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Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. Prephenate dehydrogenase (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 37NADSequence analysisAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

BioCyciBSUB:BSU22610-MONOMER.
UniPathwayiUPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:BSU22610
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191921 – 371Prephenate dehydrogenaseAdd BLAST371

Proteomic databases

PaxDbiP20692.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100012421.

Structurei

3D structure databases

ProteinModelPortaliP20692.
SMRiP20692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 295Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST290
Domaini300 – 371ACTPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0287. LUCA.
HOGENOMiHOG000043494.
InParanoidiP20692.
KOiK04517.
OMAiMWRDICL.
PhylomeDBiP20692.

Family and domain databases

InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR036291. NAD(P)-bd_dom_sf.
IPR003099. Prephen_DH.
PfamiView protein in Pfam
PF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.

Sequencei

Sequence statusi: Complete.

P20692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQMKDTILL AGLGLIGGSI ALAIKKNHPG KRIIGIDISD EQAVAALKLG
60 70 80 90 100
VIDDRADSFI SGVKEAATVI IATPVEQTLV MLEELAHSGI EHELLITDVG
110 120 130 140 150
STKQKVVDYA DQVLPSRYQF VGGHPMAGSH KSGVAAAKEF LFENAFYILT
160 170 180 190 200
PGQKTDKQAV EQLKNLLKGT NAHFVEMSPE EHDGVTSVIS HFPHIVAASL
210 220 230 240 250
VHQTHHSENL YPLVKRFAAG GFRDITRIAS SSPAMWRDIL LHNKDKILDR
260 270 280 290 300
FDEWIREIDK IRTYVEQEDA ENLFRYFKTA KDYRDGLPLR QKGAIPAFYD
310 320 330 340 350
LYVDVPDHPG VISEITAILA AERISITNIR IIETREDING ILRISFQSDD
360 370
DRKRAEQCIE ARAEYETFYA D
Length:371
Mass (Da):41,434
Last modified:August 29, 2003 - v2
Checksum:i9254360B94526C00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80245 Genomic DNA. Translation: AAA20868.1.
AL009126 Genomic DNA. Translation: CAB14177.1.
RefSeqiNP_390142.1. NC_000964.3.
WP_003230615.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14177; CAB14177; BSU22610.
GeneIDi939013.
KEGGibsu:BSU22610.

Similar proteinsi

Entry informationi

Entry nameiTYRA_BACSU
AccessioniPrimary (citable) accession number: P20692
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 29, 2003
Last modified: October 25, 2017
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families