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P20684 (COX3_ONCCL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:mt-co3
Synonyms:coiii, coxiii, mtco3
Encoded onMitochondrion
OrganismOncorhynchus clarkii (Cutthroat trout) (Salmo clarkii)
Taxonomic identifier30962 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183816

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane32 – 5221Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P20684 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 434ECAA20954626E

FASTA26129,705
        10         20         30         40         50         60 
MAHQAHAYHM VDPSPWPLTG AIAALLLTSG TAVWFHFHSL TLLTLGNILL LLTMYQWWRD 

        70         80         90        100        110        120 
IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA FYHASLAPTP ELGGCWPPTG 

       130        140        150        160        170        180 
ITTLDPFEVP LLNTAVLLAS GVTVTWAHHS IMEGERKQTI QALTLTILLG FYFTFLQGME 

       190        200        210        220        230        240 
YYEAPFTIAD GVYGSTFFVA TGFHGLHVII GSTFLAVCLL RQVQYHFTSE HHFGFEAAAW 

       250        260 
YWHFVDVVWL FLYVSIYWWG S 

« Hide

References

[1]"Variation in salmonid mitochondrial DNA: evolutionary constraints and mechanisms of substitution."
Thomas W.K., Beckenbach A.T.
J. Mol. Evol. 29:233-245(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

PIRD30396.

3D structure databases

ProteinModelPortalP20684.
SMRP20684. Positions 1-261.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG016686.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_ONCCL
AccessionPrimary (citable) accession number: P20684
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families