Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P20692

- TYRA_BACSU

UniProt

P20692 - TYRA_BACSU

Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (29 Aug 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 3731NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. prephenate dehydrogenase (NADP+) activity Source: InterPro
    3. prephenate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tyrosine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBSUB:BSU22610-MONOMER.
    UniPathwayiUPA00122; UER00961.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prephenate dehydrogenase (EC:1.3.1.12)
    Short name:
    PDH
    Gene namesi
    Name:tyrA
    Ordered Locus Names:BSU22610
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU22610. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Prephenate dehydrogenasePRO_0000119192Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU22610.

    Structurei

    3D structure databases

    ProteinModelPortaliP20692.
    SMRiP20692. Positions 3-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 295290Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
    BLAST
    Domaini300 – 37172ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000043494.
    KOiK04517.
    OMAiLQITFKN.
    OrthoDBiEOG6B8XMB.
    PhylomeDBiP20692.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR002912. ACT_dom.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view]
    PfamiPF01842. ACT. 1 hit.
    PF02153. PDH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20692-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQMKDTILL AGLGLIGGSI ALAIKKNHPG KRIIGIDISD EQAVAALKLG    50
    VIDDRADSFI SGVKEAATVI IATPVEQTLV MLEELAHSGI EHELLITDVG 100
    STKQKVVDYA DQVLPSRYQF VGGHPMAGSH KSGVAAAKEF LFENAFYILT 150
    PGQKTDKQAV EQLKNLLKGT NAHFVEMSPE EHDGVTSVIS HFPHIVAASL 200
    VHQTHHSENL YPLVKRFAAG GFRDITRIAS SSPAMWRDIL LHNKDKILDR 250
    FDEWIREIDK IRTYVEQEDA ENLFRYFKTA KDYRDGLPLR QKGAIPAFYD 300
    LYVDVPDHPG VISEITAILA AERISITNIR IIETREDING ILRISFQSDD 350
    DRKRAEQCIE ARAEYETFYA D 371
    Length:371
    Mass (Da):41,434
    Last modified:August 29, 2003 - v2
    Checksum:i9254360B94526C00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80245 Genomic DNA. Translation: AAA20868.1.
    AL009126 Genomic DNA. Translation: CAB14177.1.
    RefSeqiNP_390142.1. NC_000964.3.
    WP_003230615.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB14177; CAB14177; BSU22610.
    GeneIDi939013.
    KEGGibsu:BSU22610.
    PATRICi18976331. VBIBacSub10457_2356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80245 Genomic DNA. Translation: AAA20868.1 .
    AL009126 Genomic DNA. Translation: CAB14177.1 .
    RefSeqi NP_390142.1. NC_000964.3.
    WP_003230615.1. NZ_CM000487.1.

    3D structure databases

    ProteinModelPortali P20692.
    SMRi P20692. Positions 3-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU22610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB14177 ; CAB14177 ; BSU22610 .
    GeneIDi 939013.
    KEGGi bsu:BSU22610.
    PATRICi 18976331. VBIBacSub10457_2356.

    Organism-specific databases

    GenoListi BSU22610. [Micado ]

    Phylogenomic databases

    HOGENOMi HOG000043494.
    KOi K04517.
    OMAi LQITFKN.
    OrthoDBi EOG6B8XMB.
    PhylomeDBi P20692.

    Enzyme and pathway databases

    UniPathwayi UPA00122 ; UER00961 .
    BioCyci BSUB:BSU22610-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR002912. ACT_dom.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view ]
    Pfami PF01842. ACT. 1 hit.
    PF02153. PDH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The organization and nucleotide sequence of the Bacillus subtilis hisH, tyrA and aroE genes."
      Henner D.J., Band L., Flaggs G., Chen E.
      Gene 49:147-152(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiTYRA_BACSU
    AccessioniPrimary (citable) accession number: P20692
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: August 29, 2003
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3