAAdd to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEENEYSGYW EPPRKRCCCA RRGTQLMLVG LLSTAMWAGL LALLLLWHWE
60 70 80 90 100
TEKNLKQLGD TAIQNVSHVT KDLQKFQSNQ LAQKSQVVQM SQNLQELQAE
110 120 130 140 150
QKQMKAQDSR LSQNLTGLQE DLRNAQSQNS KLSQNLNRLQ DDLVNIKSLG
160 170 180 190 200
LNEKRTASDS LEKLQEEVAK LWIEILISKG TACNICPKNW LHFQQKCYYF
210 220 230 240 250
GKGSKQWIQA RFACSDLQGR LVSIHSQKEQ DFLMQHINKK DSWIGLQDLN
260 270 280 290 300
MEGEFVWSDG SPVGYSNWNP GEPNNGGQGE DCVMMRGSGQ WNDAFCRSYL
310 320 330
DAWVCEQLAT CEISAPLASV TPTRPTPKSE P
Length:331
Mass (Da):37,648
Last modified:February 1, 1991 - v1
Checksum:iB8C6D65F34ACCDB2
GO
Isoform 2 (identifier: P20693-2) [UniParc]FASTAAdd to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEENEYS → MNSQNQ

Show »
Length:330
Mass (Da):37,467
Checksum:i61D2B82297CF8D79
GO
Isoform 3 (identifier: P20693-3) [UniParc]FASTAAdd to basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEENEYS → MDTHHT

Show »
Length:330
Mass (Da):37,487
Checksum:i4DEDD630A27B80F7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77MEENEYS → MNSQNQ in isoform 2. 1 PublicationVSP_003058
Alternative sequencei1 – 77MEENEYS → MDTHHT in isoform 3. 1 PublicationVSP_003059

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99371 mRNA. Translation: AAA74898.1.
M34163 mRNA. Translation: AAA37603.1.
X64223 mRNA. Translation: CAA45532.1.
X64224 mRNA. Translation: CAA45533.1.
CCDSiCCDS22071.1. [P20693-1]
PIRiA43518. LNMSER.
RefSeqiNP_001240666.1. NM_001253737.1. [P20693-2]
NP_001240668.1. NM_001253739.1. [P20693-3]
NP_001240672.1. NM_001253743.1.
NP_001240674.1. NM_001253745.1.
NP_001240675.1. NM_001253746.1.
NP_001240676.1. NM_001253747.1.
NP_038545.1. NM_013517.4. [P20693-1]
UniGeneiMm.1233.

Genome annotation databases

EnsembliENSMUST00000005678; ENSMUSP00000005678; ENSMUSG00000005540. [P20693-1]
GeneIDi14128.
KEGGimmu:14128.
UCSCiuc009ksl.1. mouse. [P20693-3]
uc009ksm.1. mouse. [P20693-2]
uc009ksn.1. mouse. [P20693-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99371 mRNA. Translation: AAA74898.1.
M34163 mRNA. Translation: AAA37603.1.
X64223 mRNA. Translation: CAA45532.1.
X64224 mRNA. Translation: CAA45533.1.
CCDSiCCDS22071.1. [P20693-1]
PIRiA43518. LNMSER.
RefSeqiNP_001240666.1. NM_001253737.1. [P20693-2]
NP_001240668.1. NM_001253739.1. [P20693-3]
NP_001240672.1. NM_001253743.1.
NP_001240674.1. NM_001253745.1.
NP_001240675.1. NM_001253746.1.
NP_001240676.1. NM_001253747.1.
NP_038545.1. NM_013517.4. [P20693-1]
UniGeneiMm.1233.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HLJmodel-A196-308[»]
ProteinModelPortaliP20693.
SMRiP20693. Positions 147-311.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP20693.

Proteomic databases

PRIDEiP20693.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005678; ENSMUSP00000005678; ENSMUSG00000005540. [P20693-1]
GeneIDi14128.
KEGGimmu:14128.
UCSCiuc009ksl.1. mouse. [P20693-3]
uc009ksm.1. mouse. [P20693-2]
uc009ksn.1. mouse. [P20693-1]

Organism-specific databases

CTDi14128.
MGIiMGI:95497. Fcer2a.

Phylogenomic databases

eggNOGiNOG235454.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000089951.
HOVERGENiHBG051599.
InParanoidiP20693.
KOiK06468.
OMAiKCYYFGE.
OrthoDBiEOG7FV3QQ.
PhylomeDBiP20693.
TreeFamiTF333341.

Miscellaneous databases

NextBioi285218.
PROiP20693.
SOURCEiSearch...

Gene expression databases

BgeeiP20693.
GenevestigatoriP20693.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular structure and expression of the murine lymphocyte low-affinity receptor for IgE (Fc epsilon RII)."
    Bettler B., Hofstetter H., Rao M., Yokoyama W.M., Kilchherr F., Conrad D.H.
    Proc. Natl. Acad. Sci. U.S.A. 86:7566-7570(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Isolation, characterization, and expression of cDNA clones encoding the mouse Fc receptor for IgE (Fc epsilon RII)1."
    Gollnick S.O., Trounstine M.L., Yamashita L.C., Kehry M.R., Moore K.W.
    J. Immunol. 144:1974-1982(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning of cDNAs for new subtypes of murine low-affinity Fc receptor for IgE (Fc epsilon RII/CD23)."
    Kondo H., Ichikawa Y., Nakamura K., Tsuchiya S.
    Int. Arch. Allergy Immunol. 105:38-48(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
    Strain: DBA/2.
  4. "Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23)."
    Padlan E.A., Helm B.A.
    Receptor 3:325-341(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF LECTIN DOMAIN.

Entry informationi

Entry nameiFCER2_MOUSE
AccessioniPrimary (citable) accession number: P20693
Secondary accession number(s): Q61556, Q61557
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 4, 2015
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.