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Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 3731NADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. tyrosine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSUB:BSU22610-MONOMER.
UniPathwayiUPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:BSU22610
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU22610. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Prephenate dehydrogenasePRO_0000119192Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU22610.

Structurei

3D structure databases

ProteinModelPortaliP20692.
SMRiP20692. Positions 3-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 295290Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
BLAST
Domaini300 – 37172ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000043494.
InParanoidiP20692.
KOiK04517.
OMAiMWRDICL.
OrthoDBiEOG6B8XMB.
PhylomeDBiP20692.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20692-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQMKDTILL AGLGLIGGSI ALAIKKNHPG KRIIGIDISD EQAVAALKLG
60 70 80 90 100
VIDDRADSFI SGVKEAATVI IATPVEQTLV MLEELAHSGI EHELLITDVG
110 120 130 140 150
STKQKVVDYA DQVLPSRYQF VGGHPMAGSH KSGVAAAKEF LFENAFYILT
160 170 180 190 200
PGQKTDKQAV EQLKNLLKGT NAHFVEMSPE EHDGVTSVIS HFPHIVAASL
210 220 230 240 250
VHQTHHSENL YPLVKRFAAG GFRDITRIAS SSPAMWRDIL LHNKDKILDR
260 270 280 290 300
FDEWIREIDK IRTYVEQEDA ENLFRYFKTA KDYRDGLPLR QKGAIPAFYD
310 320 330 340 350
LYVDVPDHPG VISEITAILA AERISITNIR IIETREDING ILRISFQSDD
360 370
DRKRAEQCIE ARAEYETFYA D
Length:371
Mass (Da):41,434
Last modified:August 29, 2003 - v2
Checksum:i9254360B94526C00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80245 Genomic DNA. Translation: AAA20868.1.
AL009126 Genomic DNA. Translation: CAB14177.1.
RefSeqiNP_390142.1. NC_000964.3.
WP_003230615.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14177; CAB14177; BSU22610.
GeneIDi939013.
KEGGibsu:BSU22610.
PATRICi18976331. VBIBacSub10457_2356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80245 Genomic DNA. Translation: AAA20868.1.
AL009126 Genomic DNA. Translation: CAB14177.1.
RefSeqiNP_390142.1. NC_000964.3.
WP_003230615.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliP20692.
SMRiP20692. Positions 3-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU22610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14177; CAB14177; BSU22610.
GeneIDi939013.
KEGGibsu:BSU22610.
PATRICi18976331. VBIBacSub10457_2356.

Organism-specific databases

GenoListiBSU22610. [Micado]

Phylogenomic databases

HOGENOMiHOG000043494.
InParanoidiP20692.
KOiK04517.
OMAiMWRDICL.
OrthoDBiEOG6B8XMB.
PhylomeDBiP20692.

Enzyme and pathway databases

UniPathwayiUPA00122; UER00961.
BioCyciBSUB:BSU22610-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The organization and nucleotide sequence of the Bacillus subtilis hisH, tyrA and aroE genes."
    Henner D.J., Band L., Flaggs G., Chen E.
    Gene 49:147-152(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiTYRA_BACSU
AccessioniPrimary (citable) accession number: P20692
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 29, 2003
Last modified: January 7, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.