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P20693 (FCER2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low affinity immunoglobulin epsilon Fc receptor
Alternative name(s):
Fc-epsilon-RII
Lymphocyte IgE receptor
CD_antigen=CD23
Gene names
Name:Fcer2
Synonyms:Fcer2a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Subcellular location

Cell membrane; Single-pass type II membrane protein By similarity. Cell membrane; Lipid-anchor By similarity.

Post-translational modification

N- and O-glycosylated By similarity.

Miscellaneous

There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

Sequence similarities

Contains 1 C-type lectin domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P20693-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P20693-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEENEYS → MNSQNQ
Isoform 3 (identifier: P20693-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEENEYS → MDTHHT

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Low affinity immunoglobulin epsilon Fc receptor
PRO_0000046640

Regions

Topological domain1 – 2323Cytoplasmic Potential
Transmembrane24 – 4926Helical; Signal-anchor for type II membrane protein; Potential
Topological domain50 – 331282Extracellular Potential
Repeat71 – 9121
Repeat92 – 11221
Repeat113 – 13321
Domain185 – 298114C-type lectin

Sites

Metal binding2721Calcium By similarity
Metal binding2921Calcium By similarity
Metal binding2931Calcium By similarity

Amino acid modifications

Lipidation171S-palmitoyl cysteine By similarity
Lipidation181S-palmitoyl cysteine By similarity
Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Disulfide bond183 ↔ 311 By similarity
Disulfide bond186 ↔ 197 By similarity
Disulfide bond214 ↔ 305 By similarity
Disulfide bond282 ↔ 296 By similarity

Natural variations

Alternative sequence1 – 77MEENEYS → MNSQNQ in isoform 2.
VSP_003058
Alternative sequence1 – 77MEENEYS → MDTHHT in isoform 3.
VSP_003059

Secondary structure

................. 331
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: B8C6D65F34ACCDB2

FASTA33137,648
        10         20         30         40         50         60 
MEENEYSGYW EPPRKRCCCA RRGTQLMLVG LLSTAMWAGL LALLLLWHWE TEKNLKQLGD 

        70         80         90        100        110        120 
TAIQNVSHVT KDLQKFQSNQ LAQKSQVVQM SQNLQELQAE QKQMKAQDSR LSQNLTGLQE 

       130        140        150        160        170        180 
DLRNAQSQNS KLSQNLNRLQ DDLVNIKSLG LNEKRTASDS LEKLQEEVAK LWIEILISKG 

       190        200        210        220        230        240 
TACNICPKNW LHFQQKCYYF GKGSKQWIQA RFACSDLQGR LVSIHSQKEQ DFLMQHINKK 

       250        260        270        280        290        300 
DSWIGLQDLN MEGEFVWSDG SPVGYSNWNP GEPNNGGQGE DCVMMRGSGQ WNDAFCRSYL 

       310        320        330 
DAWVCEQLAT CEISAPLASV TPTRPTPKSE P 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 61D2B82297CF8D79
Show »

FASTA33037,467
Isoform 3 (C) [UniParc].

Checksum: 4DEDD630A27B80F7
Show »

FASTA33037,487

References

[1]"Molecular structure and expression of the murine lymphocyte low-affinity receptor for IgE (Fc epsilon RII)."
Bettler B., Hofstetter H., Rao M., Yokoyama W.M., Kilchherr F., Conrad D.H.
Proc. Natl. Acad. Sci. U.S.A. 86:7566-7570(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Isolation, characterization, and expression of cDNA clones encoding the mouse Fc receptor for IgE (Fc epsilon RII)1."
Gollnick S.O., Trounstine M.L., Yamashita L.C., Kehry M.R., Moore K.W.
J. Immunol. 144:1974-1982(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Cloning of cDNAs for new subtypes of murine low-affinity Fc receptor for IgE (Fc epsilon RII/CD23)."
Kondo H., Ichikawa Y., Nakamura K., Tsuchiya S.
Int. Arch. Allergy Immunol. 105:38-48(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
Strain: DBA/2.
[4]"Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23)."
Padlan E.A., Helm B.A.
Receptor 3:325-341(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF LECTIN DOMAIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M99371 mRNA. Translation: AAA74898.1.
M34163 mRNA. Translation: AAA37603.1.
X64223 mRNA. Translation: CAA45532.1.
X64224 mRNA. Translation: CAA45533.1.
CCDSCCDS22071.1. [P20693-1]
PIRLNMSER. A43518.
RefSeqNP_001240666.1. NM_001253737.1. [P20693-2]
NP_001240668.1. NM_001253739.1. [P20693-3]
NP_001240672.1. NM_001253743.1.
NP_001240674.1. NM_001253745.1.
NP_001240675.1. NM_001253746.1.
NP_001240676.1. NM_001253747.1.
NP_038545.1. NM_013517.4. [P20693-1]
UniGeneMm.1233.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1HLJmodel-A196-308[»]
ProteinModelPortalP20693.
SMRP20693. Positions 147-311.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP20693.

Proteomic databases

PRIDEP20693.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000005678; ENSMUSP00000005678; ENSMUSG00000005540. [P20693-1]
GeneID14128.
KEGGmmu:14128.
UCSCuc009ksl.1. mouse. [P20693-3]
uc009ksm.1. mouse. [P20693-2]
uc009ksn.1. mouse. [P20693-1]

Organism-specific databases

CTD14128.
MGIMGI:95497. Fcer2a.

Phylogenomic databases

eggNOGNOG235454.
GeneTreeENSGT00750000117265.
HOGENOMHOG000089951.
HOVERGENHBG051599.
InParanoidP20693.
KOK06468.
OMAKCYYFGE.
OrthoDBEOG7FV3QQ.
PhylomeDBP20693.
TreeFamTF333341.

Gene expression databases

BgeeP20693.
GenevestigatorP20693.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285218.
PROP20693.
SOURCESearch...

Entry information

Entry nameFCER2_MOUSE
AccessionPrimary (citable) accession number: P20693
Secondary accession number(s): Q61556, Q61557
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot