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P20692 (TYRA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prephenate dehydrogenase

Short name=PDH
EC=1.3.1.12
Gene names
Name:tyrA
Ordered Locus Names:BSU22610
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.

Sequence similarities

Contains 1 ACT domain.

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Prephenate dehydrogenase
PRO_0000119192

Regions

Domain6 – 295290Prephenate/arogenate dehydrogenase
Domain300 – 37172ACT
Nucleotide binding7 – 3731NAD Potential

Sequences

Sequence LengthMass (Da)Tools
P20692 [UniParc].

Last modified August 29, 2003. Version 2.
Checksum: 9254360B94526C00

FASTA37141,434
        10         20         30         40         50         60 
MNQMKDTILL AGLGLIGGSI ALAIKKNHPG KRIIGIDISD EQAVAALKLG VIDDRADSFI 

        70         80         90        100        110        120 
SGVKEAATVI IATPVEQTLV MLEELAHSGI EHELLITDVG STKQKVVDYA DQVLPSRYQF 

       130        140        150        160        170        180 
VGGHPMAGSH KSGVAAAKEF LFENAFYILT PGQKTDKQAV EQLKNLLKGT NAHFVEMSPE 

       190        200        210        220        230        240 
EHDGVTSVIS HFPHIVAASL VHQTHHSENL YPLVKRFAAG GFRDITRIAS SSPAMWRDIL 

       250        260        270        280        290        300 
LHNKDKILDR FDEWIREIDK IRTYVEQEDA ENLFRYFKTA KDYRDGLPLR QKGAIPAFYD 

       310        320        330        340        350        360 
LYVDVPDHPG VISEITAILA AERISITNIR IIETREDING ILRISFQSDD DRKRAEQCIE 

       370 
ARAEYETFYA D 

« Hide

References

« Hide 'large scale' references
[1]"The organization and nucleotide sequence of the Bacillus subtilis hisH, tyrA and aroE genes."
Henner D.J., Band L., Flaggs G., Chen E.
Gene 49:147-152(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M80245 Genomic DNA. Translation: AAA20868.1.
AL009126 Genomic DNA. Translation: CAB14177.1.
RefSeqNP_390142.1. NC_000964.3.

3D structure databases

ProteinModelPortalP20692.
SMRP20692. Positions 3-370.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU22610.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB14177; CAB14177; BSU22610.
GeneID939013.
KEGGbsu:BSU22610.
PATRIC18976331. VBIBacSub10457_2356.

Organism-specific databases

GenoListBSU22610. [Micado]

Phylogenomic databases

HOGENOMHOG000043494.
KOK04517.
OMAQRAIRWG.
OrthoDBEOG6B8XMB.
ProtClustDBPRK06545.

Enzyme and pathway databases

BioCycBSUB:BSU22610-MONOMER.
UniPathwayUPA00122; UER00961.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamPF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRA_BACSU
AccessionPrimary (citable) accession number: P20692
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 29, 2003
Last modified: November 13, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList