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P20682 (COX2_PODAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina) [Complete proteome]
Taxonomic identifier515849 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Cytochrome c oxidase subunit 2
PRO_0000183665

Regions

Topological domain1 – 3939Mitochondrial intermembrane Potential
Transmembrane40 – 6021Helical; Potential
Topological domain61 – 8121Mitochondrial matrix Potential
Transmembrane82 – 10423Helical; Potential
Topological domain105 – 250146Mitochondrial intermembrane Potential

Sites

Metal binding1851Copper A Probable
Metal binding2201Copper A Probable
Metal binding2241Copper A Probable
Metal binding2281Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P20682 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 4A3E094E9C682997

FASTA25028,541
        10         20         30         40         50         60 
MFFLINKLVM NFDAPSPWGI YFQDSATPQM EGLNELHDNI MYYLVVILFA VGWILLSIVI 

        70         80         90        100        110        120 
NYVSTKSPIS HKYLNHGTLI ELIWTITPAV ILILIAFPSF KLLYLMDEVS DPSMSVLAEG 

       130        140        150        160        170        180 
HQWYWSYQYP DFLDSNDQFI EFDSYIVPES DLDEGGLRML EVDNRVVLPE LTHVRFIITA 

       190        200        210        220        230        240 
GDVIHSFAAP ALGIKCDAYP GRLNQVSVFI NREGVFYGQC SEICGILHSS MPIVIESVSL 

       250 
EKFLIWLKEQ 

« Hide

References

« Hide 'large scale' references
[1]"Mitochondrial DNA sequence analysis of the cytochrome oxidase subunit II gene from Podospora anserina. A group IA intron with a putative alternative splice site."
Cummings D.J., Michel F., Domenico J.M., McNally K.L.
J. Mol. Biol. 212:287-294(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: A and s.
[2]"The complete DNA sequence of the mitochondrial genome of Podospora anserina."
Cummings D.J., McNally K.L., Domenico J.M., Matsuura E.T.
Curr. Genet. 17:375-402(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: s.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55026 Genomic DNA. Translation: CAA38803.1.
PIROBJJMP. S09135.
RefSeqNP_074950.1. NC_001329.3.

3D structure databases

ProteinModelPortalP20682.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID802467.
KEGGpan:PoanfMp43.

Phylogenomic databases

KOK02261.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_PODAN
AccessionPrimary (citable) accession number: P20682
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 19, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families