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Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. Prephenate dehydrogenase (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 37NADSequence analysisAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

BioCyciBSUB:BSU22610-MONOMER
UniPathwayiUPA00122; UER00961

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:BSU22610
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191921 – 371Prephenate dehydrogenaseAdd BLAST371

Proteomic databases

PaxDbiP20692
PRIDEiP20692

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100012421

Structurei

3D structure databases

ProteinModelPortaliP20692
SMRiP20692
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 295Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST290
Domaini300 – 371ACTPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0287 LUCA
HOGENOMiHOG000043494
InParanoidiP20692
KOiK04517
OMAiMWRDICL
PhylomeDBiP20692

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR002912 ACT_dom
IPR036291 NAD(P)-bd_dom_sf
IPR003099 Prephen_DH
PfamiView protein in Pfam
PF01842 ACT, 1 hit
PF02153 PDH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS51176 PDH_ADH, 1 hit

Sequencei

Sequence statusi: Complete.

P20692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQMKDTILL AGLGLIGGSI ALAIKKNHPG KRIIGIDISD EQAVAALKLG
60 70 80 90 100
VIDDRADSFI SGVKEAATVI IATPVEQTLV MLEELAHSGI EHELLITDVG
110 120 130 140 150
STKQKVVDYA DQVLPSRYQF VGGHPMAGSH KSGVAAAKEF LFENAFYILT
160 170 180 190 200
PGQKTDKQAV EQLKNLLKGT NAHFVEMSPE EHDGVTSVIS HFPHIVAASL
210 220 230 240 250
VHQTHHSENL YPLVKRFAAG GFRDITRIAS SSPAMWRDIL LHNKDKILDR
260 270 280 290 300
FDEWIREIDK IRTYVEQEDA ENLFRYFKTA KDYRDGLPLR QKGAIPAFYD
310 320 330 340 350
LYVDVPDHPG VISEITAILA AERISITNIR IIETREDING ILRISFQSDD
360 370
DRKRAEQCIE ARAEYETFYA D
Length:371
Mass (Da):41,434
Last modified:August 29, 2003 - v2
Checksum:i9254360B94526C00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80245 Genomic DNA Translation: AAA20868.1
AL009126 Genomic DNA Translation: CAB14177.1
RefSeqiNP_390142.1, NC_000964.3
WP_003230615.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14177; CAB14177; BSU22610
GeneIDi939013
KEGGibsu:BSU22610

Similar proteinsi

Entry informationi

Entry nameiTYRA_BACSU
AccessioniPrimary (citable) accession number: P20692
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 29, 2003
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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