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Reviewed, UniProtKB/Swiss-Prot P20691 (AROA_BACSU)

Last modified November 3, 2009. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS
Gene names
Name: aroE
Ordered Locus Names: BSU22600
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the EPSP synthase family.

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Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4284283-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_0000088227

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Sequences

Sequence LengthMass (Da)Tools
P20691-1 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: DE3F7B96E761CB40

FASTA42845,240
        10         20         30         40         50         60 
MKRDKVQTLH GEIHIPGDKS ISHRSVMFGA LAAGTTTVKN FLPGADCLST IDCFRKMGVH 

        70         80         90        100        110        120 
IEQSSSDVVI HGKGIDALKE PESLLDVGNS GTTIRLMLGI LAGRPFYSAV AGDESIAKRP 

       130        140        150        160        170        180 
MKRVTEPLKK MGAKIDGRAG GEFTPLSVSG ASLKGIDYVS PVASAQIKSA VLLAGLQAEG 

       190        200        210        220        230        240 
TTTVTEPHKS RDHTERMLSA FGVKLSEDQT SVSIAGGQKL TAADIFVPGD ISSAAFFLAA 

       250        260        270        280        290        300 
GAMVPNSRIV LKNVGLNPTR TGIIDVLQNM GAKLEIKPSA DSGAEPYGDL IIETSSLKAV 

       310        320        330        340        350        360 
EIGGDIIPRL IDEIPIIALL ATQAEGTTVI KDAAELKVKE TNRIDTVVSE LRKLGAEIEP 

       370        380        390        400        410        420 
TADGMKVYGK QTLKGGAAVS SHGDHRIGMM LGIASCITEE PIEIEHTDAI HVSYPTFFEH 


LNKLSKKS

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References

« Hide 'large scale' references
[1]"The organization and nucleotide sequence of the Bacillus subtilis hisH, tyrA and aroE genes."
Henner D.J., Band L., Flaggs G., Chen E.
Gene 49:147-152(1986) [PubMed: 3106153] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

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Cross-references

Sequence databases

M80245 Genomic DNA. Translation: AAA20869.1.
AL009126 Genomic DNA. Translation: CAB14176.1.
PIRC26532.
RefSeqNP_390141.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID939014.
GenomeReviewsGene locus BSU22600 in contig AL009126_GR.
KEGGbsu:BSU22600.
NMPDRfig|224308.1.peg.2264.

Organism-specific databases

SubtiListBG10294. aroE. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMP20691.
OMADPLELMG.

Enzyme and pathway databases

BioCycBSUB224308:BSU2259-MON.
BRENDA2.5.1.19. 150.

Family and domain databases

HAMAPMF_00210.
[Tree]
InterProIPR016228. EPSP_synthase.
IPR001986. EPSP_synthase_core.
IPR006264. EPSP_synthase_subgroup.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
ProDomPD001867. EPSP_synth. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01356. aroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameAROA_BACSU
AccessionPrimary (citable) accession number: P20691
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 3, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents