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P20681

- COX1_PODAN

UniProt

P20681 - COX1_PODAN

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi68 – 681Iron (heme A axial ligand)Curated
    Metal bindingi247 – 2471Copper BCurated
    Metal bindingi251 – 2511Copper BCurated
    Metal bindingi296 – 2961Copper BCurated
    Metal bindingi297 – 2971Copper BCurated
    Metal bindingi382 – 3821Iron (heme A3 axial ligand)Curated
    Metal bindingi384 – 3841Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Synonyms:CO1
    Encoded oniMitochondrion
    OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
    Taxonomic identifieri515849 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
    ProteomesiUP000001197: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541Cytochrome c oxidase subunit 1PRO_0000183397Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP20681.
    SMRiP20681. Positions 7-527.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei383 – 40321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK02256.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P20681-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGGVSLWIE RWMLSTNAKD IGNLYLIFAL FSGLLGTAFS VLIRMELSGP    50
    SVQYIADNQL YNSIITAHAL LMIFFMVMPA LIGGFGNFLL PLLVGGPDMA 100
    FPRLNNISFW LLPPSLILLV FSACIEGGAG TGWTIYPPLS GVQSHSGPSV 150
    DLAIFALHLS GVSSLLGAMN FITTIMNMRT PSIRLHKLAL FGWAVIITAV 200
    LLLLSLPVLA GAITMLLTDR NFNTSFFETA GGGDPILFQH LFWFFGHPEV 250
    YILIIPAFGI ISTTISAYSN KSVFGYIGMV YAMMSIGILG FIVWSHHMYT 300
    VGLDVDTRAY FTAATLIIAV PTGIKIFSWL ATCYGGSIRL TPSMLFALGF 350
    VFMFTIGGLS GVVLANASLD IAFHDTYYVV AHFHYVLSMG AVFAMFSGWY 400
    FWIPKMLGLN YNMTLSKVQF WILFIGVNVT FFPQHFLGLQ GMPRRISDYP 450
    DAFAGWNLIS SFGSIISVVA AWLFLYIVYL QLVEGEYAGR FPWLNPQFYT 500
    DTLQALLNRS YPSLEWALSS PPKPHAFVSL PLQSNILRSL F 541
    Length:541
    Mass (Da):59,737
    Last modified:July 1, 1993 - v2
    Checksum:i06AF3D497D03DAF2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231N → T no nucleotide entry (PubMed:2357736)Curated
    Sequence conflicti23 – 231N → T in CAA30131. (PubMed:2836091)Curated
    Sequence conflicti51 – 511S → G no nucleotide entry (PubMed:2357736)Curated
    Sequence conflicti51 – 511S → G in CAA30131. (PubMed:2836091)Curated
    Sequence conflicti414 – 4141T → I in AAA32001. (PubMed:3246349)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55026 Genomic DNA. Translation: CAA38777.1.
    M28703 Genomic DNA. Translation: AAA32001.2.
    X07119, X07120 Genomic DNA. Translation: CAA30131.1.
    X07121 Genomic DNA. Translation: CAA30132.1.
    PIRiA48327.
    RefSeqiNP_074924.1. NC_001329.3.

    Genome annotation databases

    GeneIDi802462.
    KEGGipan:PoanfMp17.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55026 Genomic DNA. Translation: CAA38777.1 .
    M28703 Genomic DNA. Translation: AAA32001.2 .
    X07119 , X07120 Genomic DNA. Translation: CAA30131.1 .
    X07121 Genomic DNA. Translation: CAA30132.1 .
    PIRi A48327.
    RefSeqi NP_074924.1. NC_001329.3.

    3D structure databases

    ProteinModelPortali P20681.
    SMRi P20681. Positions 7-527.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 802462.
    KEGGi pan:PoanfMp17.

    Phylogenomic databases

    KOi K02256.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence analysis of the 24.5 kilobase pair cytochrome oxidase subunit I mitochondrial gene from Podospora anserina: a gene with sixteen introns."
      Cummings D.J., Michel F., McNally K.L.
      Curr. Genet. 16:381-406(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete DNA sequence of the mitochondrial genome of Podospora anserina."
      Cummings D.J., McNally K.L., Domenico J.M., Matsuura E.T.
      Curr. Genet. 17:375-402(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: s.
    3. "Senescence in Podospora anserina: a possible role for nucleic acid interacting proteins suggested by the sequence analysis of a mitochondrial DNA region specifically amplified in senescent cultures."
      Vierny-Jamet C.
      Gene 74:387-398(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 376-541.
      Strain: s.
    4. "The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina."
      Kueck U., Osiewacz H.D., Schmidt U., Kappelhoff B., Schulte E., Stahl U., Esser K.
      Curr. Genet. 9:373-382(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-86 AND 212-242.

    Entry informationi

    Entry nameiCOX1_PODAN
    AccessioniPrimary (citable) accession number: P20681
    Secondary accession number(s): O21208, Q35363
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3