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P20681

- COX1_PODAN

UniProt

P20681 - COX1_PODAN

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Protein
Cytochrome c oxidase subunit 1
Gene
COI, CO1
Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Iron (heme A axial ligand) Inferred
Metal bindingi247 – 2471Copper B Inferred
Metal bindingi251 – 2511Copper B Inferred
Metal bindingi296 – 2961Copper B Inferred
Metal bindingi297 – 2971Copper B Inferred
Metal bindingi382 – 3821Iron (heme A3 axial ligand) Inferred
Metal bindingi384 – 3841Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Synonyms:CO1
Encoded oniMitochondrion
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321Helical; Reviewed prediction
Add
BLAST
Transmembranei70 – 9021Helical; Reviewed prediction
Add
BLAST
Transmembranei107 – 12721Helical; Reviewed prediction
Add
BLAST
Transmembranei152 – 17221Helical; Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Reviewed prediction
Add
BLAST
Transmembranei241 – 26121Helical; Reviewed prediction
Add
BLAST
Transmembranei273 – 29321Helical; Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Reviewed prediction
Add
BLAST
Transmembranei344 – 36421Helical; Reviewed prediction
Add
BLAST
Transmembranei383 – 40321Helical; Reviewed prediction
Add
BLAST
Transmembranei418 – 43821Helical; Reviewed prediction
Add
BLAST
Transmembranei458 – 47821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Cytochrome c oxidase subunit 1
PRO_0000183397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP20681.
SMRiP20681. Positions 7-527.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02256.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20681-1 [UniParc]FASTAAdd to Basket

« Hide

MSGGVSLWIE RWMLSTNAKD IGNLYLIFAL FSGLLGTAFS VLIRMELSGP    50
SVQYIADNQL YNSIITAHAL LMIFFMVMPA LIGGFGNFLL PLLVGGPDMA 100
FPRLNNISFW LLPPSLILLV FSACIEGGAG TGWTIYPPLS GVQSHSGPSV 150
DLAIFALHLS GVSSLLGAMN FITTIMNMRT PSIRLHKLAL FGWAVIITAV 200
LLLLSLPVLA GAITMLLTDR NFNTSFFETA GGGDPILFQH LFWFFGHPEV 250
YILIIPAFGI ISTTISAYSN KSVFGYIGMV YAMMSIGILG FIVWSHHMYT 300
VGLDVDTRAY FTAATLIIAV PTGIKIFSWL ATCYGGSIRL TPSMLFALGF 350
VFMFTIGGLS GVVLANASLD IAFHDTYYVV AHFHYVLSMG AVFAMFSGWY 400
FWIPKMLGLN YNMTLSKVQF WILFIGVNVT FFPQHFLGLQ GMPRRISDYP 450
DAFAGWNLIS SFGSIISVVA AWLFLYIVYL QLVEGEYAGR FPWLNPQFYT 500
DTLQALLNRS YPSLEWALSS PPKPHAFVSL PLQSNILRSL F 541
Length:541
Mass (Da):59,737
Last modified:July 1, 1993 - v2
Checksum:i06AF3D497D03DAF2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231N → T no nucleotide entry 1 Publication
Sequence conflicti23 – 231N → T in CAA30131. 1 Publication
Sequence conflicti51 – 511S → G no nucleotide entry 1 Publication
Sequence conflicti51 – 511S → G in CAA30131. 1 Publication
Sequence conflicti414 – 4141T → I in AAA32001. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55026 Genomic DNA. Translation: CAA38777.1.
M28703 Genomic DNA. Translation: AAA32001.2.
X07119, X07120 Genomic DNA. Translation: CAA30131.1.
X07121 Genomic DNA. Translation: CAA30132.1.
PIRiA48327.
RefSeqiNP_074924.1. NC_001329.3.

Genome annotation databases

GeneIDi802462.
KEGGipan:PoanfMp17.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55026 Genomic DNA. Translation: CAA38777.1 .
M28703 Genomic DNA. Translation: AAA32001.2 .
X07119 , X07120 Genomic DNA. Translation: CAA30131.1 .
X07121 Genomic DNA. Translation: CAA30132.1 .
PIRi A48327.
RefSeqi NP_074924.1. NC_001329.3.

3D structure databases

ProteinModelPortali P20681.
SMRi P20681. Positions 7-527.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 802462.
KEGGi pan:PoanfMp17.

Phylogenomic databases

KOi K02256.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence analysis of the 24.5 kilobase pair cytochrome oxidase subunit I mitochondrial gene from Podospora anserina: a gene with sixteen introns."
    Cummings D.J., Michel F., McNally K.L.
    Curr. Genet. 16:381-406(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of the mitochondrial genome of Podospora anserina."
    Cummings D.J., McNally K.L., Domenico J.M., Matsuura E.T.
    Curr. Genet. 17:375-402(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: s.
  3. "Senescence in Podospora anserina: a possible role for nucleic acid interacting proteins suggested by the sequence analysis of a mitochondrial DNA region specifically amplified in senescent cultures."
    Vierny-Jamet C.
    Gene 74:387-398(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 376-541.
    Strain: s.
  4. "The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina."
    Kueck U., Osiewacz H.D., Schmidt U., Kappelhoff B., Schulte E., Stahl U., Esser K.
    Curr. Genet. 9:373-382(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-86 AND 212-242.

Entry informationi

Entry nameiCOX1_PODAN
AccessioniPrimary (citable) accession number: P20681
Secondary accession number(s): O21208, Q35363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 1, 1993
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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