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P20681

- COX1_PODAN

UniProt

P20681 - COX1_PODAN

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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Iron (heme A axial ligand)Curated
Metal bindingi247 – 2471Copper BCurated
Metal bindingi251 – 2511Copper BCurated
Metal bindingi296 – 2961Copper BCurated
Metal bindingi297 – 2971Copper BCurated
Metal bindingi382 – 3821Iron (heme A3 axial ligand)Curated
Metal bindingi384 – 3841Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Synonyms:CO1
Encoded oniMitochondrion
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence AnalysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Transmembranei383 – 40321HelicalSequence AnalysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence AnalysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Cytochrome c oxidase subunit 1PRO_0000183397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP20681.
SMRiP20681. Positions 7-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02256.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20681-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGGVSLWIE RWMLSTNAKD IGNLYLIFAL FSGLLGTAFS VLIRMELSGP
60 70 80 90 100
SVQYIADNQL YNSIITAHAL LMIFFMVMPA LIGGFGNFLL PLLVGGPDMA
110 120 130 140 150
FPRLNNISFW LLPPSLILLV FSACIEGGAG TGWTIYPPLS GVQSHSGPSV
160 170 180 190 200
DLAIFALHLS GVSSLLGAMN FITTIMNMRT PSIRLHKLAL FGWAVIITAV
210 220 230 240 250
LLLLSLPVLA GAITMLLTDR NFNTSFFETA GGGDPILFQH LFWFFGHPEV
260 270 280 290 300
YILIIPAFGI ISTTISAYSN KSVFGYIGMV YAMMSIGILG FIVWSHHMYT
310 320 330 340 350
VGLDVDTRAY FTAATLIIAV PTGIKIFSWL ATCYGGSIRL TPSMLFALGF
360 370 380 390 400
VFMFTIGGLS GVVLANASLD IAFHDTYYVV AHFHYVLSMG AVFAMFSGWY
410 420 430 440 450
FWIPKMLGLN YNMTLSKVQF WILFIGVNVT FFPQHFLGLQ GMPRRISDYP
460 470 480 490 500
DAFAGWNLIS SFGSIISVVA AWLFLYIVYL QLVEGEYAGR FPWLNPQFYT
510 520 530 540
DTLQALLNRS YPSLEWALSS PPKPHAFVSL PLQSNILRSL F
Length:541
Mass (Da):59,737
Last modified:July 1, 1993 - v2
Checksum:i06AF3D497D03DAF2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231N → T no nucleotide entry (PubMed:2357736)Curated
Sequence conflicti23 – 231N → T in CAA30131. (PubMed:2836091)Curated
Sequence conflicti51 – 511S → G no nucleotide entry (PubMed:2357736)Curated
Sequence conflicti51 – 511S → G in CAA30131. (PubMed:2836091)Curated
Sequence conflicti414 – 4141T → I in AAA32001. (PubMed:3246349)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55026 Genomic DNA. Translation: CAA38777.1.
M28703 Genomic DNA. Translation: AAA32001.2.
X07119, X07120 Genomic DNA. Translation: CAA30131.1.
X07121 Genomic DNA. Translation: CAA30132.1.
PIRiA48327.
RefSeqiNP_074924.1. NC_001329.3.

Genome annotation databases

GeneIDi802462.
KEGGipan:PoanfMp17.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55026 Genomic DNA. Translation: CAA38777.1 .
M28703 Genomic DNA. Translation: AAA32001.2 .
X07119 , X07120 Genomic DNA. Translation: CAA30131.1 .
X07121 Genomic DNA. Translation: CAA30132.1 .
PIRi A48327.
RefSeqi NP_074924.1. NC_001329.3.

3D structure databases

ProteinModelPortali P20681.
SMRi P20681. Positions 7-527.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 802462.
KEGGi pan:PoanfMp17.

Phylogenomic databases

KOi K02256.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence analysis of the 24.5 kilobase pair cytochrome oxidase subunit I mitochondrial gene from Podospora anserina: a gene with sixteen introns."
    Cummings D.J., Michel F., McNally K.L.
    Curr. Genet. 16:381-406(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of the mitochondrial genome of Podospora anserina."
    Cummings D.J., McNally K.L., Domenico J.M., Matsuura E.T.
    Curr. Genet. 17:375-402(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: s.
  3. "Senescence in Podospora anserina: a possible role for nucleic acid interacting proteins suggested by the sequence analysis of a mitochondrial DNA region specifically amplified in senescent cultures."
    Vierny-Jamet C.
    Gene 74:387-398(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 376-541.
    Strain: s.
  4. "The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina."
    Kueck U., Osiewacz H.D., Schmidt U., Kappelhoff B., Schulte E., Stahl U., Esser K.
    Curr. Genet. 9:373-382(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-86 AND 212-242.

Entry informationi

Entry nameiCOX1_PODAN
AccessioniPrimary (citable) accession number: P20681
Secondary accession number(s): O21208, Q35363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3