Reviewed, UniProtKB/Swiss-Prot P20692 (TYRA_BACSU)

Names and origin

Protein names

Recommended name:
    Prephenate dehydrogenase
      Short name=PDH
    EC=1.3.1.12

Gene names

Name:	tyrA
Ordered Locus Names:	BSU22610

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.
Pathway	Amino-acid biosynthesis; L-tyrosine biosynthesis; L-tyrosine from prephenate: step 1/2.
Sequence similarities	Contains 1 ACT domain. Contains 1 prephenate/arogenate dehydrogenase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Prephenate dehydrogenase		PRO_0000119192
Regions
	Domain	6 – 295	290	Prephenate/arogenate dehydrogenase
	Domain	299 – 371	73	ACT
	Nucleotide binding	7 – 37	31	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	P20692-1 [UniParc]. Last modified August 29, 2003. Version 2. Checksum: 9254360B94526C00	FASTA	371	41,434
	10 20 30 40 50 60 MNQMKDTILL AGLGLIGGSI ALAIKKNHPG KRIIGIDISD EQAVAALKLG VIDDRADSFI 70 80 90 100 110 120 SGVKEAATVI IATPVEQTLV MLEELAHSGI EHELLITDVG STKQKVVDYA DQVLPSRYQF 130 140 150 160 170 180 VGGHPMAGSH KSGVAAAKEF LFENAFYILT PGQKTDKQAV EQLKNLLKGT NAHFVEMSPE 190 200 210 220 230 240 EHDGVTSVIS HFPHIVAASL VHQTHHSENL YPLVKRFAAG GFRDITRIAS SSPAMWRDIL 250 260 270 280 290 300 LHNKDKILDR FDEWIREIDK IRTYVEQEDA ENLFRYFKTA KDYRDGLPLR QKGAIPAFYD 310 320 330 340 350 360 LYVDVPDHPG VISEITAILA AERISITNIR IIETREDING ILRISFQSDD DRKRAEQCIE 370 ARAEYETFYA D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The organization and nucleotide sequence of the Bacillus subtilis hisH, tyrA and aroE genes." Henner D.J., Band L., Flaggs G., Chen E. Gene 49:147-152(1986) [PubMed: 3106153] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M80245 Genomic DNA. Translation: AAA20868.1. AL009126 Genomic DNA. Translation: CAB14177.1.
RefSeq	NP_390142.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	939013.
GenomeReviews	Gene locus BSU22610 in contig AL009126_GR.
KEGG	bsu:BSU22610.
NMPDR	fig|224308.1.peg.2265.
Organism-specific databases
SubtiList	BG10293. tyrA. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	P20692.
OMA	P20692. QRAIRWG.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU2260-MON.
BRENDA	1.3.1.12. 150.
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR003099. Prephen_DH. [Graphical view]
PANTHER	PTHR21363. Prephen_DH. 1 hit.
Pfam	PF01842. ACT. 1 hit. PF02153. PDH. 1 hit. [Graphical view]
PROSITE	PS51176. PDH_ADH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRA_BACSU

Accession

Primary (citable) accession number: P20692

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	August 29, 2003
Last modified:	June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)